University of Algarve
Department of Biomedical Sciences and Medicine, Bld 7
Neurodegeneration and Injury-induced Neurogenesis Group
Phone: +351 289 800 095 (internal extn. 7534)
Brain injury is characterized by neuronal loss and dysfunction, accompanied by neuroinflammation and an upregulation of the formation of new neurons (neurogenesis). Nevertheless, the phenomena of Injury-induced neurogenesis is far from being efficient. In our group, we are interested in understanding how the inflammatory microenvironment of the brain regulates the neurogenic response. Establishing the mechanisms by which inflammatory factors influence the formation of new neurons after injury will help in the identification of new strategies to repair the damaged brain.
2013 – 2015 - Role: Principal investigator. Research project “Enhancement of endogenous neurogenesis by nitric oxide: identification of S-nitrosylation targets”. Supported by FCT, PTDC/SAU-OSD/0473/2012.
2011-2014 – Role: Principal investigator. Research project “iCALP - Identification of the physiological roles of calpains in the control of cell proliferation and migration in the central nervous system”. Supported by FCT, PTDC/SAU-NMC/112183/2009.
2010-2013 – Role: Team member. PTDC/SAU-NEU/102612/2008.
2007 – 2010 – Role: Team member. PTDC/SAU-NEU/73119/2006.
2007 – 2010 – Role: Team member. PTDC/SAU-NEU/81064/2006.
2013 - present – Delegate of the COST action BM1005 - Gasotransmitters: from basic science to therapeutic applications (ENOG: European Network on Gasotransmitters)
2006 - 2010 - FP6-LIFESCIHEALTH-Ref.19063, Network of European Neuroscience Institutes (ENI-NET), Young Investigator.
Science outreach grants:
2011-2013 – Role: Team member. “Quero mais e melhores células! (Células estaminais: o que são? onde estão? para que servem?)". Supported by COMPETE – Ciência Viva - 1325.
Selected Publications (2010-2014)
Santos AI, Martinez-Ruiz A, Araújo IM (2014) S-nitrosation and neuronal plasticity. British Journal of Pharmacology (in press, online early June 24, 2014).
Santos AI, Carreira BP, Nobre RJ, Carvalho CM, Araújo IM(2014) Stimulation of neural stem cell proliferation by inhibition of phosphodiesterase 5. Stem Cells International 2014:878397.
Carreira BP, Santos AI, Carvalho CM and Araújo IM (2013) Modulation of adult neurogenesis by the nitric oxide system in Neural Stem Cells. Edited by Intech. Editor: Luca Bonfati. ISBN:980-953-307-863-7
Morte MI, Carreira BP, Falcão MJ, Ambrósio AF, Soares-da-Silva P, Araújo IM, Carvalho CM, (2013) Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic drugs in cultured hippocampal neurons. Toxicology in vitro 27(8):2193-9202.
Martinez-Ruiz A, Araújo IM, Izquierdo-Álvarez A, Hernansanz-Agustín P, Lamas S, Serrador JM (2013) Specificity in S-nitrosylation: a short-range mechanism for NO signaling? Antioxidants and Redox Signaling, epub January 4, 2013.
Morte MI, Carreira BP, Machado VM, Carmo A, Nunes-Correia I, Carvalho CM, Araújo IMCA (2013) Evaluation of proliferation of neural stem cells in vitro and in vivo. Current Protocols in Stem Cell Biology 2013 Feb; Chapter 2:Unit2D.14.
Carreira BP, Carvalho CM, Araújo IM (2012) Regulation of injury-induced neurogenesis by nitric oxide. Stem Cells International, 2012:895659. Epub 2012 Sep 10.
Carreira BP, Morte MI, Lourenço AS, Santos AI, Inácio Â, Ambrósio AF, Carvalho CM, Araújo IM (2012) Differential contribution of the guanylyl cyclase-cyclic GMP-Protein kinase G pathway to the proliferation of neural stem cells stimulated by nitric oxide. Neurosignals, epub Feb 23.
Carreira BP, Morte MI, Carvalho CM and Araújo IM (2012) Assessing the influence of neuroinflammation on neurogenesis: in vitro models using neural stem cells and microglia as valuable research tools in Neural Stem Cells and Therapy. Edited by Intech. Editor: Tao Sun. ISBN 979-953-307-213-4
Araújo IM, Carreira BP, Carvalho CM, Carvalho AP (2010) Calpains and delayed calcium deregulation in excitotoxicity. Neurochemical Research35(12):1966-1969.
Carreira BP, Morte MI, Inácio Â, Rosmaninho-Salgado J, Costa G, Agasse F, Carmo A, Couceiro P, Brundin P, Ambrósio AF, Carvalho CM, Araújo IM (2010) Nitric oxide stimulates the proliferation of neural stem cells bypassing the epidermal growth factor receptor. Stem Cells 28(7):1219-1230.