Silhueta de pessoa indiferenciada

Leonor Cancela

Professor catedrático
Faculdade de Medicina e Ciências Biomédicas
Subsistema
Orgãos de Gestão
Regime
Exclusividade
Vínculo
CT em Funções Públicas por tempo indeterminado
Leonor Cancela /LC is Full Professor at the Faculty of Medicine and Biomedical Sciences of the University of Algarve/UALG, member of the Algarve Biomedical Centre and founding member of the Centre for Marine Sciences /CCMAR. - She developed her undergraduate/graduate studies at University Paris VI- Pierre et Marie Curie and her PhD work at INSERM/ Hospital Lariboisière, in Paris where she was awarded her PhD in 1985 with honors. She was hired as a postdoctoral researcher by the Univ. of California between Jan 1986-Jan 1988 at the UC Riverside campus and between Feb1988- Nov1992 at the UC San Diego campus. She obtained a position at UALG in Dec1992 and became full professor in 2006. - She was elected President of the Portuguese Biochemical Society between 2005-2008 and is member of the board of the Portuguese Society of Genetics since 2010, elected as President in January 2020 to present. - She is Director of the Bachelor and PhD programs in Biomedical Sciences of the UALG since their implementation, Director of the UALG Doctoral College by rector nomination since 2019 and held several academic positions including director of the Department of Biomedical Sciences and Medicine and President of the Pedagogic and Scientific councils for several terms. - - She is currently President of the Scientific Council of the newly created Faculty of Medicine and Biomedical Sciences of the University of Algarve. - She implemented in 1994 the BIOSKEL research laboratory that she leads since then (http://bioskel.ccmar.ualg.pt) and has coordinated over 150 undergraduate, PhDs and postdoctoral fellows, published over 200 articles in international journals, 15 book chapters, and is co-author of 7 patents and 3 registered marks. - She has implemented in 2008 the Lab.it project to provide hands-on training in molecular biology to high school students and teachers and contribute to disseminate information on the use of molecular tools to different society applications. - She is the co-founder of Technozeb, a Business Unit of Technophage SA involved in the discovery of molecules with therapeutic interest using zebrafish. - She is regularly invited to give seminars and integrate academic juris and evaluation panels in national/international institutions and agencies, including chair of ERC committees. - Research interests focus in molecular, environmental and epigenetic determinants of skeletogenesis in health and disease and the use of zebrafish as model for human pathologies with skeletal phenotypes. - LC participated in the development of several in vitro cell systems and in vivo assays that were used to uncover cellular and molecular mechanisms of bone formation and regeneration but also bone matrix mineralization in zebrafish and farmed fish. Recently these tools are being applied to the screening of natural extracts (e.g. from seaweeds and microalgae) and compound libraries to discover molecules that could serve as the next generation therapeutics against human pathologies including rare diseases such as the Keutel or the CDKL5 syndromes, and skeletal disorders such as osteoporosis and Paget's Disease of bone.

Atividades

Atividades
2020/03/01 - Presente. Orientação. IDENTIFICATION OF NOVEL CDKL5 MOLECULAR TARGETS/PATHWAYS ASSOCIATED WITH SKELETAL DEFECTS PRESENT IN CDKL5 ASSOCIATED DISORDERS.Biomedical Sciences (Doutoramento). Coorientador.
2019/03/01 - Presente. Orientação. Epigenetic regulation of ZNF687 in bone cells: elucidation of its role in the progression of Paget’s disease towards giant cell tumor of bone.Biomedical Sciences (Doutoramento). Coorientador.
2019/01 - Presente. Orientação. Effect of marine derived extract on osteogenesis and mineralogenesis.Biomedical Sciences (Doutoramento). Coorientador.
2019/01 - Presente. Orientação. Effects of anti- and pro-oxidants in bone mineralization and remodelling.Biomedical Sciences (Doutoramento). Coorientador.
2017/10 - Presente. Orientação. How microplastics and adsorbed pollutants affect zebrafish development?.PhD Program in Marine, Earth and Environmental Sciences, (Doutoramento). Coorientador.
2017 - Presente. Orientação. Molecular basis for the epigenetic regulation of MGP in cancer.Ciencias Biomédicas (Doutoramento). Coorientador.
Membro de associação. European Calcified Tissue Society. member.
Membro de associação. Sociedade Portuguesa de Bioquimica-Member(ongoing). Presidente elect 2005-2008. President of the General Assembly2009-2010. Member.
Membro de associação. President of the Portuguese Society of Genetics, elected in January 2020 for 2 year period. Re-elected for a second 2yr term until January 2024. President.
2021 - 2025. Membro de comissão. Presidente do Conselho Cientifico . Presidente / Vice-presidente. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2020/02 - 2025/01. Membro de comissão. Presidente da Socidade Portuguesa de Genética / President of the Portuguese Society of Genetics . Presidente / Vice-presidente. Sociedade Portuguesa de Genética.
2019 - 2025. Membro de comissão. Director of the Doctoral College, University of Algarve, by appointment of the rector. Diretor. Universidade do Algarve.
2006 - 2025. Membro de comissão. Director of the Bachelor degree (Licenciatura) in Biomedical Sciences. Diretor. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2022/01/24. Júri de grau académico. PhD em Ciências Biomédicas, especialidade de Neurociências, Faculdade Medicina da Universidade de Lisboa, . Arguente principal. Catarina Miranda Lourenço, (Doutoramento). Universidade de Lisboa Faculdade de Medicina.
2022/01/14. Júri de grau académico. Provas de Agregação em ECOLOGIA HUMANA E ADAPTAÇÃO. Arguente principal. Cristina Maria Proença Padez (Agregação). Universidade de Coimbra Faculdade de Ciencias e Tecnologia.
2019/01 - 2022/12. Comissão de avaliação. Convite para integrar painel de avaliação dos relatorios finais de projectos da FCT 2019-2022, area da Biologia Experimental e Bioquimica. Fundação para a Ciência e a Tecnologia. Fundação para a Ciência e a Tecnologia.
2022/01 - 2022/07. Comissão de avaliação. A3ES: convite para avaliar novos cursos, área da biotecnologia.
2021/12 - 2022/05. Membro de comissão. procedimento concursal internacional para professor catedrático na Faculdade de Ciências e Tecnologia referência: P053-21-11331, area das ciencias da vida. Edital_1480_2021. Membro. Universidade de Coimbra.
2021/12 - 2022/01/04. Comissão de avaliação. Evaluation of postdoctoral fellowships- PARIS REGION FELLOWSHIP PROGRAMME. Paris Region FP. European Commission Marie Sklodowska-Curie Actions.
2021/06 - 2022/05. Arbitragem científica em conferência. Meeting of the European Calcified Tissue Society. Helsinquia 2022. ECTS.
2021/01/14. Júri de grau académico. Provas de Agregação em Ciencias Biomédicas- Celulas Estaminais. Vogal. José Eduardo Marques Bragança (Agregação). Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2021/11/05 - 2022/02/28. Comissão de avaliação. Invitation to participate in evaluation of the proposal(s) submitted in response to the following
call(s) for proposal(s):
- HORIZON-MSCA-2021-PF-01. European Commission. European Commission.
2021/11/01 - 2022/02/28. Membro de comissão. Membro da Comissão de avaliação das candidaturas ao curso de medicina da Universidade do Algarve- Avaliação e creditação de formação anterior de + de 100 candidaturas. Membro. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2021/02/12 - 2022/02/10. Membro de comissão. concurso documental internacional, para recrutamento na modalidade de contrato de trabalho em funções públicas por tempo indeterminado, para 1 posto de trabalho e provimento da respetiva vaga na categoria de professor catedrático na área disciplinar de Biomedicina, do mapa de pessoal docente da Universidade da Beira Interior, Edital n.º 192/2021 de 12 de Fev de 2021. Membro. Universidade da Beira Interior.
2021/12 - 2022/02/07. Comissão de avaliação.
21-FWO-PDOC-0556 - Harnessing transcriptome and proteome wide analyses and engineered reporter assays to unravel the immunopathogenesis of 'multisystem inflammatory syndrome in children' (MIS-C).. European Science Foundation. Research Foundation Flanders’ (FWO) .
2022/02. Júri de grau académico. PhD: Stress granules in Polyglutamine diseases: new targets for therapeutic intervention? . Presidente do júri. Adriana do Vale Marcelo (Doutoramento). Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2021/12 - 2022. Comissão de avaliação. A3ES_Convite para participar na avaliação de novos ciclos de estudo na area da Biologia / Biomedicina. A3ES.
2021/12 - 2022/01. Comissão de avaliação. Avaliação do relatório de atividades da Prof Associada do departamento de Biologia Animal da FCUL. Universidade de Lisboa, Faculdade de Ciências.
2021/12/01 - 2021/12/31. Comissão de avaliação. European Calcified Tissue Society- evaluation of applications for ECTS Academy. European Calcified Tissue Society. European Calcified Tissue Society.
2015/09 - 2021/12/13. Comissão de avaliação. Invitation to be part of the evaluation committee for annual applications for Medalhas l'Oreal. Fundação para a Ciência e a Tecnologia. Fundação L'Oreal.
2021/04 - 2021/10/31. Organização de evento. Organização do Encontro anual de doutorandos da Universidade do Algarve https://www.ualg.pt/en/doctoral-college (2021). Universidade do Algarve.
2021/09/21. Apresentação oral de trabalho. Holt Oram syndrome and Thalidomide toxicity: same molecular targets??
. Webinar series_COST action Eurosoftcalcnet. Tamas Aranyi (online, Hungria).
2021/09. Júri de grau académico. PhD: Development of a high throughput screening strategy for drug discovery: from marine fungi to stem cell application. Arguente principal. Pietro Marchese (Doutoramento). National University of Ireland Galway School of Medicine.
2021/07 - 2021/09. Comissão de avaliação. Participate in peer review of scientific proposals submitted to ERC starting grant 2021 call. European Research Council. European Research Council.
2021/07/30. Júri de grau académico. Provas de Agregação em Biomedicina: Celulas estaminais e terapias celulares. Arguente principal. Liliana Inácio Bernardino (Agregação). Universidade da Beira Interior Faculdade de Ciências da Saúde.
2020/06 - 2021/06. Arbitragem científica em conferência. European Calcified Tissue Society Congress . ECTS.
2021/05/28. Júri de grau académico. Provas de Agregação em Biologia, especialidade de Biologia Celular e Saúde. Arguente principal. Sandra Cristina Almeida Paiva (Agregação). Universidade do Minho Escola de Ciências.
2021 - 2021/04/26. Membro de comissão. Concurso internacional para ocupação de um posto de trabalho da carreira docente universitária, na categoria de Professor Associado, área disciplinar de Ciências da Vida, especialidade de Biofísica, Bioeletrónica e Biosensores da Faculdade de Ciências e Tecnologia da Universidade de Coimbra, cujo edital Edital n.º 273/2021, publicado em Diário da República, 2.ª série, n.º 44, de 04/03.. Membro. Universidade de Coimbra Departamento de Ciências da Vida.
2021/02 - 2021/03. Comissão de avaliação. Invitation to integrate evaluation committee for FWO postdoctoral applications. Research Foundation Flanders’ (FWO) . Research Foundation Flanders’ (FWO) .
Membro de associação. American Society for Bone and Mineral Research. member.
2012 - 2017. Orientação. "CONTRIBUTION TO THE MOLECULAR CHARACTERIZATION OF OSTEOARTHRITIS AND OSTEOPOROSIS PHENOTYPES ASSOCIATED WITH HEREDITARY HEMOCHROMATOSIS".Ciências Biomédicas (Doutoramento). Orientador.
2013 - 2016/10. Orientação. Characterization of the histological and genetic profile of articular damage in a hemochromatosis mouse model". .Medicina (Doutoramento). Orientador.
2011 - 2016. Orientação. Characterization of bone pathologies in the ins2+/akita mouse, a new model for diabetes insulindependent: contribution for a better understanding of the disease in humans.Ciências Biomédicas (Doutoramento). Orientador.
2015. Júri de grau académico. DRUG REPURPOSING IN THE TREATMENT OF MELANOMA BRAIN METASTASIS. Vogal. BILLY SAMUEL HILL (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.
2012 - 2015. Orientação. Genetic and functional analysis of the PDB6 locus in Paget´s disease of bone.Ciências Biomédicas (Doutoramento). Orientador.
2010 - 2015. Orientação. Mef2c: Expression, Regulation and Interaction with Target Genes in Health and Diseases.Ciências Biomédicas (Doutoramento). Orientador.
2010 - 2015. Orientação. Molecular Characterization of Gla Rich Protein (GRP) Gene Expression and Function.Ciências Biomédicas (Doutoramento). Orientador.
2009 - 2015. Orientação. IDENTIFICATION OF NOVEL MOLECULAR DETERMINANTS OF TISSUE MINERALIZATION IN FISH.Ciências Biomédicas (Doutoramento). Orientador.
2008 - 2015. Orientação. EVOLUTION, GENE REGULATION AND FUNCTIONAL ANALYSISN OF BMP2 IN FISH.Ciências Biomédicas (Doutoramento). Orientador.
2007 - 2014. Orientação. MOLECULAR STRUCTURE AND FUNCTIONAL ANALYSIS OF RUNX3 IN ZEBRAFISH.Ciências Biomédicas (Doutoramento). Orientador.
2009 - 2012/12. Orientação. Insights into molecular and cellular events involved in human pathological fusion of vertebral joints through the use of zebrafish as model organism.Molecular and Cellular Biology (Doutoramento). Coorientador.
2008 - 2012/05. Orientação. Characterization of metabolic pathways in the protozoan parasite Perkinsus atlanticus/olseni: Identification of potential targets for therapeutic drugs.Bioquimica (Doutoramento). Orientador.
2004/09/01 - 2012/02. Orientação. Abundance, site fidelity and population structure of humpbacks whales (Megaptera novaeangliae) in S. Tomé e Príncipe”.Population Genetics (Doutoramento). Coorientador.
