tfouteiro | Faculdade de Medicina e Ciências Biomédicas

Tiago Fleming de Oliveira Outeiro

Professor catedrático convidado

Faculdade de Medicina e Ciências Biomédicas

Subsistema

Docentes Universitário

Regime

Parcial

Vínculo

CT em Funções Públicas a termo resolutivo certo

Tiago Outeiro. Concluiu o(a) Mestrado integrado em Bioquímica em 1998 pelo(a) Universidade do Porto Faculdade de Ciências, Mestrado integrado em Bioquímica em 1998 pelo(a) Universidade do Porto Faculdade de Ciências, Doutoramento em Ciências Biomédicas em 2004 pelo(a) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar e Doutoramento em Ciências Biomédicas em 2004 pelo(a) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar. É Professor Catedrático no(a) Georg-August-Universität Göttingen, Full Professor, Director of the Department of Experimental Neurodegeneration no(a) Georg-August-Universität Göttingen e Professor Catedrático no(a) Into Newcastle University. Publicou 568 artigos em revistas especializadas. Possui 11 capítulo(s) de livros. Possui 1 patente(s) registada(s). Recebeu 10 prémio(s) e/ou homenagens. Nas suas atividades profissionais interagiu com 10147 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Teses de doutoramento - 2014; Sistema nervoso simpático; Hipertensão; Núcleo hipotalâmico paraventricular; Órgãos-alvo; Barorreflexo; Doença de Parkinson; Saccharomyces cerevisiae; Fosforilação; Agregação celular; Teses de mestrado - 2013; lpha-synuclein; Autophagy; Mitophagy; Sirtuins; Chronological aging; Yeast; Synucleinopathies; alpha-synuclein; Science & Technology; Journal Article; Cromatina; Doença de Alzheimer; Aging; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Disease Models, Animal; Drosophila; Enzyme Inhibitors; Female; Glycosylation; Hippocampus; Humans; Induced Pluripotent Stem Cells; Male; Mice; Mice, Transgenic; Neurodegenerative Diseases; Protein Aggregation, Pathological; Protein Processing, Post-Translational; Pyruvaldehyde; Rats; Yeasts; alpha-Synuclein; Genómica Funcional e Estrutural; Neurociências; Peixe-zebra; Trifosfato de adenosina; Modelos genéticos; Biologia computacional; Teses de mestrado - 2010; accidental cell death; apoptosis; autophagic cell death; autophagy; caspases; mitochondrial membrane permeabilization; mitotic catastrophe; model organism; necrosis; reactive oxygen species; regulated cell death; Post-translational Modi¿cations; Parkinson's Disease; Proteomics; a-synuclein; Quinurenina 3-mono-oxigenase; Doença de Huntington; Doenças neurodegenerativas; Terapêutica; Teses de doutoramento - 2013; Alpha-synuclein; a-syn oligomers; Parkinson's disease; Cell aggregation; Cell death; Sir2; Parkinson disease; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylation; Cell Membrane; Cerebral Cortex; Dopaminergic Neurons; Gene Deletion; Gene Knockdown Techniques; HEK293 Cells; Lysine; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neuroprotection; Parkinson Disease; Protein Aggregates; Protein Binding; Sirtuin 2; Biomedicina; Prevenção; Fisiologia; Investigação de translação; Glycation; Parkinson¿s disease; Neurodegeneration; Leveduras; Deficiências na proteostase; Hsp27; Hsp70; Methylglyoxal; Familial amyloidotic polyneuropathy; FTICR; Saliva; Systemic amyloidosis; Transthyretin; General; Alfa-sinucleína; Autofagia; Teses de mestrado- 2013; Complementação de fluorescência bimolecular; Oligomerização; Mutações; Teses de doutoramento - 2016; Ataxia de Friedreich; Heterocromatina; Transcrição genética; Expansão das repetições de trinucleotídeos; Domínio/Área Científica::Ciências Médicas::Medicina Básica; Biologia celular; RNA interferência; Teses de mestrado; Variações do número de cópias de DNA; Genes modificadores; Biologia humana; Fósforilação; Teses de mestrado - 2012; Secretion; Hyperexpression techniques; Oligomers; Toxicity; Cytotoxicity; Immunoblotting; Immunocytochemistry; Fluorescence microscopy; Corpos de Lewy; Drug discovery; Hyperkinesia; Hypokinesia; Movement disorders; Zebrafish models; Neurology; Clinical Neurology; Teses de doutoramento - 2015; Proteínas tau; LRRK2; Teses de doutor

Atividades

2022/03/01 - Presente. Curso / Disciplina lecionado. Bases Moleculares de Neurodegeneração. Ciências Biomédicas (Licenciatura). Universidade do Algarve.

Projetos

2019/10 - Presente. The role of lead exposure in the nervous system and Parkinson¿s disease onset and progression, Bolsas de Doutoramento. Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa; Universitätsmedizin Göttingen Experimental Neurodegeneration; Lancaster University Department of Biological Sciences.

2023/03/01 - 2024/08/31. Estudo do BUB1 em neurodesenvolvimento: identificação de novas funções, Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022.

2019/01/01 - 2022/02/28. Oligómeros difusíveis de alfa-sinucleína e ataxina-3: uma oportunidade para o reposicionamento de fármacos em doenças neurodegenerativas, Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017. Universidade do Porto Instituto de Biologia Molecular e Celular; Universidade NOVA de Lisboa.

2019/01/01 - 2021/12/31. Oligómeros difusíveis de alfa-sinucleína e ataxina-3: uma oportunidade para o reposicionamento de fármacos em doenças neurodegenerativas, 9471 - RIDTI. Instituto de Biologia Molecular e Celular; Universidade Nova de Lisboa.

2016/06/01 - 2020/02/29. Defesas anti-glicação como alvo terapêutico para a doença de Parkinson, 3599-PPCDT. Universidade Nova de Lisboa Faculdade de Ciências Médicas; iNOVA4Health; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2016/06/01 - 2020/02/29. Defesas anti-glicação como alvo terapêutico para a doença de Parkinson, Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014. Universidade NOVA de Lisboa NOVA Medical School; iNOVA4Health; Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2016/05/01 - 2020/02/29. Desenvolvimento de péptidos translocadores da barreira hematoencefálica - novas moléculas terapêuticas para sistema nervoso central, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes; Universidade Nova de Lisboa Faculdade de Ciências Médicas; Universidade de Lisboa Faculdade de Medicina Veterinária; Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento.

2016/05/01 - 2020/02/29. Desenvolvimento de péptidos translocadores da barreira hematoencefálica - novas moléculas terapêuticas para sistema nervoso central, Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes; Universidade NOVA de Lisboa NOVA Medical School; Universidade de Lisboa Faculdade de Medicina Veterinária; Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas; Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento; Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares.

2019/01/01 - 2019/10/31. iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB), 6817 - DCRRNI ID. Instituto Português de Oncologia de Lisboa Francisco Gentil EPE; Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier; Universidade Nova de Lisboa; Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas; Universidade Nova de Lisboa Medical School; Instituto de Biologia Experimental e Tecnológica.

2016/05/01 - 2019/10/31. Alzheimer3D: Conjugados Trifuncionais para o Transporte Selectivo de Fármacos para a Doença de Alzheimer, 3599-PPCDT. Universidade Nova de Lisboa Faculdade de Ciências Médicas; Universidade de Lisboa Faculdade de Medicina Veterinária; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2016/05/01 - 2019/10/31. Alzheimer3D: Conjugados Trifuncionais para o Transporte Selectivo de Fármacos para a Doença de Alzheimer, Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014. Universidade NOVA de Lisboa NOVA Medical School; Universidade de Lisboa Faculdade de Medicina Veterinária; Universidade de Lisboa Faculdade de Farmácia; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2014/03/01 - 2017/10/31. Avaliação Abrangente e Não Enviesada de Fatores de Risco Genéticos e Ambientais para a Doença de Parkinson, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2013/05/01 - 2015/10/31. Glucocerebrosidase na Doença de Parkinson: do factor de risco ao biomarcador, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2013/05/01 - 2015/10/31. Glucocerebrosidase na Doença de Parkinson: do factor de risco ao biomarcador, Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2012. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2011/09 - 2014/06. PARK- Identification of molecules to treat Parkinson´s Disease using a novel zebrafish model. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2013/06/01 - 2014/05/31. Alfa-sinucleína como biomarcador sanguíneo para a doença de Parkinson, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes; Instituto Nacional de Saúde Doutor Ricardo Jorge.

2013/06/01 - 2014/05/31. Alfa-sinucleína como biomarcador sanguíneo para a doença de Parkinson, Projetos de Investigação Exploratória - 2012. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes; Instituto Nacional de Saúde Doutor Ricardo Jorge.

2010/02/05 - 2013/08/04. Análise das alterações da transcrição em modelos cerebrais e periféricos da doença de Huntington - influência da modulação das desacetilases das histonas, 5876-PPCDTI. Universidade de Coimbra Centro de Neurociências e Biologia Celular.

2010/02/05 - 2013/07/31. Análise dos mecanismos moleculares que determinam disfunção da alfa-sinucleína e a citoxicidade na doença de Parkinson - o papel do GDNF, 5876-PPCDTI. Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2010/02/01 - 2013/07/31. Da fosforilação à clivagem: um "switch" para a agregação e a toxicidade da alfa-sinucleína, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2010/02/01 - 2013/07/31. Da fosforilação à clivagem: um "switch" para a agregação e a toxicidade da alfa-sinucleína, Concurso para Projectos de I&D em todos os Domínios Científicos - 2008. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2010/02/01 - 2013/07/31. Modificação genética das células do núcleo paraventricular do hipotálamo (PVN) e medula rostroventrolateral (RVLM) para controlar cronicamente a hipertensão., Concurso para Projectos de I&D em todos os Domínios Científicos - 2008. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2010/01/01 - 2013/06/30. Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide, 3599-PPCDT. Universidade de Lisboa Instituto Superior Técnico; Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2010/01/01 - 2013/06/30. Disgenesia tubular renal associada a misfolding da ACE: efeitos moleculares da nova mutação Q1069R, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2010/01/01 - 2013/06/30. Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide, Concurso para Projectos de I&D em todos os Domínios Científicos - 2008. Universidade de Lisboa Instituto Superior Técnico; Universidade de Coimbra; Universidade de Coimbra Faculdade de Medicina; Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2010/01/01 - 2013/06/30. Disgenesia tubular renal associada a misfolding da ACE: efeitos moleculares da nova mutação Q1069R, Concurso para Projectos de I&D em todos os Domínios Científicos - 2008. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2010/02/05 - 2013/05/31. Alteração do tráfego intracelular mediado pela mitocôndria na doença de Parkinson, 5876-PPCDTI. Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2011/01/01 - 2013/02/17. Strategic Project - LA 5 - 2011-2012, 6817 - DCRRNI ID. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2010/01/01 - 2012/12/31. Papel dos receptores A2A de adenosina no stress crónico - implicações na aprendizagem e memória, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2010/01/01 - 2012/12/31. Papel dos receptores A2A de adenosina no stress crónico - implicações na aprendizagem e memória, Concurso para Projectos de I&D em todos os Domínios Científicos - 2008. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2009/01/01 - 2012/12/31. Doença de Parkinson de Progressão Lenta e Rápida: Determinantes Moleculares e Biomarcadores, 5646-ICCMS. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2009/01/01 - 2012/12/31. Doença de Parkinson de Progressão Lenta e Rápida: Determinantes Moleculares e Biomarcadores, Concurso de Projectos de Investigação Científica e de Desenvolvimento Tecnológico no domínio da Investigação Clínica - 2007. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.

2008/01/02 - 2011/12/31. A glicação de proteínas e amiloidogenese da transtiretina em levedura: Um sistema modelo de doenças neurodegenerativas amiloidóticas, Concurso para Projectos de I&D em todos os Domínios Científicos - 2006. Fundação da Faculdade de Ciências da Universidade de Lisboa; Universidade de Lisboa Centro de Química e Bioquímica; Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier; Egas Moniz - Cooperativa de Ensino Superior Crl; Universidade de Lisboa Faculdade de Ciências.

2008/01/01 - 2011/06/30. Efeito da glicação em proteínas chave da doença de Parkinson: estudos in vivo e in vitro dos mecanismos de folding, agregação e degradação da alfa-sinucleina, da sinfilina e da parkina em condições glicantes., Concurso para Projectos de I&D em todos os Domínios Científicos - 2006. Fundação da Faculdade de Ciências da Universidade de Lisboa; Universidade de Lisboa Centro de Química e Bioquímica; Egas Moniz - Cooperativa de Ensino Superior Crl; Universidade de Lisboa Faculdade de Ciências.

1999/01/01 - 2002/12/31. AMYLOID FORMATION IN YEAST: COMPARATIVE STUDIES ON THE INFLUENCE OF CHAPERONES ON THE AGGREGATION PROCESS OF TRANSTHYRETIN AND OTHER AMYLOIDOGENIC PROTEINS, POCTI. Universidade do Porto Faculdade de Ciências.

Produções

Tiago Fleming Outeiro; David J. Koss; Daniel Erskine; Lauren Walker; Marzena Kurzawa-Akanbi; David Burn; Paul Donaghy; et al. 2019. "Dementia with Lewy bodies: an update and outlook". Molecular Neurodegeneration, 14 (1). https://doi.org/10.1186/s13024-019-0306-8

Diana Macedo; Carolina Jardim; Inês Figueira; A. Filipa Almeida; Gordon J. McDougall; Derek Stewart; Jose E. Yuste; et al. 2018. "(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis". Scientific Reports. https://doi.org/10.1038/s41598-018-25118-z

Diana F. Lázaro; Maria Angeliki S. Pavlou; Tiago Fleming Outeiro. 2017. "Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease". Experimental Neurology, 298: 162-171. https://doi.org/10.1016/j.expneurol.2017.05.007

Diana G Ferreira; Mariana Temido-Ferreira; Hugo Vicente Miranda; Vânia L Batalha; Joana E Coelho; Éva M Szegö; Inês Marques-Morgado; et al. 2017. "a-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B". Nature Neuroscience, 20 (11): 1569-1579. https://doi.org/10.1038/nn.4648

Rodrigues TM; Jerónimo-Santos A; Outeiro TF; Sebastião AM; Diógenes MJ. 2014. "Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease.". https://doi.org/10.1007/s40266-014-0160-x

McFarland KN; Huizenga MN; Darnell SB; Sangrey GR; Berezovska O; Cha JH; Outeiro TF; Sadri-Vakili G. 2014. "MeCP2: a novel Huntingtin interactor.". https://doi.org/10.1093/hmg/ddt499

Sajjad MU; Green EW; Miller-Fleming L; Hands S; Herrera F; Campesan S; Khoshnan A; et al. 2014. "DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease.". https://doi.org/10.1093/hmg/ddt466

Vittori A; Breda C; Repici M; Orth M; Roos RA; Outeiro TF; Giorgini F; Hollox EJ; the REGISTRY investigators of the European Huntington's Disease Network. 2014. "Copy number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease.". http://europepmc.org/abstract/med/24452335

Vittori A; Orth M; Roos RA; Outeiro TF; Giorgini F; Hollox EJ; REGISTRY investigators of the European Huntington’s Disease Network. 2013. "ß-Defensin Genomic Copy Number Does Not Influence the Age of Onset in Huntington's Disease.". http://europepmc.org/abstract/med/24587836

Donmez, G.; Outeiro, T.F.. 2013. "SIRT1 and SIRT2: Emerging targets in neurodegeneration". EMBO Molecular Medicine, 5 (3): 344-352. https://doi.org/10.1002/emmm.201302451

Gonçalves, S.; Outeiro, T.F.. 2013. "Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy". Molecular Neurobiology, 1-12. https://doi.org/10.1007/s12035-013-8406-x

Szego, É.M.; Outeiro, T.F.; Kermer, P.; Schulz, J.B.. 2013. "Impairment of the septal cholinergic neurons in MPTP-treated A30P a-synuclein mice". Neurobiology of Aging, 34 (2): 589-601. https://doi.org/10.1016/j.neurobiolaging.2012.04.012

Lopes da Fonseca, T.; Correia, A.; Hasselaar, W.; van der Linde, H.C.; Willemsen, R.; Outeiro, T.F.. 2013. "The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival". Brain Research Bulletin, 90 (1): 118-126. https://doi.org/10.1016/j.brainresbull.2012.09.017

Repici, M.; Straatman, K.R.; Balduccio, N.; Enguita, F.J.; Outeiro, T.F.; Giorgini, F.. 2013. "Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells". Journal of Molecular Medicine, 91 (5): 599-611. https://doi.org/10.1007/s00109-012-0976-y

Amaral, M.; Levy, C.; Heyes, D.J.; Lafite, P.; Outeiro, T.F.; Giorgini, F.; Leys, D.; Scrutton, N.S.. 2013. "Structural basis of kynurenine 3-monooxygenase inhibition". Nature, 496 (7445): 382-385. https://doi.org/10.1038/nature12039

Guerreiro, P.S.; Huang, Y.; Gysbers, A.; Cheng, D.; Gai, W.P.; Outeiro, T.F.; Halliday, G.M.. 2013. "LRRK2 interactions with a-synuclein in Parkinson's disease brains and in cell models". Journal of Molecular Medicine, 91 (4): 513-522. https://doi.org/10.1007/s00109-012-0984-y

Amaral, J.D.; Herrera, F.; Rodrigues, P.M.; Dionísio, P.A.; Outeiro, T.F.; Rodrigues, C.M.P.. 2013. "Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system". Biochemical Pharmacology, 85 (6): 745-752. https://doi.org/10.1016/j.bcp.2012.12.009

Gonçalves, S.; Outeiro, T.F.. 2013. "Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.". Molecular neurobiology, 47 (3): 1081-1092. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887273441&partnerID=MN8TOARS

Amaral, M.; Outeiro, T.F.; Scrutton, N.S.; Giorgini, F.. 2013. "The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease". Journal of Molecular Medicine, 91 (6): 705-713. https://doi.org/10.1007/s00109-013-1046-9

Faria, C.; Jorge, C.D.; Borges, N.; Tenreiro, S.; Outeiro, T.F.; Santos, H.. 2013. "Inhibition of formation of a-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease". Biochimica et Biophysica Acta - General Subjects, 1830 (8): 4065-4072. https://doi.org/10.1016/j.bbagen.2013.04.015

Schildknecht, S.; Gerding, H.R.; Karreman, C.; Drescher, M.; Lashuel, H.A.; Outeiro, T.F.; Di Monte, D.A.; Leist, M.. 2013. "Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: Implications for disease mechanisms and interventions in synucleinopathies". Journal of Neurochemistry, 125 (4): 491-511. https://doi.org/10.1111/jnc.12226

Pais, T.F.; Szego, É.M.; Marques, O.; Miller-Fleming, L.; Antas, P.; Guerreiro, P.; De Oliveira, R.M.; Kasapoglu, B.; Outeiro, T.F.. 2013. "The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation". EMBO Journal, 32 (19): 2603-2616. https://doi.org/10.1038/emboj.2013.200

Miranda, H.V.; Xiang, W.; De Oliveira, R.M.; Simões, T.; Pimentel, J.; Klucken, J.; Penque, D.; Outeiro, T.F.. 2013. "Heat-mediated enrichment of a-synuclein from cells and tissue for assessing post-translational modifications". Journal of Neurochemistry, 126 (5): 673-684. https://doi.org/10.1111/jnc.12251

Taschenberger, G.; Toloe, J.; Tereshchenko, J.; Akerboom, J.; Wales, P.; Benz, R.; Becker, S.; et al. 2013. "ß-synuclein aggregates and induces neurodegeneration in dopaminergic neurons". Annals of Neurology, 74 (1): 109-118. https://doi.org/10.1002/ana.23905

Eisbach, S.E.; Outeiro, T.F.. 2013. "Alpha-Synuclein and intracellular trafficking: Impact on the spreading of Parkinson's disease pathology". Journal of Molecular Medicine, 91 (6): 693-703. https://doi.org/10.1007/s00109-013-1038-9

Marques S; Outeiro TF. 2013. "Epigenetics in Parkinson's and Alzheimer's diseases.". https://doi.org/10.1007/978-94-007-4525-4_22

Wales P; Pinho R; Lázaro DF; Outeiro TF. 2013. "Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration.". https://doi.org/10.3233/JPD-130216

Fagerqvist, T.; Näsström, T.; Ihse, E.; Lindström, V.; Sahlin, C.; Fangmark Tucker, S.M.; Kasaryan, A.; et al. 2013. "Off-pathway a-synuclein oligomers seem to alter a-synuclein turnover in a cell model but lack seeding capability in vivo". Amyloid, 20 (4): 233-244. https://doi.org/10.3109/13506129.2013.835726

Basso, E.; Antas, P.; Marijanovic, Z.; Gonçalves, S.; Tenreiro, S.; Outeiro, T.F.. 2013. "PLK2 modulates a-synuclein aggregation in yeast and mammalian cells". Molecular Neurobiology, 48 (3): 854-862. https://doi.org/10.1007/s12035-013-8473-z

Tenreiro, S.; Munder, M.C.; Alberti, S.; Outeiro, T.F.. 2013. "Harnessing the power of yeast to unravel the molecular basis of neurodegeneration". Journal of Neurochemistry, 127 (4): 438-452. https://doi.org/10.1111/jnc.12271

