Silhueta de pessoa indiferenciada

Clévio David Rodrigues Nóbrega

Professor auxiliar
Faculdade de Medicina e Ciências Biomédicas
Subsistema
Orgãos de Gestão
Unidade ID externa
Programa Champalimaud de Investigação (CR)
Regime
Exclusividade
Vínculo
CT em Funções Públicas por tempo indeterminado

Atividades

Atividades
2017 - 2022. Orientação. Stress granules in Polyglutamine diseases: new targets for therapeutic intervention?.Ciências Biomédicas (Doutoramento). Orientador.
2021 - Presente. Orientação. Brain-targeted lipid-based nanovesicles to deliver brain plasticity modulators – a strategy to enhance brain cell-replacement therapeutics in Machado-Joseph disease.Ciências Farmacêuticas (Doutoramento). Coorientador.
2021. Apresentação oral de trabalho. MAPPING THE DOMAINS OF RBP-X TOWARDS MITIGATION OF THE PATHOLOGICAL PHENOTYPE IN POLYGLUTAMINE DISEASE MODELS. 51ª Reunião da Sociedade Portuguesa de Farmacologia.
2021. Apresentação oral de trabalho. "RBP-X PROTEIN MITIGATES MOTOR DEFICITS
IN DIFFERENT MICE MODELS OF POLYGLUTAMINE DISEASES". 51ª Reunião da Sociedade Portuguesa de Farmacologia.
2021. Apresentação oral de trabalho. CRISPR/CAS9-MEDIATED SILENCING OF ATXN2 EXPRESSION. 51ª Reunião da Sociedade Portuguesa de Farmacologia.
2021. Apresentação oral de trabalho. MIXCAPAAV1/2 VECTOR: A NOVEL GENE DELIVERY SYSTEM DISTRIBUTION, SPREADING AND TROPISM ANALYSIS IN NORMAL MICE. 51ª Reunião da Sociedade Portuguesa de Farmacologia.
2021. Apresentação oral de trabalho. AUTOPHAGY DYSFUNCTION IN SPINOCEREBELLAR ATAXIA TYPE 2 MODELS AND A POTENTIAL THERAPEUTIC STRATEGY. 51ª Reunião da Sociedade Portuguesa de Farmacologia.
2021. Apresentação oral de trabalho. HYPOTHALAMIC NEUROPEPTIDE Y (NPY) AMELIORATES THE AGING PHENOTYPE OF A MOUSE MODEL OF HUMAN AGING. 51ª Reunião da Sociedade Portuguesa de Farmacologia.
2021. Apresentação oral de trabalho. Development of gene therapy strategies: lessons from preclinical studies. Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck.
2021. Apresentação oral de trabalho. Molecular therapies for Polyglutamine diseases: lessons from preclinical studies. Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM).
2020 - 2021. Orientação. Spreading of mutant ataxin-2 through extracellular vesicles.Ciências Biomédicas (Mestrado). Orientador.
2019 - 2021. Orientação. On the role of brain ataxin-2 in whole-body aging.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2019 - 2021. Orientação. Role of neuronal cholesterol in peripheric tissues.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2020 - Presente. Orientação. Unraveling the role of RNA-binding proteins in Polyglutamine Diseases: from pathogenesis to therapeutics.Ciências Biomédicas (Doutoramento). Orientador.
2018 - 2020. Orientação. Targeting hypothalamus: diet impact, bacterial composition and memory impair.Biologia Molecular e Microbiana (Mestrado). Coorientador.
2018 - 2020. Orientação. Silencing of CYPX gene in the hypothalamus and its impact on whole-body metabolism.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2020. Apresentação oral de trabalho. Overexpression of a Specific RNA-binding Protein Ameliorates Several Abnormalities in Cellular Models of Progeria. 50th SPF Annual Meeting.
2020. Apresentação oral de trabalho. RNA-binding proteins as potential therapeutic targets for Polyglutamine diseases. 50th SPF Annual Meeting.
2020. Apresentação oral de trabalho. Stress granules crosstalk with autophagy in a context of polyglutamine diseases. 50th SPF Annual Meeting.
2020. Apresentação oral de trabalho. Stress Granules dynamics in Polyglutamine diseases. International Meeting of the Portuguese Society of Genetics.
2020. Apresentação oral de trabalho. Activation of autophagy as a molecular target for neurodegenerative diseases. 2nd Joint WG4-WG5 Transautophagy Translational Workshop - European Network of Multidisciplinary Research and Translation of Autophagy knowledge (TRANSAUTOPHAGY).
2020. Apresentação oral de trabalho. Towards a therapy for polyglutamine diseases: lessons from preclinical studies. Recent Trends in CNS Regenerative Medicine, ICVS. Universidade do Minho.
2020. Júri de grau académico. Silencing of CYPX gene in the hypothalamus and its impact on whole-body metabolism. Orientador. Adriana Arrulo (Mestrado). Universidade do Algarve.
2020. Júri de grau académico. Targeting hypothalamus: diet impact, bacterial composition and memory impair. Orientador. Bruno Várzea (Mestrado). Universidade do Algarve.
2020 - Presente. Orientação. Connecting mutant Ataxin-2 and synaptic disfunction: are stress granules the link?.Ciências Biomédicas (Doutoramento). Orientador.
2019 - 2020. Orientação. A neuroendocrine strategy to delay aging.Ciências Biomédicas (Mestrado). Coorientador.
2019 - 2020. Orientação. Silencing ATXN2 through CRISPR-mediated insertion of a premature STOP codon.Ciências Biomédicas (Mestrado). Coorientador.
2019 - 2020. Orientação. Ciliary recruitment of Dynein-2 motor and its role in C. elegans sensory functions, with emphasis in male mating behavior.Ciências Biomédicas (Mestrado). Coorientador.
2019 - 2020. Orientação. Terapia génica: Sistemas de Entrega, Mecanismos Moleculares e Abordagens Terapêuticas Aprovadas.Ciências Farmacêuticas (Mestrado). Orientador.
2019 - 2020. Orientação. Controlling the effect of injection in the hypothalamus of diet-induced obese mice.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2019 - 2020. Orientação. On the role of an RNA-binding protein in a transgenic mouse model of Polyglutamine diseases.Ciências Biomédicas (Mestrado). Orientador.
2019 - 2020. Orientação. The impact of aging in mutant ataxin-2 induced neurodegeneration.Ciências Biomédicas (Mestrado). Orientador.
2020. Apresentação oral de trabalho. Hypothalamic ataxin-2 prevents obesity through the regulation of the circadian clock. European and International Congress of Obesity 2020 (ECO-ICO).
2020. Apresentação oral de trabalho. PERMANENT INACTIVATION OF THE ATXN3 GENE: A POSSIBLE THERAPEUTIC APPROACH FOR MACHADO-JOSEPH DISEASE. 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana.
2020. Apresentação oral de trabalho. A renovação do colesterol cerebral nas ataxias espinocerebelosas: dos estudos pré-clínicos ao desenvolvimento de uma terapia. III SIMPÓSIO EM INVESTIGAÇÃO DAS ESCOLAS MÉDICAS PORTUGUESAS.
2020 - Presente. Orientação. Protein synthesis and ageing: is translation rate a major regulator?.Ciências Biomédicas (Mestrado). Orientador.
2020 - Presente. Orientação. Connecting aging genes and mutant ataxin-2 induced neurodegeneration.Ciências Biomédicas (Mestrado). Orientador.
2020. Júri de grau académico. InCited2 secrete cardiogenic molecules. Arguente principal. João André Lopes (Mestrado). Universidade do Algarve.
2020. Júri de grau académico. Terapia génica: Sistemas de Entrega, Mecanismos Moleculares e Abordagens Terapêuticas Aprovadas. Orientador. Carolina Biscaia (Mestrado). Universidade do Algarve.
2020. Júri de grau académico. A NEUROENDOCRINE STRATEGY TO DELAY AGING. Orientador. Hélio Conceição (Mestrado). Universidade do Algarve.
2020. Júri de grau académico. Estudo do papel de uma proteína ligante de RNA num modelo animal das doenças de poliglutaminas. Orientador. Joana Pinto (Mestrado). Universidade do Algarve.
2020. Júri de grau académico. The impact of aging in mutant ataxin-2 induced neurodegeneration. Orientador. Patrícia Lima (Mestrado). Universidade do Algarve.
