R&D Projects

The research developed at UAlg goes far beyond the walls of academia, extending to the most varied spheres of society. Find out where UAlg is in the country and in the world and learn about the projects in progress.
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INTERGEN: GWAS innovation in breast cancer through the integration of functional genomics

The specific objectives of this project are: 1) Identify genes with DAEs associated with breast cancer risk. We have already started phase I of a GWAS using DAE as a quantitative phenotype (preliminary data). In this proposal, we will perform the second phase of the GWAS through target RNA-seq in normal tissue of 50 patients with BC and 50 controls, of the most promising genes in phase I, followed by case-control association studies. 2) Map the cis-regulatory variants (rSNPs) for the identified risk genes. DAE analysis detects the cis-regulation target gene but not on the rSNP location. We have experience in successfully mapping cis-regulatory variants by correlating DAE information with genotype/haplotype data. 3) Characterise the new risk variants functionally. To characterise the underlying cis-regulation mechanism, in-silico, in vitro and in-vivo analyses of the best candidate genes will be performed in human breast cell lines and fresh tissue.

Objetivo principal
Strengthening research, technological development and innovation
Referência do projeto
ALG-01-0145-FEDER-030895
Tipologia
Investigação e Desenvolvimento
Data de aprovação
Data de início/fim
/
Data de prorrogação
Região de Intervenção
Algarve
Lisboa
Investigador principal
Joana Xavier
Programa financiador
FCT
CRESC Algarve 2020
Portugal 2020
União Europeia (FEDER)
Tipo de Financiamento
Fundos da União Europeia
Custo total elegível
236221.43
Custo total elegível UAlg
235721.43
Apoio financeiro da União Europeia
94488.57
Financiamento EU UAlg
94288.57
Apoio Financeiro Público Nac./Reg.
141732.86
Financiamento Nac./Reg. UAlg
141432.86
Entidades beneficiárias

Universidade do Algarve (Coordenador)
Instituto de Medicina Molecular

Financiamento