Herrera, F.; Gonalves, S.; Outeiro, T.F.. 2012. "Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation". Methods in Enzymology, 506: 157-174. https://doi.org/10.1016/B978-0-12-391856-7.00033-0

Herrera, F.; Outeiro, T.F.. 2012. "a-Synuclein modifies huntingtin aggregation in living cells". FEBS Letters, 586 (1): 7-12. https://doi.org/10.1016/j.febslet.2011.11.019

Kemppainen, S.; Rantamäki, T.; Jerónimo-Santos, A.; Lavasseur, G.; Autio, H.; Karpova, N.; Kärkkäinen, E.; et al. 2012. "Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice". Neurobiology of Aging, 33 (6). https://doi.org/10.1016/j.neurobiolaging.2011.11.006

Sancenon, V.; Lee, S.-A.; Patrick, C.; Griffith, J.; Paulino, A.; Outeiro, T.F.; Reggiori, F.; Masliah, E.; Muchowski, P.J.. 2012. "Suppression of a-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context". Human Molecular Genetics, 21 (11): 2432-2449. https://doi.org/10.1093/hmg/dds058

Gonçalves, S.; Miranda, H.V.; Outeiro, T.F.. 2012. "Novel Molecular Therapeutics in Parkinson's Disease". Molecular and Cellular Therapeutics, 245-265. https://doi.org/10.1002/9781119967309.ch11

Rosa, P.; Tenreiro, S.; Chu, V.; Outeiro, T.F.; Conde, J.P.. 2012. "High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment". Biomicrofluidics, 6 (1). https://doi.org/10.1063/1.3683161

Diógenes, M.J.; Dias, R.B.; Rombo, D.M.; Miranda, H.V.; Maiolino, F.; Guerreiro, P.; Näsström, T.; et al. 2012. "Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation". Journal of Neuroscience, 32 (34): 11750-11762. https://doi.org/10.1523/JNEUROSCI.0234-12.2012

Petroi, D.; Popova, B.; Taheri-Talesh, N.; Irniger, S.; Shahpasandzadeh, H.; Zweckstetters, M.; Outeiro, T.F.; Braus, G.H.. 2012. "Aggregate clearance of a-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome". Journal of Biological Chemistry, 287 (33): 27567-27579. https://doi.org/10.1074/jbc.M112.361865

Marques, O.; Outeiro, T.F.. 2012. "Alpha-synuclein: From secretion to dysfunction and death". Cell Death and Disease, 3 (7). https://doi.org/10.1038/cddis.2012.94

Maxwell, M.M.; Zaldivar-Jolissaint, J.F.; Mai, A.; Outeiro, T.F.; Kazanstev, A.G.. 2012. "Highlights of the Keystone Symposium: Sirtuins in metabolism, aging and disease". EMBO Molecular Medicine, 4 (7): 557-560. https://doi.org/10.1002/emmm.201201452

Sampaio-Marques, B.; Felgueiras, C.; Silva, A.; Rodrigues, M.; Tenreiro, S.; Franssens, V.; Reichert, A.S.; et al. 2012. "SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy". Autophagy, 8 (10): 1494-1509. https://doi.org/10.4161/auto.21275

Marques, S.C.F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonça, A.; Santana, I.; Outeiro, T.F.; Pereira, C.M.F.. 2012. "Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice". Neuroscience, 220: 256-266. https://doi.org/10.1016/j.neuroscience.2012.06.029

de Oliveira, R.M.; Sarkander, J.; Kazantsev, A.G.; Outeiro, T.F.. 2012. "SIRT2 as a therapeutic target for age-related disorders". Frontiers in Pharmacology, 3 MAY. https://doi.org/10.3389/fphar.2012.00082

Kazantsev, A.G.; Outeiro, T.F.. 2012. "Editorial on special topic: Sirtuins in metabolism, aging, and disease". Frontiers in Pharmacology, 3 APR. https://doi.org/10.3389/fphar.2012.00071

Tauber, E.; Miller-Fleming, L.; Mason, R.P.; Kwan, W.; Clapp, J.; Butler, N.J.; Outeiro, T.F.; Muchowski, P.J.; Giorgini, F.. 2011. "Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity". Journal of Biological Chemistry, 286 (1): 410-419. https://doi.org/10.1074/jbc.M110.101527

Jorge, C.D.; Ventura, R.; Maycock, C.; Outeiro, T.F.; Santos, H.; Costa, J.. 2011. "Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases". Neurochemical Research, 36 (6): 1005-1011. https://doi.org/10.1007/s11064-011-0440-3

Marques, S.C.F.; Pereira, C.M.F.; Outeiro, T.F.. 2011. "Epigenetics and neurodegeneration: Unveiling the complexity". Bio Tech International, 23 (JUNE): 16-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960753413&partnerID=MN8TOARS

Marques, S.C.F.; Oliveira, C.R.; Pereira, C.M.F.; Outeiro, T.F.. 2011. "Epigenetics in neurodegeneration: A new layer of complexity". Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35 (2): 348-355. https://doi.org/10.1016/j.pnpbp.2010.08.008

Hansen, C.; Angot, E.; Bergström, A.-L.; Steiner, J.A.; Pieri, L.; Paul, G.; Outeiro, T.F.; et al. 2011. "a-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells". Journal of Clinical Investigation, 121 (2): 715-725. https://doi.org/10.1172/JCI43366

Martins, M.; Rosa, A.; Guedes, L.C.; Fonseca, B.V.; Gotovac, K.; Violante, S.; Mestre, T.; et al. 2011. "Convergence of mirna expression profiling, a-synuclein interacton and GWAS in Parkinson's disease". PLoS ONE, 6 (10). https://doi.org/10.1371/journal.pone.0025443

Swinnen, E.; Büttner, S.; Outeiro, T.F.; Galas, M.-C.; Madeo, F.; Winderickx, J.; Franssens, V.. 2011. "Aggresome formation and segregation of inclusions influence toxicity of a-synuclein and synphilin-1 in yeast". Biochemical Society Transactions, 39 (5): 1476-1481. https://doi.org/10.1042/BST0391476

Outeiro, T.F.. 2011. "Amyloidogenesis: FlAsH illuminates Aß aggregation". Nature Chemical Biology, 7 (9): 581-582. https://doi.org/10.1038/nchembio.636

de Oliveira, R.M.; Marijanovic, Z.; Carvalho, F.; Miltényi, G.M.; Matos, J.E.; Tenreiro, S.; Oliveira, S.; et al. 2011. "Impaired proteostasis contributes to renal tubular dysgenesis". PLoS ONE, 6 (6). https://doi.org/10.1371/journal.pone.0020854

Herrera, F.; Tenreiro, S.; Miller-Fleming, L.; Outeiro, T.F.. 2011. "Visualization of cell-to-cell transmission of mutant huntingtin oligomers". PLoS Currents. https://doi.org/10.1371/currents.RRN1210

Szego, E.M.; Gerhardt, E.; Outeiro, T.F.; Kermer, P.. 2011. "Dopamine-depletion and increased a-synuclein load induce degeneration of cortical cholinergic fibers in mice". Journal of the Neurological Sciences, 310 (1-2): 90-95. https://doi.org/10.1016/j.jns.2011.06.048

Näsström, T.; Gonçalves, S.; Sahlin, C.; Nordström, E.; Sundquist, V.S.; Lannfelt, L.; Bergström, J.; Outeiro, T.F.; Ingelsson, M.. 2011. "Antibodies against alpha-synuclein reduce oligomerization in living cells". PLoS ONE, 6 (10). https://doi.org/10.1371/journal.pone.0027230

Badiola, N.; de Oliveira, R.M.; Herrera, F.; Guardia-Laguarta, C.; Gonçalves, S.A.; Pera, M.; Suárez-Calvet, M.; et al. 2011. "Tau enhances a-synuclein aggregation and toxicity in cellular models of synucleinopathy". PLoS ONE, 6 (10). https://doi.org/10.1371/journal.pone.0026609

Marques S; Batalha VL; Lopes LV; Outeiro TF. 2011. "Modulating Alzheimer's disease through caffeine: a putative link to epigenetics.". https://doi.org/10.3233/JAD-2011-110032

Gerhardt, E.; Gräber, S.; Szego, E.M.; Moisoi, N.; Martins, L.M.; Outeiro, T.F.; Kermer, P.. 2011. "Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice". PLoS ONE, 6 (12). https://doi.org/10.1371/journal.pone.0028855

Ribeiro Morais, G.; Vicente Miranda, H.; Santos, I.C.; Santos, I.; Outeiro, T.F.; Paulo, A.. 2011. "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes". Bioorganic and Medicinal Chemistry, 19 (24): 7698-7710. https://doi.org/10.1016/j.bmc.2011.09.065

Kazantsev AG; Outeiro TF. 2010. "Drug discovery for CNS disorders: from bench to bedside.". https://doi.org/10.2174/187152710793237395

Diógenes MJ; Outeiro TF. 2010. "Neurotrophic factors as a protective strategy in Parkinson's disease.". https://doi.org/10.2174/187152710793237449

de Oliveira RM; Pais TF; Outeiro TF. 2010. "Sirtuins: common targets in aging and in neurodegeneration.". https://doi.org/10.2174/1389450111007011270

Tenreiro, S.; Outeiro, T.F.. 2010. "Simple is good: Yeast models of neurodegeneration". FEMS Yeast Research, 10 (8): 970-979. https://doi.org/10.1111/j.1567-1364.2010.00649.x

Kazantsev, A.G.; Outeiro, T.F.. 2010. "Drug discovery for cns disorders: From bench to bedside". CNS and Neurological Disorders - Drug Targets, 9 (6): 668-668. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649337104&partnerID=MN8TOARS

Diógenes, M.J.; Outeiro, T.F.. 2010. "Neurotrophic factors as a protective strategy in Parkinson's disease". CNS and Neurological Disorders - Drug Targets, 9 (6): 754-763. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649251977&partnerID=MN8TOARS

Marques, S.C.F.; Oliveira, C.R.; Outeiro, T.F.; Pereira, C.M.F.. 2010. "Alzheimer's disease: The quest to understand complexity". Journal of Alzheimer's Disease, 21 (2): 373-383. https://doi.org/10.3233/JAD-2010-100303

da Costa, G.; Guerreiro, A.; Correia, C.F.; Gomes, R.J.; Freire, A.; Monteiro, E.; Barroso, E.; et al. 2010. "A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS". Proteomics - Clinical Applications, 4 (6-7): 674-678. https://doi.org/10.1002/prca.200900118

Miranda, H.V.; Outeiro, T.F.. 2010. "The sour side of neurodegenerative disorders: The effects of protein glycation". Journal of Pathology, 221 (1): 13-25. https://doi.org/10.1002/path.2682

Su, L.J.; Auluck, P.K.; Outeiro, T.F.; Yeger-Lotem, E.; Kritzer, J.A.; Tardiff, D.F.; Strathearn, K.E.; et al. 2010. "Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models". DMM Disease Models and Mechanisms, 3 (3-4): 194-208. https://doi.org/10.1242/dmm.004267

Büttner, S.; Delay, C.; Franssens, V.; Bammens, T.; Ruli, D.; Zaunschirm, S.; de Oliveira, R.M.; et al. 2010. "Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a sir2-dependent manner". PLoS ONE, 5 (10). https://doi.org/10.1371/journal.pone.0013700

Gonçalves, S.A.; Matos, J.E.; Outeiro, T.F.. 2010. "Zooming into protein oligomerization in neurodegeneration using BiFC". Trends in Biochemical Sciences, 35 (11): 643-651. https://doi.org/10.1016/j.tibs.2010.05.007

Nakhjavani, M.; Morteza, A.; Khajeali, L.; Esteghamati, A.; Khalilzadeh, O.; Asgarani, F.; Outeiro, T.F.. 2010. "Increased serum HSP70 levels are associated with the duration of diabetes". Cell Stress and Chaperones, 15 (6): 959-964. https://doi.org/10.1007/s12192-010-0204-z

de Oliveira, R.M.; Pais, T.F.; Outeiro, T.F.. 2010. "Irtuins: Common targets in aging and in neurodegeneration". Current Drug Targets, 11 (10): 1270-1280. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958001297&partnerID=MN8TOARS

Outeiro, T.F.; Ferreira, J.. 2009. "Current and future therapeutic strategies for Parkinson's disease". Current Pharmaceutical Design, 15 (34): 3968-3976. https://doi.org/10.2174/138161209789649321

Da Costa, G.; Gomes, R.; Correia, C.F.; Freire, A.; Monteiro, E.; Martins, A.; Barroso, E.; et al. 2009. "Identification and quantitative analysis of human transthyretin variants in human serum by Fourier transform ion-cyclotron resonance mass spectrometry". Amyloid, 16 (4): 201-207. https://doi.org/10.3109/13506120903421561

Outeiro TF; Klucken J; Bercury K; Tetzlaff J; Putcha P; Oliveira LM; Quintas A; McLean PJ; Hyman BT. 2009. "Dopamine-induced conformational changes in alpha-synuclein.". https://doi.org/10.1371/journal.pone.0006906

Outeiro, T.F.. 2008. "From mad cows to neurotic yeast: Novel molecular approaches to understand neurodegeneration". Microscopy and Microanalysis, 14 (SUPPL. 3): 105-106. https://doi.org/10.1017/S143192760808954X

Tetzlaff, J.E.; Putcha, P.; Outeiro, T.F.; Ivanov, A.; Berezovska, O.; Hyman, B.T.; McLean, P.J.. 2008. "CHIP targets toxic a-synuclein oligomers for degradation". Journal of Biological Chemistry, 283 (26): 17962-17968. https://doi.org/10.1074/jbc.M802283200

Outeiro, T.F.; Marques, O.; Kazantsev, A.. 2008. "Therapeutic role of sirtuins in neurodegenerative disease". Biochimica et Biophysica Acta - Molecular Basis of Disease, 1782 (6): 363-369. https://doi.org/10.1016/j.bbadis.2008.02.010

Outeiro TF; Putcha P; Tetzlaff JE; Spoelgen R; Koker M; Carvalho F; Hyman BT; McLean PJ. 2008. "Correction: Formation of Toxic Oligomeric ?-Synuclein Species in Living Cells.". http://europepmc.org/abstract/PMC/PMC2556498

Mollenhauer, B.; Cullen, V.; Kahn, I.; Krastins, B.; Outeiro, T.F.; Pepivani, I.; Ng, J.; et al. 2008. "Direct quantification of CSF a-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration". Experimental Neurology, 213 (2): 315-325. https://doi.org/10.1016/j.expneurol.2008.06.004

Fleming, J.; Outeiro, T.F.; Slack, M.; Lindquist, S.L.; Bulawa, C.E.. 2008. "Detection of Compounds That Rescue Rab1-Synuclein Toxicity". Methods in Enzymology, 439: 339-351. https://doi.org/10.1016/S0076-6879(07)00425-9

Outeiro TF; Kazantsev A. 2008. "Drug Targeting of alpha-Synuclein Oligomerization in Synucleinopathies.". http://europepmc.org/abstract/med/19787096

Outeiro, T.F.; Kazantsev, A.. 2008. "Drug targeting of a-synuclein oligomerization in synucleinopathies". Perspectives in Medicinal Chemistry, 2008 (2): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953408910&partnerID=MN8TOARS

Outeiro, T.F.; Putcha, P.; Tetzlaff, J.E.; Spoelgen, R.; Koker, M.; Carvalho, F.; Hyman, B.T.; McLean, P.J.. 2008. "Formation of toxic oligomeric a-synuclein species in living cells". PLoS ONE, 3 (4). https://doi.org/10.1371/journal.pone.0001867

Miller-Fleming, L.; Giorgini, F.; Outeiro, T.F.. 2008. "Yeast as a model for studying human neurodegenerative disorders". Biotechnology Journal, 3 (3): 325-338. https://doi.org/10.1002/biot.200700217

St Martin, J.L.; Klucken, J.; Outeiro, T.F.; Nguyen, P.; Keller-McGandy, C.; Cantuti-Castelvetri, I.; Grammatopoulos, T.N.; et al. 2007. "Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra". Journal of Neurochemistry, 100 (6): 1449-1457. https://doi.org/10.1111/j.1471-4159.2006.04310.x

Fleming Outeiro, T.; Tetzlaff, J.. 2007. "Mechanisms of Disease II: Cellular Protein Quality Control". Seminars in Pediatric Neurology, 14 (1): 15-25. https://doi.org/10.1016/j.spen.2006.11.005

Outeiro, T.F.; McLean, P.J.; Hyman, B.T.. 2007. "Protein aggregation disorders". Neurobiology of Disease, 111-123. https://doi.org/10.1016/B978-012088592-3/50012-8

Grammatopoulos, T.N.; Outeiro, T.F.; Hyman, B.T.; Standaert, D.G.. 2007. "Angiotensin II protects against a-synuclein toxicity and reduces protein aggregation in vitro". Biochemical and Biophysical Research Communications, 363 (3): 846-851. https://doi.org/10.1016/j.bbrc.2007.09.043

Outeiro, T.F.; Kontopoulos, E.; Altmann, S.M.; Kufareva, I.; Strathearn, K.E.; Amore, A.M.; Volk, C.B.; et al. 2007. "Sirtuin 2 inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson's disease". Science, 317 (5837): 516-519. https://doi.org/10.1126/science.1143780

Outeiro, T.F.; Grammatopoulos, T.N.; Altmann, S.; Amore, A.; Standaert, D.G.; Hyman, B.T.; Kazantsev, A.G.. 2007. "Pharmacological inhibition of PARP-1 reduces a-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models". Biochemical and Biophysical Research Communications, 357 (3): 596-602. https://doi.org/10.1016/j.bbrc.2007.03.163

Outeiro TF. 2006. "A bridge from Portugal to the States.". http://europepmc.org/abstract/med/17001768

Outeiro, T.F.. 2006. "A bridge from Portugal to the States.". Nature., 443 (7107). http://www.scopus.com/inward/record.url?eid=2-s2.0-33749364368&partnerID=MN8TOARS

Bodner, R.A.; Outeiro, T.F.; Altmann, S.; Maxwell, M.M.; Cho, S.H.; Hyman, B.T.; McLean, P.J.; et al. 2006. "Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases". Proceedings of the National Academy of Sciences of the United States of America, 103 (11): 4246-4251. https://doi.org/10.1073/pnas.0511256103

Outeiro, T.F.; Giorgini, F.. 2006. "Yeast as a drug discovery platform in Huntington's and Parkinson's diseases". Biotechnology Journal, 1 (3): 258-269. https://doi.org/10.1002/biot.200500043

Outeiro, T.F.; Klucken, J.; Strathearn, K.E.; Liu, F.; Nguyen, P.; Rochet, J.-C.; Hyman, B.T.; McLean, P.J.. 2006. "Small heat shock proteins protect against a-synuclein-induced toxicity and aggregation". Biochemical and Biophysical Research Communications, 351 (3): 631-638. https://doi.org/10.1016/j.bbrc.2006.10.085

Klucken, J.; Outeiro, T.F.; Nguyen, P.; McLean, P.J.; Hyman, B.T.. 2006. "Detection of novel intracellular a-synuclein oligomeric species by fluorescence lifetime imaging". FASEB Journal, 20 (12): 2050-2057. https://doi.org/10.1096/fj.05-5422com

Lindquist, S.; Fraenkel, E.; Outeiro, T.; Gitler, A.; Su, J.; Cashikar, A.; Jagadish, S.. 2005. "Yeast cells as a discovery platform for neurodegenerative disease". Lecture Notes in Bioinformatics (Subseries of Lecture Notes in Computer Science), 3500. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444497156&partnerID=MN8TOARS

Rochet JC; Outeiro TF; Conway KA; Ding TT; Volles MJ; Lashuel HA; Bieganski RM; Lindquist SL; Lansbury PT. 2004. "Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease.". https://doi.org/10.1385/JMN:23:1-2:023

Outeiro TF; Muchowski PJ. 2004. "Molecular genetics approaches in yeast to study amyloid diseases.". https://doi.org/10.1385/JMN:23:1-2:049

Derkatch, I.L.; Uptain, S.M.; Outeiro, T.F.; Krishnan, R.; Lindquist, S.L.; Liebman, S.W.. 2004. "Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro". Proceedings of the National Academy of Sciences of the United States of America, 101 (35): 12934-12939. https://doi.org/10.1073/pnas.0404968101

Outeiro, T.F.; Muchowski, P.J.. 2004. "Molecular genetics approaches in yeast to study amyloid diseases". Journal of Molecular Neuroscience, 23 (1-2): 49-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669436&partnerID=MN8TOARS

Rochet, J.-C.; Outeiro, T.F.; Conway, K.A.; Ding, T.T.; Volles, M.J.; Lashuel, H.A.; Bieganski, R.M.; Lindquist, S.L.; Lansbury Jr., P.J.. 2004. "Interactions among a-synuclein, dopamine, and biomembranes: Some clues for understanding neurodegeneration in Parkinson's disease". Journal of Molecular Neuroscience, 23 (1-2): 23-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344641972&partnerID=MN8TOARS

Willingham, S.; Outeiro, T.F.; DeVit, M.J.; Lindquist, S.L.; Muchowski, P.J.. 2003. "Yeast Genes that Enhance the Toxicity of a Mutant Huntingtin Fragment or a-Synuclein". Science, 302 (5651): 1769-1772. https://doi.org/10.1126/science.1090389

Outeiro, T.F.; Lindquist, S.. 2003. "Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology". Science, 302 (5651): 1772-1775. https://doi.org/10.1126/science.1090439

Resende, C.G.; Outeiro, T.F.; Sands, L.; Lindquist, S.; Tuite, M.F.. 2003. "Prion protein gene polymorphisms in Saccharomyces cerevisiae". Molecular Microbiology, 49 (4): 1005-1017. https://doi.org/10.1046/j.1365-2958.2003.03608.x

Geraldes, Vera Lúcia Poço, 1983-. 2014. "Hypothalamic and medullar mechanisms for long-term autonomic regulation of arterial blood pressure". Doutoramento. http://hdl.handle.net/10451/15834

Silva, Filipa Magalhães, 1990-. 2013. "Alpha-synuclein phosphorylation role on Parkinson’s disease". Mestrado. http://hdl.handle.net/10451/10070

Marques, Belém Sampaio; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Márcio; Tenreiro, Sandra; Franssens, Vanessa; Reichert, Andreas S.; et al. 2012. SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. SNCA (a-synuclein) misfolding and aggregation is strongly associated with both idiopathic and familial forms of Parkinson disease (PD). Evidence suggests that SNCA has an impact on cell clearance routes and protein quality control systems such as the ubiquitin-proteasome system (UPS) and autophagy. Recent advances in the key role of the autosomal recessive PARK2/PARKIN and PINK1 genes in mitophagy. https://doi.org/10.4161/auto.21275

Lázaro, Diana F.; Dias, Mariana Castro; Carija, Anita; Navarro, Susanna; Madaleno, Carolina S; Tenreiro, Sandra; Ventura, Salvador; et al. 2016. The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. a-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease. In particular, multiplications and point mutations in the gene encoding for aSyn cause familial forms of PD. Moreover, the accumulation of aSyn in Lewy Bodies and Lewy neurites in disorders such as PD, dementia with Lewy bo. https://doi.org/10.1186/s40478-016-0402-8

Marques, Sueli Cristina Ferreira. 2011. "Chromatin remodeling in Alzheimer's disease pathogenesis". Doutoramento. http://hdl.handle.net/10316/20157

Vicente Miranda, Hugo; Szego, Éva M.; Oliveira, Luís M.A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. 2017. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. https://doi.org/10.1093/brain/awx056.