2020. Júri de grau académico. Functional studies on ZEB transcription factors in glioblastoma. Presidente do júri. Nuno Ramalho (Mestrado). Universidade do Algarve.
2020. Júri de grau académico. Controlling the effect of injection in the hypothalamus of diet-induced obese mice. Orientador. Renata Sandres Souza Araújo (Mestrado). Universidade do Algarve.
2017 - 2019. Orientação. On the role of stress granules in autophagy.Neurociências (Mestrado). Orientador.
2019 - Presente. Orientação. Targeting the ATXN2 gene with the CRISPR-Cas9 system as a therapeutic strategy for spinocerebellar ataxia type 2.Ciências Biomédicas (Doutoramento). Orientador.
2018 - 2019. Orientação. Insights into the role of G3BP1 on Polyglutamine diseases .Biologia Molecular e Microbiana (Mestrado). Orientador.
2019. Apresentação oral de trabalho. MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go?. Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting .
2019. Apresentação oral de trabalho. Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. International Research Ataxia Conference (IARC) 2019.
2019. Apresentação oral de trabalho. CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease. MJD International Research Conference.
2019. Apresentação oral de trabalho. Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. MJD International Research Conference.
2019. Apresentação oral de trabalho. CYP46A1- gene therapy improves Machado-Joseph disease in mouse models. 23ª Reunião Anual da Sociedade Portuguesa de Genética Humana.
2019. Apresentação oral de trabalho. Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models. 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) .
2019. Apresentação oral de trabalho. Permanent inactivation of the ATXN3 gene: A possible therapeutic approach for Machado-Joseph disease. XVI Meeting of the Portuguese Society for Neuroscience.
2019. Apresentação oral de trabalho. Repeated transplantation of mesenchymal stromal cells in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI).
2019. Apresentação oral de trabalho. Development and characterization of a lentiviral mouse model for Spinocerebellar ataxia type 2. 3as Jornadas Algarve Biomedical Center.
2019. Apresentação oral de trabalho. CYP46A1 overexpression alleviates Machado-Joseph disease. XLIX Reunião da Sociedade Portuguesa de Farmacologia.
2019. Apresentação oral de trabalho. From the molecular pathogenesis to gene therapy. 5º Meeting dos Mestrado Integrado em Medicina.
2019. Apresentação oral de trabalho. Towards a therapy for Polyglutamine diseases: lessons from preclinical studies. Interdisciplinary Center for Neuroscience.
2019. Apresentação oral de trabalho. Preclinical studies in spinocerebellar ataxias. PhD Programme in Health Sciences (PhDHS), FMUC. Universidade de Coimbra.
2019. Apresentação oral de trabalho. Polyglutamine diseases: lessons from disease pathogenesis and clues into therapy. Neurodegenerative Diseases course at PDBEB . Centro de Neurociências e Biologia Celular.
2019. Júri de grau académico. On the persistence of therapy: the potential of miRNA modulation in Alzheimer disease. Arguente principal. Ana Teresa de Barros Viegas (Doutoramento). Universidade de Coimbra.
2019. Júri de grau académico. Insights into the role of G3BP1 on Polyglutamine diseases . Orientador. Diogo Teixeira (Mestrado). Universidade do Algarve.
2019. Júri de grau académico. Estudo comparativo e diferencial dos genes Mob: os interactuantes proteicos e expressão transcricional em contextos de normalidade e tumorais. Arguente principal. Ricardo Resende (Mestrado). Universidade do Algarve.
2019. Júri de grau académico. Patient-specific iPSC-derived NESC for Machado-Joseph disease treatment. Arguente principal. Vanessa Alexandra Castanheira (Mestrado). Universidade de Coimbra.
2019. Júri de grau académico. Toward the isolation of exosomes by flow cytometry.. Arguente principal. André Mozes (Mestrado). Universidade do Algarve.
2019. Júri de grau académico. Study of the TRIB2 protein network.. Arguente principal. Catarina Raposo (Mestrado). Universidade do Algarve.
2019. Júri de grau académico. On the role of stress granules in autophagy.. Orientador. Rebekah Koppenol (Mestrado). Universidade de Lisboa Faculdade de Medicina.
2019/06 - Presente. Arbitragem científica em conferência. XVI Meeting of the Portuguese Society for Neuroscience. Lisboa.
2019/06. Apresentação oral de trabalho. Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2. Gordon Research Seminar on Clocks in Model Organisms: Circadian Networks, Physiology and Health.
2019/04. Apresentação oral de trabalho. Hypothalamic ataxin-2: Resetting the clock on obesity. European Congress on Obesity ECO 2019.
2017 - 2018. Orientação. Estudo da via da autofagia no contexto da ataxia espinocerebelosa do tipo 2.Ciências Biomédicas (Mestrado). Orientador.
2017 - 2018. Orientação. A catalogue of mammalian stress granules components: implications for neurodegeneration.Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado). Orientador.
2018. Apresentação oral de trabalho. CYP46A1-gene therapy alleviates spinocerebellar ataxia in mouse models. European Society of Gene and Cell Therapy congress.
2018. Apresentação oral de trabalho. Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebelar ataxia type-3 AND therapeutic success can be monitored by 1H-MRS. Portuguese Society of Movement Disorders (SPDMov).
2018. Apresentação oral de trabalho. Tailoring gene editing strategies for the treatment of Machado-Joseph disease. Portuguese Society of Movement Disorders (SPDMov).
2018. Apresentação oral de trabalho. Pharmacological targeting of AMPK signalling pathway as a therapeutic approach to Polyglutamine diseaes. XLVIII Reunião da Sociedade Portuguesa de Farmacologia.
2018. Apresentação oral de trabalho. Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. XLVIII Reunião da Sociedade Portuguesa de Farmacologia.
2018. Apresentação oral de trabalho. MicroRNA dysregulation in Machado-Joseph disease: from pathogenesis to therapy. XLVIII Reunião da Sociedade Portuguesa de Farmacologia.
2018. Apresentação oral de trabalho. Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease. XLVIII Reunião da Sociedade Portuguesa de Farmacologia.
2018. Apresentação oral de trabalho. Ibuprofen decreases neuroinflammation and improves neuropathology and motor impariments in Machado-Joseph disease. XLVIII Reunião da Sociedade Portuguesa de Farmacologia.
2018. Apresentação oral de trabalho. Hypothalamic ataxin-2 regulates circadian rhythm in mice. XLVIII Reunião da Sociedade Portuguesa de Farmacologia.
2018. Apresentação oral de trabalho. Towards a therapy for Polyglutamine diseases: lessons from preclinical studies. Rare Diseases and Orphan Drugs Global Forum 2018.
2018. Apresentação oral de trabalho. Polyglutamine diseases: lessons from disease pathogenesis and clues into therapy. Annual Meeting of the Portuguese Society of Genetics.
2018. Apresentação oral de trabalho. Polyglutamine disorders. 2as Jornadas do Algarve Biomedical Center.
2018. Apresentação oral de trabalho. Polyglutamine diseases: learning from molecular pathogenesis to develop therapies. Distinguished seminar, ISAZA/CBMR, Universidade do Algarve.
2018. Apresentação oral de trabalho. Polyglutamine diseases: lessons from disease pathogenesis and clues into therapy. Neurodegenerative Disorders course at PDBEB . CNC.
2018. Júri de grau académico. Understanding the potential of PDMAEMA-based vectors for gene therapy of the retina.. Arguente principal. Diogo Miguel Barros Bitoque (Doutoramento). Universidade Nova de Lisboa.
2018. Júri de grau académico. Identification of S-Nitrosylated proteins in injury-induced neurogenesis.. Vogal. Ana Sofia Lourenço (Doutoramento). Universidade do Algarve.
2018. Júri de grau académico. Estudo da via da autofagia no contexto da ataxia espinocerebelosa do tipo 2. Orientador. Marta Santos (Mestrado). Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical.
2018/11. Apresentação oral de trabalho. Hypothalamic ataxin-2: a modulator of circadian rhythm and metabolism. 22.º Congresso Português de Obesidade - Obesidade: Um peso a reduzir.
2018/11. Apresentação oral de trabalho. Hypothalamic ataxin-2 at the crossroads of metabolism and circadian rhythm. Chrononutrition: From Epidemiology to Molecular Mechanism Symposium.