2008 - 2012. Orientação. Study of Perkinsus Olseni Infection Mechanisms: Identification and Regulation of Parasite Genes Differentially Expressed in Response to Host and Environmental Stress.Biologia (Doutoramento). Orientador.
2005/04/01 - 2011/05. Orientação. Role of the transcriptional regulator FHL2 in bone formation: Identification of fish bone-specific target genes and regulatory mechanisms".Bioquimica (Doutoramento). Coorientador.
2005/04 - 2010/07. Orientação. Identification and characterization of a new calcium binding protein from sturgeon, Gla rich protein or GRP. Contribution to unveil its function in vertebrates.BIoquimica (Doutoramento). Coorientador.
2004 - 2008. Membro de comissão. Presidente da Sociedade Portuguesa de Bioquimica / President of the Portuguese Society of Biochemistry. Presidente / Vice-presidente. Sociedade Portuguesa de Bioquimica.
2003/09/01 - 2008. Orientação. Effects of vanadate and insulin treatment on proliferation, differentiation and mineralization of two fish bone derived cell lines, Vsa13 e Vsa116.Bioquimica (Doutoramento). Coorientador.
2003 - 2008. Orientação. Identification of P. Atlanticus genes differentially expressed in response to parasite-host interaction and development of an in vivo infestation system.Biologia Molecular (Doutoramento). Coorientador.
1999 - 2006/11. Orientação. Population genetics of an endangered species, the Bonelli’s eagle(Hieraaetus fasciatus).Population genetics (Doutoramento). Coorientador.
2000 - 2005/07. Orientação. “Functional analysis of bone-related Gla proteins from bony fish during skeletal development”..Biologia Molecular (Doutoramento). Orientador.
1998 - 2003/01. Orientação. Matrix Gla protein (MGP) de peixe: abordagem bioquímica e estrutural para o esclarecimento da sua função biológica.Bioqumica (Doutoramento). Orientador.
1998 - 2002/12. Orientação. Controle da expressão genética da proteina da matriz extracelular “matrix Gla protein”: estudos comparativos em anfíbios e peixes.Molecular biology. Orientador.
1995 - 2001. Orientação. Clonagem do gene da proteína BGP (Bone Gla protein) do peixe ósseo Sparus aurata (dourada). Organização molecular, expressão ao longo do desenvolvimento e implicações evolutivas”. .Molecular biology (Doutoramento). Orientador.

Projetos

Projetos
2022/10 - 2026/09. INTEC-International Network on Ectopic Calcifications, INTEC-International Network on Ectopic Calcifications. Outra. Universiteit Gent; National Institute of Biology, Slovenia.
2018/08/01 - 2024/01/31. Aquaculture meets Biomedicine: Innovation in skeletal health research /BIOMEDAQU, Marie Sklodowska-Curie Actions-Innovative Training Networks . Investigador responsável. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2021/01/01 - 2025/12/31. Centre for Marine and Environmental Research, 6817 - DCRRNI ID. Centro de Ciências do Mar; Universidade do Porto Faculdade de Desporto.
2020/01/01 - 2023/01/31. ZEBRABLOOM_Desenvolvimento de produtos comerciais formulados com microalgas para o enriquecimento de presas vivas de peixe-zebra, Projeto de co.promoção. Investigador. Universidade do Algarve.
2018/08/01 - 2023/01/31. Biomedaqu / Aquaculture meets Biomedicine: Innovation in skeletal health research, MSCA-ITN-2017 — Innovative Training Networks. Investigador responsável. Universidade do Algarve; Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2023/03/10 - 2024/09/09. ZF screen_Screening for molecules capable of rescuing CDKL5 deficiency phenotypes using Zebrafish models, Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022. Investigador responsável. Centro de Ciências do Mar.
2019 - 2024/06. European transdisciplinary networking platform for marine biotechnology, COST ACTION CA18238. Outra. National Institute of Biology, Slovenia.
2020/03/01 - 2024/04/30. IDENTIFICATION OF NOVEL CDKL5 MOLECULAR TARGETS/PATHWAYS ASSOCIATED WITH SKELETAL DEFECTS PRESENT IN CDKL5 ASSOCIATED DISORDERS, PhD fellowships. Orientador. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve; Centro de Ciências do Mar.
2020/04/01 - 2024/03/31. Understanding the pathophysiology of Keutel Syndrome: A path towards cure, European Joint Program on Rare Diseases (EJP RD) . Investigador responsável. Centro de Ciências do Mar; Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2009 - 2024. Lab-it_Laboratório Itinerante de Biologia Molecular, Lab-it_Laboratório Itinerante de Biologia Molecular. Investigador responsável. Ciência Viva.
2021/01/01 - 2023/06/30. MarEmPó, COMPETE2020, CRESC Algarve 2020, PT2020 e FEDER. Investigador. Universidade do Algarve - Campus de Gambelas.
2018/11/01 - 2022/04/30. KCITAR ALGARVE, PORegional Algarve. Investigador. Universidade do Algarve - Campus de Gambelas.
2019/02/01 - 2021/12/31. Zebrafish as model to analyse CDKL5 function, Orphan Disease Center. Investigador responsável. Centro de Ciências do Mar; Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2018/01/01 - 2021/07/31. Novos compostos marinhos como fonte nutricional para uma melhoria de Qualidade e Bem estar de peixes em aquacultura. , MAR2020. Investigador responsável. Universidade do Algarve - Campus de Gambelas.
2018/01/01 - 2021/07/31. BLUE biotechnology as a road for innovation on human health aiming smart growth in Atlantic Area., Transnational Cooperation Programme Atlantic Area (Porto). Investigador responsável. Universidade do Algarve - Campus de Gambelas.
2017/04/01 - 2021/06/30. RED transfronteriza para el desarrollo de productos innovadores con microALGAs, European Commission (Brussels, Spain) INTERREG – POCTEP.. Investigador. Universidade do Algarve.
2017/04/01 - 2021/06/30. Desenvolvimento e implementação de alimentos suplementados em macroalgas ricas em vitamina K no cultivo do Linguado, Mar2020. Investigador. Universidade do Algarve - Campus de Gambelas.
2019/01/01 - 2019/12/31. Centre of Marine Sciences, 6817 - DCRRNI ID. Centro de Ciências do Mar.
2016/09/01 - 2019/12/31. Insights into Matrix Gla protein (MGP) regulation in colorectal cancer, Prize from Portuguese Society of Gastroenterology. Investigador responsável. Centro de Ciências do Mar.
2016/04/01 - 2019/03/31. Desenvolvimento de uma prémistura de micronutrientes para optimizar as dietas para larvas de peixes marinhos. , CRESC Algarve 2020. Investigador. Universidade do Algarve.
2013/10/01 - 2018/09/30. Clinical and molecular heterogeneity of Paget's disease of bone, Canadian Institutes of Health Research (CIHR) Operating grant program. Investigador. Centro de Ciências do Mar.
2014/11/01 - 2015/12/31. Estudo piloto para melhoramento do status nutricional em vitamina K: optimização da reprodução e demonstração da melhoria na qualidade larvar de linguado, PROMAR. Investigador. Programa Operacional Pesca 2007-2013 (PROMAR).
2012/01/01 - 2015/07/31. DEEPBONE - Bone biology of deep-sea teleost fish, Concurso de Projectos de Investigação Científica e Desenvolvimento Tecnológico em todos os Domínios Científicos - 2010. Investigador. Centro de Ciências do Mar.
2012 - 2015. iONE-FP7 project Implantable Organic Nano-Electronics, I-ONE. Investigador. Universidade do Algarve.
2012 - 2015. Desenvolvimento de rações optimizados para desenvolvimennto e crescimento do peixe zebra, um modelo com aplicações biomédicas, QREN I&DT – Co-promoção. Investigador. Universidade do Algarve.
2011/06/01 - 2014/05/31. Intelligent Cell Surfaces (ICS), EUROCORES. Investigador. Universidade do Algarve.
2012 - 2014. Development of innovating biomedical products from marine resources valorisation., MARMED. Investigador. Universidade do Algarve Departamento de Ciências Biomédicas e Medicina.
2010/01/01 - 2013/07/31. Studies for the establishement of GRP as a biomarker for vascular calcification, Concurso para Projectos de I&D em todos os Domínios Científicos - 2008. Investigador. Centro de Ciências do Mar; Hospital de Faro; University of Minnesota Twin Cities Department of Medicine; Instituto de Biotecnologia e Bioengenharia; Universidade do Algarve.
2010 - 2013. Effects of dietary vitamin K supplementation on growth and skeletal development of teleost fish , SpecialK . Investigador. Centro de Ciências do Mar.
2009 - 2013. Development and characterization of zebrafish stem cells: implications for transgenesis , FISHCell. Investigador. Centro de Ciências do Mar.
2011/01/01 - 2012/12/31. Strategic Project - LA 15 - 2011-2012, 6820 - DCRRNI ID. Centro de Investigação Marinha e Ambiental; Universidade do Porto Faculdade de Desporto; Centro de Ciências do Mar.
2008/08/01 - 2011/12/31. Dietary fatty acids as modulators of bone metabolism in gilthead sea bream (Sparus aurata) - FATTYBONE, Concurso para Projectos de I&D em todos os Domínios Científicos - 2006. Investigador. Centro de Ciências do Mar.
2007/08/01 - 2010/07/31. Characterization of isoprenoids biosynthesis and determination of potential therapeutic targets, Concurso para Projectos de I&D em todos os Domínios Científicos - 2006. Investigador responsável. Centro de Ciências do Mar.
2006/01/01 - 2008/12/31. Effects of xenobiotics in skeleton development and fin regeneration in fish, Concurso para Projectos de I&D em todos os Domínios Científicos - 2004. Investigador. Centro de Ciências do Mar.
2005/06/01 - 2008/06/30. Spatial-temporal pattern of expression and regulation of Matrix Gla Protein (MGP) during early development in X. laevis, Concurso para Projectos de I&D em todos os Domínios Científicos - 2004. Investigador. Centro de Ciências do Mar; Universidade do Algarve.
2005/06/01 - 2008/05/31. Characterisation of the folate and purine metabolism in the protozoan parasite Perkinsus atlanticus: identification of genes involved in these pathways and potential therapeuthic targets, Concurso para Projectos de I&D em todos os Domínios Científicos - 2004. Investigador responsável. Centro de Ciências do Mar.