Fonseca, Tomás Ribeiro da Silva Lopes da, 1987-. 2010. "Zebrafish : a new model of Parkinson's disease". Mestrado. http://hdl.handle.net/10451/2214

Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. "Guidelines and recommendations on yeast cell death nomenclature". https://doi.org/10.15698/mic2018.01.607

Vicente Miranda, Hugo; Xiang, Wei; Oliveira, Rita M. de; Simões, Tânia; Pimentel, José; Klucken, Jochen; Penque, Deborah; Outeiro, Tiago. 2013. Heat-mediated enrichment of a-synuclein from cells and tissue for assessing post-translational modifications. a-synuclein (a-syn) is the major component of Lewy bodies, a pathological hallmark of Parkinson's disease and other synucleinopathies. The characterization of a-syn post-translational modifications (PTMs), thought to interfere with its aggregation propensity and cellular signaling, has been limited by the availability of extraction methods of endogenous protein from cells and tissues, and by the a. https://doi.org/10.1111/jnc.12251

Amaral, Marta Isabel Magalhães Mota do, 1984-. 2013. "Structure and mechanism of kynurenine 3-monooxygenase, a candidate huntington’s disease drug target". Doutoramento. http://hdl.handle.net/10451/9898

Diógenes, Maria José; Dias, Raquel B.; Rombo, Diogo M.; Miranda, Hugo Vicente; Maiolino, Francesca; Guerreiro, Patrícia; Näsström, Thomas; et al. 2012. Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation. Parkinson’s disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of -synuclein (a-syn) in various brain regions is themajorpathological hallmark. Indeed, themotorsymptomsinPDare causedby a heterogeneous degeneration of brain neurons not only in substantia nigra pars compacta but also in other extrastriatal areas of t. https://doi.org/10.1523/¿JNEUROSCI.0234-12.2012

Miranda, Hugo Vicente; Gomes, Marcos Antonio; Branco-Santos, Joana; Breda, Carlo; Lazaro, Diana F; Lopes, Lusa Vaqueiro; Herrera, Federico; et al. 2016. Glycation potentiates neurodegeneration in models of Huntington's disease. Protein glycation is an age-dependent posttranslational modification associated with several neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. By modifying aminogroups, glycation interferes with folding of proteins, increasing their aggregation potential. Here, we studied the effect of pharmacological and genetic manipulation of glycation on huntingtin (HTT), the causati. https://doi.org/10.1038/srep36798

Büttne, Sabrina; Delay, Charlotte; Franssens, Vanessa; Bammens, Tine; Ruli, Doris; Zaunschirm, Sandra; Oliveira, Rita Machado de; et al. 2010. Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. Background: Parkinson’s disease is characterized by the presence of cytoplasmic inclusions, known as Lewy bodies, containing both aggregated a-synuclein and its interaction partner, synphilin-1. While synphilin-1 is known to accelerate inclusion formation by a-synuclein in mammalian cells, its effect on cytotoxicity remains elusive. Methodology/Principal Findings: We expressed wild-type synphilin-. https://doi.org/10.1371/journal.pone.0013700

de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. 2017. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanisms involved remain unclear. Here, we provide mechanistic insight into the interplay between sirtuin . https://doi.org/10.1371/journal.pbio.2000374.

Outeiro, Tiago. 2009. A biomedicina na prevenção, diagnóstico e terapia de doenças. A biomedicina assume um papel cada vez mais importante na prevenção, diagnóstico e terapia de inúmeras doenças que afectam a população mundial, contribuindo para uma significativa melhoria das condições de vida e um consequente aumento da longevidade. A caracterização molecular das populações no contexto do seu estado de saúde, e as novas disciplinas que surgem dos avanços tecnológicos, permitem-n. http://hdl.handle.net/10400.14/9872

Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. 2017. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson’s disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. http://hdl.handle.net/10400.26/19438

Fleming, Maria Leonor Lemos Pereira Miller, 1983-. 2014. "Deciphering the molecular role of DJ-1 in the etiology of Parkinson’s and Huntingtons’s disease". Doutoramento. http://hdl.handle.net/10451/15629

Oliveira, Márcia Santos. 2013. "Modulation of a-synuclein aggregation and toxicity". Mestrado. http://hdl.handle.net/10362/11195

Igrejas Peres, Aitor Tiago; Tobio Espinho, Paulo; Fernandes Outeiro, Paula; Malvar Fernandes, Paulo. 2012. Galiza, esse lugar da Europa. Paper presented on the 6th International Anthropology Students Conference held at University Fernando Pessoa in 1998. Ponencia presentada en el 6º Congreso Internacional de Estudiantes de Antropología realizado en la Universidad Fernando Pessoa en 1998. Document présenté lors de le 6ème Congrès International des Étudiants d'Anthropologie réalisé à l'Université Fernando Pessoa en 1998. Comunicação. https://revistas.rcaap.pt/antropologicas/article/view/1052

Pinho, Raquel; Guedes, Leonor C; Soreq, Lilach; Lobo, Patricia P; Mestre, Tiago; Coelho, Miguel; Rosa, Mario M; et al. 2016. Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles. The prognosis of neurodegenerative disorders is clinically challenging due to the inexistence of established biomarkers for predicting disease progression. Here, we performed an exploratory cross-sectional, case-control study aimed at determining whether gene expression differences in peripheral blood may be used as a signature of Parkinson's disease (PD) progression, thereby shedding light into p. https://doi.org/10.1371/journal.pone.0157852

Gonçalves, Susana A.; Matos, Joana E.; Outeiro, Tiago F.. 2010. Zooming into protein oligomerization in neurodegeneration using BiFC. Several neurodegenerative diseases are characterized by the accumulation of misfolded and aggregated proteins, which lead to neurotoxicity. However, the nature of those toxic species is controversial. Developments in optical microscopy and live-cell imaging are essential in providing crucial insight into the molecular mechanisms involved. In particular, the technique of bimolecular fluorescence co. https://doi.org/10.1016/j.tibs.2010.05.007

Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. 2017. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. https://doi.org/10.1093/brain/awx056

Costa, Gonçalo da; Guerreiro, Ana; Correia, Catarina F.; Gomes, Ricardo J.; Freire, António; Monteiro, Estela; Barroso, Eduardo; et al. 2010. A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS. Purpose: To identify, characterize and perform a relative quantification of human transthyretin (TTR) variants in human saliva. Experimental design: Serum and saliva samples were collected from healthy and familial amyloidotic polyneuropathy (FAP) patients, proteins separated by SDS-PAGE, TTR bands excised, in-gel digested and analyzed by MALDI-FTICR. Results: We identified and performed a relativ. https://doi.org/10.1002/prca.200900118

Miranda, Hugo Vicente; Cássio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos António; Chegão, Ana; Miranda, Elisa; Soares, Tiago; et al. 2017. Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease. Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it is characterized by the intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and Lewy neurites. Currently, there are no established biochemical markers for diagnosing or for following disease progression, a major limitation for the clinical practic. https://doi.org/10.1038/s41598-017-14175-5

Basso, Elisa, 1983-. 2014. "The role of alpha-synuclein phosphorylation in synucleinopathies". Doutoramento. http://hdl.handle.net/10451/15477

Martinho, Renato Gomes da Silva, 1990-. 2013. "SIRT2: in the crossroad of aging, neurodegeneration and autophagy". Mestrado. http://hdl.handle.net/10451/9610

Rodrigues, Eva Sofia Ferreira. 2012. "Comparative study of the effect of selected mutations on alpha-synuclein oligomerization in living cells using bimolecular fluorescence complementation (BiFC) assay". Mestrado. http://hdl.handle.net/10316/25140

Gonçalves, Susana; Outeiro, Tiago Fleming. 2016. A disfunção cognitiva nas doenças neurodegenerativas. As doenças neurodegenerativas são neuropatias que incluem as doenças de Parkinson (DP), de Alzheimer (DA) e de Hungtington, assim como a esclerose lateral amiotrófica e demências fronto-temporais. Podendo variar na sua patofisiologia, estas doenças estão associadas ao envelhecimento geral da população, e à presença comum de formas proteicas misfolded e agregadas no cérebro dos indivíduos afectados. http://seer.upf.br/index.php/rbceh/article/view/6007

Silva, Ana Maria Ferreira da, 1983-. 2016. "Use of genomic dna-reporter tools to dissect pathological mechanisms caused by GAA expansions in Friedreich’s Ataxia". Doutoramento. http://hdl.handle.net/10451/25153

Tenreiro, Sandra; Outeiro, Tiago Fleming. 2016. A levedura como modelo para estudar as bases moleculares da doença de Parkinson. A doença de Parkinson (DP) é uma doença neurodegenerativa sem cura, está associada ao envelhecimento e caracteriza-se pela acumulação de inclusões proteicas intraneuronais conhecidas como corpos de Lewy (CL) no cérebro. Os CL são inclusões maioritariamente compostas pela proteína alfa-sinucleína (aSyn), pensando-se estarem associados à neurodegeneração característica na DP. A aSyn está sujeita a v. http://seer.upf.br/index.php/rbceh/article/view/6006

Marques, Oldriska. 2008. "SIRT2 as a putative target in parkinson's disease therapy". Mestrado. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000583288

Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. 2018. Guidelines and recommendations on yeast cell death nomenclature. Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cel-lular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the defi-ni. https://doi.org/10.15698/mic2018.01.607

Vittori, Angelica. 2014. "Copy number variation and Huntington’s disease". Doutoramento. http://hdl.handle.net/10451/15627

Lázaro, Diana Fernandes. 2012. "Systematic comparison of the effects of a-synuclein mutations on aggregation in Parkinson’s Diseases". Mestrado. http://hdl.handle.net/10451/7246

Santos, Joana Margarida Marques Branco dos, 1987-. 2012. "The role of N-terminal phosphorylation on Huntingtin oligomerization, aggregation and toxicity". Mestrado. http://hdl.handle.net/10451/7554

Gonçalves, Susana A; Macedo, Diana; Raquel, Helena; Simões, Pedro D; Giorgini, Flaviano; Ramalho, José S; Barral, Duarte C; Ferreira Moita, Luís; Outeiro, Tiago Fleming. 2016. shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. Alpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and cell-to-cell trafficking of pathological forms of aSyn may explain the typical patterns of disease progression. However, the molecular mechanisms contro. http://hdl.handle.net/10400.7/591

Fonseca, Tomás Ribeiro da Silva Lopes da, 1987-. 2016. "The interplay between alpha-synuclein and ATP13A2 : towards the understanding of the molecular basis of Parkinson’s disease". Doutoramento. http://hdl.handle.net/10451/28900

Outeiro, Tiago Fleming de Oliveira. 2004. "Yeast as a model organism to study diseases of protein misfolding". Doutoramento. http://hdl.handle.net/10216/10638

Vaz, Rita L.; Outeiro, Tiago F.; Ferreira, Joaquim J.; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders". https://doi.org/10.3389/fneur.2018.00347

Guerreiro, Patricia I. da Silva. 2015. "The role of LRRK2 in Parkinson’s disease : from function to dysfunction". Doutoramento. http://hdl.handle.net/10451/22717

Oliveira, Ana Cristina Osório Marinho. 2017. ""Deciphering the role of aß-crystallin in huntington’s disease"". Doutoramento. http://hdl.handle.net/10451/28882

Macedo, Diana; Jardim, Carolina; Figueira, Inês; Almeida, A. Filipa; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; et al. 2018. (Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis. Parkinson's disease (PD) is an age-related neurodegenerative disease associated with the misfolding and aggregation of alpha-synuclein (aSyn). The molecular underpinnings of PD are still obscure, but nutrition may play an important role in the prevention, onset, and disease progression. Dietary (poly)phenols revert and prevent age-related cognitive decline and neurodegeneration in model systems. H. https://doi.org/10.1038/s41598-018-25118-z

Menezes, R.; Macedo, Diana Leonor Constantino; Santos, Maria Claudia; Tenreiro, Sandra; Outeiro, Tiago F; Instituto de Tecnologia Química e Biológica (ITQB); NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "From the baker to the bedside: yeast models of Parkinson's disease". https://doi.org/10.15698/mic2015.08.219

Almeida, Bruno. 2009. "Elucidation of molecular pathways involved in Saccharomyces cerevisiae apoptotic cell death". Doutoramento. http://hdl.handle.net/1822/9511

Brás, Inês Filipa Caldeira. 2016. "Molecular insights into the role of alfa-synuclein phosphorylation in synucleinopathies". Mestrado. http://hdl.handle.net/10451/27689

Outeiro, Tiago Fleming. 2009. Biomedicina na prevenção, diagnóstico e terapia de doenças. Desde que o Homem povoou a Terra que procura compreender a origem da sua existência. No ano 2000, assinalou-se um marco notável na história da Biologia, mas também da Humanidade: foi apresentada a primeira versão do código da vida humana – a sequência de DNA que constitui o genoma humano. As cerca de 3x109 (3 mil milhões) de bases de DNA que constituem o genoma humano formam os cerca de 25 mil gen. http://hdl.handle.net/11144/1118

Gonçalves, Susana Alexandra de Barros, 1983-. 2017. "Unraveling the molecular mechanisms underlying alpha-synuclein oligomerization and cytotoxicity". Doutoramento. http://hdl.handle.net/10451/28406

Lopes da Fonseca, Tomás; Villar-Pique, Anna; Outeiro, Tiago F; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "The interplay between alpha-Synuclein clearance and spreading". https://doi.org/10.3390/biom5020435

Batalha, Vania L; Ferreira, Diana G; Coelho, Joana E.; Valadas, Jorge S; Gomes, Rui; Temido-Ferreira, Mariana; Shmidt, Tatiana; et al. 2016. The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A(2A) receptor (A(2A)R), which is upregulated in the human forebrain of aged and Alzheimer's disease (AD) patients. We have previously shown that an anti-A(2A)R therapy reverts age-like memory deficits, by reestablishment of the hypothalamic-pituitary-adrenal (HPA) axis feedback and corticos. https://doi.org/10.1038/srep31493

Dias, Ana Rita Abrantes. 2016. "The role of sirtuin 2 in oligodendroglia on dopaminergic neuron differentiation and regeneration". Mestrado. http://hdl.handle.net/10316/41275

Leonor Correia Guedes; Tiago Mestre; Tiago F. Outeiro; Joaquim J. Ferreira. 2020. "Are genetic and idiopathic forms of Parkinson's disease the same disease?". Journal of Neurochemistry, 152 (5): 515-522. https://doi.org/10.1111/jnc.14902

Tiago Fleming Outeiro. 2020. "The courage to change science". EMBO reports, 21 (3). https://doi.org/10.15252/embr.202050124

Hugo Vicente Miranda; Ana Chegão; Márcia Oliveira; Bárbara Fernandes Gomes; Francisco J. Enguita; Tiago Fleming Outeiro. 2020. Hsp27 reduces glycation-induced toxicity and aggregation of a-synuclein. https://doi.org/10.1101/2020.03.03.975037

Inês Caldeira Brás; Antonio Dominguez-Meijide; Ellen Gerhardt; David Koss; Diana F. Lázaro; Patrícia I. Santos; Eftychia Vasili; Mary Xylaki; Tiago Fleming Outeiro. 2020. "Synucleinopathies: Where we are and where we need to go". Journal of Neurochemistry. https://doi.org/10.1111/jnc.14965

Antonio Dominguez-Meijide; Eftychia Vasili; Annekatrin König; Maria-Sol Cima-Omori; Andrei Leonov; Sergey Ryazanov; Markus Zweckstetter; Christian Griesinger; Tiago F. Outeiro. 2020. Effects of pharmacological modulators of a-synuclein and tau aggregation and internalization. https://doi.org/10.1101/2020.01.27.921643

Vaz, R.L.; Sousa, S.; Chapela, D.; van der Linde, H.C.; Willemsen, R.; Correia, A.D.; Outeiro, T.F.; Afonso, N.D.. 2020. "Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model". Pharmacology Biochemistry and Behavior, 189. https://doi.org/10.1016/j.pbb.2019.172828

Masaracchia, C.; König, A.; Valiente-Gabioud, A.A.; Peralta, P.; Favretto, F.; Strohäker, T.; Lázaro, D.F.; et al. 2020. "Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies". Biochimica et Biophysica Acta - Proteins and Proteomics, 1868 (1). https://doi.org/10.1016/j.bbapap.2019.140298

Lázaro, D.F.; Bellucci, A.; Brundin, P.; Outeiro, T.F.. 2020. "Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases". Frontiers in Molecular Neuroscience, 12. https://doi.org/10.3389/fnmol.2019.00312

Rita L. Vaz; Diana Chapela; Joana E. Coelho; Luísa V. Lopes; Joaquim J. Ferreira; Nuno D. Afonso; Sara Sousa; Tiago F. Outeiro. 2020. "Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia". Neuroscience, 424: 58-71. https://doi.org/10.1016/j.neuroscience.2019.08.046

Vale, N.; Alves, C.; Sharma, V.; Lázaro, D.F.; Silva, S.; Gomes, P.; Outeiro, T.F.. 2020. "A new MAP-Rasagiline conjugate reduces a-synuclein inclusion formation in a cell model". Pharmacological Reports. https://doi.org/10.1007/s43440-019-00032-x

Marion Delenclos; Jeremy D. Burgess; Agaristi Lamprokostopoulou; Tiago F. Outeiro; Kostas Vekrellis; Pamela J. McLean. 2019. "Cellular models of alpha-synuclein toxicity and aggregation". Journal of Neurochemistry. https://doi.org/10.1111/jnc.14806

Amir Tayaranian Marvian; David J. Koss; Farhang Aliakbari; Dina Morshedi; Tiago Fleming Outeiro. 2019. "In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies". Journal of Neurochemistry. https://doi.org/10.1111/jnc.14707

Nazareno González; Trinidad Arcos-López; Annekatrin König; Liliana Quintanar; Mauricio Menacho Márquez; Tiago F. Outeiro; Claudio O. Fernández. 2019. "Effects of alpha-synuclein post-translational modifications on metal binding". Journal of Neurochemistry. https://doi.org/10.1111/jnc.14721

Tiago Fleming Outeiro; Tiago A. Mestre. 2019. "Synuclein Meeting 2019: where we are and where we need to go". Journal of Neurochemistry, 150 (5): 462-466. https://doi.org/10.1111/jnc.14825

Tiago Fleming Outeiro; Kirsten Harvey; Antonio Dominguez-Meijide; Ellen Gerhardt. 2019. "LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?". Biochemical Society Transactions, 47 (3): 827-838. https://doi.org/10.1042/BST20180466

Jing Gong; Éva M. Szego; Andrei Leonov; Eva Benito; Stefan Becker; Andre Fischer; Markus Zweckstetter; Tiago Outeiro; Anja Schneider. 2019. "Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism". The Journal of Neuroscience, 2070-18. https://doi.org/10.1523/JNEUROSCI.2070-18.2019

Prasad, V.; Wasser, Y.; Hans, F.; Goswami, A.; Katona, I.; Outeiro, T.F.; Kahle, P.J.; Schulz, J.B.; Voigt, A.. 2019. "Monitoring a-synuclein multimerization in vivo". FASEB Journal, 33 (2): 2116-2131. https://doi.org/10.1096/fj.201800148RRR

