Raquel Andrade

University of Algarve

Department of Biomedical Sciences and Medicine, Bld 8

Office Phone: +351 289 244 481 (internal extn. 7481)
Lab Phone: +351 289 244 490 (internal extn. 7490)

Email: rgandrade@ualg.pt

Academic Degrees

• 1998-2002 - PhD in Sciences, University of Minho, Braga, Portugal.
• 1991-1996 - Degree in Biochemistry, University of Lisbon, Lisbon, Portugal

Positions

• 1998 - 2002, PhD studies, Biology Dept, School of Sciences, University of Minho, Braga, Portugal and Institute of Molecular Biosciences, Johann Wolfgang Goethe University, Frankfurt, Germany.
   
• 1996 - 1998, Research assistant, Instituto de Tecnologia Química e Biológica (ITQB), New University of Lisbon, Oeiras, Portugal.
   
• 1995 - 1996, Undergraduate researcher in training, Instituto de Tecnologia Química e Biológica (ITQB), New University of Lisbon, Oeiras, Portugal

Research Interests

TIME is considered the fourth dimension of all biological processes, operating during development, ageing and disease. The developing embryo is a paradigmatic model to study molecular mechanisms of temporal control, since body structures need to be formed at the right time and place for the generation of a functional new organism. My group studies the embryo molecular clock (EC) in temporal control of embryo development (Palmeirim et al, Cell 1997). We are studying the functional relevance of the EC in TEMPORAL CONTROL OF CELL SPECIFICATION and the molecular mechanisms of EC PACE REGULATION. The knowledge obtained represents great promise to multiple Science fields, in particular Cancer and Regenerative Medicine.

Project Grants

PTDC/SAU-OBD/105111/2008 (FCT/COMPETE, Portugal) “The role of molecular clock genes in temporal control of mesoderm patterning in vertebrate embryos”. 2010-2013

Selected Publications

Analuce Gouveia^1,2, Hugo M. Marcelino^1,2, Lisa Gonçalves^3,4, Isabel Palmeirim^3,4 and Raquel P. Andrade^1,2. 2015. Patterning in Time and Space: HoxB Cluster Gene Expression in the Developing Chick Embryo. Cell Cycle (doi:10.4161/15384101.2014.972868).

Gil Carraco^1,2,*, Ana N. Gonçalves^1,2,*, Carlos Serra^1,2 and Raquel P. Andrade^1,2,3. 2014. MicroRNA processing machinery in the developing chick embryo. Gene Expr Patterns 16:114–121.

Filipe Pinto^1,2, Nelma Pértega-Gomes^1,2, Márcia S Pereira^1,2, José R Vizcaíno³, Pedro Monteiro⁴, Rui M Henrique^5,6,7, Fátima Baltazar^1,2,Raquel P Andrade^1,2, Rui M Reis^1,2,8. 2014. T-box transcription factor Brachyury is associated with prostate cancer progression and aggressiveness. Clin Cancer Res 20: 1–13. 

Caroline J. Sheeba^1,2, Raquel P. Andrade¹* and Isabel Palmeirim²*. 2014. Limb patterning: from signalling gradients to molecular oscillations. J Mol Biol 426:780-4.*These authors contributed equally to this work. 

Caroline J. Sheeba^1,2, Raquel P. Andrade¹* and Isabel Palmeirim²*. 2012. Joint Interpretation of AER/FGF and ZPA/SHH Signaling Underlies Dynamic hairy2 Expression in the Chick Limb. Biology Open 1:1102-1110. *These authors contributed equally to this work.

Tatiana P. Resende¹, Mónica Ferreira¹, Ana Teresa Tavares^2,3, Marie-Aimée Teillet^4,5, Raquel P. Andrade¹* and Isabel Palmeirim⁶*. 2010.Sonic hedgehog in temporal control of somite formation. Proc Natl Acad Sci U S A. 107:12907-12. *These authors contributed equally to this work.

Caroline J. Sheeba, Isabel Palmeirim and Raquel P. Andrade. 2007. Chick Hairy1 protein interacts with Sap18, a component of the SIN3/HDAC transcriptional repressor complex. BMC Developmental Biology 7:83. 

Andrade, R.P., Kotter, P., Entian, K.-D. and Casal, M. 2005. Multiple transcripts regulate Saccharomyces cerevisiae JEN1 mRNA glucose-triggered decay. Biochem Bioph Res Co. 332:254-62.