Produções

Fernández, I.; Gavaia, P.J.; Laizé, V.; Cancela, M.L.. 2018. "Fish as a model to assess chemical toxicity in bone". Aquatic Toxicology, 194: 208-226. https://doi.org/10.1016/j.aquatox.2017.11.015
Marques, C.; Roberto, V.P.; Granadeiro, L.; Trindade, M.; Gavaia, P.J.; Laizé, V.; Cancela, M.L.; Fernández, I.. 2017. "The xenobiotic sensor PXR in a marine flatfish species (Solea senegalensis): Gene expression patterns and its regulation under different physiological conditions". Marine Environmental Research, 130: 187-199. https://doi.org/10.1016/j.marenvres.2017.07.021
Saavedra, Carlos; Milan, Massimo; Leite, Ricardo B.; Cordero, David; Patarnello, Tomaso; Cancela, M. Leonor; Bargelloni, Luca. 2017. "A Microarray Study of Carpet-Shell Clam (Ruditapes decussatus) Shows Common and Organ-Specific Growth-Related Gene Expression Differences in Gills and Digestive Gland". Frontiers in Physiology, 8. https://doi.org/10.3389/fphys.2017.00943
Surget, G.; Roberto, V.P.; Le Lann, K.; Mira, S.; Guérard, F.; Laizé, V.; Poupart, N.; Cancela, M.L.; Stiger-Pouvreau, V.. 2017. "Marine green macroalgae: a source of natural compounds with mineralogenic and antioxidant activities". Journal of Applied Phycology, 29 (1): 575-584. https://doi.org/10.1007/s10811-016-0968-3
Carvalho, Filipe R.; Fernandes, Ana R.; Cancela, M. Leonor; Gavaia, Paulo J.. 2017. "Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with paricalcitol and cinacalcet". Wound Repair and Regeneration, 25 (3): 432-442. https://doi.org/10.1111/wrr.12536
Ferreira-Rodríguez, N.; Fernández, I.; Varandas, S.; Cortes, R.; Cancela, M.L.; Pardo, I.. 2017. "The role of calcium concentration in the invasive capacity of Corbicula fluminea in crystalline basins". Science of the Total Environment, 580: 1363-1370. https://doi.org/10.1016/j.scitotenv.2016.12.100
Tarasco, M.; Laizé, V.; Cardeira, J.; Cancela, M.L.; Gavaia, P.J.. 2017. "The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance". Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 197: 45-52. https://doi.org/10.1016/j.cbpc.2017.04.006
Tiago, D.M.; Conceição, N.; Caiado, H.; Laizé, V.; Cancela, M.L.. 2016. "Matrix Gla protein repression by MIR-155 promotes oncogenic signals in breast cancer MCF-7 cells". FEBS Letters, 590 (8): 1234-1241. https://doi.org/10.1002/1873-3468.12155
Rosa, J.; Tiago, D.M.; Marques, C.L.; Vijayakumar, P.; Fonseca, L.; Cancela, M.L.; Laizé, V.; et al. 2016. "Central role of betaine-homocysteine S-methyltransferase 3 in chondral ossification and evidence for sub-functionalization in neoteleost fish". Biochimica et Biophysica Acta - General Subjects, 1860 (7): 1373-1387. https://doi.org/10.1016/j.bbagen.2016.03.034
Marques, C.L.; Fernández, I.; Viegas, M.N.; Cox, C.J.; Martel, P.; Rosa, J.; Cancela, M.L.; Laizé, V.. 2016. "Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: Molecular and evolutionary perspectives". Cellular and Molecular Life Sciences, 73 (4): 841-857. https://doi.org/10.1007/s00018-015-2024-x
Roberto, V.P.; Tiago, D.M.; Gautvik, K.; Cancela, M.L.. 2016. "Corrigendum to "Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function" [Gene 566/1 (2015) 54-62], doi: 10.1016/j.gene.2015.04.022". Gene, 576 (1). https://doi.org/10.1016/j.gene.2015.10.001
Correia, E.; Conceição, N.; Cancela, M.L.; Belo, J.A.. 2016. "Matrix Gla protein expression pattern in the early avian embryo". International Journal of Developmental Biology, 60 (1-3): 71-76. https://doi.org/10.1387/ijdb.150365jb
Adrião, A.; Conceição, N.; Cancela, M.L.; Adrião, Andreia Lúcia Gonçalves; Conceição, Natércia; Cancela, Leonor. 2016. "MEF2C orthologues from zebrafish: Evolution, expression and promoter regulation". Archives of Biochemistry and Biophysics, 591: 43-56. https://doi.org/10.1016/j.abb.2015.12.004
Bensimon-Brito, A.; Cardeira, J.; Dionísio, G.; Huysseune, A.; Cancela, M.L.; Witten, P.E.. 2016. "Revisiting in vivo staining with alizarin red S - A valuable approach to analyse zebrafish skeletal mineralization during development and regeneration". BMC Developmental Biology, 16 (1). https://doi.org/10.1186/s12861-016-0102-4
Medeiros, M.C.R.; Mestre, A.; Inácio, P.; Asgarif, S.; Araújo, I.M.; Hubbard, P.C.; Velez, Z.; et al. 2016. "An electrical method to measure low-frequency collective and synchronized cell activity using extracellular electrodes". Sensing and Bio-Sensing Research, 10: 1-8. https://doi.org/10.1016/j.sbsr.2016.06.002
Marques, C.L.; Cancela, M.L.; Laizé, V.. 2016. "Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors". Gene, 576 (1): 229-236. https://doi.org/10.1016/j.gene.2015.10.005
Cardeira, J.; Gavaia, P.J.; Fernández, I.; Cengiz, I.F.; Moreira-Silva, J.; Oliveira, J.M.; Reis, R.L.; Cancela, M.L.; Laizé, V.. 2016. "Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin". Scientific Reports, 6. https://doi.org/10.1038/srep39191
Camacho, A.; Funck-Brentano, T.; Simão, M.; Cancela, L.; Ottaviani, S.; Cohen-Solal, M.; Richette, P.. 2015. "Effect of C282Y genotype on self-reported musculoskeletal complications in hereditary hemochromatosis". PLoS ONE, 10 (3). https://doi.org/10.1371/journal.pone.0122817
Simões, B.; Conceição, N.; Matias, A.C.; Bragança, J.; Kelsh, R.N.; Cancela, M.L.. 2015. "Molecular characterization of cbfß gene and identification of new transcription variants: Implications for function". Archives of Biochemistry and Biophysics, 567: 1-12. https://doi.org/10.1016/j.abb.2014.12.023
Diogo, P.; Martins, G.; Gavaia, P.; Pinto, W.; Dias, J.; Cancela, L.; Martínez-Páramo, S.. 2015. "Assessment of nutritional supplementation in phospholipids on the reproductive performance of zebrafish, Danio rerio (Hamilton, 1822)". Journal of Applied Ichthyology, 31 (S1): 3-9. https://doi.org/10.1111/jai.12733
Rodrigues, E.T.; Pardal, M.Â.; Laizé, V.; Cancela, M.L.; Oliveira, P.J.; Serafim, T.L.. 2015. "Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin". Environmental Pollution, 206: 619-626. https://doi.org/10.1016/j.envpol.2015.08.026
Cardeira, J.; Mendes, A.C.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. 2015. "Micro-anatomical characterization of vertebral curvatures in Senegalese sole Solea senegalensis". Journal of Fish Biology, 86 (6): 1796-1810. https://doi.org/10.1111/jfb.12686
Roberto, V.P.; Tiago, D.M.; Gautvik, K.; Cancela, M.L.. 2015. "Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function". Gene, 566 (1): 54-62. https://doi.org/10.1016/j.gene.2015.04.022
Fernández, I.; Vijayakumar, P.; Marques, C.; Cancela, M.L.; Gavaia, P.J.; Laizé, V.. 2015. "Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure". Fish Physiology and Biochemistry, 41 (3): 745-759. https://doi.org/10.1007/s10695-015-0043-z
Fazenda, C.; Conceição, N.; Cancela, M.L.. 2015. "Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene". Gene, 572 (1): 57-62. https://doi.org/10.1016/j.gene.2015.06.079
Witten, P.E.; Cancela, M.L.. 2014. "Fish skeletal biology and beyond". Journal of Applied Ichthyology, 30 (4): 597-599. https://doi.org/10.1111/jai.12506
Simões, B.; Conceição, N.; Kelsh, R.N.; Cancela, M.L.. 2014. "Identification of cis-regulatory elements in the upstream regions of zebrafish runx3 through in silico analysis: Implications for function". Journal of Applied Ichthyology, 30 (4): 661-670. https://doi.org/10.1111/jai.12536
Cancela, M.L.; Laizé, V.; Conceição, N.. 2014. "Matrix Gla protein and osteocalcin: From gene duplication to neofunctionalization". Archives of Biochemistry and Biophysics, 561: 56-63. https://doi.org/10.1016/j.abb.2014.07.020
Tiago, D.M.; Marques, C.L.; Roberto, V.P.; Cancela, M.L.; Laizé, V.. 2014. "Mir-20a regulates in vitro mineralization and BMP signaling pathway by targeting BMP-2 transcript in fish". Archives of Biochemistry and Biophysics, 543: 23-30. https://doi.org/10.1016/j.abb.2013.12.009
Silva, I.A.L.; Conceição, N.; Michou, L.; Cancela, M.L.. 2014. "Can zebrafish be a valid model to study Paget's disease of bone?". Journal of Applied Ichthyology, 30 (4): 678-688. https://doi.org/10.1111/jai.12523
Rosa, J.T.; Cancela, M.L.; Laizé, V.. 2014. "Ets1 regulates the transcription of a cartilage-specific S100 protein in gilthead seabream". Journal of Applied Ichthyology, 30 (4): 707-712. https://doi.org/10.1111/jai.12534
Silva, I.A.L.; Cox, C.J.; Leite, R.B.; Cancela, M.L.; Conceição, N.. 2014. "Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation". Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology, 172-173 (1): 9-20. https://doi.org/10.1016/j.cbpb.2014.03.007
Roberto, V.P.; Tiago, D.M.; Silva, I.A.; Cancela, M.L.. 2014. "MiR-29a is an enhancer of mineral deposition in bone-derived systems". Archives of biochemistry and biophysics, 564: 173-183. https://doi.org/10.1016/j.abb.2014.09.006
Marques, C.L.; Fernández, I.; Rosa, J.; Viegas, M.N.; Cancela, M.L.; Laizé, V.. 2014. "Spatiotemporal expression and retinoic acid regulation of bone morphogenetic proteins 2, 4 and 16 in Senegalese sole". Journal of Applied Ichthyology, 30 (4): 713-720. https://doi.org/10.1111/jai.12539
Fernández, I.; Santos, A.; Cancela, M.L.; Laizé, V.; Gavaia, P.J.. 2014. "Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and ¿-glutamyl carboxylation of vitamin K-dependent proteins". Environmental Pollution, 194: 86-95. https://doi.org/10.1016/j.envpol.2014.07.015
Richard, N.; Fernández, I.; Wulff, T.; Hamre, K.; Cancela, L.; Conceição, L.E.C.; Gavaia, P.J.. 2014. "Dietary Supplementation with Vitamin K Affects Transcriptome and Proteome of Senegalese Sole, Improving Larval Performance and Quality". Marine Biotechnology, 16 (5): 522-537. https://doi.org/10.1007/s10126-014-9571-2
Laizé, V.; Gavaia, P.J.; Cancela, M.L.. 2014. "Fish: A suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities". Drug Discovery Today: Disease Models, 13: 29-37. https://doi.org/10.1016/j.ddmod.2014.08.001
Cavaco, S.; Williamson, M.K.; Rosa, J.; Roberto, V.; Cordeiro, O.; Price, P.A.; Leonor Cancela, M.; et al. 2014. "Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase". Fish Physiology and Biochemistry, 40 (3): 731-738. https://doi.org/10.1007/s10695-013-9880-9
Fernández, I.; Tiago, D.M.; Laizé, V.; Leonor Cancela, M.; Gisbert, E.. 2014. "Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: Different gene expression of nuclear receptors and ECM proteins". Journal of Steroid Biochemistry and Molecular Biology, 140: 34-43. https://doi.org/10.1016/j.jsbmb.2013.11.012
Vijayakumar, P.; Laizé, V.; Cardeira, J.; Trindade, M.; Cancela, M.L.. 2013. "Development of an in vitro cell system from zebrafish suitable to study bone cell differentiation and extracellular matrix mineralization". Zebrafish, 10 (4): 500-509. https://doi.org/10.1089/zeb.2012.0833
Mira, S.; Arnaud-Haond, S.; Palma, L.; Cancela, M.L.; Beja, P.. 2013. "Large-scale population genetic structure in Bonelli's Eagle Aquila fasciata". Ibis, 155 (3): 485-498. https://doi.org/10.1111/ibi.12065
Leite, R.B.; Milan, M.; Coppe, A.; Bortoluzzi, S.; dos Anjos, A.; Reinhardt, R.; Saavedra, C.; et al. 2013. "MRNA-Seq and microarray development for the Grooved carpet shell clam, Ruditapes decussatus: A functional approach to unravel host -parasite interaction". BMC Genomics, 14 (1). https://doi.org/10.1186/1471-2164-14-741
Conceição, N.; Viegas, M.; Fidalgo, J.; Cancela, M.L.. 2013. "Development and characterization of Xl1, a Xenopus laevis chondrocyte-like cell culture". Molecular and Cellular Biochemistry, 373 (1-2): 41-51. https://doi.org/10.1007/s11010-012-1473-x
Viegas, C.S.B.; Simes, D.C.; Williamson, M.K.; Cavaco, S.; Laizé, V.; Price, P.A.; Cancela, M.L.. 2013. "Sturgeon osteocalcin shares structural features with matrix Gla protein: Evolutionary relationship and functional implications". Journal of Biological Chemistry, 288 (39): 27801-27811. https://doi.org/10.1074/jbc.M113.450213
Adriao, A.; Conceicao, N.; Gavaia, P. J.; Cancela, M. L.; Conceição, N.; Gavaia, Paulo J.; Cancela, Leonor. 2013. "Zebrafish as a model to study craniofacial phenotypes related to human MEF2Cmutations". European Journal of Clinical Investigation, 43: 102-102. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000294&KeyUID=WOS:000317141000294
Silva, I. A. L.; Conceicao, N.; Michou, L.; Cancela, M. L.. 2013. "Genetic variation in pdb6 locus and Paget's disease of bone". European Journal of Clinical Investigation, 43: 81-81. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000235&KeyUID=WOS:000317141000235
Conceição, N.; Fazenda, C.; Cancela, M.L.. 2012. "Comparative gene promoter analysis: An in silico strategy to identify candidate regulatory factors for Gla Rich Protein". Journal of Applied Ichthyology, 28 (3): 372-376. https://doi.org/10.1111/j.1439-0426.2012.02001.x
Cardeira, J.; Bensimon-Brito, A.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. 2012. "Lordotic-kyphotic vertebrae develop ectopic cartilage-like tissue in Senegalese sole (Solea senegalensis)". Journal of Applied Ichthyology, 28 (3): 460-463. https://doi.org/10.1111/j.1439-0426.2012.01978.x
Fazenda, C.; Silva, I.A.L.; Cancela, M.L.; Conceição, N.. 2012. "Molecular characterization of two paralog genes encoding Gla-rich protein (Grp) in zebrafish". Journal of Applied Ichthyology, 28 (3): 377-381. https://doi.org/10.1111/j.1439-0426.2012.02004.x
Silva, I.A.L.; Cancela, M.L.; Conceição, N.. 2012. "Molecular cloning and expression analysis of XPD from zebrafish (Danio rerio)". Molecular Biology Reports, 39 (5): 5339-5348. https://doi.org/10.1007/s11033-011-1333-x
Cardeira, J.; Vallés, R.; Dionísio, G.; Estévez, A.; Gisbert, E.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. 2012. "Osteology of the axial and appendicular skeletons of the meagre Argyrosomus regius (Sciaenidae) and early skeletal development at two rearing facilities". Journal of Applied Ichthyology, 28 (3): 464-470. https://doi.org/10.1111/j.1439-0426.2012.01979.x