2017. Apresentação oral de trabalho. Role of RNA binding proteins in polyglutamine diseases. 21ª Reunião Anual da Sociedade Portuguesa de Genética Humana.
2017. Apresentação oral de trabalho. miRNA-mediated cis-regulation in breast cancer susceptibility. 21ª Reunião Anual da Sociedade Portuguesa de Genética Humana.
2017. Apresentação oral de trabalho. Targeting AMPK as a therapeutic strategy to spinocerebellar ataxias. 2nd CBMR/ProRegeM Annual Meeting.
2017. Apresentação oral de trabalho. TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease. 2nd International Ataxia Research Conference (IARC).
2017. Apresentação oral de trabalho. Role of stress granules in spinocerebellar ataxias. XLVII Reunião da Sociedade Portuguesa de Farmacologia.
2017. Apresentação oral de trabalho. Gene editing strategies for Machado-Joseph disease. XLVII Reunião da Sociedade Portuguesa de Farmacologia.
2017. Apresentação oral de trabalho. Sustainable alleviation of motor impairments and neuropathology upon repeated intravenous transplantation of mesenchymal stromal cells in Machado-Joseph disease mice. XLVII Reunião da Sociedade Portuguesa de Farmacologia.
2017. Apresentação oral de trabalho. Ibuprofen reduces neuroinflammation and neuropathology in Machado-Joseh disease. XLVII Reunião da Sociedade Portuguesa de Farmacologia.
2017. Apresentação oral de trabalho. Vasconcelos-Ferreira A, NÓBREGA CLÉVIO, Verbeek D, Schmidt T, Pereira de Almeida L, Investigating transcriptional modifications of the autophagy pathway in Machado-Joseph disease. XLVII Reunião da Sociedade Portuguesa de Farmacologia.
2017. Apresentação oral de trabalho. PERK inhibition in spinocerebellar ataxias. XLVII Reunião da Sociedade Portuguesa de Farmacologia.
2017. Apresentação oral de trabalho. Hypothalamic ataxin-2 modulates body weight and insulin sensitivity. XLVII Reunião da Sociedade Portuguesa de Farmacologia.
2017. Apresentação oral de trabalho. Autophagy is stimulated by NPY Y1 and Y5 receptors activation in hypothalamic neurons. XLVII Reunião da Sociedade Portuguesa de Farmacologia.
2017. Apresentação oral de trabalho. Machado-Joseph disease: from pathogenic mechanisms to therapeutic strategies. 26th ISN-ESN Biennial Meeting.
2017. Apresentação oral de trabalho. Viral-based systems for gene delivery. Workshop Gene Delivery for Biomedical Applications. Universidade do Algarve.
2017. Júri de grau académico. Role of microRNA deregulation in the pathogenesis of Machado-Joseph disease.. Arguente principal. Udaya Geetha Vijayakumar (Doutoramento). Universidade de Coimbra.
2017. Júri de grau académico. Unravelling the role of ataxin-2 in the hypothalamus: a new player in metabolism.. Arguente. Sara Matias Carmo Silva (Doutoramento). Universidade de Coimbra.
2017. Júri de grau académico. Abordagem terapêutica na doença de Alzheimer?. Arguente principal. Bárbara Martins Sousa (Mestrado). Universidade do Algarve.
2015 - 2016. Orientação. PERK inhibition role in Spinocerebellar ataxias.Biotecnologia Farmacêutica (Mestrado). Orientador.
2015 - 2016. Orientação. INSIGHTS INTO THE ROLE OF STRESS GRANULES IN SPINOCEREBELLAR ATAXIAS.Biologia Celular e Molecular (Mestrado). Orientador.
2015 - 2016. Orientação. Development of a striatal lentiviral mouse model of Spinocerebellar ataxia type 2.Biologia Celular e Molecular (Mestrado). Orientador.
2016. Apresentação oral de trabalho. Repeated intravenous transplantation of mesenchymal stromal cells sustainable alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease. Brain Without Borders Meeting.
2016. Apresentação oral de trabalho. Hypothalamic ataxin-2 contributes to energy balance regulation and metabolism. XLVI Reunião da Sociedade Portuguesa de Farmacologia.
2016. Apresentação oral de trabalho. Cordycepin: a pharmacological approach to modulate mutant ataxin-3 and it use as a potential therapeutic effect in Machado-Joseph Disease. XLVI Reunião da Sociedade Portuguesa de Farmacologia.
2016. Apresentação oral de trabalho. Reestablishing Ataxin -2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease. 20ª Reunião Anual da Sociedade Portuguesa de Genética Humana.
2016. Apresentação oral de trabalho. Regulation of translation of Ataxin-3 by Ataxin-2. The 10th World Congress on Controversies in Neurology (CONy).
2016. Apresentação oral de trabalho. Understanding Molecular Mechanisms in Disease for the Development of Gene Therapy Approaches. CBMR, Universidade do Algarve.
2016. Apresentação oral de trabalho. Understanding Molecular Mechanisms in Disease for the Development of Gene Therapy Approaches. Advanced therapies course at PDBEB . CNC.
2016. Apresentação oral de trabalho. Understanding Molecular Mechanisms in Disease for the Development of Gene Therapy Approaches. Principles and practice in drug development course at PDBEB . CNC.
2016. Júri de grau académico. Neuropeptide Y gene transfer for neuroprotection in Machado-Joseph Disease. Vogal. Joana Filipa Duarte das Neves (Doutoramento). Universidade de Coimbra.
2016. Júri de grau académico. Clarifying the mechanism of action of trehalose on alleviating MJD.. Arguente principal. Allyson Trevino Garcia (Mestrado). Universidade de Coimbra.
2016. Júri de grau académico. Development of a striatal lentiviral mouse model of Spinocerebellar ataxia type.. Orientador. João Alves-Cruzeiro (Mestrado). Hospitais da Universidade de Coimbra.
2016. Júri de grau académico. Insights into the role of stress granules in spinocerebellar ataxias.. Orientador. Sandra Tomé (Mestrado). Universidade de Coimbra.
2016. Júri de grau académico. Strategies to reverse celular senescence and enhance progerin clearance in Hutchinson-Gilford progeria syndrome.. Arguente principal. Ana Sofia Leal (Mestrado). Universidade de Coimbra.
2016. Júri de grau académico. Characterization of mitochondrial function and dynamics in models of Machado-Joseph disease.. Arguente principal. Filipa Almeida (Mestrado). Universidade de Coimbra.
2011 - 2015. Orientação. Study of genetic variants associated with obesity in Portuguese children.Doutoramento em Antropologia, na especialidade de Antropologia Biológica (Doutoramento). Coorientador.
2014 - 2015. Orientação. Pharmacological modulation of mutant ataxin-3 translation and it potential therapeutic effect in Machado Joseph disease.Investigação Biomédica (Mestrado). Orientador.
2015. Apresentação oral de trabalho. Scanning of animal brain sections as tool for research. Quantitative Fluorescence Microscopy Course, CNC. CNC.
2015. Apresentação oral de trabalho. Interacting ataxins: from regulated to pathological protein aggregation. Neurodegenerative Disorders course at PDBEB . CNC.
2015. Apresentação oral de trabalho. Lentiviral vectors for in vivo gene transfer: gene silencing and autophagy activation. Principles and practice in drug development course at PDBEB . CNC.
2015. Júri de grau académico. Optimization of a viral culture system to evaluate antiviral activity. Arguente principal. Nânci Lúcia Ferreira (Mestrado). Universidade de Coimbra.
2014. Apresentação oral de trabalho. Lauroyl derivatives of H5-S413-PV as novel cell-penetrating peptides for siRNA delivery. XVIII Congress of the Portuguese Biochemical Society (SPB).
2014. Apresentação oral de trabalho. Mesenchymal stem cells for Machado-Joseph disease therapy. XVIII Congress of the Portuguese Biochemical Society (SPB).
2014. Apresentação oral de trabalho. Protein phosphorylation as a toxicity modulator in Machado-Joseph disease. XVIII Congress of the Portuguese Biochemical Society (SPB).
2014. Apresentação oral de trabalho. Autophagic Flux Is Stimulated By Npy In Hypothalamic Neurons And Is Relevant To Synaptic Plasticity Of Pomc Hypothalamic Neurons. XII CNC Meeting.
