Leonor Cancela


University of Algarve

Department of Biomedical Sciences and Medicine, Bld 7

Phone: +351 289 800 095 (internal extn. 7463)

Email: lcancela@ualg.pt


Academic Degrees

  • 2003 Agregação, Molecular and Celular Biology, University of Algarve (by unanimity)
  • 1985 PhD - "Docteur de l’Université Pierre et Marie Curie, Mention Très honorable", Paris, France
  • 1982 Diplôme dÉtudes Approfondies (DEA) in Biochemistry, University Pierre et Marie Curie, Paris, France
  • 1981 Maîtrise - "Biology of Organisms and Populations, option Animal Biology ", University Pierre et Marie Curie, Paris VI - France


  • Positions

  • April 2006 on          Full Professor, University of Algarve/Dept of Biomedical Sciences and Medicine
  • Jan/April 2000:       Visiting Associate Project Scientist, Department of Biology, University of California San Diego, La Jolla, CA, USA.
  • Nov 98/Mar 06:     Associate Professor, University of Algarve/FCMA
  • Nov 92/Oct 98:       Assistant Professor, University of Algarve/UCTRA
  • Jul 91/Oct 92:         Assistant Research Biologist, Department of Biology, University of California, San Diego, California, USA.
  • Feb 88/Jun 91:        Post Graduate Research Biologist, Department of Biology, University of California, San Diego, California, USA.
  • Jan 86/Jan 88:        Post Graduate Research Biochemist, Department of Biochemistry, University of California, Riverside, California, USA.
  • Jul 85/Dec 85:         Post Graduate Research Biochemist, INSERM, Hôpital Lariboisière, Paris, France.


Research Interests

Main: Control of gene expression during onset of skeletogenesis and vertebrate skeletal development with special emphasis on vitamin K dependent proteins. Molecular determinants of mineralization in normal and pathological conditions. Cellular differentiation and transformation in bone. Evolution of bone and cartilage and its implications in the onset of skeletal adaptations to stress and environmental conditions.

Others: Host-parasite interaction in marine bivalves. Genetic variability and evolution. Biotechnological applications of marine resources



01. Patent Number(s): WO2010044689-A2 ; WO2010044689-A3

Inventor(s): Brito AB, Cancela ML, Gavaia PJ, Laizé V


Date: October 16, 2009


02. Patent Number(s): WO2010128115-A1; EP2248893-A1

Inventor(s): Danielsen S, Skov LK, Leite R, Laizé V, Cancela ML

Patent Assignee(s): NOVOZYMES AS

Date: May 06, 2010


03. Patent Number(s): WO2010128116-A1

Inventor(s): Danielsen S, Skov LK, Leite R, Laizé V, Cancela ML

Patent Assignee(s): NOVOZYMES AS

Date: May 06, 2010


04. Patent Number(s): WO/2010/024704

Inventor(s): Simes DC, Viegas CSB, Cancela ML

Patent Assignee(s): University of Algarve

Date of deposit: March 03, 2010


Selected Publications (2008-2012)

Cancela ML, N Conceição,V Laizé (2012) Gla rich protein, a new player in tissue calcification? Adv. Nutr. 3: 1–8 (doi:10.3945/an.111.001685)

Rafael MS, V Laizé, C Florindo, S Ferraresso, L Bargelloni,.ML Cancela (2012) Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts. Biochimie 94:1128-1134   ( doi:10.1016/j.biochi.2012.01.013)

Bensimon-Brito A, ML Cancela, A Huysseune, PE Witten.(2012) Vestiges, rudiments and fusion events: the zebrafish caudal fin endoskeleton in an evo-devo perspective. Evolution & Development 14:1, 1–12  (DOI: 10.1111/j.1525-142X.2011.00526.x)

Silva IA, Cancela ML, Conceição N. (2012) Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio). Mol Biol Rep. 2011 Dec 21. [Epub ahead of print] (DOI10.1007/s11033-01101333-x.)

Rafael MS, V. Laizé V, A Bensimon-Brito, RB Leite, R Schüle, ML Cancela (2012) Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata. Cell. Mol. Life Sci. (2012) 69:423–434. (DOI 10.1007/s00018-011-0754-y)

Sousa S, Afonso N, Bensimon-Brito A, Fonseca M, Simões M, Leon J, Roehl H, Cancela ML, Jacinto A (2011) Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration. Development. 2011 Sep;138(18):3897-905.

Fonseca VG, Rosa J, Laizé V, Gavaia PJ, Cancela ML. Identification of a new cartilage-specific S100-like protein up-regulated during endo/perichondral mineralization in gilthead seabream. Gene Expr Patterns. 2011 Oct;11(7):448-55. (doi: 10.1016/j.gep.2011.07.003)

Milan M, A Coppe, R Reinhardt, LM Cancela, RB. Leite, C Saavedra, C Ciofi, G Chelazzi, T Patarnello, S Bertoluzzi, L Bargelloni (2011) Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring. BMC Genomics 12:234.

Tiago DM, V Laizé, L Bargelloni, S Ferraresso, C Romualdi, M L Cancela (2011) Global analysis of gene expression in mineralizing fish vertebra-derived cell lines: new insights into anti-mineralogenic effect of vanadate. BMC Genomics, 12: 310. (doi: 10.1186/1471-2164-12-310)

Tiago DM, Cancela ML, Laizé V. (2011) Proliferative and mineralogenic effects of insulin, IGF-1, and vanadate in fish osteoblast-like cells. J Bone Mineral Metabolism 29:377-382 (doi:10.1007/s00774-010-0243-7)




Share Partilhar