Bensimon-Brito, A.; Cardeira, J.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. 2012. "Distinct patterns of notochord mineralization in zebrafish coincide with the localization of Osteocalcin isoform 1 during early vertebral centra formation". BMC Developmental Biology, 12. https://doi.org/10.1186/1471-213X-12-28
Dionísio, G.; Campos, C.; Valente, L.M.P.; Conceição, L.E.C.; Cancela, M.L.; Gavaia, P.J.. 2012. "Effect of egg incubation temperature on the occurrence of skeletal deformities in Solea senegalensis". Journal of Applied Ichthyology, 28 (3): 471-476. https://doi.org/10.1111/j.1439-0426.2012.01996.x
Rafael, M.S.; Laizé, V.; Bensimon-Brito, A.; Leite, R.B.; Schüle, R.; Cancela, M.L.. 2012. "Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata". Cellular and Molecular Life Sciences, 69 (3): 423-434. https://doi.org/10.1007/s00018-011-0754-y
Michou, L.; Conceição, N.; Morissette, J.; Gagnon, E.; Miltenberger-Miltenyi, G.; Siris, E.S.; Brown, J.P.; Cancela, M.L.. 2012. "Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone". Bone, 51 (4): 720-728. https://doi.org/10.1016/j.bone.2012.06.028
Rafael, M.S.; Laizé, V.; Florindo, C.; Ferraresso, S.; Bargelloni, L.; Cancela, M.L.. 2012. "Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts". Biochimie, 94 (5): 1128-1134. https://doi.org/10.1016/j.biochi.2012.01.013
Viegas, M.N.; Dias, J.; Cancela, M.L.; Laizé, V.. 2012. "Polyunsaturated fatty acids regulate cell proliferation, extracellular matrix mineralization and gene expression in a gilthead seabream skeletal cell line". Journal of Applied Ichthyology, 28 (3): 427-432. https://doi.org/10.1111/j.1439-0426.2012.01994.x
Bensimon-Brito, A.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. 2012. "Vestiges, rudiments and fusion events: The zebrafish caudal fin endoskeleton in an evo-devo perspective". Evolution and Development, 14 (1): 116-127. https://doi.org/10.1111/j.1525-142X.2011.00526.x
Rosa, J. T.; Cancela, M. L.; Laize, V.. 2012. "Identification of novel molecular determinants of tissue mineralization in fish". Febs Journal, 279: 538-539. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000308128602753&KeyUID=WOS:000308128602753
Parameswaran, V.; Laizé, V.; Gavaia, P.J.; Leonor Cancela, M.. 2012. "ESSA1 embryonic stem like cells from gilthead seabream: A new tool to study mesenchymal cell lineage differentiation in fish". Differentiation, 84 (3): 240-251. https://doi.org/10.1016/j.diff.2012.07.004
Leonor Cancela, M.; Conceição, N.; Laizé, V.; Cancela, M. L.; Conceicao, N.; Laize, V.. 2012. "Gla-rich protein, a new player in tissue calcification?". Advances in Nutrition, 3 (2): 174-181. https://doi.org/10.3945/an.111.001685
Eckhard Witten, P.; Leonor Cancela, M.. 2012. "Interdisciplinary approaches in fish skeletal biology". Journal of Applied Ichthyology, 28 (3): 297-299. https://doi.org/10.1111/j.1439-0426.2012.02015.x
Fonseca, V.G.; Rosa, J.; Laizé, V.; Gavaia, P.J.; Cancela, M.L.. 2011. "Identification of a new cartilage-specific S100-like protein up-regulated during endo/perichondral mineralization in gilthead seabream". Gene Expression Patterns, 11 (7): 448-455. https://doi.org/10.1016/j.gep.2011.07.003
Tiago, D.M.; Cancela, M.L.; Laizé, V.. 2011. "Proliferative and mineralogenic effects of insulin, IGF-1, and vanadate in fish osteoblast-like cells". Journal of Bone and Mineral Metabolism, 29 (3): 377-382. https://doi.org/10.1007/s00774-010-0243-7
Sousa, S.; Afonso, N.; Bensimon-Brito, A.; Fonseca, M.; Simões, M.; Leon, J.; Roehl, H.; Cancela, M.L.; Jacinto, A.. 2011. "Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration". Development, 138 (18): 3897-3905. https://doi.org/10.1242/dev.064717
Fazenda, C.; Simões, B.; Kelsh, R.N.; Cancela, M.L.; Conceição, N.. 2010. "Dual transcriptional regulation by runx2 of matrix Gla protein in Xenopus laevis". Gene, 450 (1-2): 94-102. https://doi.org/10.1016/j.gene.2009.10.007
Viegas, C.S.B.; Conceiçao, N.; Fazenda, C.; Simes, D.C.; Cancela, M.L.. 2010. "Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon (Acipenser naccarii)". Journal of Applied Ichthyology, 26 (2): 214-218. https://doi.org/10.1111/j.1439-0426.2010.01408.x
Rafael, M.S.; Marques, C.L.; Parameswaran, V.; Cancela, M.L.; Laizé, V.. 2010. "Fish bone-derived cell lines: An alternative in vitro cell system to study bone biology". Journal of Applied Ichthyology, 26 (2): 230-234. https://doi.org/10.1111/j.1439-0426.2010.01411.x
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Cancela, M.L.; Witten, P.E.. 2010. "Advances in skeletal biology by understanding the fish skeleton: A multidisciplinary challenge". Journal of Applied Ichthyology, 26 (2). https://doi.org/10.1111/j.1439-0426.2010.01393.x
Simão, M.F.; Leite, R.B.; Rocha, C.; Cancela, M.L.. 2010. "Changes in bioturbation of iron biogeochemistry and in molecular response of the clam ruditapes decussates upon perkinsus olseni infection". Archives of Environmental Contamination and Toxicology, 59 (3): 433-443. https://doi.org/10.1007/s00244-010-9490-9
Conceição, N.; Cox, C.J.; Simões, B.; Viegas, M.; Cancela, M.L.. 2010. "Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes". Journal of Applied Ichthyology, 26 (2): 245-250. https://doi.org/10.1111/j.1439-0426.2010.01415.x
Rosa, J.; Tiago, D.M.; Dias, J.; Cancela, M.L.; Laizé, V.. 2010. "Serum-specific stimulation of proliferation and mineralization of fish bone-derived cells". Journal of Applied Ichthyology, 26 (2): 251-256. https://doi.org/10.1111/j.1439-0426.2010.01414.x
Bensimon-Brito, A.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. 2010. "The zebrafish (Danio rerio) caudal complex - a model to study vertebral body fusion". Journal of Applied Ichthyology, 26 (2): 235-238. https://doi.org/10.1111/j.1439-0426.2010.01412.x
Rafael, S. M.; Laize, V.; Schule, R.; Cancela, M. L.. 2010. "Fish as a suitable model to unveil the function of the four and half LIM domains protein 2". Febs Journal, 277: 183-183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278565100642&KeyUID=WOS:000278565100642
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Ascenso, R.M.T.; Leite, R.B.; Afonso, R.; Cancela, M.L.. 2009. "Expression pattern of Perkinsus olseni genes in response to bivalves with different susceptibility to perkinsosis". Journal of Fish Diseases, 32 (7): 633-636. https://doi.org/10.1111/j.1365-2761.2009.01039.x
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Leite, R.B.; Brito, A.B.; Cancela, M.L.. 2008. "An Oxygen Molecular Sensor, the HIF Prolyl 4-Hydroxylase, in the Marine Protist Perkinsus olseni". Protist, 159 (3): 355-368. https://doi.org/10.1016/j.protis.2008.03.002
Elandalloussi, L.M.; Leite, R.B.; Rodrigues, P.M.; Afonso, R.; Cancela, M.L.. 2008. "Effect of the herbicide Roundup® on Perkinsus olseni in vitro proliferation and in vivo survival when infecting a permissive host, the clam Ruditapes decussatus". Bulletin of Environmental Contamination and Toxicology, 80 (6): 512-515. https://doi.org/10.1007/s00128-008-9412-y
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Tiago, D.M.; Laizé, V.; Cancela, M.L.. 2008. "Alternatively spliced transcripts of Sparus aurata insulin-like growth factor 1 are differentially expressed in adult tissues and during early development". General and Comparative Endocrinology, 157 (2): 107-115. https://doi.org/10.1016/j.ygcen.2008.04.006
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Conceição, N.; Laizé, V.; Simões, B.; Pombinho, A.R.; Cancela, M.L.. 2008. "Retinoic acid is a negative regulator of matrix Gla protein gene expression in teleost fish Sparus aurata". Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1779 (1): 28-39. https://doi.org/10.1016/j.bbagrm.2007.11.003
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Fonseca, V.G.; Laizé, V.; Valente, M.S.; Cancela, M.L.. 2007. "Identification of an osteopontin-like protein in fish associated with mineral formation". FEBS Journal, 274 (17): 4428-4439. https://doi.org/10.1111/j.1742-4658.2007.05972.x
Robles, V.; Cancela, M.L.. 2007. "Lipid-based transfection as a method for gene delivery in zebrafish (Danio rerio) embryos". Aquaculture Research, 38 (12): 1317-1322. https://doi.org/10.1111/j.1365-2109.2007.01806.x
Rønnestad, I.; Gavaia, P.J.; Viegas, C.S.B.; Verri, T.; Romano, A.; Nilsen, T.O.; Jordal, A.-E.O.; Kamisaka, Y.; Cancela, M.L.. 2007. "Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): Cloning, tissue expression and comparative aspects". Journal of Experimental Biology, 210 (22): 3883-3896. https://doi.org/10.1242/jeb.007898
Robles, V.; Barbosa, V.; Herráez, M.P.; Martínez-Páramo, S.; Cancela, M.L.. 2007. "The antifreeze protein type I (AFP I) increases seabream (Sparus aurata) embryos tolerance to low temperatures". Theriogenology, 68 (2): 284-289. https://doi.org/10.1016/j.theriogenology.2007.05.003
Ortiz-Delgado, J.B.; Simes, D.C.; Viegas, C.S.B.; Schaff, B.J.; Sarasquete, C.; Cancela, M.L.. 2006. "Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: Preferential protein accumulation in skeletal and vascular systems". Histochemistry and Cell Biology, 126 (1): 89-101. https://doi.org/10.1007/s00418-005-0125-6
Gavaia, P.J.; Simes, D.C.; Ortiz-Delgado, J.B.; Viegas, C.S.B.; Pinto, J.P.; Kelsh, R.N.; Sarasquete, M.C.; Cancela, M.L.. 2006. "Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): Comparative gene and protein expression during larval development through adulthood". Gene Expression Patterns, 6 (6): 637-652. https://doi.org/10.1016/j.modgep.2005.11.010
Braga, D.; Laizé, V.; Tiago, D.M.; Cancela, M.L.. 2006. "Enhanced DNA transfer into fish bone cells using polyethylenimine". Molecular Biotechnology, 34 (1): 51-54. https://doi.org/10.1385/MB:34:1:51
Simões, B.; Conceição, N.; Viegas, C.S.B.; Pinto, J.P.; Gavaia, P.J.; Hurst, L.D.; Kelsh, R.N.; Cancela, M.L.. 2006. "Identification of a promoter element within the Zebrafish colXa1 gene responsive to Runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2aA2". Calcified Tissue International, 79 (4): 230-244. https://doi.org/10.1007/s00223-006-0111-6
Laizé, V.; Viegas, C.S.B.; Price, P.A.; Cancela, M.L.. 2006. "Identification of an osteocalcin isoform in fish with a large acidic prodomain". Journal of Biological Chemistry, 281 (22): 15037-15043. https://doi.org/10.1074/jbc.M600373200
Rafael, M.S.; Laizé, V.; Cancela, M.L.. 2006. "Identification of Sparus aurata bone morphogenetic protein 2: Molecular cloning, gene expression and in silico analysis of protein conserved features in vertebrates". Bone, 39 (6): 1373-1381. https://doi.org/10.1016/j.bone.2006.06.021
Engrola, S.; Conceição, L.E.C.; Gavaia, P.J.; Cancela, M.L.; Dinis, M.T.. 2005. "Effects of pre-weaning feeding frequency on growth, survival, and deformation of Senegalese sole, Solea senegalensis (Kaup, 1858)". Israeli Journal of Aquaculture - Bamidgeh, 57 (1): 10-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344396118&partnerID=MN8TOARS
Laizé, V.; Pombinho, A.R.; Cancela, M.L.; Laizé, Vincent; Pombinho, A. R.; Cancela, Leonor. 2005. "Characterization of Sparus aurata osteonectin cDNA and in silico analysis of protein conserved features: Evidence for more than one osteonectin in Salmonidae". Biochimie, 87 (5): 411-420. https://doi.org/10.1016/j.biochi.2005.01.008
Elandalloussi, L.M.; Leite, R.B.; Rodrigues, P.M.; Afonso, R.; Nunes, P.A.; Cancela, M.L.. 2005. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". Aquaculture, 243 (1-4): 9-17. https://doi.org/10.1016/j.aquaculture.2004.09.038
Fonseca, V.G.; Lago-Lestón, A.; Laizé, V.; Cancela, M.L.; Fonseca, V. G.; Laizé, Vincent; Cancela, Leonor. 2005. "Rapid identification of differentially expressed genes by in situ screening of bacteria". Molecular Biotechnology, 30 (2): 163-165. https://doi.org/10.1385/MB:30:2:163
Elandalloussi, L.M.; Rodrigues, P.M.; Afonso, R.; Leite, R.B.; Nunes, P.A.; Cancela, M.L.. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". Molecular and Biochemical Parasitology, 142 (1): 106-109. https://doi.org/10.1016/j.molbiopara.2005.03.014
Frazão, C.; Simes, D.C.; Coelho, R.; Alves, D.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; Carrondo, M.A.. 2005. "Structural evidence of a fourth Gla residue in fish osteocalcin: Biological implications". Biochemistry, 44 (4): 1234-1242. https://doi.org/10.1021/bi048336z
Conceição, N.; Silva, A.C.; Fidalgo, J.; Belo, J.A.; Cancela, M.L.. 2005. "Identification of alternative promoter usage for the matrix Gla protein gene: Evidence for differential expression during early development in Xenopus laevis". FEBS Journal, 272 (6): 1501-1510. https://doi.org/10.1111/j.1742-4658.2005.04590.x
Mira, S.; Wolff, K.; Cancela, M.L.. 2005. "Isolation and characterization of microsatellite markers in Bonelli's eagle (Hieraaetus fasciatus)". Molecular Ecology Notes, 5 (3): 493-495. https://doi.org/10.1111/j.1471-8286.2005.00967.x
Gomes, H.L.; Leite, R.B.; Afonso, R.; Stallinga, P.; Cancela, M.L.; Gomes, Henrique L.; Leite, R. B.; Stallinga, Peter; Cancela, M. Leonor. 2004. "A microelectrode impedance method to measure interaction of cells". https://doi.org/10.1109/ICSENS.2004.1426344
Simes, D.C.; Williamson, M.K.; Schaff, B.J.; Gavaia, P.J.; Ingleton, P.M.; Price, P.A.; Cancela, M.L.; et al. 2004. "Characterization of Osteocalcin (BGP) and Matrix Gla Protein (MGP) Fish Specific Antibodies: Validation for Immunodetection Studies in Lower Vertebrates". Calcified Tissue International, 74 (2): 170-180. https://doi.org/10.1007/s00223-003-0079-4
Elandalloussi, L.M.; Leite, R.M.; Afonso, R.; Nunes, P.A.; Robledo, J.A.F.; Vasta, G.R.; Cancela, M.L.. 2004. "Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs". Molecular and Cellular Probes, 18 (2): 89-96. https://doi.org/10.1016/j.mcp.2003.09.008
Streiff, R.; Mira, S.; Castro, M.; Cancela, M.L.. 2004. "Multiple paternity in Norway lobster (Nephrops norvegicus L.) assessed with microsatellite markers". Marine Biotechnology, 6 (1): 60-66. https://doi.org/10.1007/s10126-003-0015-7