2014. Apresentação oral de trabalho. Cerebellar transplantation of mesenchymal stromal cells alleviates motor impairments and neuropathology of a transgenic mouse model of Machado-Joseph disease. Term Stem Conference.
2014. Apresentação oral de trabalho. Hypothalamic Neuropeptide Y ameliorates the phenotype of a mouse model of human premature aging. XLIII Reunião da Sociedade Portuguesa de Farmacologia.
2014. Apresentação oral de trabalho. Neuropeptide Y, a caloric restriction mimetic, promotes autophagy in hypothalamic neurons. XLIII Reunião da Sociedade Portuguesa de Farmacologia.
2014. Apresentação oral de trabalho. Ataxin-2 as a molecular target in Machado-Joseph disease: from translation modulation to disease alleviation. CNC Seminars.
2013 - Presente. Orientação. Investigating transcriptional modifications of the autophagy pathway in Machado-Joseph disease.Ciências Farmacêuticas (Doutoramento). Coorientador.
2013. Apresentação oral de trabalho. Beclin-1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease. XIII Reunião da Sociedade Portuguesa de Neurociências.
2013. Apresentação oral de trabalho. Estudo de polimorfismos genéticos associados à obesidade comum em crianças de naturalidade Portuguesa. 17º congresso da Sociedade Portuguesa para o Estudo da Obesidade.
2013. Apresentação oral de trabalho. Screening for melanocortin-4 receptor mutations in a cohort of Portuguese children with severe obesity. I BioAnthropological Meeting: a multidisciplinary approach (IBAM).
2013. Apresentação oral de trabalho. Silencing Machado-Joseph disease in the cerebellum. Gene and Cell therapy of CNS: from microRNAs to iPS cells and gene repair course at PDBEB. CNC.
2013. Júri de grau académico. Caracterização do perfil genómico do carcinoma pulmonar. Arguente principal. Sérgio Portovedo (Mestrado). Universidade de Coimbra.
2011 - 2012. Orientação. Pharmacological activation of autophagy in Machado-Joseph disease.Biotecnologia Farmacêutica (Mestrado). Coorientador.
2012. Apresentação oral de trabalho. Silencing of mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice. Ataxia Research Conference.
2012. Apresentação oral de trabalho. Beclin-1 mitigates motor and neuropathological deficits in lentiviral and transgenic mouse models of Machado-Joseph disease. Ataxia Research Conference.
2012. Apresentação oral de trabalho. Genetic profile of obesity-related polymorphisms among Portuguese children. 16º Congresso Português de Obesidade.
2012. Júri de grau académico. Pharmacological activation of autophagy in Machado Joseph disease. Orientador. Ana Cristina Vasconcelos Ferreira (Mestrado). Universidade de Coimbra.
2012. Júri de grau académico. Immobilization of Metalloproteins for Biotechnogical Applications. Arguente principal. Tânia Isabel Rodrigues Genebra (Mestrado). Universidade de Coimbra.
2011. Apresentação oral de trabalho. RNA interference rescues motor and neuropathological deficits in Machado-Joseph disease rodent models. 41th annual meeting of the Society for Neurosciences.
2011. Apresentação oral de trabalho. Associação do polimorfismo rs9939609 à obesidade em crianças Portuguesas. 15º Congresso Português de Obesidade.
2011. Apresentação oral de trabalho. Silencing of mutant ataxin-3 rescues motor deficits and neurological abnormalities in Machado-Joseph disease transgenic mice. European Society for Gene and Cell Therapy / British Society for Gene Therapy collaborative Congress.
2011. Apresentação oral de trabalho. Beclin-1 gene transfer rescues the motor phenotype of a transgenic mouse model of Machado-Joseph disease. XXXVI Portuguese Workshops in Genetics.
2011. Apresentação oral de trabalho. Overexpression of mutant ataxin-3 in the cerebellum induces behavioural deficits. XLI Reunião da Sociedade Portuguesa de Farmacologia.
2011. Apresentação oral de trabalho. Activation of the autophagy pathway rescues motor and neurological deficits in a transgenic mouse model of Machado- Joseph disease. XLI Reunião da Sociedade Portuguesa de Farmacologia.
2009. Apresentação oral de trabalho. Effects of overexpression or silencing of neuropeptide Y in the rat hypothalamic arcuate nucleus achieved by viral vector approach in feeding behaviour. XL Reunião da Sociedade Portuguesa de Farmacologia.
2009. Apresentação oral de trabalho. Inhibition of calpains in a lentiviral mouse model of MJD prevents nuclear localization and reduces neuronal dysfunction and degeneration. V International Workshop on Machado-Joseph disease.
2006. Apresentação oral de trabalho. Molecular characterization of D. madeirensis: an endemic species closely related to D. subobscura. VI Jornadas de Biologia Evolutiva.
2005. Apresentação oral de trabalho. Variabilitat nucleotídica a gens candidats. V Jornadas de Biologia Evolutiva.
2004. Apresentação oral de trabalho. Aproximación multilocus o genómica. XV Seminario de Genética de Poblaciones y Evolución.
2003. Apresentação oral de trabalho. Evolució Molecular a regiones Genòmiques implicades, directa o indirectament, en característiques adaptatives. III Jornadas de Biologia Evolutiva.

Projetos

Projetos
2019/03/01 - Presente. Overexpression of the RNA-binding protein X as a therapeutic strategy to Machado-Joseph disease and other Polyglutamine diseases.. Investigador responsável.
2018/10/01 - Presente. The role of stress granules in Polyglutamine disease: from pathogenesis to molecular therapy. Investigador responsável.
2014/01/01 - 2015/12/31. The role of ataxin-2 in Machado-Joseph disease: a molecular therapy approach with viral vectors.. Investigador responsável.
2010/01/01 - 2010/12/31. Modulation of autophagy as a novel therapeutic strategy for Machado-Joseph disease.. Investigador.
2010/01/01 - 2011/12/31. Role of the autophagy-related protein Beclin-1 in Machado-Joseph disease. Investigador.
2017/01/01 - 2017/12/31. Integración de varias omicas para el estudio de la obesidad. Investigador.
2018/01/01 - 2021/12/31. Using an OMICS approach to found new genetic profiles associated with obesity. Investigador.
2020/05/11 - 2020/08/11. Development of a new assay do detect SARS-CoV-2 directly from clinical samples, Apoio especial no âmbito do RESEARCH4COVID 19. Investigador responsável. Universidade do Algarve Centro de Investigação em Biomedicina.
2021/04/01 - Presente. ALgarve Fit Ageing Score: uma nova ferramenta integrada para melhorar a qualidade de vida e o envelhecimento saudável. Investigador.
2021/01/01 - Presente. Investigação de terapias experimentais em estudos pré-clínicos para o Síndroma de Cockayne. Investigador responsável.
2018/02 - 2020/01. Neuroprotective therapeutic approach for Spinocerebellar Ataxia type 2: pharmacological targeting of AMPK. Investigador responsável.
2015/03 - 2017/03. Ataxin-2 as a new molecular target in Machado-Joseph disease: from translation regulation to disease alleviation. Investigador responsável.
2013/03 - 2015/02. Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease. Investigador.
2013/03 - 2014/04. Silencing Machado-Joseph Disease through the systemic route. Investigador.
2010/02 - 2013/04. The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors. Investigador.

Produções

Vasconcelos-Ferreira, Ana; Martins, Inês Morgado; Lobo, Diana; Pereira, Dina; Lopes, Miguel M.; Faro, Rosário; Lopes, Sara M.; et al. 2022. "ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease". Molecular Therapy, 30 (1): 370-387. https://doi.org/10.1016/j.ymthe.2021.07.012
Nóbrega, Clévio David Rodrigues . 2021. "Mapping gene expression in social anxiety reveals the main brain structures involved in this disorder". Brain Behavioural Research, 394.
Nóbrega, Clévio David Rodrigues . 2021. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy.