Szego, É.M.; Dominguez-Meijide, A.; Gerhardt, E.; König, A.; Koss, D.J.; Li, W.; Pinho, R.; et al. 2019. "Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies". Cell Reports, 28 (1): 65-77.e6. https://doi.org/10.1016/j.celrep.2019.06.009

Rossetti, G.; Kless, A.; Lai, L.; Outeiro, T.F.; Carloni, P.. 2019. "Investigating targets for neuropharmacological intervention by molecular dynamics simulations". Biochemical Society Transactions, 47 (3): 909-918. https://doi.org/10.1042/BST20190048

Brás, I.C.; König, A.; Outeiro, T.F.. 2019. "Glycation in Huntington's disease: A possible modifier and target for intervention". Journal of Huntington's Disease, 8 (3): 245-256. https://doi.org/10.3233/JHD-190366

Paiva, I.; Carvalho, K.; Santos, P.; Cellai, L.; Pavlou, M.A.S.; Jain, G.; Gnad, T.; et al. 2019. "A<inf>2A</inf>R-induced transcriptional deregulation in astrocytes: An in vitro study". GLIA, 67 (12): 2329-2342. https://doi.org/10.1002/glia.23688

Xylaki, M.; Atzler, B.; Outeiro, T.F.. 2019. "Epigenetics of the Synapse in Neurodegeneration". Current Neurology and Neuroscience Reports, 19 (10). https://doi.org/10.1007/s11910-019-0995-y

Chiang, A.N.; Liang, M.; Dominguez-Meijide, A.; Masaracchia, C.; Goeckeler-Fried, J.L.; Mazzone, C.S.; Newhouse, D.W.; et al. 2019. "Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding". Bioorganic and Medicinal Chemistry, 27 (1): 79-91. https://doi.org/10.1016/j.bmc.2018.11.011

Ferreira, C.; Couceiro, J.; Família, C.; Jardim, C.; Antas, P.; Santos, C.N.; Outeiro, T.F.; Tenreiro, S.; Quintas, A.. 2019. "The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism". FEMS Yeast Research, 19 (5). https://doi.org/10.1093/femsyr/foz042

de Araújo Brasil, A.; de Carvalho, M.D.C.; Gerhardt, E.; Queiroz, D.D.; Pereira, M.D.; Outeiro, T.F.; Eleutherio, E.C.A.. 2019. "Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1". Proceedings of the National Academy of Sciences of the United States of America, 116 (51): 25991-26000. https://doi.org/10.1073/pnas.1902483116

Vasili, E.; Dominguez-Meijide, A.; Outeiro, T.F.. 2019. "Spreading of a-synuclein and tau: A systematic comparison of the mechanisms involved". Frontiers in Molecular Neuroscience, 12. https://doi.org/10.3389/fnmol.2019.00107

Wu, J.-Z.; Ardah, M.; Haikal, C.; Svanbergsson, A.; Diepenbroek, M.; Vaikath, N.N.; Li, W.; et al. 2019. "Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy". Translational Neurodegeneration, 8 (1). https://doi.org/10.1186/s40035-019-0159-7

Repici, M.; Hassanjani, M.; Maddison, D.C.; Garção, P.; Cimini, S.; Patel, B.; Szegö, É.M.; et al. 2019. "The Parkinson’s Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration". Molecular Neurobiology, 56 (1): 61-77. https://doi.org/10.1007/s12035-018-1084-y

Pinho, R.; Wang, B.; Becker, A.; Rothenberger, A.; Outeiro, T.F.; Herrmann-Lingen, C.; Meyer, T.. 2019. "Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study". World Journal of Biological Psychiatry, 20 (6): 496-504. https://doi.org/10.1080/15622975.2017.1417636

Carija, A.; Pinheiro, F.; Pujols, J.; Brás, I.C.; Lázaro, D.F.; Santambrogio, C.; Grandori, R.; et al. 2019. "Biasing the native a-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity". Redox Biology, 22. https://doi.org/10.1016/j.redox.2019.101135

Candelise, N.; Schmitz, M.; Llorens, F.; Villar-Piqué, A.; Cramm, M.; Thom, T.; da Silva Correia, S.M.; et al. 2019. "Seeding variability of different alpha synuclein strains in synucleinopathies". Annals of Neurology, 85 (5): 691-703. https://doi.org/10.1002/ana.25446

Sampaio-Marques, B.; Guedes, A.; Vasilevskiy, I.; Gonçalves, S.; Outeiro, T.F.; Winderickx, J.; Burhans, W.C.; Ludovico, P.. 2019. "a-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1". Aging Cell, 18 (4). https://doi.org/10.1111/acel.12922

Pinho, R.; Paiva, I.; Jercic, K.G.; Fonseca-Ornelas, L.; Gerhardt, E.; Fahlbusch, C.; Garcia-Esparcia, P.; et al. 2019. "Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein". Human Molecular Genetics, 28 (1): 31-50. https://doi.org/10.1093/hmg/ddy326

Brás, I.C.; Popova, B.; Braus, G.H.; Outeiro, T.F.. 2019. "Yeast-based screens to target alpha-synuclein toxicity". 145-156. Vol. 1948. https://doi.org/10.1007/978-1-4939-9124-2_12

Brás, I.C.; Xylaki, M.; Outeiro, T.F.. 2019. "Mechanisms of alpha-synuclein toxicity: An update and outlook". https://doi.org/10.1016/bs.pbr.2019.10.005

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Pujols, J.; Peña-Díaz, S.; Lázaro, D.F.; Peccati, F.; Pinheiro, F.; González, D.; Carija, A.; et al. 2018. "Small molecule inhibits a-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons". Proceedings of the National Academy of Sciences of the United States of America, 115 (41): 10481-10486. https://doi.org/10.1073/pnas.1804198115

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Vittori, A.; Breda, C.; Repici, M.; Orth, M.; Roos, R.A.C.; Outeiro, T.F.; Giorgini, F.; Hollox, E.J.. 2014. "Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease". Human Molecular Genetics, 23 (12): 3129-3137. https://doi.org/10.1093/hmg/ddu022

Yin, G.; Lopes da Fonseca, T.; Eisbach, S.E.; Anduaga, A.M.; Breda, C.; Orcellet, M.L.; Szego, T.M.; et al. 2014. "a-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner". Neurobiology of Disease, 70: 149-161. https://doi.org/10.1016/j.nbd.2014.06.018

Fonseca-Ornelas, L.; Eisbach, S.E.; Paulat, M.; Giller, K.; Fernández, C.O.; Outeiro, T.F.; Becker, S.; Zweckstetter, M.. 2014. "Small molecule-mediated stabilization of vesicle-associated helical a-synuclein inhibits pathogenic misfolding and aggregation". Nature communications, 5: 5857-5857. https://doi.org/10.1038/ncomms6857

Tenreiro, S.; Eckermann, K.; Outeiro, T.F.. 2014. "Protein phosphorylation in neurodegeneration: Friend or foe?". Frontiers in Molecular Neuroscience, 7 (MAY). https://doi.org/10.3389/fnmol.2014.00042

Fernandes, J.T.S.; Tenreiro, S.; Gameiro, A.; Chu, V.; Outeiro, T.F.; Conde, J.P.. 2014. "Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator". Lab on a Chip, 14 (20): 3949-3957. https://doi.org/10.1039/c4lc00756e

Miller-Fleming, L.; Antas, P.; Pais, T.F.; Smalley, J.L.; Giorgini, F.; Outeiro, T.F.. 2014. "Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase". Proceedings of the National Academy of Sciences of the United States of America, 111 (19): 7012-7017. https://doi.org/10.1073/pnas.1319221111

Shahpasandzadeh, H.; Popova, B.; Kleinknecht, A.; Fraser, P.E.; Outeiro, T.F.; Braus, G.H.. 2014. "Interplay between sumoylation and phosphorylation for protection against a-synuclein inclusions". Journal of Biological Chemistry, 289 (45): 31224-31240. https://doi.org/10.1074/jbc.M114.559237

Tenreiro, S.; Reimão-Pinto, M.M.; Antas, P.; Rino, J.; Wawrzycka, D.; Macedo, D.; Rosado-Ramos, R.; et al. 2014. "Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease". PLoS Genetics, 10 (5). https://doi.org/10.1371/journal.pgen.1004302

Lázaro, D.F.; Rodrigues, E.F.; Langohr, R.; Shahpasandzadeh, H.; Ribeiro, T.; Guerreiro, P.; Gerhardt, E.; et al. 2014. "Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation". PLoS Genetics, 10 (11). https://doi.org/10.1371/journal.pgen.1004741

Poehler, A.-M.; Xiang, W.; Spitzer, P.; May, V.E.L.; Meixner, H.; Rockenstein, E.; Chutna, O.; et al. 2014. "Autophagy modulates SNCA/a-synuclein release, thereby generating a hostile microenvironment". Autophagy, 10 (12): 2171-2192. https://doi.org/10.4161/auto.36436

Zondler, L.; Miller-Fleming, L.; Repici, M.; Gonçalves, S.; Tenreiro, S.; Rosado-Ramos, R.; Betzer, C.; et al. 2014. "DJ-1 interactions with a-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease". Cell Death and Disease, 5 (7). https://doi.org/10.1038/cddis.2014.307

Poças, G.M.; Branco-Santos, J.; Herrera, F.; Outeiro, T.F.; Domingos, P.M.. 2014. "a-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila". Human Molecular Genetics, 24 (7): 1898-1907. https://doi.org/10.1093/hmg/ddu606

Chutna, O.; Gonçalves, S.; Villar-Piqué, A.; Guerreiro, P.; Marijanovic, Z.; Mendes, T.; Ramalho, J.; et al. 2014. "The small GTPase Rab11 co-localizes with a-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity". Human molecular genetics, 23 (25): 6732-6745. https://doi.org/10.1093/hmg/ddu391

Perfeito, R.; Lázaro, D.F.; Outeiro, T.F.; Rego, A.C.. 2014. "Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells". Molecular and Cellular Neuroscience, 62: 51-59. https://doi.org/10.1016/j.mcn.2014.08.002

Vittori, A.; Orth, M.; Roos, R.A.C.; Outeiro, T.F.; Giorgini, F.; Hollox, E.J.; Bachoud-Lévi, A.-C.; et al. 2013. "ß-defensin genomic copy number does not influence the age of onset in huntington’s disease". Journal of Huntington's Disease, 2 (1): 107-124. https://doi.org/10.3233/JHD-130047

Herrera, F.; Gonçalves, S.; Branco dos Santos, J.; Fleming Outeiro, T.. 2013. "Studying the Molecular Determinants of Protein Oligomerization in Neurodegenerative Disorders by Bimolecular Fluorescence Complementation". 133-145. https://doi.org/10.1016/B978-0-12-394431-3.00012-2

Gonçalves, S.; Miranda, H.V.; Outeiro, T.F.. 2012. "Novel Molecular Therapeutics in Parkinson's Disease". 245-265. https://doi.org/10.1002/9781119967309.ch11

Outeiro, T.F.; Lopes, L.V.. 2011. "Synaptic dysfunction in Parkinson's disease: From protein misfolding to functional alterations". 257-267. https://doi.org/10.1007/978-1-4419-7061-9-13

Marques, S.C.F.; Pereira, C.M.F.; Outeiro, T.F.. 2011. "Epigenetics and neurodegeneration: A connection overlooked". 241-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895241928&partnerID=MN8TOARS

Miller-Fleming, L.; Giorgini, F.; Outeiro, T.F.. 2008. "Erratum: Yeast as a model for studying human neurodegenerative disorders (Biotechnology Journal (2008) vol. 3 (325-338))". Biotechnology Journal, 3 (3): 421-421. https://doi.org/10.1002/biot.421

Outeiro, T.F.; McLean, P.J.; Hyman, B.T.. 2007. "Protein aggregation disorders". 111-123. https://doi.org/10.1016/B978-012088592-3/50012-8

Da Cruz E Silva, E.F.; Outeiro, T.F.; Da Cruz E Silva, O.A.B.. 2004. "Symposium on novel therapeutic opportunities for neurodegenerative disease". Journal of Molecular Neuroscience, 23 (1-2): 1-2. https://doi.org/10.1385/JMN:23:1-2:001

MI Oliveira da Silva; M Santejo; IW Babcock; A Magalhães; LS Minamide; E Castillo; E Gerhardt; et al. 2021. Cofilin pathology is a new player on a-synuclein-induced spine impairment in models of hippocampal synucleinopathy. https://doi.org/10.1101/2021.02.02.425931

David J. Koss; Odeta Bondarevaite; Sara Adams; Marta Leite; Flaviano Giorgini; Johannes Attems; Tiago F. Outeiro. 2021. "RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aß plaques and Lewy bodies". Brain Pathology. https://doi.org/10.1111/bpa.12890

Tiago Fleming Outeiro. 2021. "Alpha-Synuclein Antibody Characterization: Why Semantics Matters". Molecular Neurobiology. https://doi.org/10.1007/s12035-020-02269-7

Patrícia I. Santos; Tiago F. Outeiro. 2020. "Protein trapping leads to altered synaptic proteostasis in synucleinopathies". The FEBS Journal. https://doi.org/10.1111/febs.15364

Panagiota S. Filippou; Tiago F. Outeiro. 2020. "Cancer and Parkinson's Disease: Common Targets, Emerging Hopes". Movement Disorders. https://doi.org/10.1002/mds.28425

Tiago Fleming Outeiro. 2020. "Alpha-synuclein oligomerization and aggregation: a model will always be a model". Journal of Neurochemistry. https://doi.org/10.1111/jnc.15264

Tiago F. Outeiro; Peter Heutink; Erwan Bezard; Angela M. Cenci. 2020. "From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease". Movement Disorders. https://doi.org/10.1002/mds.28387

Antonio Dominguez-Meijide; Eftychia Vasili; Tiago Fleming Outeiro. 2020. "Pharmacological Modulators of Tau Aggregation and Spreading". Brain Sciences. https://doi.org/10.3390/brainsci10110858

Tiago F. Outeiro; Anita Krisko. 2020. "Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases". Movement Disorders. https://doi.org/10.1002/mds.28178

Alice Lippi; Renato Domingues; Cristian Setz; Tiago F. Outeiro; Anita Krisko. 2020. "SARS-CoV -2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders. https://doi.org/10.1002/mds.28084

Ferreira, Mariana Temido Mendes. 2018. "The role of A2A receptors in cognitive decline : decoding the molecular shift towards neurodegeneration". Doutoramento. http://hdl.handle.net/10451/37953

Vaz, Rita Leitão Landeiro, 1988-. 2018. "Screening and validation of molecules with therapeutic properties in in vivo models of parkinson’s disease". Doutoramento. http://hdl.handle.net/10451/37407

Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. 2017. "Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies". https://doi.org/10.1093/brain/awx056

Macedo, Diana; Jardim, Carolina; Figueira, Inês; Almeida, A. Filipa; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; et al. 2018. "(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis". https://doi.org/10.1038/s41598-018-25118-z

Sampaio-Marques, Belém; Guedes, Ana; Vasilevskiy, Igor; Gonçalves, Susana; Outeiro, Tiago F.; Winderickx, Joris; Burhans, William C.; Ludovico, Paula. 2019. "a-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1". https://doi.org/10.1111/acel.12922

Belo, Rita F.; Martins, Margarida L.F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, Vera; et al. 2020. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid ß Peptide-Induced Alzheimer’s Disease Pathophysiology". https://doi.org/10.3389/fphar.2020.00985

Guedes, Leonor Correia; Reimão, Sofia; Paulino, Patrícia; Nunes, Rita G.; Bouça-Machado, Raquel; Abreu, Daisy; Gonçalves, Nilza; et al. 2017. "Neuromelanin magnetic resonance imaging of the Substantia Nigra in LRRK2-related Parkinson’s Disease". https://doi.org/10.1002/mds.27083

Dionísio, Pedro A.. 2020. "Tuning cell death and inflammation in parkinson's disease". Doutoramento. http://hdl.handle.net/10451/42843

Menezes, Regina; Foito, Alexandre; Jardim, Carolina; Costa, Inês; Garcia, Gonçalo; Rosado-Ramos, Rita; Freitag, Sabine; et al. 2020. "Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases". https://doi.org/10.3390/antiox9090789

Vaz, Rita L.; Outeiro, Tiago F.; Ferreira, Joaquim J.. "Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders". https://doi.org/10.3389/fneur.2018.00347

Vicente Miranda, Hugo; Szego, Éva M.; Oliveira, Luís M.A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. 2017. "Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies". https://doi.org/10.1093/brain/awx056

Gonçalves, Susana Alexandra de Barros, 1983-. 2017. "Unraveling the molecular mechanisms underlying alpha-synuclein oligomerization and cytotoxicity". Doutoramento. http://hdl.handle.net/10451/28406

Marques, Maria Belém Sousa Sampaio; Guedes, Ana; Vasilevskiy, Igor; Gonçalves, Susana; Outeiro, Tiago F.; Winderickx, Joris; Burhans, William C.; Ludovico, Paula. 2019. "a-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1". https://doi.org/10.1111/acel.12922

Branco-Santos, J. 2018. "The role of post-translational modifications on the oligomerization, aggregation and toxicity of mutant huntingtin". Doutoramento. http://hdl.handle.net/10451/38930

Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. 2018. "Guidelines and recommendations on yeast cell death nomenclature". https://doi.org/10.15698/mic2018.01.607

Barcelos, Tiago Soares; Carvalho, Marina de Macedo; Outeiro, Gabriel Moraes de; Mota, Loyslene de Freitas. 2019. "Interdisciplinary analysis of the mineral question and its reject barrings". http://www.periodicos.unc.br/index.php/drd/article/view/2091

Miranda, Hugo Vicente; Cássio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos António; Chegão, Ana; Miranda, Elisa; Soares, Tiago; et al. 2017. "Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease". https://doi.org/10.1038/s41598-017-14175-5

de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. 2017. "The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". https://doi.org/10.1371/journal.pbio.2000374

Tiago Fleming Outeiro. 2021. "Emerging concepts in synucleinopathies". Acta Neuropathologica. https://doi.org/10.1007/s00401-021-02290-7

Inês C. Brás; Tiago F. Outeiro. 2021. "Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies". Cells, 10 (2): 375-375. https://doi.org/10.3390/cells10020375

Tiago F. Outeiro; Anita Krisko. 2021. "Reply to: “Parkinson's Disease and COVID-19: Do We Need to Be More Patient?”". Movement Disorders. https://doi.org/10.1002/mds.28482

Eftychia Vasili; Antonio Dominguez-Meijide; Manuel Flores-León; Mohammed Al-Azzani; Angeliki Kanellidi; Ronald Melki; Leonidas Stefanis; Tiago Fleming Outeiro. 2021. Alpha-synuclein levels modulate seeding and aggregation in cultured cells. https://doi.org/10.21203/rs.3.rs-666210/v1

Inês Caldeira Brás; Mohammad Hossein Khani; Dietmar Riedel; Iwan Parfentev; Ellen Gerhardt; Christoph van Riesen; Henning Urlaub; Tim Gollisch; Tiago Fleming Outeiro. 2021. Ectosomes and exosomes are distinct proteomic entities that modulate spontaneous activity in neuronal cells. https://doi.org/10.1101/2021.06.24.449731

Rita Rosado-Ramos; Joana Godinho-Pereira; Daniela Marques; Inês Figueira; Tiago Fleming Outeiro; Regina Menezes; Cláudia Nunes dos Santos. 2021. "Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation". Molecules. https://doi.org/10.3390/molecules26113353

Koss, David J.; Bondarevaite, Odeta; Adams, Sara; Leite, Marta; Giorgini, Flaviano; Attems, Johannes; Outeiro, Tiago F.. 2021. "RAB39B is redistributed in dementia with Lewy bodies and is sequestered within a beta plaques and Lewy bodies". Brain Pathology. https://doi.org/10.1111/BPA.12890

Vaz, Rita L.; Chapela, Diana; Coelho, Joana E.; Lopes, Luisa, V; Ferreira, Joaquim J.; Afonso, Nuno D.; Sousa, Sara; Outeiro, Tiago F.. 2020. "Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia". Neuroscience. https://doi.org/10.1016/J.NEUROSCIENCE.2019.08.046

Guedes, Leonor Correia; Mestre, Tiago; Outeiro, Tiago F.; Ferreira, Joaquim J.. 2020. "Are genetic and idiopathic forms of Parkinson's disease the same disease?". Journal of Neurochemistry. https://doi.org/10.1111/JNC.14902

Vaz, Rita L.; Sousa, Sara; Chapela, Diana; van der Linde, Hernia C.; Willemsen, Rob; Correia, Ana D.; Outeiro, Tiago F.; Afonso, Nuno D.. 2020. "Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model". Pharmacology, Biochemistry and Behavior. https://doi.org/10.1016/J.PBB.2019.172828

Lazaro, Diana F.; Bellucci, Arianna; Brundin, Patrik; Outeiro, Tiago F.. 2020. "Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases". Frontiers in Molecular Neuroscience. https://doi.org/10.3389/FNMOL.2019.00312

Masaracchia, Caterina; Koenig, Annekatrin; Valiente-Gabioud, Ariel A.; Peralta, Pablo; Favretto, Filippo; Strohaeker, Timo; Lazaro, Diana F.; et al. 2020. "Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. https://doi.org/10.1016/J.BBAPAP.2019.140298