Leite, R.B.; Afonso, R.; Cancela, M.L.. 2004. "Perkinsus sp. infestation in carpet-shell clams, Ruditapes decussatus (L), along the Portuguese coast. Results from a 2-year survey". Aquaculture, 240 (1-4): 39-53. https://doi.org/10.1016/j.aquaculture.2004.05.014
Aurelle, D.; Guillemaud, T.; Afonso, P.; Morato, T.; Wirtz, P.; Serrão Santos, R.; Cancela, M.L.. 2003. "Genetic study of Coris julis (Osteichtyes, Perciformes, Labridae) evolutionary history and dispersal abilities". Comptes Rendus - Biologies, 326 (8): 771-785. https://doi.org/10.1016/j.crvi.2003.08.001
Pinto, J.P.; Conceição, N.; Gavaia, P.J.; Cancela, M.L.. 2003. "Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata". Bone, 32 (3): 201-210. https://doi.org/10.1016/S8756-3282(02)00981-X
Simes, D.C.; Williamson, M.K.; Ortiz-Delgado, J.B.; Viegas, C.S.B.; Price, P.A.; Cancela, M.L.; Simes, DC; et al. 2003. "Purification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: Calcified cartilage and not bone as the primary site of MGP accumulation in fish". Journal of Bone and Mineral Research, 18 (2): 244-259. https://doi.org/10.1359/jbmr.2003.18.2.244
Robledo, J.A.F.; Nunes, P.A.; Cancela, M.L.; Vasta, G.R.. 2002. "Development of an in vitro clonal culture and characterization of the rRNA gene cluster of Perkinsus atlanticus, a protistan parasite of the clam Tapes decussatus". Journal of Eukaryotic Microbiology, 49 (5): 414-422. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036710887&partnerID=MN8TOARS
Viegas, C.S.B.; Pinto, J.P.; Conceição, N.; Simes, D.C.; Cancela, M.L.. 2002. "Cloning and characterization of the cDNA and gene encoding Xenopus laevis osteocalcin". Gene, 289 (1-2): 97-107. https://doi.org/10.1016/S0378-1119(02)00480-8
Mira, S.; Billot, C.; Guillemaud, T.; Palma, L.; Cancela, M.L.. 2002. "Isolation and characterization of polymorphic microsatellite markers in Eurasian vulture Gyps fulvus". Molecular Ecology Notes, 2 (4): 557-558. https://doi.org/10.1046/j.1471-8286.2002.00314.x
Conceição, N.; Henriques, N.M.; Ohresser, M.C.P.; Hublitz, P.; Schüle, R.; Cancela, M.L.. 2002. "Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis: Functional analysis of the promoter identifies a calcium sensitive region required for basal activity". European Journal of Biochemistry, 269 (7): 1947-1956. https://doi.org/10.1046/j.1432-1327.2002.02846.x
Streiff, R.; Guillemaud, T.; Alberto, F.; Magalhães, J.; Castro, M.; Cancela, M.L.. 2001. "Isolation and characterization of microsatellite loci in the Norway lobster (Nephrops norvegicus)". Molecular Ecology Notes, 1 (1-2): 71-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346342219&partnerID=MN8TOARS
Cancela, M.L.; Ohresser, M.C.P.; Reia, J.P.; Viegas, C.S.B.; Williamson, M.K.; Price, P.A.. 2001. "Matrix Gla protein in Xenopus laevis: Molecular cloning, tissue distribution, and evolutionary considerations". Journal of Bone and Mineral Research, 16 (9): 1611-1621. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034868048&partnerID=MN8TOARS
Palma, L.; Mira, S.; Cardia, P.; Beja, P.; Guillemaud, T.; Ferrand, N.; Cancela, M.L.; Da Fonseca, L.C.. 2001. "Sexing bonelli's eagle nestlings: Morphometrics versus molecular techniques". Journal of Raptor Research, 35 (3): 187-193. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344361957&partnerID=MN8TOARS
Pinto, J.P.; Ohresser, M.C.P.; Cancela, M.L.. 2001. "Cloning of the bone Gla protein gene from the teleost fish Sparus aurata. Evidence for overall conservation in gene organization and bone-specific expression from fish to man". Gene, 270 (1-2): 77-91. https://doi.org/10.1016/S0378-1119(01)00426-7
Gavaia, P.J.; Sarasquete, C.; Cancela, M.L.. 2000. "Detection of mineralized structures in early stages of development of marine Teleostei using a modified alcian blue-alizarin red double staining technique for bone and cartilage". Biotechnic and Histochemistry, 75 (2): 79-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033860776&partnerID=MN8TOARS
Guillemaud, T.; Cancela, M.L.; Afonso, P.; Morato, T.; Santos, R.S.; Wirtz, P.. 2000. "Molecular insights into the taxonomic status of Coris atlantica (Pisces: Labridae)". Journal of the Marine Biological Association of the United Kingdom, 80 (5): 929-933. https://doi.org/10.1017/S0025315400002915
Guillemaud, T.; Almada, F.; Santos, R.S.; Cancela, M.L.. 2000. "Interspecific utility of microsatellites in fish: A case study of (CT)(n) and (GT)(n) markers in the shanny Lipophrys pholis (Pisces: Blenniidae) and their use in other blennioidei". Marine Biotechnology, 2 (3): 248-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034190159&partnerID=MN8TOARS
Carvalho, M.C.; Streiff, R.; Guillemaud, T.; Afonso, P.; Santos, R.S.; Cancela, M.L.. 2000. "Isolation and characterization of polymorphic microsatellite markers in Abudefduf luridus (Pisces: Pomacentridae)". Molecular Ecology, 9 (7): 993-994. https://doi.org/10.1046/j.1365-294X.2000.00939.x
Guillemaud, T.; Streiff, R.; Santos, R.S.; Afonso, P.; Morato, T.; Cancela, M.L.. 2000. "Microsatellite characterization in the rainbow wrasse Coris julis (Pisces: Labridae)". Molecular Ecology, 9 (5): 631-632. https://doi.org/10.1046/j.1365-294X.2000.00882-1.x
Cancela, M.L.; Hu, B.; Price, P.A.. 1997. "Effect of cell density and growth factors on matrix GLA protein expression by normal rat kidney cells". Journal of Cellular Physiology, 171 (2): 125-134. https://doi.org/10.1002/(SICI)1097-4652(199705)171:2<125::AID-JCP2>3.0.CO;2-Q
Kirfel, J.; Kelter, M.; Cancela, L.M.; Price, P.A.; Schüle, R.. 1997. "Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene". Proceedings of the National Academy of Sciences of the United States of America, 94 (6): 2227-2232. https://doi.org/10.1073/pnas.94.6.2227
Cancela, M.L.; Williamson, M.K.; Price, P.A.. 1995. "Amino-acid sequence of bone Gla protein from the African clawed toad Xenopus laevis and the fish Sparus aurata". International Journal of Peptide and Protein Research, 46 (5): 419-423. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028864789&partnerID=MN8TOARS
Cancela, M.L.; Williamson, M.K.; Price, P.A.. 1994. "The putative RGD-dependent cell adhesion activity of matrix Gla protein is due to higher molecular weight contaminants". Journal of Biological Chemistry, 269 (16): 12185-12189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028233411&partnerID=MN8TOARS
Rannels, S.R.; Cancela, M.L.; Wolpert, E.B.; Price, P.A.. 1993. "Matrix Gla protein mRNA expression in cultured type II pneumocytes". American Journal of Physiology - Lung Cellular and Molecular Physiology, 265 (3 9-3). http://www.scopus.com/inward/record.url?eid=2-s2.0-0027453375&partnerID=MN8TOARS
Cancela, M.L.; Williamson, M.K.; Price, P.A.. 1993. "Retinoic acid increases matrix gla protein in rat plasma". Nutrition Research, 13 (1): 87-91. https://doi.org/10.1016/S0271-5317(05)80659-1
Cancela, M.L.; Price, P.A.. 1992. "Retinoic acid induces matrix gla protein gene expression in human cells". Endocrinology, 130 (1): 102-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026553049&partnerID=MN8TOARS
Cancela, L.; Ishida, H.; Bishop, J.E.; Norman, A.W.. 1992. "Local chromatin changes accompany the expression of the calbindin-D28K gene: Tissue specificity and effect of vitamin D activation". Molecular Endocrinology, 6 (3): 468-475. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026525323&partnerID=MN8TOARS
Cancela, L.; Hsieh, C.-L.; Francke, U.; Price, P.A.. 1990. "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". Journal of Biological Chemistry, 265 (25): 15040-15048. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025029949&partnerID=MN8TOARS
Cancela, L.; Theofan, G.; Norman, A.W.. 1988. Chapter 15 The pleiotropic vitamin D hormone. Editado por BA Cooke, RJB King, HJ Van der Molen. Vol. 18. New York, Estados Unidos: Elsevier Science Publishers B.V. https://doi.org/10.1016/S0167-7306(08)60650-X
PARISI, M; CANCELA, L; Parisi, M.; Cancela, L.. 1988. "TIME COURSE STUDIES ON PHOSPHATE TRANSFER IN FROG URINARY-BLADDER". Kidney International, 33 (1): 58-63. https://doi.org/10.1038/ki.1988.9
Cancela, L.; Nemere, I.; Norman, A.W.. 1988. "1a,25 (OH)2 vitamin D3: A steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms". Journal of Steroid Biochemistry, 30 (1-6): 33-39. https://doi.org/10.1016/0022-4731(88)90073-8
De Vernejoul, M.C.; Benamout, M.P.; Cancela, L.; Miravet, L.; Kuntz, D.; Gueris, J.; Gardin, J.P.. 1988. "Primary hyperparathyroidism seen in rheumatology. Clinical manifestations and relationship between bone history and biological parameters ". Revue du Rhumatisme et des Maladies Osteo-Articulaires, 55 (7): 489-494. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024005167&partnerID=MN8TOARS
Minghetti, P.P.; Cancela, L.; Fujisawa, Y.; Theofan, G.; Norman, A.W.. 1988. "Molecular structure of the chicken vitamin D-induced calbindin-D(28K) gene reveals eleven exons, six Ca2+-binding domains, and numerous promoter regulatory elements". Molecular Endocrinology, 2 (4): 355-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023879973&partnerID=MN8TOARS
Rebut-Bonneton, C.; Ly, S.Y.; Cancela, L.. 1988. "Calcium-transport in quiescent and 1,25-dihydroxycholecalciferol-stimulated human osteosarcoma cells. Role in 24 hydroxylase enhancement". Hormone and Metabolic Research, 20 (6): 339-343. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023941120&partnerID=MN8TOARS
Cancela, L.; Rebut-Bonneton, C.. 1987. "Regulation of 24-hydroxylase activity in mouse skin fibroblasts by cholecalciferol derivatives, triamcinolone acetonide and a calcium modulating agent, nicardipine". Journal of Steroid Biochemistry, 28 (5): 479-484. https://doi.org/10.1016/0022-4731(87)90505-X
Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. 1987. "Lack of biological activity of vitamin D3-3ß sulfate during lactation in vitamin D-deficient rats". Reproduction Nutrition Developpement, 27 (6): 979-997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023502969&partnerID=MN8TOARS
Le Boulch, N.; Cancela, L.; Miravet, L.; Lange, C.. 1986. "Assessment of vitamin D sulphate in human milk using desorption chemical ionization mass spectrometry". Biomedical Mass Spectrometry, 13 (2): 53-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022572865&partnerID=MN8TOARS
Gruson, M.; Cancela, L.; Denne, M.A.; Miravet, L.. 1986. "Relationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants.". Endocrinologia experimentalis, 20 (2-3): 329-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022759472&partnerID=MN8TOARS
Cancela, L.; Le Boulch, N.; Miravet, L.. 1986. "Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants". Journal of Endocrinology, 110 (1): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022445355&partnerID=MN8TOARS
Marie, P.J.; Cancela, L.; Le Boulch, N.; Miravet, L.. 1986. "Bone changes due to pregnancy and lactation: Influence of vitamin D status". American Journal of Physiology - Endocrinology and Metabolism, 251 (4). http://www.scopus.com/inward/record.url?eid=2-s2.0-0022966994&partnerID=MN8TOARS
Le Boulch, N.; Cancela, L.; Miravet, L.. 1986. "Calcidiol in human milk. The effect of prohormone on vitamin D status of breast fed unsupplemented infants". Endocrinologia Experimentalis, 20 (2-3): 325-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022981264&partnerID=MN8TOARS
Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. 1985. "Vitamin D3 3ß sulfate has less biological activity than free vitamin D3 during pregnancy in rats". Biology of the Neonate, 48 (5): 274-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022271864&partnerID=MN8TOARS
Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. 1985. "Influence of vitamin D on mineral metabolism, hormonal status and bone histology in lactating rats and their pups". Journal of Endocrinology, 105 (3): 303-309. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021848253&partnerID=MN8TOARS
Rebut-Bonneton, C.; Demignon, J.; Cancela, L.; Miravet, L.. 1985. "Effect of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 maternal loads on maternal and fetal vitamin D metabolite levels in the rat". Reproduction Nutrition Developpement, 25 (3): 583-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021870967&partnerID=MN8TOARS
Cancela, L.; Le Boulch, N.; Miravet, L.. 1984. "Action of vitamin D3-3 beta-sulfate during lactation in the rat.". World review of nutrition and dietetics, 43: 153-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021143980&partnerID=MN8TOARS
de Vernejoul, M.C.; Girot, R.; Gueris, J.; Cancela, L.; Bang, S.; Bielakoff, J.; Mautalen, C.; Goldberg, D.; Miravet, L.. 1982. "Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia". Journal of Clinical Endocrinology and Metabolism, 54 (2): 276-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019960606&partnerID=MN8TOARS
Boulch, N.L.; Cancela, L.; Miravet, L.. 1982. "Cholecalciferol sulfate identification in human milk by HPLC". Steroids, 39 (4): 391-398. https://doi.org/10.1016/0039-128X(82)90063-0
Cancela, Maria Leonor; Branco, Jaime da Cunha; Camacho, António Manuel Mendonça Romão de Brito. 2016. "Characterization of the clinical, histological and genetic profile of articular damage in hereditary hemochromatosis". Doutoramento. http://hdl.handle.net/10362/19226
Fonseca, Maria Leonor Quintais Cancela da; Fonseca, Luís Daniel Salsinha. 2012. "Spatio-temporal gene expression and evolutionary relationship of seabream betainehomocysteine S-methyltransferases". Mestrado. http://hdl.handle.net/10400.1/10516
Cancela, Maria Leonor; Leite, Ricardo B.. 2011. "Exploring an uncommon host-parasite interaction to unveil the uniqueness of Perkinsus sp as a model organism". Doutoramento. http://hdl.handle.net/10400.1/5704
Gavaia, Paulo J.; Richard, N.; Dâmaso, L.; Dinis, Maria Teresa; Pousão-Ferreira, P.; Engrola, S.; Conceição, L. E. C.; Cancela, Leonor. 2009. "Skeletal evaluation and technical improvements to decrease the incidence of skeletal deformities in Solea senegalensis, Kaup".