Nóbrega, Clévio David Rodrigues . 2021. "PERMANENT INACTIVATION OF THE ATXN3 GENE: A POSSIBLE THERAPEUTIC APPROACH FOR MACHADO-JOSEPH DISEASE". https://doi.org/10.1097/MD.0000000000023585
Nóbrega, Clévio David Rodrigues . 2021. "MITIGATING THE PROGEROID PHENOTYPE: A GENE DELIVERY STRATEGY TO IMPROVE PROGERIN-ASSOCIATED ABNORMALITIES". https://doi.org/10.1097/MD.0000000000023585
Nóbrega, Clévio David Rodrigues . 2021. "AN RNA BINDING PROTEIN ALLEVIATES PATHOLOGY IN TWO DIFFERENT MOUSE MODELS OF POLYGLUTAMINE DISEASES". https://doi.org/10.1097/MD.0000000000023585
Nóbrega, Clévio David Rodrigues . 2021. "AUTOPHAGY IMPAIRMENT IN SPINOCEREBELLAR ATAXIA TYPE 2: FIRST EVIDENCES AND A POTENTIAL THERAPEUTIC STRATEGY". https://doi.org/10.1097/MD.0000000000023585
Nóbrega, Clévio David Rodrigues . 2021. "SILENCING ATXN2 EXPRESSION USING CRISPR/CAS9". https://doi.org/10.1097/MD.0000000000023585
Vasconcelos-Ferreira, Ana; Carmo-Silva, Sara; Codêsso, José Miguel; Silva, Patrick; Martinez, Alberto Rolim Muro; França Jr, Marcondes Cavalcante; Nóbrega, Clévio; Pereira de Almeida, Luís. 2021. "The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado–Joseph disease". Neuropathology and Applied Neurobiology, 48 (1). https://doi.org/10.1111/nan.12763
Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David V. C.; Costa, Rafael G.; Rosa, Ana; Alves-Cruzeiro, João; et al. 2021. "Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy". Cell Death & Disease, 12 (12). https://doi.org/10.1038/s41419-021-04404-1
Marcelo, Adriana; Koppenol, Rebekah; de Almeida, Luís Pereira; Matos, Carlos A.; Nóbrega, Clévio. 2021. "Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?". Cell Death & Disease, 12 (6). https://doi.org/10.1038/s41419-021-03873-8
Afonso-Reis, Ricardo; Afonso, Inês T.; Nóbrega, Clévio. 2021. "Current Status of Gene Therapy Research in Polyglutamine Spinocerebellar Ataxias". International Journal of Molecular Sciences, 22 (8). https://doi.org/10.3390/ijms22084249
Nóbrega, Clévio David Rodrigues ; Liliana Mendonça; Carlos A Matos. 2020. A Handbook of Gene and Cell Therapy. Springer.
Nóbrega, Clévio David Rodrigues . 2020. Silencing of CypX gene in the hypothalamus and its impact on whole-body metabolism. Em International Meeting of the Portuguese Society of Genetics.
Nóbrega, Clévio David Rodrigues . 2020. A lentiviral genetic mouse model for spinocerebellar ataxia type 2. Em International Meeting of the Portuguese Society of Genetics.
Nóbrega, Clévio David Rodrigues . 2020. RBP-X modulates progerin levels and ameliorates its associated abnormalities in cellular models of HGPS. Em International Meeting of the Portuguese Society of Genetics.
Nóbrega, Clévio David Rodrigues . 2020. "CYP46A1- gene therapy improves Machado-Joseph disease in mouse models".
Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia S.; Nóbrega, Clévio; et al. 2020. "Trehalose alleviates the phenotype of Machado–Joseph disease mouse models". Journal of Translational Medicine, 18 (1). https://doi.org/10.1186/s12967-020-02302-2
Nóbrega, Clévio; Conceição, André; Costa, Rafael G.; Koppenol, Rebekah; Sequeira, Raquel L.; Nunes, Ricardo; Carmo-Silva, Sara; et al. 2020. "The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease". BMC Research Notes, 13 (1). https://doi.org/10.1186/s13104-020-05053-x
Nóbrega, Clévio David Rodrigues . 2020. "Lauroylated Histidine-Enriched S4 13-PV Peptide as an Efficient Gene Silencing Mediator in Cancer Cells". Pharmaceutical Research, 37.
Nóbrega, Clévio David Rodrigues . 2020. "Hypothalamic ataxin-2 prevents obesity through the regulation of the circadian clock". https://doi.org/10.1111/obr.13115
Nóbrega, Clévio David Rodrigues . 2020. Mitigating the Progeroid Phenotype: A Gene Delivery Strategy to Improve Progerin-Associated Abnormalities. Em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana.
Nóbrega, Clévio David Rodrigues . 2020. Striatal neuropathology in spinocerebellar ataxia type 2: a new lentiviral mouse model. Em FENS 2020 Virtual Forum.
Nóbrega, Clévio David Rodrigues . 2020. An RNA binding protein alleviates pathology in two different mouse models of polyglutamine diseases.. Em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana.
Nóbrega, Clévio David Rodrigues . 2020. Autophagy Impairment in Spinocerebellar Ataxia Type 2: First Evidences and a Potential Therapeutic Strategy. Em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana.
Nóbrega, Clévio David Rodrigues . 2020. Silencing ATXN2 expression using CRISPR/Cas9. Em 24ª Reunião Anual da Sociedade Portuguesa de Genética Humana.
Catarina Nunes; Isa Mestre; Adriana Marcelo; Rebekah Koppenol; Carlos A Matos; Clévio Nóbrega. 2019. "MSGP: the first database of the protein components of the mammalian stress granules". Database. https://doi.org/10.1093/database/baz031
Adriana Marcelo; Filipa Brito; Sara Carmo-Silva; Carlos A Matos; João Alves-Cruzeiro; Ana Vasconcelos-Ferreira; Rebekah Koppenol; et al. 2019. "Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models". Human Molecular Genetics. https://doi.org/10.1093/hmg/ddy328
Nóbrega, C.; Mendonça, L.; Marcelo, A.; Lamazière, A.; Tomé, S.; Despres, G.; Matos, C.A.; et al. 2019. "Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia". Acta Neuropathologica, 138 (5): 837-858. https://doi.org/10.1007/s00401-019-02019-7
Mendonça, L.S.; Nóbrega, C.; Tavino, S.; Brinkhaus, M.; Matos, C.; Tomé, S.; Moreira, R.; et al. 2019. "Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models". Human molecular genetics, 28 (22): 3691-3703. https://doi.org/10.1093/hmg/ddz097
Nóbrega, C.; Codêsso, J.M.; Mendonça, L.; Pereira De Almeida, L.. 2019. "RNA Interference Therapy for Machado-Joseph Disease: Long-Term Safety Profile of Lentiviral Vectors Encoding Short Hairpin RNAs Targeting Mutant Ataxin-3". Human Gene Therapy, 30 (7): 841-854. https://doi.org/10.1089/hum.2018.157
Albuquerque, David; Carmo-Silva, Sara; Álvarez-Vaca, Daniel; Aveleira, Célia; Nóbrega, Clévio. 2019. "Role of Mitochondrial Dysfunction in Human Obesity". Em Handbook of Mitochondrial Dysfunction, 379-388. CRC Press. https://doi.org/10.1201/9780429443336-30
Albuquerque, D.; Manco, L.; Nóbrega, C.. 2019. "Molecular biology of human obesity: Nonepigenetics in comparison with epigenetic processes". 585-602. Vol. 2. https://doi.org/10.1007/978-3-319-55530-0_7
Nóbrega, Clévio David Rodrigues . 2019. CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease. Em MJD International Research Conference.
Nóbrega, Clévio David Rodrigues . 2019. CYP46A1-Gene therapy alleviates Machado-Joseph disease. Em XVI Meeting of the Portuguese Society for Neuroscience.
Nóbrega, Clévio David Rodrigues . 2019. On the role of stress granules in autophagy. Em XVI Meeting of the Portuguese Society for Neuroscience.
Nóbrega, Clévio David Rodrigues . 2019. RNA-binding proteins: new molecular targets for Polyglutamine diseases?. Em XVI Meeting of the Portuguese Society for Neuroscience.
Nóbrega, Clévio David Rodrigues . 2019. Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease. Em XVI Meeting of the Portuguese Society for Neuroscience.
Nóbrega, Clévio David Rodrigues . 2019. Estudo do papel de uma proteína de ligação ao RNA na expressão de lamina e progerina. Em 5th MEEting of UAlg Medicine Students.
