Alexandra Binnie
Professor auxiliar convidado
Faculdade de Medicina e Ciências Biomédicas
Subsistema
Docentes Universitário
Regime
Parcial
Vínculo
CT em Funções Públicas a termo resolutivo certo
Projetos
Projetos
2019/10 - 2024/09. EpiGen Marks for Human Sepsis.
2021/09 - 2024/08. Factors Influencing Canadian Community Intensive Care Unit (ICU) Participation in Clinical Research: A Qualitative Descriptive Study.
2021/01 - 2022/06. The Canadian Network of COVID-19 Clinical Trials Networks.
2020/07 - 2021/06. Canadian COVID-19 Prospective Cohort Study (CanCOV).
2015/05 - 2016/04. Epigenetic Profiling in Severe Sepsis (EPSIS).
Produções
Alexandra Binnie; Kyra Moura; Claire Moura; Frédérick D’Aragon; Jennifer L. Y. Tsang. 2021. "Psychosocial distress amongst Canadian intensive care unit healthcare workers during the acceleration phase of the COVID-19 pandemic". PLOS ONE. https://doi.org/10.1371/journal.pone.0254708
Alexandra Binnie; Emanuel Fernandes; Helder Almeida-Lousada; Ramon Andrade de Mello; Pedro Castelo-Branco. 2021. "CRISPR-based strategies in infectious disease diagnosis and therapy". Infection. https://doi.org/10.1007/s15010-020-01554-w
Jennifer L. Y. Tsang; Alexandra Binnie; Robert A. Fowler. 2021. "Twenty articles that critical care clinicians should read about COVID-19". Intensive Care Medicine, 47 (3): 337-341. https://doi.org/10.1007/s00134-020-06329-3
Tsang JLY; Fowler R; Cook DJ; Ma H; Binnie A. 2021. "How can we increase participation in pandemic research in Canada?". Canadian journal of anaesthesia = Journal canadien d'anesthesie. https://doi.org/10.1007/s12630-021-02119-7
Sholzberg M; Tang GH; Rahhal H; AlHamzah M; Kreuziger LB; Áinle FN; Alomran F; et al. 2021. "Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial.". BMJ (Clinical research ed.). https://doi.org/10.1136/bmj.n2400
Writing Committee for the REMAP-CAP Investigators; Estcourt LJ; Turgeon AF; McQuilten ZK; McVerry BJ; Al-Beidh F; Annane D; et al. 2021. "Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.". JAMA. https://doi.org/10.1001/jama.2021.18178
Johnstone J; Meade M; Lauzier F; Marshall J; Duan E; Dionne J; Arabi YM; et al. 2021. "Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial.". JAMA. https://doi.org/10.1001/jama.2021.13355
Taher J; Mighton C; Chowdhary S; Casalino S; Frangione E; Arnoldo S; Bearss E; et al. 2021. "Implementation of serological and molecular tools to inform COVID-19 patient management: protocol for the GENCOV prospective cohort study.". BMJ open. https://doi.org/10.1136/bmjopen-2021-052842
ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators; Lawler PR; Goligher EC; Berger JS; Neal MD; et al. 2021. "Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.". The New England journal of medicine. https://doi.org/10.1056/nejmoa2105911
REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators; Goligher EC; Bradbury CA; McVerry BJ; Lawler PR; et al. 2021. "Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.". The New England journal of medicine. https://doi.org/10.1056/nejmoa2103417
Arabi YM; Gordon AC; Derde LPG; Nichol AD; Murthy S; Beidh FA; Annane D; et al. 2021. "Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.". Intensive care medicine. https://doi.org/10.1007/s00134-021-06448-5
Salluh JIF; Arabi YM; Binnie A. 2021. "COVID-19 research in critical care: the good, the bad, and the ugly.". Intensive care medicine. https://doi.org/10.1007/s00134-021-06367-5
REMAP-CAP Investigators; Gordon AC; Mouncey PR; Al-Beidh F; Rowan KM; Nichol AD; Arabi YM; et al. 2021. "Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.". The New England journal of medicine. https://doi.org/10.1056/nejmoa2100433
Arabi YM; Azoulay E; Al-Dorzi HM; Phua J; Salluh J; Binnie A; Hodgson C; et al. 2021. "How the COVID-19 pandemic will change the future of critical care.". Intensive care medicine. https://doi.org/10.1007/s00134-021-06352-y
Binnie, Alexandra. 2020. "Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.". JAMA. https://doi.org/10.1001/jama.2020.17022
Binnie, Alexandra. 2020. "Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.". The New England journal of medicine. https://doi.org/10.1056/nejmoa2023184
Binnie, Alexandra. 2020. "Participation of more community hospitals in randomized trials of treatments for COVID-19 is needed.". CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. https://doi.org/10.1503/cmaj.75585
Binnie, A.; Walsh, C.J.; Hu, P.; Dwivedi, D.J.; Fox-Robichaud, A.; Liaw, P.C.; Tsang, J.L.Y.; et al. 2020. "Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness". Critical care medicine, 48 (2): 142-150. https://doi.org/10.1097/CCM.0000000000004097
Lau VI; Cook DJ; Fowler R; Rochwerg B; Johnstone J; Lauzier F; Marshall JC; et al. 2020. "Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol.". BMJ open. https://doi.org/10.1136/bmjopen-2019-036047
Binnie A; Tsang JLY; Hu P; Carrasqueiro G; Castelo-Branco P; Dos Santos CC. 2020. "Epigenetics of Sepsis.". Critical care medicine. https://doi.org/10.1097/ccm.0000000000004247
Binnie, Alexandra. 2019. "Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.". Critical care medicine. https://doi.org/10.1097/ccm.0000000000004097
Binnie, Alexandra. 2019. "Fostering community hospital research.". CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. https://doi.org/10.1503/cmaj.190055
Binnie, Alexandra. 2019. "Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers.". BMC cancer. https://doi.org/10.1186/s12885-019-5403-0
Binnie A; Lage J; Dos Santos C. 2019. "How can biomarkers be used to differentiate between infection and non-infectious causes of inflammation?". Evidence-Based Practice of Critical Care. http://europepmc.org/abstract/PMC/PMC7152028
Binnie, Alexandra. 2017. "Epigenetic therapy in urologic cancers: an update on clinical trials.". Oncotarget. https://doi.org/10.18632/oncotarget.14226
Binnie, Alexandra. 2014. "Biomarkers in acute respiratory distress syndrome.". Current opinion in critical care. https://doi.org/10.1097/mcc.0000000000000048
Binnie, A.; Tsang, J.L.Y.; Dos Santos, C.C.. 2014. "Biomarkers in acute respiratory distress syndrome". Current Opinion in Critical Care, 20 (1): 47-55. https://doi.org/10.1097/MCC.0000000000000048
Binnie, Alexandra. 2006. "Homologous gene sequences mediate transcription-domain formation.". Journal of cell science. https://doi.org/10.1242/jcs.03050
Binnie, Alexandra. 2002. "Promoter proximal splice sites enhance transcription.". Genes & development. https://doi.org/10.1101/gad.983602
Binnie, Alexandra. 1999. "Gamma-irradiation directly affects the formation of coding joints in SCID cell lines.". Journal of immunology (Baltimore, Md. : 1950). http://europepmc.org/abstract/med/10553067
Binnie, A.; Olson, S.; Wu, G.E.; Lewis, S.M.. 1999. "Gamma-irradiation directly affects the formation of coding joints in SCID cell lines". Journal of Immunology, 163 (10): 5418-5426. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033571736&partnerID=MN8TOARS
