Bibiana Isabel da Silva Ferreira
Professor auxiliar convidado
Faculdade de Medicina e Ciências Biomédicas
Subsistema
Docentes Universitário
Regime
Parcial
Vínculo
CT em Funções Públicas a termo resolutivo certo
Atividades
Atividades
2021/02/11 - Presente. Entrevista / Programa (rádio / tv). TSF- igualdade de genero
. Mulheres na ciência: muitas habilitações e ainda sem estabilidade na vida.
. Mulheres na ciência: muitas habilitações e ainda sem estabilidade na vida.
2022/03 - Presente. Membro de associação. Sociedade Portuguesa de Genética Humana. Member.
2016 - 2021/11/19. Orientação. Characterization of TRIB2 mediated drug resistance and its validation as a novel diagnostic marker.ProREGEM (Doutoramento). Coorientador.
2019 - 2021/11/05. Orientação. Generation of drug resistant cell lines as a model to study melanoma, pancreatic cancer and glioblastoma.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2021/01 - Presente. Membro de comissão. Member of the Algarve Biomedical Center Research Institute (ABC-Ri). Membro. Universidade do Algarve Centro Académico de Investigação e Formação Biomédica do Algarve.
2020 - Presente. Membro de associação. Sociedade Portuguesa de Genética. Vogal da Direcção.
2020/05/05 - 2020/05/08. Participação em evento. Laboratory Leadership for Group Leaders:
Leadership and management skills are critical for a successful career in science. This course has been designed to meet the specific needs of researchers progression into an independent position. . Oficina (workshop). Laboratory Leadership for Group Leaders.
Leadership and management skills are critical for a successful career in science. This course has been designed to meet the specific needs of researchers progression into an independent position. . Oficina (workshop). Laboratory Leadership for Group Leaders.
2020/03/30 - Presente. Organização de evento. Coordinator of the "COVID19 Testing Unit" at ABC. Responsible for the implementation of the COVID19 diagnostic lab at the Universidade do Algarve. (2020). Universidade do Algarve.
2020/02 - Presente. Organização de evento. MIcromundo- Programa de sensibilizaçao do uso de antibioticos na populaçao a longo prazo.
https://tinyearth.wisc.edu/ (2020). Universidade do Algarve - Campus de Gambelas.
https://tinyearth.wisc.edu/ (2020). Universidade do Algarve - Campus de Gambelas.
2020/01 - 2020/01. Organização de evento. INTERNATIONAL MEETING OF THE PORTUGUESE SOCIETY OF GENETICS (2020). Universidade do Algarve - Campus de Gambelas.
2020/01/30 - 2020/01/31. Organização de evento. 2nd Joint COST-WG4-WG5 TRANSAUTOPHAGY Translational Workshop (2020). Universidade do Algarve Centro de Investigação em Biomedicina.
2018 - 2019. Orientação. Study of the TRIB2 protein network.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2018 - 2019. Orientação. Efeito de diferentes terapêuticas citotóxicas na expressão do CD133, Wnt/ß-catenina no cancro do colo do útero.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2019 - Presente. Orientação. Studying the role of hypoxia in glioblastoma.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2019 - Presente. Orientação. Characterizing the role of FOXO regulators and FOXO isoforms in cancer.Ciências Biomédicas (Doutoramento). Orientador.
2019 - 2019. Orientação. Study of a panel of inhibitors on TRIB2 –AKT association by Protein Complementation Assay.Mestrado Integrado em Medicina (Outra). Orientador.
2019. Júri de grau académico. Avaliação da expressão de PD-L1 e de subpopulações linfocitárias em Cancro da mama. Arguente principal. Cátia Neto (Mestrado). Universidade do Algarve.
2019. Júri de grau académico. MAGNETIC NANOPARTICLES FOR BIOSENSING AND IMMUNOPRECIPITATION. Arguente principal. Christian Perez (Mestrado).
2019. Júri de grau académico. Study of the TRIB2 protein network . Orientador. Catarina Raposo (Mestrado).
2019/11/25 - 2019/11/27. Organização de evento. Flow Cytometry Course - CBMR Training Program (2019). Universidade do Algarve Centro de Investigação em Biomedicina.