Malik, Nauman; Miah, Mohi; McAleese, Kirsty; Outeiro, Tiago; Thomas, Alan; Koss, David J.. 2020. "Contribution of amyloid and tau white matter pathology to the spatial spread of Alzheimer's disease pathology". Neuropathology and Applied Neurobiology. https://publons.com/publon/36281129/

Placido, E.; Koss, D. J.; Brocardo, P. S.; Outeiro, T. F.. 2020. "Cell proliferation and differentiation in Parkinson's disease". Neuropathology and Applied Neurobiology. https://publons.com/publon/36281130/

Bras, Ines Caldeira; Dominguez-Meijide, Antonio; Gerhardt, Ellen; Koss, David; Lazaro, Diana F.; Santos, Patricia, I; Vasili, Eftychia; Xylaki, Mary; Outeiro, Tiago Fleming. 2020. "Synucleinopathies: Where we are and where we need to go". Journal of Neurochemistry. https://doi.org/10.1111/JNC.14965

Outeiro, Tiago Fleming. 2020. "The courage to change science". EMBO Reports. https://doi.org/10.15252/EMBR.202050124

Lazaro, Diana F.; Outeiro, Tiago F.. 2020. "The Interplay Between Proteostasis Systems and Parkinson's Disease". Advances in Experimental Medicine and Biology. https://doi.org/10.1007/978-3-030-38266-7_9

Outeiro, Tiago. 2020. "Effects of pharmacological modulators of alpha-synuclein and tau aggregation and internalization". Scientific Reports. https://doi.org/10.1038/S41598-020-69744-Y

Torres, C. Alejandra Morato; Wassouf, Zinah; Zafar, Faria; Sastre, Danuta; Outeiro, Tiago Fleming; Schule, Birgitt. 2020. "The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders". International Journal of Molecular Sciences. https://doi.org/10.3390/IJMS21165724

Outeiro, Tiago. 2020. "Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases". Movement Disorders. https://doi.org/10.1002/mds.28178

Domingues, Renato; Lippi, Alice; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. 2020. "SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime". Aging. https://doi.org/10.18632/AGING.103989

Temido-Ferreira, Mariana; Ferreira, Diana G.; Batalha, Vsnia L.; Marques-Morgado, Ines; Coelho, Joana E.; Pereira, Pedro; Gomes, Rui; et al. 2020. "Age-related shift in LTD is dependent on neuronal adenosine A(2A)receptors interplay with mGluR5 and NMDA receptors". Molecular Psychiatry. https://doi.org/10.1038/S41380-018-0110-9

Belo, Rita F.; Martins, Margarida L. F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, Joao; Neves, Vera; et al. 2020. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid beta Peptide-Induced Alzheimer's Disease Pathophysiology". Frontiers in Pharmacology. https://doi.org/10.3389/FPHAR.2020.00985

Vale, Nuno; Alves, Claudia; Sharma, Vaishali; Lazaro, Diana F.; Silva, Sara; Gomes, Paula; Outeiro, Tiago Fleming. 2020. "A new MAP-Rasagiline conjugate reduces alpha-synuclein inclusion formation in a cell model". Pharmacological Reports. https://doi.org/10.1007/S43440-019-00032-X

Miranda, Hugo Vicente; Chegao, Ana; Oliveira, Marcia S.; Gomes, Barbara Fernandes; Enguita, Francisco J.; Outeiro, Tiago Fleming. 2020. "Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein". The FASEB Journal. https://doi.org/10.1096/FJ.201902936R

Koss, D. J.; Erskine, D.; Attems, J.; Outeiro, T.. 2020. "Resolving the issue of nuclear localisation of alpha-synuclein in Lewy body diseases". Neuropathology and Applied Neurobiology. https://publons.com/publon/36281127/

Koss, D. J.; Bondarevaite, O.; Adams, S.; Leite, M.; Attems, J.; Giorgini, F.; Outeiro, T.. 2020. "Determination of the pathological involvement of the vesicular trafficking protein RAB39B in idiopathic variants of neurodegenerative disease". Neuropathology and Applied Neurobiology. https://publons.com/publon/36281128/

Lippi, Alice; Domingues, Renato; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. 2020. "SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders. https://doi.org/10.1002/MDS.2808410.1002/MDS.28084

Santos, Patricia, I; Outeiro, Tiago F.. 2020. "Protein trapping leads to altered synaptic proteostasis in synucleinopathies". The FEBS Journal. https://doi.org/10.1111/FEBS.15364

Francelle, Laetitia; Outeiro, Tiago F.; Rappold, Gudrun A.. 2020. "Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity". Scientific Reports. https://doi.org/10.1038/S41598-020-62678-5

Outeiro, Tiago F.; Heutink, Peter; Bezard, Erwan; Cenci, Angela M.. 2020. "From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease". Movement Disorders. https://doi.org/10.1002/MDS.28387

Hentrich, Thomas; Wassouf, Zinah; Ehrhardt, Christine; Haas, Eva; Mills, James D.; Aronica, Eleonora; Outeiro, Tiago Fleming; et al. 2020. "Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson's disease patients". Aging. https://doi.org/10.18632/AGING.103935

Menezes, Regina; Foito, Alexandre; Jardim, Carolina; Costa, Ines; Garcia, Goncalo; Rosado-Ramos, Rita; Freitag, Sabine; et al. 2020. "Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases". Antioxidants. https://doi.org/10.3390/ANTIOX9090789

Filippou, PanagiotaS.; Outeiro, Tiago F.. 2020. "Cancer and Parkinson's Disease: Common Targets, Emerging Hopes". Movement Disorders. https://doi.org/10.1002/MDS.28425

Cukierman, Daphne S.; Lazaro, Diana F.; Sacco, Pamela; Ferreira, Patricia R.; Diniz, Renata; Fernandez, Claudio O.; Outeiro, Tiago F.; Rey, Nicolas A.. 2020. "X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(I)/copper(II)-alpha-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy". Dalton Transactions. https://doi.org/10.1039/D0DT01138J

Dominguez-Meijide, Antonio; Vasili, Eftychia; Outeiro, Tiago Fleming. 2020. "Pharmacological Modulators of Tau Aggregation and Spreading". Brain Sciences. https://doi.org/10.3390/BRAINSCI10110858

Brown, Peter; Tan, Aik-Choon; El-Esawi, Mohamed A.; Liehr, Thomas; Blanck, Oliver; Gladue, Douglas P.; Almeida, Gabriel M. F.; et al. 2019. "Large expert-curated database for benchmarking document similarity detection in biomedical literature search". Database. https://doi.org/10.1093/DATABASE/BAZ085

Outeiro, Tiago Fleming; Mestre, Tiago A.. 2019. "Synuclein Meeting 2019: where we are and where we need to go". Journal of Neurochemistry. https://doi.org/10.1111/JNC.14825

Xylaki, Mary; Atzler, Benedict; Outeiro, Tiago Fleming. 2019. "Epigenetics of the Synapse in Neurodegeneration". Current Neurology and Neuroscience Reports. https://doi.org/10.1007/S11910-019-0995-Y

Delenclos, Marion; Burgess, Jeremy D.; Lamprokostopoulou, Agaristi; Outeiro, Tiago F.; Vekrellis, Kostas; McLean, Pamela J.. 2019. "Cellular models of alpha-synuclein toxicity and aggregation". Journal of Neurochemistry. https://doi.org/10.1111/JNC.14806

Brasil, Aline de Araujo; Castela de Carvalho, Mariana Dias; Gerhardt, Ellen; Queiroz, Daniela Dias; Pereira, Marcos Dias; Outeiro, Tiago Fleming; Araujo Eleutherio, Elis Cristina. 2019. "Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.1902483116

Gonzalez, Nazareno; Arcos-Lopez, Trinidad; Koenig, Annekatrin; Quintanar, Liliana; Menacho Marquez, Mauricio; Outeiro, Tiago F.; Fernandez, Claudio O.. 2019. "Effects of alpha-synuclein post-translational modifications on metal binding". Journal of Neurochemistry. https://doi.org/10.1111/JNC.14721

Paiva, Isabel; Carvalho, Kevin; Santos, Patricia; Cellai, Lucrezia; Pavlou, Maria Angeliki S.; Jain, Gaurav; Gnad, Thorsten; et al. 2019. "A(2A)R-induced transcriptional deregulation in astrocytes: An in vitro study". Glia. https://doi.org/10.1002/GLIA.23688

Ferreira, Carla; Couceiro, Joana; Familia, Carlos; Jardim, Carolina; Antas, Pedro; Santos, Claudia N.; Outeiro, Tiago F.; Tenreiro, Sandra; Quintas, Alexandre. 2019. "The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism". FEMS Yeast Research. https://doi.org/10.1093/FEMSYR/FOZ042

Sampaio-Marques, Belem; Guedes, Ana; Vasilevskiy, Igor; Goncalves, Susana; Outeiro, Tiago F.; Winderickx, Joris; Burhans, William C.; Ludovico, Paula. 2019. "alpha-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1". Aging Cell. https://doi.org/10.1111/ACEL.12922

Marvian, Amir Tayaranian; Koss, David J.; Aliakbaris, Farhang; Morshedi, Dina; Outeiro, Tiago Fleming. 2019. "In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies". Journal of Neurochemistry. https://doi.org/10.1111/JNC.14707

Wu, Jia-Zhen; Ardah, Mustafa; Haikal, Caroline; Svanbergsson, Alexander; Diepenbroek, Meike; Vaikath, Nishant N.; Li, Wen; et al. 2019. "Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy". Translational Neurodegeneration. https://doi.org/10.1186/S40035-019-0159-7

Vasili, Eftychia; Dominguez-Meijide, Antonio; Outeiro, Tiago Fleming. 2019. "Spreading of alpha-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved". Frontiers in Molecular Neuroscience. https://doi.org/10.3389/FNMOL.2019.00107

Candelise, Niccolo; Schmitz, Matthias; Llorens, Franc; Villar-Pique, Anna; Cramm, Maria; Thom, Tobias; Correia, Susana Margarida da Silva; et al. 2019. "Seeding variability of different alpha synuclein strains in synucleinopathies". Annals of Neurology. https://doi.org/10.1002/ANA.25446

Szego, Eva M.; Dominguez-Meijide, Antonio; Gerhardt, Ellen; Koenig, Annekatrin; Koss, David J.; Li, Wen; Pinho, Raquel; et al. 2019. "Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies". Cell Reports. https://doi.org/10.1016/J.CELREP.2019.06.009

Chiang, Annette N.; Liang, Mary; Dominguez-Meijide, Antonio; Masaracchia, Caterina; Goeckeler-Fried, Jennifer L.; Mazzone, Carly S.; Newhouse, David W.; et al. 2019. "Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding". Bioorganic & Medicinal Chemistry. https://doi.org/10.1016/J.BMC.2018.11.011

Repici, Mariaelena; Hassanjani, Mahdieh; Maddison, Daniel C.; Garcao, Pedro; Cimini, Sara; Patel, Bhavini; Szegoe, Eva M.; et al. 2019. "The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration". Molecular Neurobiology. https://doi.org/10.1007/S12035-018-1084-Y

Pinho, Raquel; Paiva, Isabel; Jercic, Kristina Gotovac; Fonseca-Ornelas, Luis; Gerhardt, Ellen; Fahlbusch, Christiane; Garcia-Esparcia, Paula; et al. 2019. "Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDY326

Carija, Anita; Pinheiro, Francisca; Pujols, Jordi; Bras, Ines C.; Lazaro, Diana Fernandes; Santambrogio, Carlo; Grandori, Rita; et al. 2019. "Biasing the native alpha-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity". Redox Biology. https://doi.org/10.1016/J.REDOX.2019.101135

Outeiro, Tiago Fleming; Koss, David J.; Erskine, Daniel; Walker, Lauren; Kurzawa-Akanbi, Marzena; Burn, David; Donaghy, Paul; et al. 2019. "Dementia with Lewy bodies: an update and outlook". Molecular Neurodegeneration. https://doi.org/10.1186/S13024-019-0306-8

Prasad, Vibha; Wasser, Yasmine; Hans, Friederike; Goswami, Anand; Katona, Istvan; Outeiro, Tiago F.; Kahle, Philipp J.; Schulz, Joerg B.; Voigt, Aaron. 2019. "Monitoring -synuclein multimerization in vivo". The FASEB Journal. https://doi.org/10.1096/FJ.201800148RRR

Biosa, Alice; Outeiro, Tiago F.; Bubacco, Luigi; Bisaglia, Marco. 2018. "Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View". Molecular Neurobiology. https://doi.org/10.1007/S12035-018-1025-9

Richter, Katharina N.; Revelo, Natalia H.; Seitz, Katharina J.; Helm, Martin S.; Sarkar, Deblina; Saleeb, Rebecca S.; D'Este, Elisa; et al. 2018. "Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy". The EMBO Journal. https://doi.org/10.15252/EMBJ.201695709

Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andres; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. 2018. "Guidelines and recommendations on yeast cell death nomenclature". Microbial Cell. https://doi.org/10.15698/MIC2018.01.607

Brasil, Aline A.; Magalhes, Rayne S. S.; De Carvalho, Mariana D. C.; Paiva, Isabel; Gerhardt, Ellen; Pereira, Marcos D.; Outeiro, Tiago F.; Eleutherio, Elis C. A.. 2018. "Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models". Molecular Neurobiology. https://doi.org/10.1007/S12035-017-0755-4

Masaracchia, Caterina; Hnida, Marilena; Gerhardt, Ellen; da Fonseca, Tomas Lopes; Villar-Pique, Anna; Branco, Tiago; Stahlberg, Markus A.; et al. 2018. "Membrane binding, internalization, and sorting of alpha-synuclein in the cell". Acta Neuropathologica Communications. https://doi.org/10.1186/S40478-018-0578-1

Vaz, Rita L.; Outeiro, Tiago F.; Ferreira, Joaquim J.. 2018. "Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review". Frontiers in Neurology. https://doi.org/10.3389/FNEUR.2018.00347

Bras, Ines Caldeira; Lopes, Luisa V.; Outeiro, Tiago Fleming. 2018. "Sensing alpha-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration". Movement Disorders. https://doi.org/10.1002/MDS.27478

Szego, Eva M.; Outeiro, Tiago F.; Kazantsev, Aleksey G.. 2018. "SIRTUINS IN BRAIN AND NEURODEGENERATIVE DISEASE". Introductory Review on Sirtuins in Biology, Aging, and Disease. https://doi.org/10.1016/B978-0-12-813499-3.00013-7

Magalhaes, Rayne S. S.; Popova, Blagovesta; Braus, Gerhard H.; Outeiro, Tiago F.; Eleutherio, Elis C. A.. 2018. "The trehalose protective mechanism during thermal stress in Saccharomyces cerevisiae: the roles of Ath1 and Agt1". FEMS Yeast Research. https://doi.org/10.1093/FEMSYR/FOY066

Oliveira da Silva, M. I.; Outeiro, T. F.; Bamburg, J. R.; Liz, M. A.. 2018. "Alpha-Synuclein induces cofilin pathology: implications on the molecular basis of Parkinson's disease". Molecular Biology of the Cell. https://publons.com/publon/33900397/

Gustafsson, Gabriel; Loov, Camilla; Persson, Emma; Lazaro, Diana F.; Takeda, Shuko; Bergstrom, Joakim; Erlandsson, Anna; et al. 2018. "Secretion and Uptake of -Synuclein Via Extracellular Vesicles in Cultured Cells". Cellular and Molecular Neurobiology. https://doi.org/10.1007/S10571-018-0622-5

Bras, Ines Caldeira; Tenreiro, Sandra; Silva, Andreia M.; Outeiro, Tiago F.. 2018. "Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast". FEMS Yeast Research. https://doi.org/10.1093/FEMSYR/FOY108

Pujols, Jordi; Pena-Diaz, Samuel; Lazaro, Diana F.; Peccati, Francesca; Pinheiro, Francisca; Gonzalez, Danilo; Carija, Anita; et al. 2018. "Small molecule inhibits alpha-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.1804198115

Macedo, Diana; Jardim, Carolina; Figueira, Ines; Filipa Almeida, A.; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; et al. 2018. "(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis". Scientific Reports. https://doi.org/10.1038/S41598-018-25118-Z

Pardo, Joaquin; Abba, Martin C.; Lacunza, Ezequiel; Ogundele, Olalekan M.; Paiva, Isabel; Morel, Gustavo R.; Outeiro, Tiago F.; Goya, Rodolfo G.. 2018. "IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function". The Journals of Gerontology: Series A Biological Sciences and Medical Sciences. https://doi.org/10.1093/GERONA/GLX125

Outeiro, Tiago. 2018. "Binding Modes of Phthalocyanines to Amyloid ß Peptide and Their Effects on Amyloid Fibril Formation". Biophysical Journal. https://doi.org/10.1016/J.BPJ.2018.01.003

Isabel Paiva; Gaurav Jain; Diana F. Lázaro; Kristina Gotovac Jercic; Thomas Hentrich; Cemil Kerimoglu; Raquel Pinho; et al. 2018. "Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function". Neurobiology of Disease. https://doi.org/10.1016/J.NBD.2018.08.001

Tiago Outeiro. 2018. "SIRT2 in age-related neurodegenerative disorders". Aging. https://doi.org/10.18632/AGING.101397

Outeiro, Tiago. 2018. "Tau protein in normal and pathological brain". European Journal of Neurology. https://publons.com/publon/16533521/

Lissek, Thomas; Adams, Michelle; Adelman, John; Ahissar, Ehud; Akaaboune, Mohammed; Akil, Huda; a'Absi, Mustafa; et al. 2017. "Building Bridges through Science". Neuron. https://doi.org/10.1016/J.NEURON.2017.09.028

Menges, Stefanie; Minakaki, Georgia; Schaefer, Patrick M.; Meixner, Holger; Prots, Iryna; Schloetzer-Schrehardt, Ursula; Friedland, Kristina; et al. 2017. "Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress". Scientific Reports. https://doi.org/10.1038/SREP42942

Ferreira, Diana G.; Batalha, Vania L.; Vicente Miranda, Hugo; Coelho, Joana E.; Gomes, Rui; Goncalves, Francisco Q.; Real, Joana I.; et al. 2017. "Adenosine A(2A) Receptors Modulate alpha-Synuclein Aggregation and Toxicity". Cerebral Cortex. https://doi.org/10.1093/CERCOR/BHV268

Ferreira, Diana G.; Temido-Ferreira, Mariana; Miranda, Hugo Vicente; Batalha, Vania L.; Coelho, Joana E.; Szego, Eva M.; Marques-Morgado, Ines; et al. 2017. "alpha-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B". Nature Neuroscience. https://doi.org/10.1038/NN.4648

Guedes, Leonor Correia; Reimao, Sofia; Paulino, Patricia; Nunes, Rita G.; Bouca-Machado, Raquel; Abreu, Daisy; Goncalves, Nilza; et al. 2017. "Neuromelanin Magnetic Resonance Imaging of the Substantia Nigra in LRRK2-Related Parkinson's Disease". Movement Disorders. https://doi.org/10.1002/MDS.27083

Vicente Miranda, Hugo; Szego, Eva M.; Oliveira, Luis M. A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. 2017. "Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies". Brain. https://doi.org/10.1093/BRAIN/AWX056

Guerreiro, Patricia S.; Coelho, Joana E.; Sousa-Lima, Ines; Macedo, Paula; Lopes, Luisa V.; Outeiro, Tiago F.; Pais, Teresa F.. 2017. "Mutant A53T alpha-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways". NeuroMolecular Medicine. https://doi.org/10.1007/S12017-016-8435-5

Paiva, Isabel; Pinho, Raquel; Pavlou, Maria Angeliki; Hennion, Magali; Wales, Pauline; Schuetz, Anna-Lena; Rajput, Ashish; et al. 2017. "Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDX114

Lemos, Vera; de Oliveira, Rita M.; Naia, Luana; Szego, Eva; Ramos, Elisabete; Pinho, Sonia; Magro, Fernando; et al. 2017. "The NAD(+)-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDX298

Cukierman, Daphne Schneider; Pinheiro, Ana Beatriz; Castineiras-Filho, Sergio L. P.; da Silva, Anastacia Sa P.; Miotto, Marco C.; De Falco, Anna; Ribeiro, Thales de P.; et al. 2017. "A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies". Journal of Inorganic Biochemistry. https://doi.org/10.1016/J.JINORGBIO.2017.02.020

Outeiro, Tiago. 2017. "Disease-modification in Translational Models of Parkinson's disease by the Rho Kinase Inhibitor Fasudil". Movement Disorders. https://publons.com/publon/9713493/

Vicente Miranda, Hugo; Cassio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos Antonio; Chegao, Ana; Miranda, Elisa; Soares, Tiago; et al. 2017. "Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease". Scientific Reports. https://doi.org/10.1038/S41598-017-14175-5

Guedes, Leonor Correia; Chan, Robin Barry; Gomes, Marcos Antonio; Conceicao, Vasco A.; Machado, Raquel Bouca; Soares, Tiago; Xu, Yimeng; et al. 2017. "Serum lipid alterations in GBA-associated Parkinson's disease". Parkinsonism and Related Disorders. https://doi.org/10.1016/J.PARKRELDIS.2017.08.026

Morais, Goreti Ribeiro; Palma, Elisa; Marques, Fernanda; Gano, Lurdes; Oliveira, Maria Cristina; Abrunhosa, Antero; Vicente Miranda, Hugo; et al. 2017. "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents". Journal of Heterocyclic Chemistry. https://doi.org/10.1002/JHET.2575

