Álvaro Tavares

 

University of Algarve

Department of Biomedical Sciences and Medicine, Bld 8

Phone: +351 289 244 480 (internal extn. 7480)

Email: aatavares@ualg.pt

 

Academic Degrees

  • 1982-1987 - Degree in Biochemistry , Faculty of Sciences, University of Lisbon.
  • 1988-1990 - MSc. in Molecular Biology, New University of Lisbon.
  • 1991-1994 - PhD in Biomedical Sciences, University of Porto

 

Positions

  • 2009 – Present,  Assistant Professor, Department of Biomedical Sciences and Medicine, University of Algarve.
  • 1999-2009 - Group leader, Cell Division Group, Instituto Gulbenkian de Ciência, Oeiras, Portugal.
  • 1999-2009 - Assistant Professor at Dept. Chemical and Biological Engeenering, Instituto Superior Técnico, Univ. Técnica Lisboa, Portugal.
  • 1994-1999 - Post-Doctoral, Cell Cycle Genetics Group with Prof. David Glover, Univ. of Dundee, Scotland.

 

Research Interests

In our group we examine the components and regulatory mechanisms of the mitotic machinary, and explore mechanisms by which chromosome missegregation could lead to cancer. We have been focusing our attention in two different aspects of mitosis:  chromosome attachment to the spindle (by analysing the function of kinetochore proteins) and  completion of cell division (by studying genes involved in the execution of cytokinesis). Through a combination of biochemical, genetic and cytologic techniques, and taking advantage of Drosophila genetics and human tissue cultured cells, we have identified a set of new genes that when mutated result in chromosome missegregation, spindle assembly defects and cytokinesis failure

 

Project Grants

PTDC/SAU-OBD/105234/2008- Role of Mob1 and Unc119 proteins in cytokinesis and tumorogenesis. (2010 - 2012)

PTDC/BIA-BCM/69912/2006 (as colaborator) (2008 - 2010)

PTDC/SAU-NEU/81153/2006 (as colaborator) (2008 - 2010)

 

Selected Publications (2008-2012)

Lince-Faria, M., Maffini, S., Orr, B., Ding, Y., Florindo, C., Sunkel, C.E., Tavares, A.A., Johansen, J., Johansen, K. M. and Maiato, H. (2009) “Spatio-temporal control of mitosis by the  conserved spindle matrix protein Megator” J. Cell Biology 184:647-657.

Godinho, S. and Tavares, A.A. (2008) “A role for Drosophila Polo protein in chromosome resolution and segregation during mitosis”, Cell Cycle 7:2529 – 2534.

 

 

 

Share Partilhar