2019/10/03 - 2019/10/03. Curso / Disciplina lecionado. Seminar: "Keep your cells CRISPr" . Ciências Biomédicas (Licenciatura). Universidade de Aveiro.
2019/06/05 - 2019/06/07. Participação em evento. Workshop on Genome Editing using CRISPR-Cas9:
The aim of this workshop is to provide hands-on training in genome editing in mammalian cells using the powerful CRISPR/Cas9 system. It will cover topics from sgRNA design, molecular cloning and transfection, through off-target assessment, validation and different applications.. Oficina (workshop). Workshop on Genome Editing using CRISPR-Cas9. Universidade do Porto Instituto de Investigação e Inovação em Saúde.
The aim of this workshop is to provide hands-on training in genome editing in mammalian cells using the powerful CRISPR/Cas9 system. It will cover topics from sgRNA design, molecular cloning and transfection, through off-target assessment, validation and different applications.. Oficina (workshop). Workshop on Genome Editing using CRISPR-Cas9. Universidade do Porto Instituto de Investigação e Inovação em Saúde.
2019/02. Apresentação oral de trabalho. Discovering drugs to overcome anti-cancer drug resistance. Challenging organic synthesis inspired by nature - from natural products chemistry to drug discovery, COST action-CM1407.
2017 - 2018. Orientação. CRISPR: Appplications in Human pathologies and future prospects.Ciências Farmacêuticas (Mestrado). Coorientador.
2018 - 2018. Orientação. CRISPR/Cas9-mediated genome editing: from basic research to translational medicine.Mestrado Integrado em Medicina (Outra). Orientador.
2016 - 2017. Orientação. Characterization of TRIB2-mediated resistance to pharmacological inhibition of MEK.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2017. Júri de grau académico. Analysis of transcriptional and post- transcriptional regulators of DUSP4, a human gene associated with CRC. Arguente principal. Tatiana Varela (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.
2017. Júri de grau académico. Nanoparticulas de ouro no tratamento do cancro da mama. Arguente principal. Raquel Marques (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.
2017. Júri de grau académico. Integrin alpha5beta1 and resistance to cancer therapies: Role of endocytosis in resistance to gefitinib. Orientador. Elisabete Cruz da SILVA (Mestrado). Universidade do Algarve.
2017. Júri de grau académico. Characterization of TRIB2-mediated resistance to pharmacological inhibition of MEK. Orientador. Vanessa Henriques (Mestrado).
2017/06 - Presente. Arbitragem científica em revista. Scientific Reports (2045-2322). Springer Science and Business Media LLC.
2016 - Presente. Orientação. Integrin alpha5beta1 and resistance to cancer therapies: Role of endocytosis in resistance to gefitinib.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Coorientador.
2016 - 2016. Orientação. Generating Cellular Models to Unravel the Oncogenic Properties of TRIB2 in Melanoma Cells Using the CRISPR-Cas9 System.mestrado integrado em medicina (Outra). Orientador.
2016. Júri de grau académico. Contribuição para a identificação do papel da MGP no desenvolvimento tumoral no cancro colorretal. Arguente principal. Inês Martins Silva (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.
2016/09 - Presente. Curso / Disciplina lecionado. Progressão Tumoral. Oncobiologia- Mecanismos Moleculares do Cancro (Mestrado). Universidade do Algarve - Campus de Gambelas; Universidade do Algarve Departamento de Ciências Biomédicas e Medicina.
2016/07. Apresentação oral de trabalho. Melanoma is in TRIBBLES. 1st CBMR/ProRegeM Annual Meeting.
2016/06. Apresentação oral de trabalho. A CRISPR view on TRIBBLES proteins. Tribbles Proteins at the Interface of Metabolism and Cancer.
2016/04. Apresentação oral de trabalho. Characterization of TRIB2-mediated resistance to anti-melanoma drugs. Jornadas de Investigação em Oncologia em Portugal.
2015 - Presente. Membro de associação. Associaçao Portuguesa de Investigação em Cancro.
2013 - 2013. Participação em evento. Modern Marketing for Scientists: “How to Sell Yourself and Your Work” (Marc Kuchner). Salk Institute for Biological Studies.