Fonseca, Maria Leonor Quintais Cancela da; Vasta, Gerardo; Ascenso, Rita Margarida Teixeira. 2008. "Study of Perkinsus olseni infection mechanisms: identification and regulation of parasite genes differentially expressed in response to host and environmental stress". Doutoramento. http://hdl.handle.net/10400.1/301
Fonseca, Maria Leonor Quintais Cancela da; Gama, Francisco Miguel Portela da; Afonso, Ricardo. 2008. "Estudos sobre aproveitamento biotecnológico da quitina produzida por organismos marinhos". Mestrado. http://hdl.handle.net/10400.1/710
Abreu, Maria Manuela Silva Nunes Reis; Santos, Maria Cristina Amaral Penas Nabais dos; Fonseca, Maria Leonor Quintais Cancela da; Santos, Erika Silva. 2007. "Potencial de utilização de Cistus ladanifer L. na vegetalização de áreas mineiras". Mestrado. http://hdl.handle.net/10400.1/1798
Cancela, Maria Leonor; Dias, Pedro Beja; Dias, Paula; Mira, Sara. 2006. "Population genetics of an endangered species: the Bonelli's eagle (Hieraaetus fasciatus)". Doutoramento. http://hdl.handle.net/10400.1/10627
Cancela, Maria Leonor; Gavaia, Paulo; Roberto, Vânia Cristina Palma. 2006. "Gla protein localization and histological characterization of bone stuctures in relevant aquaculture fish". Mestrado. http://hdl.handle.net/10400.1/11026
Gavaia, Paulo J.; Dinis, Maria Teresa; Cancela, Leonor. 1998. "Detection of skeletal abnormalities in hatchery reared Solea senegalensis (Kaup, 1858) by a whole mount double staining technique". Em Detection of Skeletal abnormalities in hatchery reared Solea senegalensis (Kaup, 1858) by a whole mount double staining technique, editado por Sociedade Portuguesa de Biotecnologia;. Portugal: Sociedade Portuguesa de Biotecnologia; Universidade do Minho.
Gil Martins; Laura Ribeiro; Ana Candeias-Mendes; Patrícia Diogo; Margarida Gamboa; Marisa Barata; Maria Leonor Cancela; Pedro Pousão-Ferreira; Paulo Jorge Gavaia. 2019. "Reduction of skeletal anomalies in meagre ( Argyrosomus regius , Asso, 1801) through early introduction of inert diet". Aquaculture Research, 50 (10): 2782-2792. https://doi.org/10.1111/are.14230
Fernandez, Ignacio; Fernandes, Jorge M. O.; Roberto, Vania P.; Kopp, Martina; Oliveira, Catarina; Riesco, Marta F.; Dias, Jorge; et al. 2019. "Circulating small non-coding RNAs provide new insights into vitamin K nutrition and reproductive physiology in teleost fish". Biochimica Et Biophysica Acta-General Subjects, 1863 (1): 39-51. https://doi.org/10.1016/j.bbagen.2018.09.017
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Vitorino, Marta; Cunha, Nidia; Conceicao, Natercia; Leonor Cancela, M.. 2018. "Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome". Molecular Biology Reports, 45 (4): 445-451. https://doi.org/10.1007/s11033-018-4180-1
Fazenda, C.; Martins, G.; Gavaia, P. J.; Cancela, M. L.; Conceicao, N.. 2018. "Generation of zebrafish Danio rerio (Hamilton, 1822) transgenic lines overexpressing a heat-shock mediated Gla-rich protein". Journal of Applied Ichthyology, 34 (2): 472-480. https://doi.org/10.1111/jai.13662
Cardeira, J.; Laize, V.; Martins, G.; Cancela, M. L.; Gavaia, P. J.. 2018. "An overview on the teleost bone mechanophysiology". Journal of Applied Ichthyology, 34 (2): 440-448. https://doi.org/10.1111/jai.13661
Carson, Matthew A.; Nelson, John; Cancela, M. Leonor; Laize, Vincent; Gavaia, Paulo J.; Rae, Margaret; Heesch, Svenja; et al. 2018. "Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum". Plos One, 13 (11). https://doi.org/10.1371/journal.pone.0207303
Eckhard Witten, P.; Leonor Cancela, M.. 2018. "What aquaculture does for taxonomy, evo-devo, palaeontology, biomechanics and biomedical research". Journal of Applied Ichthyology, 34 (2): 429-430. https://doi.org/10.1111/jai.13670
Vitorino, M.; Conceicao, N.; Cancela, M. L.; Conceição, N.. 2018. "Zebrafish (Danio rerio, Hamilton-Buchanan, 1822) as a model to study bone diseases associated with Rett syndrome". Journal of Applied Ichthyology, 34 (2): 489-500. https://doi.org/10.1111/jai.13667
Silva, Iris A. L.; Conceiceao, Natercia; Gagnon, Edith; Brown, Jacques P.; Cancela, M. Leonor; Michou, Laetitia. 2018. "Molecular effect of an OPTN common variant associated to Paget's disease of bone". Plos One, 13 (5). https://doi.org/10.1371/journal.pone.0197543
Ferreira-Rodriguez, Noe; Fernandez, Ignacio; Leonor Cancela, M.; Pardo, Isabel. 2018. "Multibiomarker response shows how native and non-native freshwater bivalves differentially cope with heat-wave events". Aquatic Conservation-Marine and Freshwater Ecosystems, 28 (4): 934-943. https://doi.org/10.1002/aqc.2884
Laize, Vincent; Gavaia, Paulo J.; Tarasco, Marco; Viegas, Michael N.; Caria, Joana; Luis, Nuno; Leonor Cancela, M.. 2018. "Osteotoxicity of 3-methylcholanthrene in fish". Ecotoxicology and Environmental Safety, 161: 721-728. https://doi.org/10.1016/j.ecoenv.2018.06.035
Carson, Matthew A.; Nelson, John; Cancela, M. Leonor; Laize, Vincent; Gavaia, Paulo J.; Rae, Margaret; Heesch, Svenja; et al. 2018. "Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae". Scientific Reports, 8. https://doi.org/10.1038/s41598-018-26024-0
Rosa, Joana; Cox, Cymon J.; Leonor Cancela, M.; Laize, Vincent. 2018. "Identification of a fish short-chain dehydrogenase/reductase associated with bone metabolism". Gene, 645: 137-145. https://doi.org/10.1016/j.gene.2017.12.021
Roberto, V. P.; Martins, G.; Pereira, A.; Rodrigues, S.; Grenha, A.; Pinto, W.; Cancela, M. L.; Dias, J.; Gavaia, P. J.. 2018. "Insights from dietary supplementation with zinc and strontium on the skeleton of zebrafish, Danio rerio (Hamilton, 1822) larvae: From morphological analysis to osteogenic markers". Journal of Applied Ichthyology, 34 (2): 512-523. https://doi.org/10.1111/jai.13664
Simao, Marcio; Camacho, Antonio; Cohen-Solal, Martine; Jorge Pinto, I.; Porto, Graca; Korng, Ea Hang; Leonor Cancela, M.. 2018. "Iron enriched diet in association with Hfe loss of function promote iron toxicity mechanism and accelerate bone loss phenotype". Free Radical Biology and Medicine, 120: S148-S148. https://doi.org/10.1016/j.freeradbiomed.2018.04.489
Simao, Marcio; Camacho, Antonio; Ostertag, Agnes; Cohen-Solal, Martine; Jorge Pinto, I.; Porto, Graca; Korng, Ea Hang; Leonor Cancela, M.. 2018. "Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis". Plos One, 13 (11). https://doi.org/10.1371/journal.pone.0207441
Gavaia, Paulo J.; Dinis, Maria Teresa; Cancela, Leonor. 2000. "Skeletal development as an assessment criteria for larval Solea senegalensis (Kaup) quality". Em Skeletal development as an assessment criteria for larval Solea senegalensis (Kaup) quality.
Gavaia, Paulo Jorge; Domingues, Susana; Engrola, Sofia; Drake, Pilar; Sarasquete, Carmen; Dinis, M Teresa; Cancela, M Leonor; et al. 2009. "Comparing skeletal development of wild and hatchery-reared Senegalese sole (Solea senegalensis, Kaup 1858): evaluation in larval and postlarval stages". Aquaculture Research, 40 (14): 1585-1593. https://doi.org/10.1111/j.1365-2109.2009.02258.x
Varela, Débora Cristina Domingos. 2017. "Genetic and functional analysis of specific TBX5 mutations associated with Holt-Oram Syndrome". Mestrado. http://hdl.handle.net/10400.1/10470
Bäck, Magnus; Aranyi, Tamas; Cancela, M. Leonor; Carracedo, Miguel; Conceição, Natércia; Leftheriotis, Georges; Macrae, Vicky; et al. 2019. "Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet". Frontiers in Cardiovascular Medicine, 5. https://doi.org/10.3389/fcvm.2018.00196
Simão, Márcio Alexandre Filipe. 2017. "Contribution to the molecular characterization of osteoarthritis and osteoporosis phenotypes associated with hereditary hemochromatosis". Doutoramento. http://hdl.handle.net/10400.1/10812
Santos, João; Mendes-Silva, Leonardo; Afonso, Vanessa; Martins, Gil; Machado, Rui; Lopes, Joao; Cancela, M. Leonor; et al. 2019. "Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants". Cell Death & Disease, 10 (8). https://doi.org/10.1038/s41419-019-1816-6
Silva, Iris A. L.; Conceição, Natércia; Gagnon, Edith; Caiado, Helena; Brown, Jacques P.; Gianfrancesco, Fernando; Michou, Laëtitia; et al. 2018. "Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone". Biochimica et Biophysica Acta - Molecular Basis of Disease, 1864 (1): 143-151. https://doi.org/10.1016/j.bbadis.2017.10.008
Franco, Hannah Sabrina. 2018. "CRISPR: applications in human pathologies and future prospects". Mestrado. http://hdl.handle.net/10400.1/12618
Hill, Billy Samuel. 2015. "Drug repurposing in the treatment of Melanoma Brain Metastasis". Mestrado. http://hdl.handle.net/10400.1/8219
Silva, Iris Alexandra Lopes da. 2015. "Genetic and functional analysis of the PDB6 locus in Paget's disease of bone". Doutoramento. http://hdl.handle.net/10400.1/7669
Silva, Inês Martins. 2016. "Contribuição para a identificação do papel da MGP no desenvolvimento tumoral no cancro colorretal". Mestrado. http://hdl.handle.net/10400.1/9899
Rosa, Joana Alexandra Teixeira. 2015. "Identification of novel molecular determinants of tissue mineralization in fish". Doutoramento. http://hdl.handle.net/10400.1/8756
Adrião, Andreia Lúcia Gonçalves. 2015. "MEF2C: expression, regulation and interaction with target genes in health and diseases". Doutoramento. http://hdl.handle.net/10400.1/8751
Carvalho, Filipe Ricardo Pires de. 2016. "Characterization of bone pathologies in the ins2+/akita mouse, a new model for diabetes insulindependent: contribution for a better understanding of the disease in humans". Doutoramento. http://hdl.handle.net/10400.1/8680
Tarasco, Marco. 2016. "Screening natural resources for mineralogenic and osteogenic bioactivities using in vitro and in vivo fish systems". Mestrado. http://hdl.handle.net/10400.1/8653
Rodrigues, Brigite Sandra Nunes Simões. 2014. "Molecular structure and functional analysis of runx3 in zebrafish". Doutoramento. http://hdl.handle.net/10400.1/6851
Roberto, V.. 2014. "Identification and molecular characterization of bone-related micrornas: functional implications". Doutoramento. http://hdl.handle.net/10400.1/7080
Fazenda, Cindy Vitória. 2014. "Molecular characterization of Gla-rich protein (GRP) gene expression and function". Doutoramento. http://hdl.handle.net/10400.1/6842
Dias, J.; Colen, Rita; Rodrigues, V.; Aragão, C.; Engrola, S.; Viegas, Michel; Laizé, Vincent; Gavaia, Paulo J.; Cancela, Leonor. 2012. "Effect of variable levels of dietary cholesterol and plant sterols on the growth performance and bone metabolism in gilthead seabream (Sparus aurata) juveniles". Em Effect of variable levels of dietary cholesterol and plant sterols on the growth performance and bone metabolism in gilthead seabream (Sparus aurata) juveniles. Noruega: National Institute of Nutrition and Seafood Research; Norwegian University of Life Sciences; Aquaculture Protein Centre; Norwegian School of Veterinary Science; Nofima.
