Raquel Andrade

 

University of Algarve

Department of Biomedical Sciences and Medicine, Bld 8

Office Phone: +351 289 244 481 (internal extn. 7481)
Lab Phone: +351 289 244 490 (internal extn. 7490)

Email: rgandrade@ualg.pt

 

Academic Degrees

  • 1998-2002 - PhD in Sciences, University of Minho, Braga, Portugal.
  • 1991-1996 - Degree in Biochemistry, University of Lisbon, Lisbon, Portugal

 

Positions

  • Since 2014, Assistant Professor at the Department of Biomedical Sciences and Medicine of University of Algarve, Faro, Portugal. Head of the research group on Temporal Control of Cell Differentiation.
     
  • 2013 - 2014, Investigadora Auxiliar Convidada Position at ICVS - School of Health Sciences, University of Minho, Braga, Portugal. Head of research group.
     
  • 2008 – 2013, Investigadora Auxiliar Ciência 2007 Position at ICVS - School of Health Sciences, University of Minho, Braga, Portugal. Head of research group.
     
  • 2002 – 2008, Post-Doc studies, ICVS - School of Health Sciences, University of Minho, Braga, Portugal.
  • 1998 - 2002, PhD studies, Biology Dept, School of Sciences, University of Minho, Braga, Portugal and Institute of Molecular Biosciences, Johann Wolfgang Goethe University, Frankfurt, Germany.
     
  • 1996 - 1998, Research assistant, Instituto de Tecnologia Química e Biológica (ITQB), New University of Lisbon, Oeiras, Portugal.
     
  • 1995 - 1996, Undergraduate researcher in training, Instituto de Tecnologia Química e Biológica (ITQB), New University of Lisbon, Oeiras, Portugal

 

Research Interests

TIME is considered the fourth dimension of all biological processes, operating during development, ageing and disease. The developing embryo is a paradigmatic model to study molecular mechanisms of temporal control, since body structures need to be formed at the right time and place for the generation of a functional new organism. My group studies the embryo molecular clock (EC) in temporal control of embryo development (Palmeirim et al, Cell 1997). We are studying the functional relevance of the EC in TEMPORAL CONTROL OF CELL SPECIFICATION and the molecular mechanisms of EC PACE REGULATION. The knowledge obtained represents great promise to multiple Science fields, in particular Cancer and Regenerative Medicine.

 

Project Grants

PTDC/SAU-BID/121459/2010 (FCT/COMPETE, Portugal) “Regulating the pace of the Embryonic Clock: a step forward towards temporal control of cell differentiation”. 2012-2015. 

PTDC/SAU-OBD/105111/2008 (FCT/COMPETE, Portugal) “The role of molecular clock genes in temporal control of mesoderm patterning in vertebrate embryos”. 2010-2013

 

Selected Publications

Analuce Gouveia1,2, Hugo M. Marcelino1,2, Lisa Gonçalves3,4, Isabel Palmeirim3,4 and Raquel P. Andrade1,2. 2015. Patterning in Time and Space: HoxB Cluster Gene Expression in the Developing Chick Embryo. Cell Cycle (doi:10.4161/15384101.2014.972868).

Gil Carraco1,2,*, Ana N. Gonçalves1,2,*, Carlos Serra1,2 and Raquel P. Andrade1,2,3. 2014. MicroRNA processing machinery in the developing chick embryo. Gene Expr Patterns 16:114–121.

Filipe Pinto1,2, Nelma Pértega-Gomes1,2, Márcia S Pereira1,2, José R Vizcaíno3, Pedro Monteiro4, Rui M Henrique5,6,7, Fátima Baltazar1,2,Raquel P Andrade1,2, Rui M Reis1,2,8. 2014. T-box transcription factor Brachyury is associated with prostate cancer progression and aggressiveness. Clin Cancer Res 20: 1–13. 

Caroline J. Sheeba1,2, Raquel P. Andrade1* and Isabel Palmeirim2*. 2014. Limb patterning: from signalling gradients to molecular oscillations. J Mol Biol 426:780-4.*These authors contributed equally to this work. 

Caroline J. Sheeba1,2, Raquel P. Andrade1* and Isabel Palmeirim2*. 2012. Joint Interpretation of AER/FGF and ZPA/SHH Signaling Underlies Dynamic hairy2 Expression in the Chick Limb. Biology Open 1:1102-1110. *These authors contributed equally to this work.

Tatiana P. Resende1, Mónica Ferreira1, Ana Teresa Tavares2,3, Marie-Aimée Teillet4,5, Raquel P. Andrade1* and Isabel Palmeirim6*. 2010.Sonic hedgehog in temporal control of somite formation. Proc Natl Acad Sci U S A. 107:12907-12. *These authors contributed equally to this work.

Caroline J. Sheeba, Isabel Palmeirim and Raquel P. Andrade. 2007. Chick Hairy1 protein interacts with Sap18, a component of the SIN3/HDAC transcriptional repressor complex. BMC Developmental Biology 7:83. 

Andrade, R.P., Kotter, P., Entian, K.-D. and Casal, M. 2005. Multiple transcripts regulate Saccharomyces cerevisiae JEN1 mRNA glucose-triggered decay. Biochem Bioph Res Co. 332:254-62. 

 

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