2008 - 2010. Curso / Disciplina lecionado. Identificación de alteraciones en el genoma utilizando array-CGH
. Centro Nacional de Investigaciones Oncológicas.
. Centro Nacional de Investigaciones Oncológicas.
2008/09. Apresentação oral de trabalho. Patterns of Genomic Instability associated with cell cycle and DNA repair in Ewing sarcomas – gene expression and aCGH profiling. 11th European Workshop on Cytogenetics and Molecular Genetics of Solid Tumours (11th EWCMGST).
2008/03/10 - 2008/03/11. Organização de evento. CNIO ONCOTRAIN Workshop: “New Battlefields in Cancer- Attacking in Many Fronts (2008). Centro Nacional de Investigaciones Oncológicas.
2007/05. Apresentação oral de trabalho. MOLECULAR PROFILING OF THE GENOME. MC-GARD Conference.
2006/09. Apresentação oral de trabalho. t(11;22) Ewing sarcomas genomic characterization by high resolution CGH array reveals distinct subgroups. 3rd Marie Curie Conference on array CGH and molecular cytogenetics.
2005 - 2005. Participação em evento. Workshop on molecular biology and cellular of cancer – Introduction to the cellular and molecular
mechanisms.
mechanisms.
Projetos
Projetos
2017/05/01 - Presente. Characterizing the clinical relevance and the mechanism underlying TRIB2-mediated drug resistance to MEK inhibitors in the context of melanoma. Investigador responsável.
2017 - 2019. RED transfronteriza para el desarrollo de productos innovadores con microALGAs (ALGARED+), Programa Cooperación Transfronteriza Espanha Portugal (POCTEP). Investigador.
2019 - 2021. Targeting TRIB2-mediated drug resistance in melanoma (RESIST), Ministerio de Ciencia, Innovación y Universidades. Investigador.
2021/04/01 - Presente. ENDURING- Desvendar mecanismos de resistência em Glioblastoma. Investigador responsável.
2021 - Presente. PtCAC- ABC, PtCAC- Portuguese Network of Clinical Academic Centers. Investigador responsável.
2018/09/01 - 2021. TRIBBLES, H2020. Investigador responsável.
2019 - 2021. Using natural products from regional grapes/wine capable of regulating FOXO factors as potential anti-aging drugs. Investigador. Universidade do Algarve Centro de Investigação em Biomedicina.
2020/01/05 - 2021. Development of a new assay do detect SARS-CoV-2 directly from clinical samples, RESEARCH4COVID 19. Investigador. Universidade do Algarve.
Produções
Pérez-Beltrán, Christian Hazael; García-Guzmán, Juan José; Ferreira, Bibiana; Estévez-Hernández, Osvaldo; López-Iglesias, David; Cubillana-Aguilera, Laura; Link, Wolfgang; et al. 2021. "One-minute and green synthesis of magnetic iron oxide nanoparticles assisted by design of experiments and high energy ultrasound: Application to biosensing and immunoprecipitation". Materials Science and Engineering: C. https://doi.org/10.1016/j.msec.2021.112023
Jacinto, Filipe V.; Link, Wolfgang; Ferreira, Bibiana I.. 2020. "CRISPR/Cas9-mediated genome editing: From basic research to translational medicine". Journal of Cellular and Molecular Medicine. https://doi.org/10.1111/jcmm.14916
Ferreira, Bibiana I.. 2020. TARGETING THE TRIB2/FOXO AXIS TO OVERCOME THERAPY RESISTANCE. Em International Symposium „Pseudokinases and Tribbles – from Molecules to Therapy”..
Ferreira, Bibiana I.. 2020. "Inhibition of second layer regulatory kinases differentially induces nuclear FOXO translocation". Cancer Drug Resistance.
Ferreira, Bibiana I.. 2020. "Connectivity Map-based discovery of Harmine to overcome TRIB2-mediated therapy resistance". Oncogene.
Ferreira, Bibiana I.; Link, Wolfgang. 2020. "Small molecule inhibitors of CRM1". Frontiers in Pharmacology.