Fernández, Ignacio; Cancela, Leonor; Gavaia, Paulo J.. 2012. "Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development.". Em Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development.. prague, República Checa: European Aquaculture Society; World Aquaculture Society.
Marques, Cátia Andreia Lourenço. 2013. "Evolution, gene regulation and functional analysis of BMP2 in fish". Doutoramento. http://hdl.handle.net/10400.1/6751
Dionísio, G.; Cancela, Leonor; Gavaia, Paulo J.. 2011. Effect of dietary vitamin K supplementation on skeletal development of Danio rerio. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Gavaia, Paulo J.; Dionísio, G.; Conceição, L. E. C.; Hamre, K.; Cancela, Leonor. 2011. Effects of phylloquinone on Solea senegalensis skeletogenesis. Em World Aquaculture 2011- Aquaculture for a changing world. June 6-10 2011, Natal convention center, Natal, Brazil..
Brito, Anabela Ben-Simon. 2012. "Insights into molecular and cellular events involved in normal and pathological vertebral development and fusion using zebrafish as model organism". Doutoramento. http://hdl.handle.net/10400.1/5754
Cardeira, J.; Mendes, A. C.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. 2011. "Development of chondroid tissues in lordotic-kyphotic Senegalese sole (Solea senegalensis)". Em Development of chondroid tissues in lordotic-kyphotic Senegalese sole (Solea senegalensis). Faro, Portugal: Centro de Ciências do Mar.
Dionísio, G.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, Leonor. 2011. Effect of warfarin in zebrafish (Danio rerio) bone formation during caudal fin regeneration. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Gavaia, Paulo J.; Nicolau, L.; Cancela, Leonor; Pousão-Ferreira, P.. 2011. Early osteological development and deformities of Diplodus sargus (Linnaeus, 1758) and Diplodus vulgaris (Saint-Hillaire, 1817). Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Valles, E.; Cardeira, J.; Dionísio, G.; Estévez, A.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. 2011. Early axial and appendicular skeletal development of the meagre (Argyrosomus regius). A comparison of two rearing systems. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Lisboa, Rodrigo. 2012. "Cytogenetic and histological studies of the brook trout (Salvelinus fontinalis) x arctic charr (Salvelinus alpinus) hybrids". Mestrado. http://hdl.handle.net/10400.1/5733
Carvalho, Inês Costa de. 2012. "Population structure of humpback whales (Megaptera novaeangliae) in west coast of Africa". Mestrado. http://hdl.handle.net/10400.1/12188
Cardeira, J.; Nicolau, L.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. 2010. "Early skeletal development of meagre (Argyrosomus regius, Asso 1801)".
Roberto, V.; Cavaco, S.; Simes, Dina; Gavaia, Paulo J.; Cancela, Leonor. 2009. "Mgp expression and accumulation in heart and kidney of turbot (Scophthalmus maximus)".
Simão, Márcio Alexandre Filipe. 2011. "Identificação e caracterização de duas isoformas da Ferritina da amêijoa R. decussatus e avaliação de algumas das suas propriedades biológicas". Mestrado. http://hdl.handle.net/10400.1/2655
Gavaia, Paulo J.; Dionísio, G.; Campos, C.; Carvalho, A. P.; Conceição, L. E. C.; Cancela, Leonor. 2011. Temperature affects skeletogenesis during Senegalese sole (Solea senegalensis, Kaup) larval development. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Silva, Iris Alexandra Lopes da. 2011. "Molecular cloning and analysis of Xeroderma pigmentosum group-D (xpd) in zebrafish". Mestrado. http://hdl.handle.net/10400.1/2233
Anastácio, Fábio Miguel Vicente. 2015. "Estudo do papel desempenhado pela proteína anexina A2 na regulação de vias de transdução de sinal ativadas por Ras". Mestrado. http://hdl.handle.net/10400.1/7870
Gavaia, Paulo J.; Richard, Nadège; Dâmaso, L.; Dinis, Maria Teresa; Pousão-Ferreira, P.; Engrola, S.; Conceição, L. E. C.; Cancela, Leonor. 2010. "Evaluation of the skeletal quality in Senegalese sole (Solea Senegalensis, Kaup) reared under intensive vs extensive conditions".
Milan, Massimo; Coppe, Alessandro; Reinhardt, Richard; Cancela, Leonor; Leite, Ricardo B.; Saavedra, Carlos; Ciofi, Claudio; et al. 2011. "Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring". BMC Genomics, 12 (1). https://doi.org/10.1186/1471-2164-12-234
Cardeira da Silva, J.; Dionísio, G.; Bensimon-Brito, A.; Cancela, Leonor; Gavaia, Paulo J.. 2009. "Skeletal development and performance of zebrafish Danio rerio (Hamilton, 1822) larvae and juvenile fish fed with different diets".
Rafael, M. S.. 2011. "Role of the transcriptional regulator FHL2: identification of fish target genes and regulatory mechanisms". Doutoramento. http://hdl.handle.net/10400.1/3734
Dionísio, G.; Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. 2008. "Diets affect skeletal development in zebrafish (Danio rerio)".
Cardeira da Silva, J.; Gavaia, Paulo J.; Brito, A. B.; Cancela, Leonor. 2008. "The use of enhanced green fluorescent protein to track matrix Gla protein expression during zebrafish (Danio rerio) development".
Santos, Rui Pedro Peres dos. 2009. "O efeito da Varfarina no desenvolvimento esquelético de larvas de peixe zebra (Danio rerio)". Mestrado. http://hdl.handle.net/10400.1/11039
Roberto, V.; Cavaco, S.; Viegas, C. S. B.; Simes, Dina; Ortiz-Delgado, J. B.; Sarasquete, C.; Gavaia, Paulo J.; et al. 2009. "Matrix gla protein in turbot (Scophthalmus maximus): gene expression analysis and identification of sites of protein accumulation". Aquaculture, 294 (3-4): 202-211. https://doi.org/10.1016/j.aquaculture.2009.06.020
Peres dos Santos, R.; Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. 2008. "Developmental effects of warfin in the skeletogenesis of zebrafish (Danio rerio) larvae".
Silva, João Pedro Gonçalves Cardeira da. 2009. "O efeito da dieta na sobrevivência e no desenvolvimento esquelético e digestivo de larvas e juvenis de peixe-zebra Danio rerio (Hamilton, 1822)". Mestrado. http://hdl.handle.net/10400.1/672
Gavaia, Paulo J.; Cancela, Leonor. 2008. "Fish as a model organism to study skeletal development and associated pathologies".
Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor. 2007. "Gene expression during regeneration of zebrafish (danio rerio) fins: relative expression levels of mineralization – related gla proteins". Em Meeting of European COST B23 Action "Oral Development and Regeneration”oceedings of the . Barcelona, Espanha: Universitat de Barcelona.
Marques, C. L.; Rafael, M. S.; Cancela, Leonor; Laizé, Vincent; Marques, C.L.; Rafael, M.S.; Cancela, M.L.; Laizé, V.. 2007. "Establishment of primary cell cultures from fish calcified tissues". Cytotechnology, 55 (1): 9-13. https://doi.org/10.1007/s10616-007-9098-8
Tiago, Daniel M.; Laizé, Vincent; Cancela, Leonor; Aureliano, M.. 2007. "Vanadate and bone metabolism: effect on proliferation and mineralization of fish bone-derived cells".
Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. 2007. "Expression of osteonectin correlates with levels of fin regeneration in zebrafish (Danio rerio". Em Conference Proceedings, 265-306.: Elsevier.
Rainha, Rita Vanessa Cardoso de Almeida. 2008. "Estudo da variabilidade genética de marcadores moleculares ligados ao gene da MGP e sua aplicação para paternidades em Sparus aurata". Mestrado. http://hdl.handle.net/10400.1/530
Madeira, Céline Rodrigues. 2008. "Contribuição parental do linguado do Senegal, Solea senegalensis (KAUP 1858), em aquacultura". Mestrado. http://hdl.handle.net/10400.1/245
Tiago, Daniel M.. 2008. "Role of insulin and insulin-like peptides in bone formation: identification of bone-specific target genes and regulatory mechanisms, and characterization of the insulin-mimetic effect of vanadium". Doutoramento. http://hdl.handle.net/10400.1/422
Tiago, Daniel M.; Laizé, Vincent; Aureliano, M.; Cancela, Leonor. 2007. "Vanadate effects on bone metabolism: fish cell lines as an alternative to mammalian in vitro systems". Em Vanadium Biochemistry , 1-12. Vol. chapter 14. Kerala, Índia: Research Signpost. http://hdl.handle.net/10400.1/1302
Ortiz-Delgado, J. B.; Simes, Dina; Gavaia, Paulo J.; Sarasquete, C.; Cancela, Leonor; Ortiz-Delgado, J.B.; Simes, D.C.; Gavaia, P.; Cancela, M.L.. 2005. "Osteocalcin and Matrix Gla Protein in developing teleost teeth. Identification of sites of mRNA and protein accumulation at single cell resolution". Histochemistry and Cell Biology, 124 (2): 123-130. https://doi.org/10.1007/s00418-005-0015-y
Laizé, Vincent; Gavaia, Paulo J.; Viegas, C. S. B.; Cancela, Leonor. 2006. "Whole-genome sequence analysis: Evidences for new osteocalcin isoforms in fish and tetrapods". Em Whole-genome sequence analysis: Evidences for new osteocalcin isoforms in fish and tetrapods. Prague, República Checa: European Society for Developmental Evolutionary Biology.
Mariani, Valentina; Viegas, C. A.; Gavaia, Paulo J.; Cancela, Leonor; Giuffra, Elisabetta. 2005. "Comparative analysis of gene expression profiles among distantly related fish species. Insight into skeletal and immunological systems".
Roberto, V.; Gavaia, Paulo J.; Cancela, Leonor. 2006. "Vertebral deformities and local accumulation of gla proteins in sparus aurata". Em Vertebral deformities and local accumulation of gla proteins in sparus aurata. Florence, Itália: Aqua 2006.
Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor. 2006. "Regeneration in Zebrafish (Danio rerio) fins: pattern of expression of mineralization related Gla proteins". Em Regeneration in Zebrafish (Danio rerio) fins: pattern of expression of mineralization¿related Gla proteins, editado por Sociedade Portuguesa de Bioquimica. Aveiro, Portugal: Sociedade Portuguesa de Bioquímica.
Laizé, Vincent; Martel, Paulo; Viegas, Carla; Price, P. A.; Cancela, Leonor; Laizé, V.; Martel, P.; et al. 2005. "Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates". Journal of Biological Chemistry, 280 (29): 26659-26668. https://doi.org/10.1074/jbc.M500257200
Rønnestad, I.; Gavaia, Paulo J.; Viegas, C. S. B.; Verri, T.; Cancela, Leonor. 2006. "PepT1 in a coldwater marine teleost larvae- Atlantic cod: cloning and preliminary studies of expression and phylogeny". Acta Bio Medica. , 77. http://hdl.handle.net/10400.1/4498
Cancela, Leonor; Laizé, Vincent; Simes, Dina; Gavaia, Paulo J.; Conceição, N.; Viegas, C. S. B.; Pombinho, A. R.; et al. 2005. "Proteínas gla do osso e cartilagem: importância dos anfíbios e peixes como modelos biológicos para elucidação da sua função e evolução - gla proteins in bone and cartilage: the importance of fish and amphibian models to understand their function and evolution".
Gavaia, Paulo J.; Cancela, Leonor. 2006. Skeletal development and bone-related gene expression in fish larvae. The fish skeleton; skeletal malformations; skeletal malformations in mediterranean species; Types of skeletal malformations; Senegal sole skeletal development; Senegal sole skeletal deformities; Skeletal development in Danio rerio; ALP and TRAP in skeletal development; Skeletal development in Pagrus auriga; Time course of skeletal development in Pagrus auriga; Spatio-temporal pattern of bgp expres. http://hdl.handle.net/10400.1/4397
Engrola, S.; Conceição, L. E. C.; Gavaia, Paulo J.; Cancela, Leonor; Dinis, Maria Teresa. 2005. "Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858)". Despite much interest in the production of Senegalese sole (Solea senegalensis) in southern Europe, weaning of this species onto artificial diets is problematic and varying results are obtained. The aim of this study was to test two feeding frequencies during a 13-day pre-weaning period and assess their impact on the growth and survival of Senegalese sole. Postlarvae were fed Artemia metanauplii w. http://hdl.handle.net/10400.1/4483
Viegas, C. S. B.; Gavaia, Paulo J.; Ortiz-Delgado, J. B.; Sarasquete, C.; Cancela, Leonor. 2004. "Gla proteins as markers for studies of skeletal development and malformations in new aquaculture fish species (Pagrus auriga, Diplodus sargo and Scophtalmus maximus)".
Elandalloussi, L. M.; Rodrigues, Pedro; Afonso, R.; Leite, R. B.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". https://doi.org/10.1016/j.molbiopara.2005.03.014
Inácio, Ana Rita da Silva. 2004. "Selecção de áreas prioritárias para a conservação da biodiversidade no sul de Portugal". Mestrado. http://hdl.handle.net/10400.1/1641
Pombinho, António José Ribeiro. 2004. "Reguladores da expressão do gene da proteía Gla da matriz (MGP) numa linha celular derivada de peixe". Mestrado. http://hdl.handle.net/10400.1/8554
Gavaia, Paulo J.. 2005. "Functional analysis of bone related Gla proteins from bony fish during skeletal development". Doutoramento. http://hdl.handle.net/10400.1/7614
Brito, A. B.; Rønnestad, I.; Gavaia, Paulo J.; Viegas, C. S. B.; Cancela, Leonor. 2004. "Expression of the oligopeptide transporter PepT1 (Solute carrier family 15, member 1), in fed and starved larval Zebra fish (Danio rerio)".