Nóbrega, Clévio David Rodrigues . 2019. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy".
Nóbrega, Clévio David Rodrigues . 2019. Mammalian stress granules proteome. https://msgp.pt/
Nóbrega, Clévio David Rodrigues . 2019. Resetting the clock on obesity: The tale of Hypothalamic Ataxin-2. Em Gordon Conference on Clocks in Model Organisms: Circadian Networks, Physiology and Health.
Nóbrega, Clévio; Almeida, Luís Pereira de. 2018. Polyglutamine disorders preface. https://doi.org/10.1007/978-3-319-71779-1
Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al. 2018. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy, 26 (9): 2131-2151. https://doi.org/10.1016/j.ymthe.2018.07.007
Mendonça, L.S.; Onofre, I.; Miranda, C.O.; Perfeito, R.; Nóbrega, C.; de Almeida, L.P.. 2018. "Stem Cell-Based Therapies for Polyglutamine Diseases". https://doi.org/10.1007/978-3-319-71779-1_21
Nóbrega, C.; Simões, A.T.; Duarte-Neves, J.; Duarte, S.; Vasconcelos-Ferreira, A.; Cunha-Santos, J.; Pereira, D.; et al. 2018. "Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis". https://doi.org/10.1007/978-3-319-71779-1_18
Matos, C.A.; Carmona, V.; Vijayakumar, U.-G.; Lopes, S.; Albuquerque, P.; Conceição, M.; Nobre, R.J.; Nóbrega, C.; de Almeida, L.P.. 2018. "Gene therapies for polyglutamine diseases". https://doi.org/10.1007/978-3-319-71779-1_20
Nóbrega, Clévio David Rodrigues . 2018. Polyglutamine Disorders. Editado por Clévio Nóbrega; Luís Pereira de Almeida. Springer International Publishing. https://doi.org/10.1007/978-3-319-71779-1
Nóbrega, Clévio David Rodrigues ; Sandro Alves. 2018. Gene Silencing and Editing Strategies for Neurodegenerative Diseases. Frontiers Media SA. https://doi.org/10.3389/978-2-88945-551-5
Matos, Carlos A.; de Almeida, Luís Pereira; Nóbrega, Clévio. 2018. "Machado-Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy". Journal of Neurochemistry, 148 (1): 8-28. https://doi.org/10.1111/jnc.14541
Nóbrega, Clévio; Alves, Sandro. 2018. "Editorial: Gene Silencing and Editing Strategies for Neurodegenerative Diseases". Frontiers in Neuroscience, 12. https://doi.org/10.3389/fnins.2018.00425
Nóbrega, Clévio David Rodrigues . 2018. "Expression vector for cholesterol 24-hydrolase in therapy of polyglutamine repeat spinocerebellar ataxias". Concedida/Emitida.
Nóbrega, Clévio David Rodrigues . 2018. Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers. Em 1st international symposium Secretome With]Out[ Borders.
Nóbrega, Clévio David Rodrigues . 2018. Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3. Em European Society of Gene and Cell Therapy congress.
Kumar, Sajal; Zhong, Hua; Sharma, Ruby; Li, Yiyi; Song, Mingzhou. 2018. RNA-binding proteins in Polyglutamine diseases: from pathogenesis to molecular therapy. Em 11th Forum of Neuroscience (FENS). https://doi.org/10.1109/bibm.2018.8621502
Nóbrega, Clévio David Rodrigues . 2018. Estudo do papel da autofagia na dispersão dos grânulos de stress. Em 4th MEEting of UAlg Medicine Students.
Nóbrega, Clévio David Rodrigues . 2018. "TALEN and CRISPR Gene-Editing for Treatment of Machado-Joseph Disease".
Nóbrega, Clévio David Rodrigues . 2018. Hypothalamic ataxin-2 at the crossroads of metabolism and circadian rhythm. Em Chrononutrition: From Epidemiology to Molecular Mechanism Symposium, London.
Nóbrega, Clévio David Rodrigues . 2018. Hypothalamic ataxin-2 a novel regulator of circadian rhythm. Em EMBO|EMBL Symposium: Biological Oscillators: Design, Mechanism, Function.
Carmo-Silva, S.; Nobrega, C.; Pereira de Almeida, L.; Cavadas, C.. 2017. "Unraveling the Role of Ataxin-2 in Metabolism". Trends in Endocrinology and Metabolism, 28 (4): 309-318. https://doi.org/10.1016/j.tem.2016.12.006
Albuquerque, D.; Nóbrega, C.; Manco, L.; Padez, C.. 2017. "The contribution of genetics and environment to obesity". British Medical Bulletin, 123 (1): 159-173. https://doi.org/10.1093/bmb/ldx022
Matos, C.A.; de Almeida, L.P.; Nóbrega, C.. 2017. "Proteolytic cleavage of polyglutamine disease-causing proteins: Revisiting the toxic fragment hypothesis". Current Pharmaceutical Design, 23 (5): 753-775. https://doi.org/10.2174/1381612822666161227121912
Albuquerque, David; Manco, Licínio; Nóbrega, Clévio. 2017. "Molecular Biology of Human Obesity: Non-epigenetics in Comparison with Epigenetic Processes". Em Handbook of Nutrition, Diet, and Epigenetics, 1-18. Springer International Publishing. https://doi.org/10.1007/978-3-319-31143-2_7-1
Nóbrega, Clévio David Rodrigues . 2017. Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons. Em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC).
Nóbrega, Clévio David Rodrigues . 2017. Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease. Em XV Meeting of the Portuguese Society for Neurosciences.
Nóbrega, Clévio David Rodrigues . 2017. TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease. Em 2nd International Ataxia Research Conference (IARC).
Nóbrega, Clévio David Rodrigues . 2017. Ibuprofen improves neuropathology and increases neural progenitors proliferation, synaptic function and neurite growth in Machado-Joseph disease. Em 2nd International Ataxia Research Conference (IARC).
Nóbrega, Clévio David Rodrigues . 2017. Evaluation of proinflammatory cytokines expression in cells infected with coxsakievirus. Em XXVIII Congresso Brasileiro de Virologia.
Nóbrega, Clévio David Rodrigues . 2017. "Machado-Joseph disease: from pathogenic mechanisms to therapeutic strategies".
Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al. 2016. "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype". Biomaterials, 82: 124-137. https://doi.org/10.1016/j.biomaterials.2015.12.021
Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al. 2016. "Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles". Data in Brief, 6: 700-705. https://doi.org/10.1016/j.dib.2016.01.017
Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L.. 2016. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models". Journal of Cell Biology, 212 (4): 465-480. https://doi.org/10.1083/jcb.201506025
Albuquerque, David; Manco, Licínio; Nóbrega, Clévio. 2016. "Genetics of Human Obesity". Em Obesity, 87-106. Springer International Publishing. https://doi.org/10.1007/978-3-319-19821-7_7
Alves-Cruzeiro, João M. Da Conceição; Mendonça, Liliana; Pereira de Almeida, Luís; Nóbrega, Clévio. 2016. "Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review". Frontiers in Neuroscience, 10. https://doi.org/10.3389/fnins.2016.00572
Nóbrega, Clévio David Rodrigues . 2016. Hypothalamic ataxin-2: a new player in central regulation of energy balance. Em EMBO Workshop – Neural control of metabolism and eating behaviour.
Nóbrega, Clévio David Rodrigues . 2016. "Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons". https://doi.org/10.1016/j.npep.2015.11.035
Nóbrega, Clévio David Rodrigues. 2015. "Genetic contribution: Common forms of Obesity ". Em Molecular mechanisms underpinning the development of obesity, 37-56. US: Springer.
Nóbrega, Clévio David Rodrigues; Rodríguez-López, Raquel. 2015. Molecular mechanisms underpinning the development of obesity. Editado por Clévio Nóbrega; Raquel Rodriguez-Lopez. 1ª ed. US: Springer .