Machado, Susana; Silva, Andreia; De Sousa-Coelho, Ana Luísa; Duarte, Isabel; Grenho, Inês; Santos, Bruno; Mayoral-Varo, Victor; et al. 2020. "Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance". Cancers, 12 (12). https://doi.org/10.3390/cancers12123689
Henriques, Vanessa; Martins, Teresa; Link, Wolfgang; Ferreira, Bibiana I.. 2018. "The Emerging Therapeutic Landscape of Advanced Melanoma". Current Pharmaceutical Design, 24 (5): 549-558. https://doi.org/10.2174/1381612824666180125093357
Henriques, Vanessa; Machado, Susana; Link, Wolfgang; Ferreira, Bibiana I.. 2018. "Monitoring the Transcriptional Activity of FOXO Transcription Factors by Analyzing their Target Genes". Em Methods in Molecular Biology, 103-113. Springer New York. https://doi.org/10.1007/978-1-4939-8900-3_9
Machado, Susana; Raposo, Catarina; Ferreira, Bibiana I.; Link, Wolfgang. 2018. "Image-based Identification of Chemical Compounds Capable of Trapping FOXO in the Cell Nucleus". Em Methods in Molecular Biology, 163-170. Springer New York. https://doi.org/10.1007/978-1-4939-8900-3_14
Ferreira, Bibiana; Silva, Elisabete Cruz da. 2017. "Integrin alpha5beta1 and resistance to cancer therapies: role of endocytosis in resistance to gefitinib". Mestrado. http://hdl.handle.net/10400.1/9975
Link, Wolfgang; Ferreira, Bibiana; Henriques, Vanessa Mendes. 2017. "Characterization of TRIB2-mediated resistance to pharmacological inhibition of MEK". Mestrado. http://hdl.handle.net/10400.1/10705
Hill, Richard; Madureira, Patricia A.; Ferreira, Bibiana; Baptista, Inês; Machado, Susana; Colaço, Laura; dos Santos, Marta; et al. 2017. "TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT". Nature Communications, 8 (1). https://doi.org/10.1038/ncomms14687
Ferreira, Bibiana I.; Lie, Maria K.; Engelsen, Agnete S. T.; Machado, Susana; Link, Wolfgang; Lorens, James B.. 2017. "Adaptive mechanisms of resistance to anti-neoplastic agents". MedChemComm, 8 (1): 53-66. https://doi.org/10.1039/c6md00394j
Cautain, Bastien; Castillo, Francisco; Musso, Loana; Ferreira, Bibiana I.; de Pedro, Nuria; Rodriguez Quesada, Lorena; Machado, Susana; et al. 2016. "Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling". PLOS ONE, 11 (12). https://doi.org/10.1371/journal.pone.0167491
Ferreira, Bibiana I.. 2016. "Subcellular Protein Localisation in Health and Disease". eLS.
Ferreira, Bibiana I.; Hill, Richard; Link, Wolfgang. 2015. "Special Review: Caught in the Crosshairs: Targeted Drugs and Personalized Medicine.". The Cancer Journal, 21 (6): 441-447. https://doi.org/10.1097/ppo.0000000000000161
Rio-Machin, A; Ferreira, B I; Henry, T; Gómez-López, G; Agirre, X; Alvarez, S; Rodriguez-Perales, S; et al. 2012. "Downregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype". Leukemia, 27 (4): 925-931. https://doi.org/10.1038/leu.2012.302
Rio-Machin, A.; Menezes, J.; Maiques-Diaz, A.; Agirre, X.; Ferreira, B. I.; Acquadro, F.; Rodriguez-Perales, S.; et al. 2011. "Abrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22)". Haematologica, 97 (4): 534-537. https://doi.org/10.3324/haematol.2011.050567
Sánchez-Schmidt, Júlia Ma; Salgado, Rocío; Servitje, Octavio; Gallardo, Fernando; Ortiz-Romero, Pablo L.; Karpova, Maria B.; Zipser, Marie C.; et al. 2011. "Primary Cutaneous CD30+ Anaplastic Large-Cell Lymphomas Show a Heterogeneous Genomic Profile: An Oligonucleotide ArrayCGH Approach". Journal of Investigative Dermatology, 131 (1): 269-271. https://doi.org/10.1038/jid.2010.271