Pinho, Raquel; Guedes, Leonor C.; Soreq, Lilach; Lobo, Patricia P.; Mestre, Tiago; Coelho, Miguel; Rosa, Mario M.; et al. 2017. "Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles (vol 11, e157852, 2016)". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0190552

de Oliveira, Rita Machado; Miranda, Hugo Vicente; Francelle, Laetitia; Pinho, Raquel; Szego, Eva M.; Martinho, Renato; Munari, Francesca; et al. 2017. "The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease (vol 15, e2000374, 2017)". PLoS Biology. https://doi.org/10.1371/JOURNAL.PBIO.1002601

Branco-Santos, Joana; Herrera, Federico; Pocas, Goncalo M.; Pires-Afonso, Yolanda; Giorgini, Flaviano; Domingos, Pedro M.; Outeiro, Tiago F.. 2017. "Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDX260

Oliveira da Silva, M. I.; Outeiro, T. F.; Bamburg, J. R.; Liz, M. A.. 2017. "Cofilin-actin rods as mediators of alpha-synuclein-induced synaptic dysfunction in Parkinson's disease". Molecular Biology of the Cell. https://publons.com/publon/16533540/

Bozek, Tomislav; Blazekovic, Antonela; Perkovic, Matea Nikolac; Jercic, Kristina Gotovac; Sustar, Aleksandra; Smircic-Duvnjak, Lea; Outeiro, Tiago F.; Pivac, Nela; Borovecki, Fran. 2017. "The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus". Diabetology & Metabolic Syndrome. https://doi.org/10.1186/S13098-017-0295-0

Macedo, Diana; Bertolin, Telma Elita; Oro, Tatiana; Hartmann Backes, Luana Tais; Bras, Ines Caldeira; Santos, Claudia Nunes; Tenreiro, Sandra; Outeiro, Tiago Fleming. 2017. "Phycocyanin protects against Alpha-Synuclein toxicity in yeast". Journal of Functional Foods. https://doi.org/10.1016/J.JFF.2017.09.044

Guedes, L. Correia; Reimao, S.; Paulino, P.; Nunes, R.; Bouca, R.; Abreu, D.; Goncalves, N.; et al. 2017. "Neuromelanin Magnetic Resonance Imaging of the Substatia Nigra in LRRK2-related Parkinson's disease". Movement Disorders. https://publons.com/publon/9713494/

Outeiro, Tiago. 2017. "Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats". Hippocampus. https://doi.org/10.1002/HIPO.22703

Outeiro, Tiago. 2017. "Contribution of Neuroepigenetics to Huntington’s Disease". Frontiers in Human Neuroscience. https://doi.org/10.3389/FNHUM.2017.00017

Gustafsson, Gabriel; Eriksson, Fredrik; Moller, Christer; da Fonseca, Tomas Lopes; Outeiro, Tiago F.; Lannfelt, Lars; Bergstrom, Joakim; Ingelsson, Martin. 2017. "Cellular Uptake of alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of alpha-Synuclein and Mediated via Fc gamma Receptors". Cellular and Molecular Neurobiology. https://doi.org/10.1007/S10571-016-0352-5

Outeiro, Tiago. 2017. "Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3ß/ß-catenin pathway". Neurobiology of Aging. https://doi.org/10.1016/J.NEUROBIOLAGING.2017.04.001

Outeiro, Tiago. 2017. "Motor and Nonmotor clinical phenotype in LRRK2 Parkinson's disease patients: A Case-control study". Movement Disorders. https://publons.com/publon/9713495/

Outeiro, Tiago. 2017. "Yeast models of Parkinson’s disease-associated molecular pathologies". Current Opinion in Genetics & Development. https://doi.org/10.1016/J.GDE.2017.01.013

Outeiro, Tiago. 2017. "The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". PLoS Biology. https://doi.org/10.1371/JOURNAL.PBIO.2000374

Moreira, Sara; Fonseca, Ines; Nunes, Maria Joao; Rosa, Alexandra; Lemos, Luisa; Rodrigues, Elsa; Carvalho, Andreia Neves; et al. 2017. "Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease". Experimental Neurology. https://doi.org/10.1016/J.EXPNEUROL.2017.05.009

Outeiro, Tiago. 2017. "Editorial: Molecular Chaperones and Neurodegeneration". Frontiers in Neuroscience. https://doi.org/10.3389/FNINS.2017.00565

Outeiro, Tiago. 2017. "Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain". Ageing Research Reviews. https://doi.org/10.1016/J.ARR.2017.09.002

Outeiro, Tiago. 2017. "The yin and yang of alpha-synuclein-associated epigenetics in Parkinson's disease". Brain. https://doi.org/10.1093/BRAIN/AWW227

Outeiro, Tiago. 2017. "Treatment with diphenyl–pyrazole compound anle138b/c reveals that a-synuclein protects melanoma cells from autophagic cell death". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.1700200114

Outeiro, Tiago. 2017. "Tau deletion promotes brain insulin resistance". Journal of Experimental Medicine. https://doi.org/10.1084/JEM.20161731

Pavlou MAS; Outeiro TF. 2017. "Epigenetics in Parkinson's Disease". Fortschritte der Neurologie Psychiatrie. https://doi.org/10.1055/S-0042-104501

Outeiro, Tiago. 2017. "Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease". Experimental Neurology. https://doi.org/10.1016/J.EXPNEUROL.2017.05.007

Pinho, Raquel; Guedes, Leonor C.; Soreq, Lilach; Lobo, Patricia P.; Mestre, Tiago; Coelho, Miguel; Rosa, Mario M.; et al. 2016. "Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0157852

Lazaro, Diana F.; Dias, Mariana Castro; Carija, Anita; Navarro, Susanna; Madaleno, Carolina Silva; Tenreiro, Sandra; Ventura, Salvador; Outeiro, Tiago F.. 2016. "The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation". Acta Neuropathologica Communications. https://doi.org/10.1186/S40478-016-0402-8

Outeiro, Tiago Fleming; Miranda, Hugo V.. 2016. "GLYCATION POTENTIATES NEURODEGENERATION IN MODELS OF HUNTINGTON'S DISEASE". Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/JNNP-2016-314597.38

Letra-Vilela, Ricardo; Maria Sanchez-Sanchez, Ana; Rocha, Ana Maia; Martin, Vanesa; Branco-Santos, Joana; Puente-Moncada, Noelia; Santa-Marta, Mariana; et al. 2016. "Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin". Molecular and Cellular Endocrinology. https://doi.org/10.1016/J.MCE.2016.07.012

Villar-Pique, Anna; da Fonseca, Tomas Lopes; Sant'Anna, Ricardo; Szegoe, Eva Monika; Fonseca-Ornelas, Luis; Pinho, Raquel; Carija, Anita; et al. 2016. "Environmental and genetic factors support the dissociation between alpha-synuclein aggregation and toxicity". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.1606791113

Batalha, Vania L.; Ferreira, Diana G.; Coelho, Joana E.; Valadas, Jorge S.; Gomes, Rui; Temido-Ferreira, Mariana; Shmidt, Tatiana; et al. 2016. "The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function". Scientific Reports. https://doi.org/10.1038/SREP31493

Outeiro, Tiago. 2016. "Glycation potentiates neurodegeneration in models of Huntington’s disease". Scientific Reports. https://doi.org/10.1038/SREP36798

João T. S. Fernandes; Oldriska Chutna; Virginia Chu; João P. Conde; Tiago F. Outeiro. 2016. "A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies". Frontiers in Neuroscience. https://doi.org/10.3389/FNINS.2016.00511

da Fonseca, Tomas Lopes; Pinho, Raquel; Outeiro, Tiago F.. 2016. "A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDW147

Outeiro, Tiago. 2016. "Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats". European Journal of Neuroscience. https://doi.org/10.1111/EJN.13278

Villar-Pique, Anna; da Fonseca, Tomas Lopes; Outeiro, Tiago Fleming. 2016. "Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies". Journal of Neurochemistry. https://doi.org/10.1111/JNC.13249

Outeiro, Tiago. 2016. "ROCK Inhibition by Fasudil as Disease-Modifying Translational Approach in the Treatment of Parkinson's Disease and Amyotrophic Lateral Sclerosis". Neurology. https://publons.com/publon/9713512/

Guerreiro, Patricia Silva; Gerhardt, Ellen; da Fonseca, Tomas Lopes; Baehr, Mathias; Outeiro, Tiago Fleming; Eckermann, Katrin. 2016. "LRRK2 Promotes Tau Accumulation, Aggregation and Release". Molecular Neurobiology. https://doi.org/10.1007/S12035-015-9209-Z

Outeiro, Tiago. 2016. "C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of a-Synuclein in a Yeast Model of Parkinson's Disease". PLOS Genetics. https://doi.org/10.1371/JOURNAL.PGEN.1006098

Outeiro, Tiago. 2016. "aB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDW028

Outeiro, Tiago. 2016. "Glycation in Parkinson's disease and Alzheimer's disease". Movement Disorders. https://doi.org/10.1002/MDS.26566

Outeiro, Tiago. 2016. "Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDV470

Goncalves, Susana A.; Macedo, Diana; Raquel, Helena; Simoes, Pedro D.; Giorgini, Flaviano; Ramalho, Jose S.; Barral, Duarte C.; Moita, Luis Ferreira; Outeiro, Tiago Fleming. 2016. "shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity". PLOS Genetics. https://doi.org/10.1371/JOURNAL.PGEN.1005995

Tatenhorst, Lars; Eckermann, Katrin; Dambeck, Vivian; Fonseca-Ornelas, Luis; Walle, Hagen; da Fonseca, Tomas Lopes; Koch, Jan C.; et al. 2016. "Fasudil attenuates aggregation of alpha-synuclein in models of Parkinson's disease". Acta Neuropathologica Communications. https://doi.org/10.1186/S40478-016-0310-Y

Ducic, Tanja; Carboni, Eleonora; Lai, Barry; Chen, Si; Michalke, Bernhard; Lazaro, Diana F.; Outeiro, Tiago F.; et al. 2015. "Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium". ACS Chemical Neuroscience. https://doi.org/10.1021/ACSCHEMNEURO.5B00093

Menezes, Regina; Tenreiro, Sandra; Macedo, Diana; Santos, Claudia N.; Outeiro, Tiago Fleming. 2015. "From the baker to the bedside: yeast models of Parkinson's disease". Microbial Cell. https://doi.org/10.15698/MIC2015.08.219

Outeiro, Tiago. 2015. "Modeling Neuronal Pathology in Yeast: Insights into the Molecular Basis of Parkinson's Disease". Israel Journal of Chemistry. https://doi.org/10.1002/IJCH.201500071

Nunes, Patrique; Morais, Goreti Ribeiro; Palma, Elisa; Silva, Francisco; Oliveira, Maria Cristina; Ferreira, Vera F. C.; Mendes, Filipa; et al. 2015. "Isostructural Re(I)/Tc-99m(I) tricarbonyl complexes for cancer theranostics". Organic & Biomolecular Chemistry. https://doi.org/10.1039/C5OB00124B

Pocas, Goncalo M.; Branco-Santos, Joana; Herrera, Federico; Outeiro, Tiago Fleming; Domingos, Pedro M.. 2015. "alpha-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDU606

Breda, Carlo; Nugent, Marie L.; Estranero, Jasper G.; Kyriacou, Charalambos P.; Outeiro, Tiago F.; Steinert, Joern R.; Giorgini, Flaviano. 2015. "Rab11 modulates alpha-synuclein-mediated defects in synaptic transmission and behaviour". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDU521

Mbefo, Martial Kamdem; Fares, Mohamed-Bilal; Paleologou, Katerina; Oueslati, Abid; Yin, Guowei; Tenreiro, Sandra; Pinto, Madalena; et al. 2015. "Parkinson Disease Mutant E46K Enhances alpha-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo". Journal of Biological Chemistry. https://doi.org/10.1074/JBC.M114.610774

Vreja, Ingrid C.; Nikic, Ivana; Goettfert, Fabian; Bates, Mark; Kroehnert, Katharina; Outeiro, Tiago F.; Hell, Stefan W.; Lemke, Edward A.; Rizzoli, Silvio O.. 2015. "Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies". ACS Nano. https://doi.org/10.1021/ACSNANO.5B04434

Outeiro, Tiago. 2015. "The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0116919

da Fonseca, Tomas Lopes; Villar-Pique, Anna; Outeiro, Tiago Fleming. 2015. "The Interplay between Alpha-Synuclein Clearance and Spreading". Biomolecules. https://doi.org/10.3390/BIOM5020435

Outeiro, Tiago. 2015. "Mutant huntingtin alters Tau phosphorylation and subcellular distribution". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDU421

Outeiro, Tiago. 2015. "(Poly)phenols protect from alpha-synuclein toxicity by reducing oxidative stress and promoting autophagy". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDU585

Outeiro, Tiago. 2015. "Knockout of Silent Information Regulator 2 (SIRT2) Preserves Neurological Function after Experimental Stroke in Mice". Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1038/JCBFM.2015.178

Outeiro, Tiago. 2015. "The baker, sugar, and the molecular basis of Parkinson's disease". Yeast. https://publons.com/publon/9713516/

Gomes, Pedro; Outeiro, Tiago Fleming; Cavadas, Claudia. 2015. "Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism". Trends in Pharmacological Sciences. https://doi.org/10.1016/J.TIPS.2015.08.001

Moree, Ben; Yin, Guowei; Lazaro, Diana F.; Munari, Francesca; Strohaeker, Timo; Giller, Karin; Becker, Stefan; et al. 2015. "Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric alpha-Synuclein and Reduce Its Aggregation in Cells". Journal of Biological Chemistry. https://doi.org/10.1074/JBC.M114.636027

Outeiro, Tiago. 2015. "Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells". Cell Death and Disease. https://doi.org/10.1038/CDDIS.2015.318

Poehler, Anne-Maria; Xiang, Wei; Spitzer, Philipp; May, Verena Elisabeth Luise; Meixner, Holger; Rockenstein, Edward; Chutna, Oldriska; et al. 2014. "Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment". Autophagy. https://doi.org/10.4161/AUTO.36436

Outeiro, Tiago. 2014. "Misfolded proteins in Parkinson's disease". European Journal of Neurology. https://publons.com/publon/9713511/

Perfeito, Rita; Lazar, Diana F.; Outeiro, Tiago F.; Rego, A. Cristina. 2014. "Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells". Molecular and Cellular Neuroscience. https://doi.org/10.1016/J.MCN.2014.08.002

Tenreiro, Sandra; Reimao-Pinto, Madalena M.; Antas, Pedro; Rino, Jose; Wawrzycka, Donata; Macedo, Diana; Rosado-Ramos, Rita; et al. 2014. "Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease". PLOS Genetics. https://doi.org/10.1371/JOURNAL.PGEN.1004302

Fernandes, Joao Tiago S.; Tenreiro, Sandra; Gameiro, Andreia; Chu, Virginia; Outeiro, Tiago F.; Conde, Joao P.. 2014. "Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator". Lab on a Chip. https://doi.org/10.1039/C4LC00756E

Branco dos Santos, J.; Staniforth, G.; Breda, C.; Herrera, F.; Outeiro, T. F.; Tuite, M.; Giorgini, F.. 2014. "AGGREGATION-PRONE PROTEINS EXACERBATE HUNTINGTIN TOXICITY IN YEAST AND DROSOPHILA". Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/JNNP-2014-309032.35

Miller-Fleming, Leonor; Antas, Pedro; Pais, Teresa Faria; Smalley, Joshua L.; Giorgini, Flaviano; Outeiro, Tiago Fleming. 2014. "Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.1319221111

Fernandes, Joao Tiago S.; Tenreiro, Sandra; Pedrosa, Catarina R.; Gameiro, Andreia; Chu, Virginia; Outeiro, Tiago F.; Conde, Joao Pedro. 2014. "Integration of single cell traps, chemical gradient generator and photosensors in a microfluidic platform for the study of alpha-synuclein toxicity in yeast". Procedia Engineering. https://doi.org/10.1016/J.PROENG.2014.11.273

Lazaro, Diana F.; Rodrigues, Eva F.; Langohr, Ramona; Shahpasandzadeh, Hedieh; Ribeiro, Thales; Guerreiro, Patricia; Gerhardt, Ellen; et al. 2014. "Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation". PLOS Genetics. https://doi.org/10.1371/JOURNAL.PGEN.1004741

Outeiro, Tiago. 2014. "B08 Glycation Modulates Huntingtin Aggregation And Toxicity". Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/JNNP-2014-309032.36

O. Chutna; S. Goncalves; A. Villar-Pique; P. Guerreiro; Z. Marijanovic; T. Mendes; J. Ramalho; et al. 2014. "The small GTPase Rab11 co-localizes with -synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDU391

Outeiro, Tiago. 2014. "B06 Exploring The Role Of Phosphorylation In Huntingtin Aggregation Dynamics". Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/JNNP-2014-309032.34

Outeiro, Tiago. 2014. "Protein phosphorylation in neurodegeneration: friend or foe?". Frontiers in Molecular Neuroscience. https://doi.org/10.3389/FNMOL.2014.00042

Outeiro, Tiago. 2014. "DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDT466

Outeiro, Tiago. 2014. "MeCP2: a novel Huntingtin interactor". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDT499

Yin, Guowei; Da Fonseca, Tomas Lopes; Eisbach, Sibylle E.; Anduaga, Ane Martin; Breda, Carlo; Orcellet, Maria L.; Szego, Eva M.; et al. 2014. "alpha-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner". Neurobiology of Disease. https://doi.org/10.1016/J.NBD.2014.06.018

Outeiro, Tiago. 2014. "Interplay between Sumoylation and Phosphorylation for Protection against a-Synuclein Inclusions". Journal of Biological Chemistry. https://doi.org/10.1074/JBC.M114.559237

Outeiro, Tiago. 2014. "DJ-1 interactions with a-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease". Cell Death and Disease. https://doi.org/10.1038/CDDIS.2014.307

Outeiro, Tiago. 2014. "Small molecule-mediated stabilization of vesicle-associated helical a-synuclein inhibits pathogenic misfolding and aggregation". Nature Communications. https://doi.org/10.1038/NCOMMS6857

Outeiro, Tiago. 2014. "Challenges and Promises in the Development of Neurotrophic Factor-Based Therapies for Parkinson’s Disease". Drugs & Aging. https://doi.org/10.1007/S40266-014-0160-X

Outeiro, Tiago. 2014. "Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDU022

Macedo, Diana; Tavares, Lucelia; McDougall, Gordon J.; Stewart, Derek; Ferreira, Ricardo B.; Outeiro, Tiago F.; Santos, Claudia N.; Tenreiro, Sandra. 2013. "Polyphenols protect from alpha-synuclein toxicity by increasing autophagy and reducing reactive oxygen species in a yeast model of Parkinson's disease". Yeast. https://publons.com/publon/7124406/

Guerreiro, Patricia Silva; Huang, Yue; Gysbers, Amanda; Cheng, Danni; Gai, Wei Ping; Outeiro, Tiago Fleming; Halliday, Glenda Margaret. 2013. "LRRK2 interactions with alpha-synuclein in Parkinson's disease brains and in cell models". Journal of Molecular Medicine. https://doi.org/10.1007/S00109-012-0984-Y

Vicente Miranda, Hugo; Xiang, Wei; de Oliveira, Rita M.; Simoes, Tania; Pimentel, Jose; Klucken, Jochen; Penque, Deborah; Outeiro, Tiago F.. 2013. "Heat-mediated enrichment of alpha-synuclein from cells and tissue for assessing post-translational modifications". Journal of Neurochemistry. https://doi.org/10.1111/JNC.12251

Outeiro, Tiago. 2013. "Caffeine and adenosine receptor controlling stress activated pathways: a window for depression". Journal of Neurochemistry. https://publons.com/publon/9548817/

Pais, Teresa Faria; Szego, Eva M.; Marques, Oldriska; Miller-Fleming, Leonor; Antas, Pedro; Guerreiro, Patricia; de Oliveira, Rita Machado; Kasapoglu, Burcu; Outeiro, Tiago Fleming. 2013. "The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation". The EMBO Journal. https://doi.org/10.1038/EMBOJ.2013.200

Donmez, Gizem; Outeiro, Tiago F.. 2013. "SIRT1 and SIRT2: emerging targets in neurodegeneration". EMBO Molecular Medicine. https://doi.org/10.1002/EMMM.201302451

Outeiro, Tiago. 2013. "PLK2 Modulates a-Synuclein Aggregation in Yeast and Mammalian Cells". Molecular Neurobiology. https://doi.org/10.1007/S12035-013-8473-Z

Tenreiro, Sandra; Reimao-Pinto, Madalena M.; Antas, Pedro; Rino, Jose; Waiss, Meytal; Magalhaes, Filipa; Wawrzycka, Donata; et al. 2013. "Harnessing the power of yeast to decipher the role of alpha-synuclein phosphorylation in Parkinson's disease". Yeast. https://publons.com/publon/7124394/

Outeiro, Tiago. 2013. "ß-synuclein aggregates and induces neurodegeneration in dopaminergic neurons". Annals of Neurology. https://doi.org/10.1002/ANA.23905

Repici, Mariaelena; Straatman, Kornelis R.; Balduccio, Nadia; Enguita, Francisco J.; Outeiro, Tiago F.; Giorgini, Flaviano. 2013. "Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells". Journal of Molecular Medicine. https://doi.org/10.1007/S00109-012-0976-Y