Elandalloussi, L. M.; Leite, R. M.; Afonso, R.; Nunes, Patrícia A.; Robledo, J. A. F.; Vasta, G. R.; Cancela, Leonor. 2004. "Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs". https://doi.org/10.1016/j.mcp.2003.09.008
Elandalloussi, Laurence M.; Leite, Ricardo B.; Rodrigues, Pedro; Afonso, Ricardo; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". https://doi.org/10.1016/j.aquaculture.2004.09.038
Elandalloussi, L. M.; Afonso, R.; Nunes, Patrícia A.; Cancela, Leonor; Elandalloussi, L.M.; Nunes, P.A.; Cancela, M.L.. 2003. "Effect of desferrioxamine and 2,2 '-bipyridyl on the proliferation of Perkinsus atlanticus". Biomolecular Engineering, 20 (4-6): 349-354. https://doi.org/10.1016/S1389-0344(03)00047-9
Elandalloussi, Laurence M.; Rodrigues, Pedro; Afonso, Ricardo; Leite, Ricardo B.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". https://doi.org/10.1016/j.molbiopara.2005.03.014
Elandalloussi, L. M.; Leite, R. B.; Rodrigues, Pedro; Afonso, R.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". https://doi.org/10.1016/j.aquaculture.2004.09.038
Rønnestad, I.; Gavaia, Paulo J.; Viegas, C. S. B.; Cancela, Leonor. 2004. "Cloning and ontogenetic expression of the oligopeptide transporter PepT1 (Solute carrier family 15, member 1), in fed and starved larval Atlantic cod, Gadus morhua L".
Domingues, S.; Gavaia, Paulo J.; Cancela, Leonor. 2004. "Effect of Citral in zebrafish bone structure and circulatory system during the first stages of development".
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2019. "Molecular and Functional Analysis of Mutations in the Transcription Factor ZNF687 Associated to Paget Disease of Bone". Mestrado. http://hdl.handle.net/10400.1/13585
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Poudel, Sunil; Izquierdo M; Leonor Cancela; Gavaia, P; Sunil Poudel; Marisol Izquierdo; Maria Leonor Cancela; Paulo J. Gavaia. 2022. "Reversal of Doxorubicin-induced bone loss and mineralization by supplementation of Resveratrol and MitoTEMPO in the early development of Sparus aurata. ". Nutrients, 14 (6): 1154-1154. https://doi.org/10.3390/nu14061154
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Sunil Poudel; Gil Martins; M. Leonor Cancela; Paulo J. Gavaia. 2022. "Regular Supplementation with Antioxidants Rescues Doxorubicin-Induced Bone Deformities and Mineralization Delay in Zebrafish". Nutrients. https://doi.org/10.3390/nu14234959
Adrião, Andreia; Mariano, Sara; Mariano, José; Gavaia, Paulo J.; Cancela, M. Leonor; Vitorino, Marta; Conceição, Natércia. 2023. "mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour". Biomolecules, 13 (5). https://doi.org/10.3390/biom13050805
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Márcio Simão; Natércia Conceição; Susana Imaginário; João Amaro; Maria Leonor Cancela. 2022. "Lab-It Is Taking Molecular Genetics to School". BioChem. https://doi.org/10.3390/biochem2020011
Santos, João M. A.; Laizé, Vincent; Gavaia, Paulo J.; Conceição, Natércia; Cancela, M. Leonor. 2023. "Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies". International Journal of Molecular Sciences, 24 (4). https://doi.org/10.3390/ijms24043366
Saavedra, Carlos; Milan, Massimo; Leite, Ricardo B.; Cordero, David; Patarnello, Tomaso; Cancela, M. Leonor; Bargelloni, Luca. 2023. "Transcriptional Profiling of Populations in the Clam Ruditapes decussatus Suggests Genetically Determined Differentiation in Gene Expression along Parallel Temperature Gradients and between Races of the Atlantic Ocean and West Mediterranean Sea". Fishes, 8 (4). https://doi.org/10.3390/fishes8040203
Poudel, Sunil; Martins, Gil; Cancela, M. Leonor; Gavaia, Paulo J.. 2022. "Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation". International Journal of Molecular Sciences, 23 (23). https://doi.org/10.3390/ijms232315160
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Varela, Débora; Varela, Tatiana; Conceição, Natércia; Cancela, M. Leonor. 2023. "Regulation of human ZNF687, a gene associated with Paget's disease of bone". The International Journal of Biochemistry & Cell Biology, 154. https://doi.org/10.1016/j.biocel.2022.106332
Carletti, Alessio; Rosa, Joana T.; Pes, Katia; Borges, Inês; Santos, Tamára; Barreira, Luísa; Varela, João; et al. 2023. "The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models". Cellular and Molecular Life Sciences, 80 (10). https://doi.org/10.1007/s00018-023-04953-y
Antunes, Célia M.; Costa, Ana R.; Palma, Patrícia; Gastalho, Carlos; Marques, Mariana; Galveias, Ana; Cancela, Leonor; Aureliano, Manuel. 2022. XXI SPB CONGRESS BOOK. Universidade de Évora. http://hdl.handle.net/10174/31139
Tarasco, Marco. 2022. "How microplastics and adsorbed pollutants affect zebrafish development?". Doutoramento. http://hdl.handle.net/10400.1/18456
Silva, Joel Mourato da. 2021. "Characterization of 5´ and 3´ UTRs from Bone morphogenetic protein receptor type 1A (Bmpr1A) transcripts under the context of bone metabolism". Mestrado. http://hdl.handle.net/10400.1/18181
Varela, Tatiana; Varela, Débora; Vitorino, Marta; Conceição, Natércia; Cancela, M. Leonor; Martins, Gil. 2020. "Zebrafish: an interesting model to study CDKL5 deficiency disorder". https://doi.org/10.1097/MD.0000000000019291
Saavedra, C.; Milan, M.; Cordero, D.; Leite, R.; Pena, J. B.; Delgado, M.; Liu, B.; et al. 2017. "Population genetics and transcriptomics of Manila Clam (Ruditapes philippinarum) and carpet-shell clam (R. decussatus): implications for aquaculture".
Silva, I. A. L.; Michou, L.; Cancela, M. Leonor; Conceição, Natércia; Cancela, M. L.; Conceicao, N.. 2016. "Functional study of OPTN promoter: new OPTN regulators and effect of genetic variants". European Journal of Clinical Investigation, 46: 124-124. http://hdl.handle.net/10400.1/9534
Vitorino, M.; Conceicao, N.; Adrião, Andreia Lúcia Gonçalves; Cancela, M. Leonor; Adriao, A.; Cancela, M. L.. 2016. "Zebrafish as a disease model for studying human Rett Syndrome". http://hdl.handle.net/10400.1/9535
Shapouri, M.; Cancela, Leonor; Iepure, S.; Stigter, T.; Ribeiro, L.; Silva, A.. 2016. "The variation of stygofauna along a gradient of salinization in a coastal aquifer". https://doi.org/10.2166/nh.2015.153
Diogo, Patricia; Eufrásio, Ana; Martins, Gil; Cardeira, João; Cancela, M. Leonor; Cabrita, Elsa; Gavaia, Paulo. 2016. "Analysis of sperm quality in a type I diabetes zebrafish model". http://hdl.handle.net/10400.1/9252
Camacho, A.; F. Simao, Marcio; Ea, H. -K.; Cohen-Solal, M.; Richette, P.; Branco, J.; Cancela, Leonor; et al. 2016. "Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress". Osteoarthritis and Cartilage, 24 (3): 494-502. https://doi.org/10.1016/j.joca.2015.09.007
Divisato, Giuseppina; Formicola, Daniela; Esposito, Teresa; Merlotti, Daniela; Pazzaglia, Laura; Del Fattore, Andrea; Siris, Ethel; et al. 2016. "ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor". American Journal of Human Genetics, 98 (2): 275-286. https://doi.org/10.1016/j.ajhg.2015.12.016
Araujo, Nuna C. P.; Afonso, Ricardo; Bringela, A.; Cancela, Leonor; Cristiano, Maria Lurdes Santos; Leite, Ricardo; Araujo, N.C.P.; et al. 2013. "Peroxides with antiplasmodial activity inhibit proliferation of Perkinsus olseni, the causative agent of Perkinsosis in bivalves". Parasitology International, 62 (6): 575-582. https://doi.org/10.1016/j.parint.2013.06.010
Tiago, Daniel; Laizé, Vincent; Bargelloni, Luca; Ferraresso, Serena; Romualdi, Chiara; Cancela, Leonor; Tiago, D.M.; et al. 2011. "Global analysis of gene expression in mineralizing fish vertebra-derived cell lines: new insights into anti-mineralogenic effect of vanadate". BMC Genomics, 12. https://doi.org/10.1186/1471-2164-12-310
Peres dos Santos, R.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, Leonor. 2009. "Warfarin effects in the skeletal development of zebrafish (Danio rerio)".
Laizé, Vincent; Tiago, Daniel; Aureliano, M.; Cancela, Leonor; Laizé, V.; Tiago, D.M.; Cancela, M.L.. 2009. "New insights into mineralogenic effects of vanadate". Cellular and Molecular Life Sciences, 66 (24): 3831-3836. https://doi.org/10.1007/s00018-009-0137-9
Tiago, Daniel; Cancela, Leonor; Aureliano, M.; Laizé, Vincent. 2008. "Vanadate proliferative and anti-mineralogic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line". http://hdl.handle.net/10400.1/1359
Tiago, Daniel; Laizé, Vincent; Cancela, Leonor; Aureliano, M.. 2008. "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line". https://doi.org/10.1007/s10565-007-9034-x
Tiago, Daniel; Laizé, Vincent; Cancela, Leonor; Aureliano, M.. 2008. "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line". http://hdl.handle.net/10400.1/1361
Fonseca, P. J.; Serrão, Ester; Pina-Martins, F.; Silva, P.; Mira, Sara; Quartau, J. A.; Paulo, O. S.; et al. 2008. "The evolution of Cicada songs contrasted with the relationships inferred from mitochondrial DNA (Insecta, hemiptera)". Bioacoustics, 18 (1): 17-34. https://doi.org/10.1080/09524622.2008.9753588
Silva, Maria da Conceição Monteiro Patrício. 2006. "Desenvolvimento de ferramentas interactivas para divulgação das aplicações da biotecnologia ambiental em biorremediação". Mestrado. http://hdl.handle.net/10400.1/14813
Cancela, M. Leonor; Ohresser, M. C. P.; Reia, J. P.; S B Viegas, Carla; Williamson, M. K.; Price, P. A.. 2001. "Matrix gla protein in xenopus laevis: molecular cloning, tissue distribution, and evolutionary considerations". https://doi.org/10.1359/jbmr.2001.16.9.1611
Varela, Tatiana; Varela, Débora; Martins, Gil; Conceição, Natércia; Cancela, M. Leonor. 2022. "Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder". Scientific Reports, 12 (1). https://doi.org/10.1038/s41598-022-13364-1
Silva, Iris A.L.; Varela, Débora; Cancela, M. Leonor; Conceição, Natércia. 2022. "Zebrafish optineurin: genomic organization and transcription regulation". Genome, 65 (10): 513-523. https://doi.org/10.1139/gen-2022-0019
Carletti, Alessio; Cardoso, Carlos; Lobo-Arteaga, Jorge; Sales, Sabrina; Juliao, Diana; Ferreira, Inês; Chainho, Paula; et al. 2022. "Antioxidant and Anti-inflammatory Extracts From Sea Cucumbers and Tunicates Induce a Pro-osteogenic Effect in Zebrafish Larvae". Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.888360
Rosa, Joana; Carletti, Alessio; Varela, Tatiana; Gavaia, Paulo J.; Cancela, M. Leonor; Laizé, Vincent. 2021. "Identification of bone anabolic compounds of marine origin using a zebrafish pipeline". Bone Reports, 14. https://doi.org/10.1016/j.bonr.2021.100985
Poudel, Sunil; Izquierdo, Marisol; Cancela, M. Leonor; Gavaia, Paulo J.. 2021. "Reversal of Doxorubicin-induced bone loss by antioxidant supplement". Bone Reports, 14. https://doi.org/10.1016/j.bonr.2021.100984
2009. "Lab-it". Registada.
M Leonor Cancela; Gavaia, P; Laizé, V; Anabela Bensimon-Brito. 2009. "Identification of compound that affects osteogenesis, involves inducing fin regeneration of ray-finned fish by amputating fish fin, contacting fish with test compound, and determining re-mineralization index of fin regeneration". Expirada.
Leonor Cancela; Danielsen, Steffen ; Skov LK; Leite, Ricardo B; Laizé, V.. 2010. "New isolated polypeptide having organophosphorous hydrolase activity selected from polypeptide containing amino acid sequence, polypeptide encoded by polynucleotide, variant containing deletion of amino acids, used in nucleic acid construct". Dinamarca. Concedida/Emitida.
Leonor Cancela; Laizé, V; Leite, Ricardo B; Danielsen, Steffen ; Skov LK. 2010. "New isolated polypeptide with organophosphorus hydrolase activity selected from e.g. polypeptide with amino acid sequence having specific identity to mature polypeptide and polypeptide encoded by polynucleotide, used in such as composition". Dinamarca. Concedida/Emitida.
Leonor Cancela; Simes, Dina; Viegas, Carla. 2010. " A gammacarboxyglutamate-rich protein, methods and assays for its detection, purification and quantification and uses thereof". Concedida/Emitida.
Leonor Cancela; Leite, Ricardo B; Schnorr, KM; Anderson L. 2012. "Polypeptides having cellulose activity and polynucleotides encoding same". Dinamarca. Concedida/Emitida.
M Leonor Cancela; Laizé, V.; Danielsen, Steffen ; Skov LK; Leite, Ricardo B. 2016. "DFPase enzymes from Aplysia Californica". Dinamarca. Concedida/Emitida.
Leonor Cancela; Conceição, Natércia; Tiago, Daniel. 2015. "Utilização da MGP como método de diagnóstico, prognostico e alvo terapêutico no cancro". Expirada.
 

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