Aveleira CA; Botelho M; Carmo-Silva S; Pascoal JF; Ferreira-Marques M; Nóbrega C; Cortes L; et al. 2015. "Neuropeptide Y stimulates autophagy in hypothalamic neurons.". https://doi.org/10.1073/pnas.1416609112
Albuquerque D; Stice E; Rodríguez-López R; Manco L; Nóbrega C; Albuquerque, David; Stice, Eric; et al. 2015. "Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.". https://doi.org/10.1007/s00438-015-1015-9
Nóbrega, C.; Carmo-Silva, S.; Albuquerque, D.; Vasconcelos-Ferreira, A.; Vijayakumar, U.-G.; Mendonça, L.; Hirai, H.; Pereira De Almeida, L.. 2015. "Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease". Brain, 138 (12): 3537-3554. https://doi.org/10.1093/brain/awv298
Nóbrega, Clévio David Rodrigues . 2015. Gene editing strategies towards Machado Joseph disease. Em EMBO workshop: "Modern DNA concepts and tools for safe gene transfer and modification".
Nóbrega, Clévio David Rodrigues . 2015. Ataxin-2 in the hypothalamus: a novel regulator of energy balance and metabolism. Em XIII CNC Annual Meeting.
Nóbrega, Clévio David Rodrigues . 2015. Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in mouse models of Machado-Joseph disease. Em 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC).
Nóbrega, Clévio David Rodrigues . 2015. Impact of hypothalamic ataxin-2 on energy balance and metabolic profile. Em 9th World Congress of the International Brain Research Organization (IBRO.
Nóbrega, Clévio David Rodrigues . 2015. Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons. Em 11th NPY-PYY-PP International Meeting.
Nóbrega, Clévio David Rodrigues . 2015. Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology of a mouse model of Machado-Joseph disease. Em International Society for Stem Cell Research (ISSCR) 2015 annual meeting.
Nóbrega, Clévio David Rodrigues . 2015. Neuropeptide Y rescues the aging phenotype of a mouse model of human premature aging. Em The Translational Science of Aging: From Functional Pathways to Interventions Gordon Research Conference on Biology of Aging.
Nóbrega, Clévio David Rodrigues . 2015. "Role of MicroRNA deregulation in Machado-Joseph disease". https://doi.org/10.1016/S1525-0016(16)34191-0
Nóbrega, Clévio David Rodrigues . 2015. Hypothalamic ataxin-2 regulates energy balance and metabolism. Em Keystone Symposia, Neural Control of Metabolic Physiology and Diseases.
Mendonca, L. S.; Nobrega, C.; Hirai, H.; Kaspar, B. K.; Pereira de Almeida, L.. 2014. "Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice". Brain, n (19 Dec): 1-9. https://doi.org/10.1093/brain/awu352
Nobrega, Clevio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Deglon, Nicole; Pereira de Almeida, Luis. 2014. "RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of machado-joseph disease.". PloS one, 9 (8): e100086-e100086. https://doi.org/10.1371/journal.pone.0100086
Albuquerque, David; Manco, Licínio; Nóbrega, Clévio; Nóbrega, Clévio David Rodrigues. 2014. "Epigenetics of Human Obesity: A Link Between Genetics and Nutrition". Em Molecular Mechanisms Underpinning the Development of Obesity, 101-127. US: Springer International Publishing. https://doi.org/10.1007/978-3-319-12766-8_8
Albuquerque, David; Nóbrega, Clévio; Rodríguez-López, Raquel; Manco, Licínio. 2014. "Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children". Journal of Human Genetics, 59 (6): 307-313. https://doi.org/10.1038/jhg.2014.23
Albuquerque, David; Estévez, Manuela Núñez; Víbora, Pilar Beato; Giralt, Plácida Sánchez; Balsera, Aránzazu Margallo; Cortés, Pedro Gil; López, Mercedes Jiménez; et al. 2014. "Novel Variants in theMC4RandLEPRGenes among Severely Obese Children from the Iberian Population". Annals of Human Genetics, 78 (3): 195-207. https://doi.org/10.1111/ahg.12058
Nóbrega, Clévio David Rodrigues . 2014. "Neuropeptide Y overexpression for use in the treatment of premature aging ". Concedida/Emitida.
Nóbrega, Clévio David Rodrigues . 2014. Translational inhibition in Machado-Joseph disease: Ataxin-2 as a new molecular target. Em 5th Ataxia Investigators Meeting (AIM).
Nóbrega, Clévio David Rodrigues . 2014. Modulation of catalytic activity and polyQ toxicity by phosphorylation in spinocerebellar ataxia type 3. Em 5th Ataxia Investigators Meeting (AIM).
Nóbrega, Clévio David Rodrigues . 2014. Autophagy activation mitigates motor and neuropathological deficits in mouse models of Machado-Joseph disease. Em 5th Ataxia Investigators Meeting (AIM).
Nóbrega, Clévio David Rodrigues . 2014. Autophagy activation mitigates motor and neuropathological deficits in mouse models of Machado-Joseph disease. Em 5th Ataxia Investigators Meeting (AIM).
Nóbrega, Clévio David Rodrigues . 2014. Transplantation of cerebellar neural stem cells alleviates neuropathology and motor impairments in Machado Joseph Disease. Em 5th Ataxia Investigators Meeting (AIM).
Nóbrega, Clévio David Rodrigues . 2014. Association between obesity and polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5, and OLFM4 genes among Portuguese children. Em 21st European Congress on Obesity (ECO2014).
Nóbrega, Clévio David Rodrigues . 2014. Neuropeptide Y rescues the aging phenotype of a mouse model of human premature aging. Em XII CNC Anual Meeting.
Nóbrega, Clévio David Rodrigues . 2014. Cerebellar transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in a transgenic mouse model of Machado-Joseph disease. Em XII CNC Anual Meeting.
Nóbrega, Clévio David Rodrigues . 2014. "MicroRNA-139-5p: a tool for metastasis and chemotherapeutic resistance control in pancreatic adenocarcinoma".
Osokina, Irina. 2014. "Association study of several common polymorphisms with obesity and obesity-related traits among Portuguese children". https://doi.org/10.1136/archdischild-2019-epa.639
Nascimento-Ferreira, I.; Nobrega, C.; Vasconcelos-Ferreira, A.; Onofre, I.; Albuquerque, D; Aveleira, C.; Hirai, H.; Deglon, N.; Pereira de Almeida, L.. 2013. "Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease". Brain, 136 (7): 2173-2188. https://doi.org/10.1093/brain/awt144
Albuquerque, David; Nóbrega, Clévio; Manco, Licínio. 2013. "Association of FTO Polymorphisms with Obesity and Obesity-Related Outcomes in Portuguese Children". PLoS ONE, 8 (1): e54370-e54370. https://doi.org/10.1371/journal.pone.0054370
Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Hirai, Hirokazu; Déglon, Nicole; de Almeida, Luís Pereira. 2013. "Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice". PLoS ONE, 8 (1): e52396-e52396. https://doi.org/10.1371/journal.pone.0052396
Albuquerque, David; Nóbrega, Clévio; Manco, Licínio. 2013. "The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children". Acta Paediatrica, 102 (4): e153-e157. https://doi.org/10.1111/apa.12134
Nóbrega, Clévio David Rodrigues . 2013. Post-translational modifications and polyglutamine diseases: the effects of ataxin-3 phosphorylation. Em Champalimaud Neuroscience Programme Symposium.
Nóbrega, Clévio David Rodrigues . 2013. Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms. Em 13th Meeting of the Portuguese Society for Neuroscience (SPN).
Nóbrega, Clévio David Rodrigues . 2013. Neuropeptide Y ameliorates the phenotype of a mouse model of human premature aging. Em 7th Progeria Research Foundation International Workshop – Hand in Hand: Basic and Clinical Science Working Together Toward the Cure.
Nóbrega, Clévio David Rodrigues . 2013. "Activation of autophagy rescues behavioral and neuropathological cerebellar deficits in a lentiviral mouse model of Machado-Joseph disease".