Di Lisio, L; Gómez-López, G; Sánchez-Beato, M; Gómez-Abad, C; Rodríguez, M E; Villuendas, R; Ferreira, B I; et al. 2010. "Mantle cell lymphoma: transcriptional regulation by microRNAs". Leukemia, 24 (7): 1335-1342. https://doi.org/10.1038/leu.2010.91
Salgado, Rocío; Servitje, Octavio; Gallardo, Fernando; Vermeer, Maarten H.; Ortiz-Romero, Pablo L.; Karpova, Maria B.; Zipser, Marie C.; et al. 2010. "Oligonucleotide Array-CGH Identifies Genomic Subgroups and Prognostic Markers for Tumor Stage Mycosis Fungoides". Journal of Investigative Dermatology, 130 (4): 1126-1135. https://doi.org/10.1038/jid.2009.306
Marcos, Nuno T.; Magalhães, Ana; Ferreira, Bibiana; Oliveira, Maria J.; Carvalho, Ana S.; Mendes, Nuno; Gilmartin, Tim; et al. 2008. "Helicobacter pylori induces ß3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl–Lewis x". Journal of Clinical Investigation. https://doi.org/10.1172/jci34324
Ferreira, B. I.; Garcia, J. F.; Suela, J.; Mollejo, M.; Camacho, F. I.; Carro, A.; Montes, S.; Piris, M. A.; Cigudosa, J. C.. 2008. "Comparative genome profiling across subtypes of low-grade B-cell lymphoma identifies type-specific and common aberrations that target genes with a role in B-cell neoplasia". Haematologica, 93 (5): 670-679. https://doi.org/10.3324/haematol.12221
Ferreira, B I; Alonso, J; Carrillo, J; Acquadro, F; Largo, C; Suela, J; Teixeira, M R; et al. 2007. "Array CGH and gene-expression profiling reveals distinct genomic instability patterns associated with DNA repair and cell-cycle checkpoint pathways in Ewing's sarcoma". Oncogene, 27 (14): 2084-2090. https://doi.org/10.1038/sj.onc.1210845
Largo, C.; Saez, B.; Alvarez, S.; Suela, J.; Ferreira, B.; Blesa, D.; Prosper, F.; Calasanz, M. J.; Cigudosa, J. C.. 2007. "Multiple myeloma primary cells show a highly rearranged unbalanced genome with amplifications and homozygous deletions irrespective of the presence of immunoglobulin-related chromosome translocations". Haematologica, 92 (6): 795-802. https://doi.org/10.3324/haematol.11052
Suela, J; Álvarez, S; Cifuentes, F; Largo, C; Ferreira, B I; Blesa, D; Ardanaz, M; et al. 2007. "DNA profiling analysis of 100 consecutive de novo acute myeloid leukemia cases reveals patterns of genomic instability that affect all cytogenetic risk groups". Leukemia, 21 (6): 1224-1231. https://doi.org/10.1038/sj.leu.2404653
Suela, Javier; Largo, Cristina; Ferreira, Bibiana; Álvarez, Sara; Robledo, Mercedes; González-Neira, Anna; Calasanz, Maria José; Cigudosa, Juan C.. 2007. "Neurofibromatosis 1, and Not TP53, Seems to Be the Main Target of Chromosome 17 Deletions in De Novo Acute Myeloid Leukemia". Journal of Clinical Oncology, 25 (9): 1151-1152. https://doi.org/10.1200/jco.2006.09.3013
Pinho, Sandra; Marcos, Nuno T.; Ferreira, Bibiana; Carvalho, Ana S.; Oliveira, Maria J.; Santos-Silva, Filipe; Harduin-Lepers, Anne; Reis, Celso A.. 2007. "Biological significance of cancer-associated sialyl-Tn antigen: Modulation of malignant phenotype in gastric carcinoma cells". Cancer Letters, 249 (2): 157-170. https://doi.org/10.1016/j.canlet.2006.08.010
Ferreira, Bibiana; Marcos, Nuno T.; David, Leonor; Nakayama, Jun; Reis, Celso A.. 2006. "Terminal a1,4-linked N-acetylglucosamine in Helicobacter pylori-associated Intestinal Metaplasia of the Human Stomach and Gastric Carcinoma Cell Lines". Journal of Histochemistry & Cytochemistry, 54 (5): 585-591. https://doi.org/10.1369/jhc.5a6836.2006