Amaral, Marta; Outeiro, Tiago F.; Scrutton, Nigel S.; Giorgini, Flaviano. 2013. "The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease". Journal of Molecular Medicine. https://doi.org/10.1007/S00109-013-1046-9

Outeiro, Tiago. 2013. "Harnessing the power of yeast to unravel the molecular basis of neurodegeneration". Journal of Neurochemistry. https://doi.org/10.1111/JNC.12271

Faria, Cristiana; Jorge, Carla D.; Borges, Nuno; Tenreiro, Sandra; Outeiro, Tiago F.; Santos, Helena. 2013. "Inhibition of formation of alpha-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease". Biochimica et Biophysica Acta (BBA) - General Subjects. https://doi.org/10.1016/J.BBAGEN.2013.04.015

Eisbach, Sibylle E.; Outeiro, Tiago F.. 2013. "alpha-Synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology". Journal of Molecular Medicine. https://doi.org/10.1007/S00109-013-1038-9

Outeiro, Tiago. 2013. "Impairment of the septal cholinergic neurons in MPTP-treated A30P a-synuclein mice". Neurobiology of Aging. https://doi.org/10.1016/J.NEUROBIOLAGING.2012.04.012

da Fonseca, Tomas Lopes; Correia, Ana; Hasselaar, Wiebren; van der Linde, Herma C.; Willemsen, Rob; Outeiro, Tiago Fleming. 2013. "The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival". Brain Research Bulletin. https://doi.org/10.1016/J.BRAINRESBULL.2012.09.017

Outeiro, Tiago. 2013. "Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system". Biochemical Pharmacology. https://doi.org/10.1016/J.BCP.2012.12.009

Outeiro, Tiago. 2013. "Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy". Molecular Neurobiology. https://doi.org/10.1007/S12035-013-8406-X

Outeiro, Tiago. 2013. "Structural basis of kynurenine 3-monooxygenase inhibition". Nature. https://doi.org/10.1038/NATURE12039

Stefan Schildknecht; Hanne R. Gerding; Christiaan Karreman; Malte Drescher; Hilal A. Lashuel; Tiago F. Outeiro; Donato A. Di Monte; Marcel Leist. 2013. "Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies". Journal of Neurochemistry. https://doi.org/10.1111/JNC.12226

Maxwell, Michele M.; Zaldivar-Jolissaint, Julien Francisco; Mai, Antonello; Outeiro, Tiago F.; Kazanstev, Aleksey G.. 2012. "Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease". EMBO Molecular Medicine. https://doi.org/10.1002/EMMM.201201452

Outeiro, Tiago. 2012. "Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice". Neurobiology of Aging. https://doi.org/10.1016/J.NEUROBIOLAGING.2011.11.006

Outeiro, Tiago. 2012. "Suppression of -synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDS058

Outeiro, Tiago. 2012. "Insulin resistance is associated with reduced levels of the age-related protein SIRT2". The FASEB Journal. https://publons.com/publon/9713525/

Outeiro, Tiago. 2012. "B10 The role of n-terminal phosphorylation in huntingtin's oligomerisation, aggregation and toxicity". Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/JNNP-2012-303524.26

Outeiro, Tiago. 2012. "SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy". Autophagy. https://doi.org/10.4161/AUTO.21275

Outeiro, Tiago. 2012. "Editorial on Special Topic: Sirtuins in Metabolism, Aging, and Disease". Frontiers in Pharmacology. https://doi.org/10.3389/FPHAR.2012.00071

Outeiro, Tiago. 2012. "Alpha-synuclein: from secretion to dysfunction and death". Cell Death and Disease. https://doi.org/10.1038/CDDIS.2012.94

Marques, S. C. F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonca, A.; Santana, I.; Outeiro, T. F.; Pereira, C. M. F.. 2012. "EPIGENETIC REGULATION OF BACE1 IN ALZHEIMER'S DISEASE PATIENTS AND IN TRANSGENIC MICE". Neuroscience. https://doi.org/10.1016/J.NEUROSCIENCE.2012.06.029

Outeiro, Tiago. 2012. "Aggregate Clearance of alpha-Synuclein in Saccharomyces cerevisiae Depends More on Autophagosome and Vacuole Function Than on the Proteasome". Journal of Biological Chemistry. https://doi.org/10.1074/JBC.M112.361865

Outeiro, Tiago. 2012. "SIRT2 as a Therapeutic Target for Age-Related Disorders". Frontiers in Pharmacology. https://doi.org/10.3389/FPHAR.2012.00082

Outeiro, Tiago. 2012. "alpha-Synuclein modifies huntingtin aggregation in living cells". FEBS Letters. https://doi.org/10.1016/J.FEBSLET.2011.11.019

Maxwell, Michele M.; Zaldivar-Jolissaint, Julien Francisco; Mai, Antonello; Outeiro, Tiago F.; Kazantsev, Aleksey G.. 2012. "Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease. (vol 4, pg 557, 2012)". EMBO Molecular Medicine. https://doi.org/10.1002/EMMM.201290007

Outeiro, Tiago. 2011. "Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity". Journal of Biological Chemistry. https://doi.org/10.1074/JBC.M110.101527

Jorge, Carla D.; Ventura, Rita; Maycock, Christopher; Outeiro, Tiago F.; Santos, Helena; Costa, Julia. 2011. "Assessment of the Efficacy of Solutes from Extremophiles on Protein Aggregation in Cell Models of Huntington's and Parkinson's Diseases". Neurochemical Research. https://doi.org/10.1007/S11064-011-0440-3

Outeiro, Tiago. 2011. "Dopamine-depletion and increased a-synuclein load induce degeneration of cortical cholinergic fibers in mice". Journal of the Neurological Sciences. https://doi.org/10.1016/J.JNS.2011.06.048

Outeiro, Tiago. 2011. "Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0027230

Outeiro, Tiago. 2011. "FlAsH illuminates Aß aggregation". Nature Chemical Biology. https://doi.org/10.1038/NCHEMBIO.636

Outeiro, Tiago. 2011. "A stem-cell ageing hypothesis on the origin of Parkinson's disease". Journal of Neurology. https://publons.com/publon/9713539/

Outeiro, Tiago. 2011. "Impaired Proteostasis Contributes to Renal Tubular Dysgenesis". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0020854

Outeiro, Tiago. 2011. "Synaptic Dysfunction in Parkinson's Disease: From Protein Misfolding to Functional Alterations". Folding for the Synapse. https://doi.org/10.1007/978-1-4419-7061-9_13

Outeiro, Tiago. 2011. "SIRTUINS: A NOVEL LINK BETWEEN NEUROIFLAMMATION AND NEURODEGENERATION". Glia. https://publons.com/publon/9713537/

Correia Guedes, L.; Lobo, P.; Valadas, A.; Neutel, D.; Mestre, T.; Coelho, M.; Rosa, M. M.; et al. 2011. "Non-motor symptoms in Portuguese Parkinson's disease patients". Movement Disorders. https://publons.com/publon/9713535/

Outeiro, Tiago. 2011. "SIRT2 is downregulated in insulin-resistant HepG2 cells: a possible role of oxidative stress.". Molecular Biology of the Cell. https://publons.com/publon/9713554/

Ellen Gerhardt; Simone Gräber; Éva M. Szego; Nicoleta Moisoi; L. Miguel Martins; Tiago F. Outeiro; Pawel Kermer. 2011. "Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0028855

Morais, Goreti Ribeiro; Vicente Miranda, Hugo; Santos, Isabel C.; Santos, Isabel; Outeiro, Tiago F.; Paulo, Antonio. 2011. "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes". Bioorganic & Medicinal Chemistry. https://doi.org/10.1016/J.BMC.2011.09.065

Martins, Madalena; Rosa, Alexandra; Guedes, Leonor C.; Fonseca, Benedita V.; Gotovac, Kristina; Violante, Sara; Mestre, Tiago; et al. 2011. "Convergence of miRNA Expression Profiling, alpha-Synuclein Interacton and GWAS in Parkinson's Disease". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0025443

Marques, Sueli C. F.; Oliveira, Catarina R.; Pereira, Claudia M. F.; Outeiro, Tiago F.. 2011. "Epigenetics in neurodegeneration: A new layer of complexity". Progress in Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/J.PNPBP.2010.08.008

Badiola, Nahuai; de Oliveira, Rita Machado; Herrera, Federico; Guardia-Laguarta, Cristina; Goncalves, Susana A.; Pera, Marta; Suarez-Calvet, Marc; et al. 2011. "Tau Enhances alpha-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0026609

Nakhjavani, Manouchehr; Morteza, Afsaneh; Khajeali, Leila; Esteghamati, Alireza; Khalilzadeh, Omid; Asgarani, Firouzeh; Outeiro, Tiago F.. 2010. "Increased serum HSP70 levels are associated with the duration of diabetes". Cell Stress and Chaperones. https://doi.org/10.1007/S12192-010-0204-Z

Marques, Sueli C. F.; Pereira, Claudia M. F.; Outeiro, Tiago F.. 2010. "Epigenetics and Neurodegeneration: A Connection Overlooked". Epigenetics: Mechanism, Functions and Human Effects. https://publons.com/publon/12719845/

Outeiro, Tiago. 2010. "B07 Identification of protein interaction partners for kynurenine 3-monooxygenase, a candidate therapeutic target for Huntington's disease". Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/JNNP.2010.222596.7

Outeiro, Tiago. 2010. "The sour side of neurodegenerative disorders: the effects of protein glycation". The Journal of Pathology. https://doi.org/10.1002/PATH.2682

Outeiro, Tiago. 2010. "Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models". Disease Models & Mechanisms. https://doi.org/10.1242/DMM.004267

Outeiro, Tiago. 2010. "A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS". Proteomics – Clinical Applications. https://doi.org/10.1002/PRCA.200900118

Outeiro, Tiago. 2010. "Simple is good: yeast models of neurodegeneration". FEMS Yeast Research. https://doi.org/10.1111/J.1567-1364.2010.00649.X

Outeiro, Tiago. 2010. "Zooming into protein oligomerization in neurodegeneration using BiFC". Trends in Biochemical Sciences. https://doi.org/10.1016/J.TIBS.2010.05.007

Outeiro, Tiago. 2010. "Neurotrophic factors as a protective strategy in Parkinson's disease". CNS and Neurological Disorders - Drug Targets. https://publons.com/publon/9713560/

Outeiro, Tiago. 2010. "Drug discovery for CNS disorders: from bench to bedside". CNS and Neurological Disorders - Drug Targets. https://publons.com/publon/9713556/

Buettner, Sabrina; Delay, Charlotte; Franssens, Vanessa; Bammens, Tine; Ruli, Doris; Zaunschirm, Sandra; de Oliveira, Rita Machado; et al. 2010. "Synphilin-1 Enhances alpha-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0013700

Outeiro, Tiago. 2009. "Dopamine-Induced Conformational Changes in Alpha-Synuclein". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0006906

Outeiro, Tiago. 2009. "Intracellular signaling - cellular models to investigate alpha-synuclein function and dysfunction". Journal of Neurochemistry. https://publons.com/publon/9713573/

Kazantsev, A. G.; Outeiro, T. F.; Amore, A. M.; Pallos, J.; Kontopoulos, E.; Atmann, S.; Kufareva, I.; et al. 2008. "Development small molecule inhibitors of deacetylasee sirtuin 2 for treatment aggregate-associated neurodegenerative diseases". Journal of Neurochemistry. https://publons.com/publon/9713450/

Outeiro, Tiago. 2008. "CHIP Targets Toxic a-Synuclein Oligomers for Degradation". Journal of Biological Chemistry. https://doi.org/10.1074/JBC.M802283200

Outeiro, Tiago. 2008. "Direct quantification of CSF a-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration". Experimental Neurology. https://doi.org/10.1016/J.EXPNEUROL.2008.06.004

Outeiro, Tiago Fleming; Putcha, Preeti; Tetzlaff, Julie E.; Spoelgen, Robert; Koker, Mirjam; Carvalho, Filipe; Hyman, Bradley T.; McLean, Pamela J.. 2008. "Formation of Toxic Oligomeric alpha-Synuclein Species in Living Cells". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0001867

Outeiro, Tiago Fleming; Marques, Oldriska; Kazantsev, Aleksey. 2008. "Therapeutic role of sirtuins in neurodegenerative disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. https://doi.org/10.1016/J.BBADIS.2008.02.010

Tiago Outeiro. 2008. "Drug Targeting of a-Synuclein Oligomerization in Synucleinopathies". Perspectives in Medicinal Chemistry. https://publons.com/publon/9713570/

Outeiro, Tiago. 2007. "Pharmacological inhibition of PARP-1 reduces a-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease in vitro models". Biochemical and Biophysical Research Communications. https://doi.org/10.1016/J.BBRC.2007.03.163

Outeiro, Tiago. 2007. "Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra". Journal of Neurochemistry. https://doi.org/10.1111/J.1471-4159.2006.04310.X

Outeiro, Tiago. 2007. "Angiotensin II protects against a-synuclein toxicity and reduces protein aggregation in vitro". Biochemical and Biophysical Research Communications. https://doi.org/10.1016/J.BBRC.2007.09.043

Outeiro, Tiago Fleming; Kontopoulos, Eirene; Altmann, Stephen M.; Kufareva, Irina; Strathearn, Katherine E.; Amore, Allison M.; Volk, Catherine B.; et al. 2007. "Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease". Science. https://doi.org/10.1126/SCIENCE.1143780

Bodner, RA; Outeiro, TF; Altmann, S; Maxwell, MM; Cho, SH; Hyman, BT; McLean, PJ; et al. 2006. "Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.0511256103

Outeiro, Tiago. 2006. "Small heat shock proteins protect against a-synuclein-induced toxicity and aggregation". Biochemical and Biophysical Research Communications. https://doi.org/10.1016/J.BBRC.2006.10.085

Outeiro, Tiago. 2006. "Detection of novel intracellular a-synuclein oligomeric species by fluorescence lifetime imaging". The FASEB Journal. https://doi.org/10.1096/FJ.05-5422COM

Outeiro, Tiago. 2005. "Yeast cells as a discovery platform for neurodegenerative disease". Research in Computational Molecular Biology, Proceedings. https://doi.org/10.1007/11415770_8

Outeiro, Tiago. 2004. "Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.0404968101

Resende, CG; Outeiro, TF; Sands, L; Lindquist, S; Tuite, MF. 2003. "Prion protein gene polymorphisms in Saccharomyces cerevisiae". Molecular Microbiology. https://doi.org/10.1046/J.1365-2958.2003.03608.X

Outeiro, Tiago. 2003. "Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology". Science. https://doi.org/10.1126/SCIENCE.1090439

Outeiro, Tiago. 2003. "Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or -Synuclein". Science. https://doi.org/10.1126/SCIENCE.1090389

Eftychia Vasili; Antonio Dominguez-Meijide; Manuel Flores-Léon; Mohammed Al-Azzani; Angeliki Kanellidi; Ronald Melki; Leonidas Stefanis; Tiago Outeiro. 2021. Endogenous Levels of Alpha-synuclein Modulate Seeding and Aggregation in Cultured Cells. https://doi.org/10.21203/rs.3.rs-1152192/v1

David J. Koss; Daniel Erskine; Andrew Porter; Pawel Palmoski; Marta Leite; Johannes Attems; Tiago F. Outeiro. 2021. Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies. https://doi.org/10.1101/2021.10.20.465125

2017. "SYNUCLEIN MISFOLDING AS A THERAPEUTIC TARGET". Disease-modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-modifying Therapies. https://doi.org/10.1016/B978-0-12-805120-7.00002-6

Patrick W. Cullinane; Eduardo de Pablo Fernandez; Annekatrin König; Tiago Fleming Outeiro; Zane Jaunmuktane; Thomas T. Warner. 2023. "Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts". Movement Disorders. https://doi.org/10.1002/mds.29298

Luca Marsili; Jennifer Sharma; Tiago Fleming Outeiro; Carlo Colosimo. 2023. "Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials". Biomedicines. https://doi.org/10.3390/biomedicines11020505

Liana Shvachiy; Ângela Amaro-Leal; Tiago F. Outeiro; Isabel Rocha; Vera Geraldes. 2023. "Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation". Cells. https://doi.org/10.3390/cells12050818

Aisha M. Swaih; Carlo Breda; Korrapati V. Sathyasaikumar; Natalie Allcock; Mary E. W. Collier; Robert P. Mason; Adam Feasby; et al. 2022. "Kynurenine 3-Monooxygenase Interacts with Huntingtin at the Outer Mitochondrial Membrane". Biomedicines. https://doi.org/10.3390/biomedicines10092294

Ruxanda Lungu; Francisca F. Fernandes; Tiago F. Outeiro; Noam Shemesh. 2022. Brain-wide sensory aberrations in a Parkinson’s Disease mouse model revealed by functional MRI. https://doi.org/10.1101/2022.04.06.487227

Ricardo Sant’Anna; Bruno K Robbs; Júlia Araújo de Freitas; Patrícia Pires dos Santos; Annekatrin König; Tiago Fleming Outeiro; Debora Foguel. 2023. Alpha-synuclein oligomers activate NFAT proteins modulating synaptic homeostasis and apoptosis. https://doi.org/10.1101/2023.02.21.529374

Felipe Saceanu Leser; Mirella Araújo Ribeiro; Lucas Dalsente Romano da Silva; Renato Garcia Domingues; Tiago Fleming Outeiro; Kevin Boyé; Eduardo Coelho Cerqueira; Fabiano Lacerda Carvalho; Phelippe do Carmo Gonçalves. 2023. "The relationship between anxiety and COVID-19-associated isolation and lifestyle changes in the university community as a result of the SARS-CoV-2 pandemic". Mental Health Science. https://doi.org/10.1002/mhs2.48

Tuane C. R. G. Vieira; Caroline A. Barros; Renato Domingues; Tiago Fleming Outeiro. 2023. "PrP meets alpha-synuclein: Molecular mechanisms and implications for disease". Journal of Neurochemistry. https://doi.org/10.1111/jnc.15992

Andrés D. Klein; Tiago Fleming Outeiro. 2023. "Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria". Nature Communications. https://doi.org/10.1038/s41467-023-42107-7

Quesnel, Agathe; Coles, Nathan; Angione, Claudio; Dey, Priyanka; Polvikoski, Tuomo M.; Outeiro, Tiago F.; Islam, Meez; Khundakar, Ahmad A.; Filippou, Panagiota S.. 2023. "Glycosylation spectral signatures for glioma grade discrimination using Raman spectroscopy". BMC Cancer. https://doi.org/10.1186/S12885-023-10588-W

Hassanzadeh, Kambiz; Morrone, Castrese; Akhtari, Keivan; Gerhardt, Ellen; Zaccagnini, Ludovica; Outeiro, Tiago Fleming; Feligioni, Marco. 2023. "Non-SUMOylated alternative spliced isoforms of alpha-synuclein are more aggregation-prone and toxic". Mechanisms of Ageing and Development. https://doi.org/10.1016/J.MAD.2022.111759

Outeiro, Tiago Fleming; El-Agnaf, Omar M.. 2023. "The immune system in Parkinson's disease: From biology to diagnosis and therapeutic targets". Neurobiology of Disease. https://doi.org/10.1016/J.NBD.2023.105995

Guaragnella, Nicoletta; Krisko, Anita; Outeiro, Tiago F.. 2022. "Editorial for the Special Issue "Adaptation, Aging, and Cell Death in Yeast Stress Response: Models, Mechanisms and Applications"". Microorganisms. https://doi.org/10.3390/MICROORGANISMS10061126

Shvachiy, Liana; Amaro-Leal, Angela; Outeiro, Tiago F.; Rocha, Isabel; Geraldes, Vera. 2022. "From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms". Biology. https://doi.org/10.3390/BIOLOGY11081164

Lassen, Louise Berkhoudt; Thomsen, Maj Schneider; Basso, Elisa; Fuchtbauer, Ernst-Martin; Fuchtbauer, Annette; Outeiro, Tiago Fleming; Jensen, Poul Henning; Moos, Torben. 2022. "Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation". Cells. https://doi.org/10.3390/CELLS11223673

Santos, Cleonice Creusa; Cardim-Pires, Thyago R.; Shvachiy, Liana; Fonseca-Fonseca, Luis Arturo; Munoz, Patricia; Almeida, Aurea Maria A. N.; Costa, Ana Carla S.; et al. 2022. "JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species". Neurotoxicity Research. https://doi.org/10.1007/S12640-022-00559-7

Bras, Ines C.; Khani, Mohammad H.; Riedel, Dietmar; Parfentev, Iwan; Gerhardt, Ellen; van Riesen, Christoph; Urlaub, Henning; Gollisch, Tim; Outeiro, Tiago F.. 2022. "Ectosomes and exosomes modulate neuronal spontaneous activity". Journal of Proteomics. https://doi.org/10.1016/J.JPROT.2022.104721

Vasili, Eftychia; Dominguez-Meijide, Antonio; Flores-Leon, Manuel; Al-Azzani, Mohammed; Kanellidi, Angeliki; Melki, Ronald; Stefanis, Leonidas; Outeiro, Tiago Fleming. 2022. "Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells". Molecular Neurobiology. https://doi.org/10.1007/S12035-021-02713-2

Ghanem, Simona S.; Majbour, Nour K.; Vaikath, Nishant N.; Ardah, Mustafa T.; Erskine, Daniel; Jensen, Nanna Moller; Fayyad, Muneera; et al. 2022. "alpha-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.2109617119