Nobrega, Clevio; de Almeida, L. P.. 2012. "Machado-Joseph Disease / Spinocerebellar Ataxia Type 3". Em Spinocerebellar Ataxia, 103-138. Croatia: InTech. https://doi.org/10.5772/28576
Albuquerque, David; Jacobs, J; Nóbrega, Clévio David Rodrigues; Hanen, Samouda; Manco, Licínio; Nóbrega, Clévio David Rodrigues . 2012. "The common rs9939609 polymorphism of the Fat Mass and Obesity-associated (FTO) gene is associated with obesity in Portuguese children". Trabalho apresentado em 19th European Congress on Obesity (ECO2012), Lyon, França, 5 (1), 177-177. https://doi.org/10.1159/000228822
Monteiro, António; Nóbrega, Clévio; Abrantes, Isabel; Gomes, Celeste. 2012. "Diagnosing Portuguese Students' Misconceptions about the Mineral Concept". International Journal of Science Education, (12): 1-22. https://doi.org/10.1080/09500693.2012.731617
Costa, P. M.; Cardoso, A. L.; Nobrega, C.; Pereira de Almeida, L. F.; Bruce, J. N.; Canoll, P.; Pedroso de Lima, M. C.. 2012. "MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma". Human Molecular Genetics, 22 (5): 904-918. https://doi.org/10.1093/hmg/dds496
Nóbrega, Clévio; Nascimento-Ferreira, Isabel; Onofre, Isabel; Albuquerque, David; Conceição, Mariana; Déglon, Nicole; Almeida, Luís Pereira. 2012. "Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology". The Cerebellum, (.): .-.. https://doi.org/10.1007/s12311-012-0432-0
Albuquerque D; Nóbrega C; Samouda H; Manco L; Albuquerque, D; Nóbrega, Clévio David Rodrigues; Hanene Samouda; Manco, Licínio. 2012. "Assessment of obesity and abdominal obesity among Portuguese children.". Acta Medica Portuguesa, 25 (3): 169-173. http://europepmc.org/abstract/med/23069237
Nóbrega, Clévio David Rodrigues . 2012. Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms. Em X Center for Neuroscience and Cell Biology (CNC) Annual Meeting.
Nóbrega, Clévio David Rodrigues . 2012. Associação do polimorfismo -13910C>T à obesidade abdominal em crianças portuguesas. Em 16º Congresso Português de Obesidade.
Nóbrega, Clévio David Rodrigues . 2012. Silencing of mutant ataxin-3 rescues motor deficits and neuopathology in Machado-Joseph disease transgenic mice. Em The 8th FENS Forum of Neuroscience.
Marzocchi, N.; Severi, S.; Pieri, M.; Zona, C.; Cavalcanti, S.. 2012. Beclin-1 mitigates motor and neuropathological déficits in lentiviral and transgenic mouse models of Machado-Joseph disease. Em The 8th FENS Forum of Neuroscience. https://doi.org/10.2495/bio050221
Nóbrega, Clévio David Rodrigues . 2012. RNA interference rescues cerebellar abnormalities and ataxia in a lentiviral-based model of Machado-Joseph disease. Em The National Ataxia Foundation 55th annual membership meeting.
Nóbrega, Clévio David Rodrigues . 2012. Neuropeptide Y is an autophagy inducer in hypothalamic neurons. Em IX Center for Neuroscience and Cell Biology (CNC) Annual Meetin.
Albuquerque, D.; Nóbrega, C.; Samouda, H.; Manco, L.. 2012. "Assessment of obesity and abdominal obesity among Portuguese children,Avaliação da obesidade e obesidade abdominal em crianças Portuguesas". Acta Medica Portuguesa, 25 (3): 169-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866904803&partnerID=MN8TOARS
Sousa-Ferreira, Lígia; Garrido, Manuel; Nascimento-Ferreira, Isabel; Nobrega, Clévio; Santos-Carvalho, Ana; ¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; et al. 2011. "Moderate Long-Term Modulation of Neuropeptide Y in Hypothalamic Arcuate Nucleus Induces Energy Balance Alterations in Adult Rats". PLoS ONE, 6 (7): 22333-22333. https://doi.org/10.1371/journal.pone.0022333
Khadem, M.; Camacho, R.; Nobrega, C.; Nóbrega, Clévio David Rodrigues; Mahnaz Khadem; Roberto Camacho. 2011. "Studies of the species barrier between Drosophila subobscura and D-madeirensis V: the importance of sex-linked inversion in preserving species identity". Journal of Evolutionary Biology, 24 (6): 1263-1273. https://doi.org/10.1111/j.1420-9101.2011.02263.x
Nóbrega, Clévio David Rodrigues . 2011. Polymorphism rs9939609 in the FTO gene is associated with obesity among Portuguese children. Em 15ª Reunião Anual da Sociedade Portuguesa de Genética Humana.
Kai, Kazuharu; Saya, Hideyuki; Hortobagyi, Gabriel N.; Ueno, Naoto T.. 2011. Excitotoxicity in cerebellar granule cells transduced with mutant ataxin-3. Em Champalimaud Neuroscience Symposium, Champalimaud Foundation. https://doi.org/10.1158/1538-7445.am10-2458
Nóbrega, Clévio David Rodrigues . 2011. RNA interference rescues motor and neurological deficits in Machado-Joseph disease rodent models. Em CAG triplet disorders Gordon Research Conference.
Nóbrega, Clévio David Rodrigues . 2011. Overexpression of the autophagic beclin-1 protein mitigates motor and neuropathological deficits in lentiviral and transgenic mouse models of Machado-Joseph disease. Em CAG triplet disorders Gordon Research Conference.
Nóbrega, Clévio David Rodrigues . 2011. Overexpression of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction. Em CAG triplet disorders Gordon Research Conference.
Nóbrega, Clévio David Rodrigues . 2011. "Silencing of mutant ataxin-3 rescues motor deficits and neurological abnormalities in Machado-Joseph disease transgenic mice".
Alves, S.; Nascimento-Ferreira, I.; Dufour, N.; Hassig, R.; Auregan, G.; Nobrega, C.; Brouillet, E.; et al. 2010. "Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?". Human Molecular Genetics, 19 (12): 2380-2394. https://doi.org/10.1093/hmg/ddq111
Nóbrega, Clévio David Rodrigues . 2010. Overexpression of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction. Em 40th annual meeting of the Society for Neurosciences.
Nóbrega, Clévio David Rodrigues . 2010. Lentiviral injection of mutant ataxin-3 in mouse cerebellum induces behavioral deficits and cerebellar dysfunction: can beclin-1 overexpression improve the pathological phenotype?. Em 18th ESGCT Annual Congress.
Nóbrega, Clévio David Rodrigues . 2010. Overexpression of mutant ataxin-3 in mousecerebellum induces behavioral deficits. Em Harvard Medical School: Molecular Mechanism in Neurodegeneration: from molecule to cure.
Nóbrega, Clévio David Rodrigues . 2010. "Activation of autophagy rescues behavioral and neuropathological cerebellar deficits in a lentiviral mouse model of Machado-Joseph disease".
Nóbrega, Clévio David Rodrigues . 2009. Inhibition of mutant ataxin¬3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease. Em 11th Meeting of the Portuguese Society for Neurosciences.
Nóbrega, Clévio David Rodrigues . 2009. Inhibition of calpains prevents translocation of mutant ataxin¬3 to the nucleus and reduces neurodegeneration in a lentiviral mouse model of Machado¬Joseph Disease. Em IV Meeting on the Molecular Mechanisms of Neurodegeneration.
Nóbrega, Clévio David Rodrigues . 2009. "Inhibition of mutant ataxin-3 proteolysis by calpains in a lentiviral mouse model of Machado-Joseph disease".
Nobrega, C.; Khadem, M; Aguade, M.; Segarra, C. 2008. "Genetic Exchange versus Genetic Differentiation in a Medium-Sized Inversion of Drosophila: The A2/Ast Arrangements of Drosophila subobscura". Molecular Biology and Evolution, 25 (8): 1534-1543. https://doi.org/10.1093/molbev/msn100
Nóbrega, Clévio David Rodrigues . 2008. Inhibition of calpains in a lentiviral mouse model of Machado¬Joseph Disease. Em CONSERT labcourse, Advanced Couse Symposium and Pratical Training.
Nóbrega, Clévio David Rodrigues . 2008. A new therapeutic approach to AMD (degenerative macular age-related disease). Em CONSERT labcourse, Advanced Couse Symposium and Pratical Training.
Nóbrega, Clévio David Rodrigues. 2007. "A multilocus comparative study of nucleotide variation in Drosophila madeirensis and the close relative D. subobscura: insights into the speciation process of D. madeirensis". Doutoramento. http://hdl.handle.net/10400.13/1429
Nóbrega, Clévio David Rodrigues . 2005. A multilocus survey of nucleotide variation in Drosophila madeirensis, an endemic species to Madeira Island. Em XIX European Drosophila Research Conference.
 

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