Bras, Ines C.; Khani, Mohammad H.; Vasili, Eftychia; Moebius, Wiebke; Riedel, Dietmar; Parfentev, Iwan; Gerhardt, Ellen; et al. 2022. "Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity". Journal of Parkinson's Disease. https://doi.org/10.3233/JPD-223516

Jost, Wolfgang H.; Buhmann, Carsten; Classen, Joseph; Eggert, Karla; Kohl, Zacharias; Outeiro, Tiago; Tonges, Lars; Woitalla, Dirk; Reichmann, Heinz. 2022. "Relevance of COMT inhibitors in the treatment of motor fluctuations". Der Nervenarzt. https://doi.org/10.1007/S00115-021-01237-3

Koss, David J.; Erskine, Daniel; Porter, Andrew; Palmoski, Pawel; Menon, Hariharan; Todd, Olivia G. J.; Leite, Marta; Attems, Johannes; Outeiro, Tiago F.. 2022. "Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies". Acta Neuropathologica Communications. https://doi.org/10.1186/S40478-022-01403-X

Cassotta, Manuela; Geerts, Hugo; Harbom, Lise; Outeiro, Tiago F.; Pediaditakis, Iosif; Reiner, Orly; Schildknecht, Stefan; et al. 2022. "The Future of Parkinson?s Disease Research A New Paradigm of Human Specific Investigation Is Necessary ... and Possible ...". ALTEX. https://doi.org/10.14573/ALTEX.2203161

Torres-Garcia, Laura; P. Domingues, Joana M.; Brandi, Edoardo; Haikal, Caroline; Mudannayake, Janitha M.; Bras, Ines C.; Gerhardt, Ellen; et al. 2022. "Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation". Scientific Reports. https://doi.org/10.1038/S41598-022-06846-9

Buratti, Fiamma A.; Boeffinger, Nicola; Garro, Hugo A.; Flores, Jesica S.; Hita, Francisco J.; do Carmo Goncalves, Phelippe; dos Reis Copello, Federico; et al. 2022. "Aromaticity at position 39 in alpha-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations". Protein Science. https://doi.org/10.1002/PRO.4360

Jordan, Kate L.; Koss, David J.; Outeiro, Tiago F.; Giorgini, Flaviano. 2022. "Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer's Disease". Biomedicines. https://doi.org/10.3390/BIOMEDICINES10051141

Chegao, Ana; Guarda, Mariana; Alexandre, Bruno M.; Shvachiy, Liana; Temido-Ferreira, Mariana; Marques-Morgado, Ines; Fernandes Gomes, Barbara; et al. 2022. "Glycation modulates glutamatergic signaling and exacerbates Parkinson's disease-like phenotypes". Npj Parkinson's Disease. https://doi.org/10.1038/S41531-022-00314-X

Shaib, A. H.; Chouaib, A. A.; Imani, V.; Chowdhury, R.; Georgiev, S. V.; Mougios, N.; Monga, M.; et al. 2022. "Expansion microscopy at one nanometer resolution". BioRxiv. https://doi.org/10.1101/2022.08.03.502284

Al-Azzani, Mohammed; Koenig, Annekatrin; Outeiro, Tiago Fleming. 2022. "Production of Recombinant Alpha-Synuclein: Still No Standardized Protocol in Sight". Biomolecules. https://doi.org/10.3390/BIOM12020324

Hatton, Christopher; Ghanem, Simona S.; Koss, David J.; Abdi, Ilham Y.; Gibbons, Elizabeth; Guerreiro, Rita; Bras, Jose; et al. 2022. "Prion-like a-synuclein pathology in the brain of infants with Krabbe disease". Brain. https://doi.org/10.1093/BRAIN/AWAC002

Schaffner, Samantha L.; Wassouf, Zinah; Lazaro, Diana F.; Xylaki, Mary; Gladish, Nicole; Lin, David T. S.; MacIsaac, Julia; et al. 2022. "Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDAC104

Thom, Tobias; Schmitz, Matthias; Fischer, Anna-Lisa; Correia, Angela; Correia, Susana; Llorens, Franc; Pique, Anna-Villar; et al. 2022. "Cellular Prion Protein Mediates alpha-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo". Movement Disorders. https://doi.org/10.1002/MDS.28774

Domingues, Renato; Sant'Anna, Ricardo; Carvalho da Fonseca, Anna Carolina; Robbs, Bruno K.; Foguel, Debora; Outeiro, Tiago F.. 2022. "Extracellular alpha-synuclein: Sensors, receptors, and responses". Neurobiology of Disease. https://doi.org/10.1016/J.NBD.2022.105696

Magalhaes, Rayne S. S.; Boechat, Fernanda C.; Brasil, Aline A.; Neto, Jose R. M.; Ribeiro, Gabriela D.; Paranhos, Luan H.; de Souza, Natalia Neves; et al. 2022. "Hexokinase 2: The preferential target of trehalose-6-phosphate over hexokinase 1". Journal of Cellular Biochemistry. https://doi.org/10.1002/JCB.30317

Queiroz, Daniela D.; Ribeiro, Thales de P.; Goncalves, Julliana M.; Mattos, Larissa M. M.; Gerhardt, Ellen; Freitas, Julia; Palhano, Fernando L.; et al. 2022. "A water-soluble manganese(II) octanediaoate/phenanthroline complex acts as an antioxidant and attenuates alpha-synuclein toxicity". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. https://doi.org/10.1016/J.BBADIS.2022.166475

Shvachiy, Liana; Amaro-Leal, Angela; Outeiro, Tiago; Geraldes, Vera. 2022. "Behavioral and molecular changes resulted from different environmental lead exposures: a comparative study". Journal of Neurochemistry. https://publons.com/wos-op/publon/56816366/

Pena-Diaz, Samuel; Pujols, Jordi; Vasili, Eftychia; Pinheiro, Francisca; Santos, Jaime; Manglano-Artunedo, Zoe; Outeiro, Tiago F.; Ventura, Salvador. 2022. "The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple alpha-synuclein strains". Journal of Biological Chemistry. https://doi.org/10.1016/J.JBC.2022.101902

Medina, Luciana; Gonzalez-Lizarraga, Florencia; Dominguez-Meijide, Antonio; Ploper, Diego; Parrales, Valeria; Sequeira, Sabrina; Cima-Omori, Maria-Sol; et al. 2021. "Doxycycline Interferes With Tau Aggregation and Reduces Its Neuronal Toxicity". Frontiers in Aging Neuroscience. https://doi.org/10.3389/FNAGI.2021.635760

Schaffner, S. L.; Wassouf, Z.; Lazaro, D. F.; Xylaki, M.; Gladish, N.; Lin, D. T. S.; MacIsaac, J.; et al. 2021. "Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways". BioRxiv. https://doi.org/10.1101/2021.06.12.448150

Flores-Leon, Manuel; Lazaro, Diana F.; Shvachiy, Liana; Krisko, Anita; Outeiro, Tiago F.. 2021. "In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. https://doi.org/10.1016/J.BBAPAP.2021.140693

Popova, Blagovesta; Wang, Dan; Paetz, Christina; Akkermann, Dagmar; Lazaro, Diana F.; Galka, Dajana; Kolog Gulko, Miriam; et al. 2021. "DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of alpha-synuclein toxicity and oligomerization". PLOS Genetics. https://doi.org/10.1371/JOURNAL.PGEN.1009407

Jacinto, Sandra; Guerreiro, Patricia; de Oliveira, Rita Machado; Cunha-Oliveira, Teresa; Santos, Maria Joao; Grazina, Manuela; Rego, Ana Cristina; Outeiro, Tiago F.. 2021. "MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile". Frontiers in Cellular Neuroscience. https://doi.org/10.3389/FNCEL.2021.641264

Erskine, Daniel; Koss, David; Walker, Lauren; Outeiro, Tiago; Attems, Johannes. 2021. "Lipid metabolism alterations are associated with alpha-synuclein pathology in Lewy body dementia". Neuropathology and Applied Neurobiology. https://publons.com/wos-op/publon/48287854/

Popova, Blagovesta; Wang, Dan; Rajavel, Abirami; Dhamotharan, Karthikeyan; Lazaro, Diana F.; Gerke, Jennifer; Uhrig, Joachim F.; et al. 2021. "Identification of Two Novel Peptides That Inhibit alpha-Synuclein Toxicity and Aggregation". Frontiers in Molecular Neuroscience. https://doi.org/10.3389/FNMOL.2021.659926

Oliveira, Luis M. A.; Gasser, Thomas; Edwards, Robert; Zweckstetter, Markus; Melki, Ronald; Stefanis, Leonidas; Lashuel, Hilal A.; et al. 2021. "Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease". Npj Parkinson's Disease. https://doi.org/10.1038/S41531-021-00203-9

Wong-Guerra, Maylin; Montano-Peguero, Yanay; Ramirez-Sanchez, Jeney; Jimenez-Martin, Javier; Arturo Fonseca-Fonseca, Luis; Hernandez-Ensenat, Daniela; Nonose, Yasmine; et al. 2021. "JM-20 treatment prevents neuronal damage and memory impairment induced by aluminum chloride in rats". NeuroToxicology. https://doi.org/10.1016/J.NEURO.2021.08.017

Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. 2021. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy. https://doi.org/10.1080/15548627.2020.1797280

Koss, David J.; Campesan, Susanna; Giorgini, Flaviano; Outeiro, Tiago F.. 2021. "Dysfunction of RAB39B-Mediated Vesicular Trafficking in Lewy Body Diseases". Movement Disorders. https://doi.org/10.1002/MDS.28605

Dominguez-Meijide, Antonio; Parrales, Valeria; Vasili, Eftychia; Gonzalez-Lizarraga, Florencia; Konig, Annekatrin; Lazaro, Diana F.; Lannuzel, Annie; et al. 2021. "Doxycycline inhibits alpha -synuclein-associated pathologies in vitro and in vivo". Neurobiology of Disease. https://doi.org/10.1016/J.NBD.2021.105256

Miranda, Hugo Vicente; Szego, Eva M.; Oliveira, Luis M. A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. 2021. "Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies (vol 140, pg 1399, 2017)". Brain. https://doi.org/10.1093/BRAIN/AWAB175

Hatton, C.; Ghanem, S. S.; Koss, D. J.; Abdi, I. Y.; Gibbons, E.; Guerreiro, R.; Bras, J.; et al. 2021. "Prion-like α-synuclein pathology in the brains of infants: Krabbe disease as a novel seed-competent α-synucleinopathy". BioRxiv. https://doi.org/10.1101/2021.10.12.463948

Erskine, Daniel; Koss, David; Korolchuk, Viktor I.; Outeiro, Tiago F.; Attems, Johannes; McKeith, Ian. 2021. "Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders". Acta Neuropathologica. https://doi.org/10.1007/S00401-021-02266-7

Albert, Katrina; Raymundo, Diana P.; Panhelainen, Anne; Eesmaa, Ave; Shvachiy, Liana; Araujo, Gabriela R.; Chmielarz, Piotr; et al. 2021. "Cerebral dopamine neurotrophic factor reduces a-synuclein aggregation and propagation and alleviates behavioral alterations in vivo". Molecular Therapy. https://doi.org/10.1016/J.YMTHE.2021.04.035

Arturo Fonseca-Fonseca, Luis; Amaral da Silva, Victor Diogenes; Wong-Guerra, Maylin; Ramirez-Sanchez, Jeney; Padron Yaquis, Alejandro Saul; Ochoa-Rodriguez, Estael; Verdecia-Reyes, Yamila; et al. 2021. "JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties". NeuroToxicology. https://doi.org/10.1016/J.NEURO.2020.11.005

Erskine, D.; Majbour, N.; Kauser, M.; Xylaki, M.; Attems, J.; Outeiro, T.; El-Agnaf, O.. 2020. "Regionally different expression of a novel alpha-synuclein species between Parkinson's disease dementia and dementia with Lewy bodies". Neuropathology and Applied Neurobiology. https://publons.com/wos-op/publon/48287841/

Oldriska, Marques; Oliveira Rita, M.; Ferreira, Moita Luis; Fleming, Outeiro Tiago. 2009. "Sirtuins as a link between ageing and neurodegeneration". New Trends in Alzheimer and Parkinson Related Disorders: ADPD. https://publons.com/wos-op/publon/12263479/

Juciano Gasparotto; Nauana Somensi; Carolina Saibro Girardi; Reykla Ramon Bittencourt; Laura Martinewski de Oliveira; Laura Piloneto Hoefel; Ingrid Matsubara Scheibel; et al. 2023. "Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease". Journal of Neurochemistry. https://doi.org/10.1111/jnc.15890

Tiago F. Outeiro; Tuane C. R. G. Vieira. 2023. "AI and protein structure and function in neurological disease: relevance to disease management". Nature Reviews Neurology. https://doi.org/10.1038/s41582-023-00840-z

Manuel Flores-Leon; Tiago Fleming Outeiro. 2023. "More than meets the eye in Parkinson’s disease and other synucleinopathies: from proteinopathy to lipidopathy". Acta Neuropathologica. https://doi.org/10.1007/s00401-023-02601-0

Avika Chopra; Tiago Fleming Outeiro. 2023. "Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies". Brain. https://doi.org/10.1093/brain/awad260

Viviana Brembati; Gaia Faustini; Francesca Longhena; Tiago Fleming Outeiro; Arianna Bellucci. 2023. "Changes in a-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease". International Journal of Molecular Sciences. https://doi.org/10.3390/ijms241713435

Daniel Oppermann Peixoto; Reykla Ramon Bittencourt; Juciano Gasparotto; Flávio Gabriel Carazza Kessler; Pedro Ozorio Brum; Nauana Somensi; Carolina Saibro Girardi; et al. 2023. "Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE)". Journal of Neurochemistry. https://doi.org/10.1111/jnc.15956

Mario Habek; Antonela Blazekovic; Kristina Gotovac Jercic; Nela Pivac; Tiago Fleming Outero; Fran Borovecki; Vesna Brinar. 2023. "Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis". Biomedicines. https://doi.org/10.3390/biomedicines11082209

Luisa Maria Gatzemeier; Franc Meyer; Ulf Diederichsen; Tiago Fleming Outeiro. 2023. "Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation". Chemistry – A European Journal. https://doi.org/10.1002/chem.202300649

Carmina C. Warth Perez Arias; Ivan Silbern; Lucas Caldi Gomes; Hannes Wartmann; Vivian Dambeck; Jonas Fanz; Lisa Neuenroth; et al. 2023. "Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease". Journal of Neurochemistry. https://doi.org/10.1111/jnc.15924

Tiago F. Outeiro; Roy N. Alcalay; Angelo Antonini; Johannes Attems; Vincenzo Bonifati; Francisco Cardoso; Marie-Françoise Chesselet; et al. 2023. "Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”". Movement Disorders. https://doi.org/10.1002/mds.29419

Evelini Plácido; Priscilla Gomes Welter; Ana Wink; Gabriela Duarte Karasiak; Tiago Fleming Outeiro; Alcir Luiz Dafre; Joana Gil-Mohapel; Patricia S. Brocardo. 2023. "Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice". International Journal of Molecular Sciences. https://doi.org/10.3390/ijms241612607

Anton Emil Dorn; Emile de Bruyn; Giulia Rossetti; Claudio Fernandez; Tiago F. Outeiro; Jörg B. Schulz; Paolo Carloni. 2023. Impact of Phosphorylation on alpha-Synuclein Structural Determinants. https://doi.org/10.1101/2023.03.10.531864

Günter U. Höglinger; Charles H. Adler; Daniela Berg; Christine Klein; Tiago F. Outeiro; Werner Poewe; Ronald Postuma; Jon Stoessl; Anthony E. Lang. 2023. Towards a Biological Definition of Parkinson’s Disease. https://doi.org/10.20944/preprints202304.0108.v1

Amaral, Leslie; Rego, Antonio; Outeiro, Tiago; Côrte-Real, M; Chaves, SR. 2022. A humanized yeast model system to assess the risk of environment contaminants to Parkinson's disease progression. Em The Biochemistry Global Summit.

Grunho, Miguel; Godinho, Catarina; de Matos, António; Barroso, Helena; Carregosa, Ricardo; Marx, Frederico; Tomé, Morgane; et al. 2021. "Gut Status in Parkinson¿s Disease: The GutSPark Protocol". Em The 5th International Congress of CiiEM (IC CiiEM).: MDPI. https://doi.org/10.3390/msf2021005031

Grunho, Miguel; Godinho, Catarina; Patita, Marta; Mocanu, Irina; Vieira, Ana; de Matos, António; Carregosa, Ricardo; et al. 2021. "Inflammatory Bowel Disease, Alpha-Synuclein Aggregates and Parkinson¿s Disease: The InflamaSPark Protocol". Em The 5th International Congress of CiiEM (IC CiiEM).: MDPI. https://doi.org/10.3390/msf2021005028

Pais, Teresa Faria; Guerreiro, Patrícia; Coelho, Joana; Lima, Inês; Macedo, Paula; Lopes, Luisa; Outeiro, Tiago. 2014. Role of type I IL-1R in a transgenic mouse model of alpha-synucleinopathies. Em CSHL conference on Neurodegenerative Diseases: Biology & Therapeutics.

Pais, Teresa Faria; Machado Oliveira, Rita; Marijanovic, Zrinka; Patrícia S, Guerreiro; Oliveira, Ana Osório; Outeiro, Tiago. 2009. Aging and Neurodegeneration: Common Targets, Common Hopes. Em World Parkinson Congress.

Pais, Teresa Faria; Guerreiro, Patrícia; Marques, Oldriska; Outeiro, Tiago. 2009. Sirtuins: a link between ageing and microglial cell neurotoxicity. Em Annual meeting of the Society for Neurosciences.

Soares, Rui S.; Ana Correia; Outeiro, Tiago. 2012. Zebrafish as a model for studying Parkinson¿s disease.. Em 17th Multidisciplinary International Conference of Neuroscience and Biological Psychiatry "Stress and Behavior".

Neves, Vera; Côrte-Real, Sofia; Neves, Vera; Oliveira, Soraia; Canhão, P; Outeiro, Tiago; Castanho, Miguel; Aires-da-Silva, Frederico. 2016. "Antibody molecules and peptide delivery systems for use in Alzheimer¿s disease and related disorders". Estados Unidos. Permitida.

Andreia Silva; Joana Rodrigues; Outeiro, Tiago; Tenreiro, Sandra. Autor correspondente: Tenreiro, Sandra. 2019. Dissecting the effect of aSyn familial mutations on aSyn fate and lysosomal dysfunction in a yeast model of Parkinson's disease. Em XVI Meeting of the Portuguese Society for Neuroscience, Lisbon.

Da Silva, Inês S.; Cardoso, Ana R.; Reimer, Lasse; König, Annekatrin; van Riesen, Christoph; Outeiro, Tiago; Henning Jensen, Poul; M. Goreti. F. Sales. Autor correspondente: M. Goreti. F. Sales. 2022. Molecularly imprinted polymer-based electrochemical biosensor for alpha-synuclein detection in Parkinson´s Disease (To be submitted to Biosensors and Bioelectronics).

Fernandes, J. B. ; Godinho, Catarina; Baixinho, Cristina Lavareda; Outeiro, Tiago. 2022. "Personalized Care in Neurological Diseases". Frontiers in Human Neuroscience.

Lungu, Ruxanda; F. Fernandes, Francisca; Outeiro, Tiago; Shemesh, Noam. 2021. Brain-wide olfactory aberrations in a Parkinson's Disease mouse model revealed by Functional MRI. Em ISMRM & SMRT Annual Meeting & Exhibition 15-20 May 2021.

Belo Fernandes, Júlio; Godinho, Catarina; Baixinho, Cristina Lavareda; Outeiro, Tiago. 2023. "One Health Care in Psychiatric and Neurological Diseases". Frontiers in Psychiatry.

Avika Chopra; Anthony E. Lang; Günter Höglinger; Tiago F. Outeiro. 2024. "Towards a biological diagnosis of PD". Parkinsonism & Related Disorders. https://doi.org/10.1016/j.parkreldis.2024.106078

Dajana Galka; Tariq T. Ali; Alexander Bast; Marie Niederleithinger; Ellen Gerhardt; Ryo Motosugi; Eri Sakata; et al. 2024. "Inhibition of 26S proteasome activity by a-synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1". Aging Cell. https://doi.org/10.1111/acel.14128

Juan Carlos Rubilar; Tiago Fleming Outeiro; Andrés D Klein. 2024. "The lysosomal ß-glucocerebrosidase strikes mitochondria: implications for Parkinson’s therapeutics". Brain. https://doi.org/10.1093/brain/awae070

Amaral, Leslie; Martins Márcia; Mendes, Filipa; Corte-Real M; Rego, António; Outeiro, Tiago; CHAVES, SUSANA. 2024. A versatile yeast model to screen for pesticides as risk factors for synucleinopathies. Em I CBMA Open Day & II PhD|Bio Symposium.

Lungu, Ruxanda; F. Fernandes, Francisca; Pires Monteiro, Sara; Outeiro, Tiago; Shemesh, Noam. 2024. Unveiling Visual Impairments in a Progressive Parkinson's Disease Mouse Model: Insights from Functional MRI, validated via C-FOS and CBF. Em European Society for Molecular Imaging.

Tiago Fleming de Oliveira Outeiro

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