Silhueta de pessoa indiferenciada

Tiago Fleming de Oliveira Outeiro

Professor catedrático convidado
Faculdade de Medicina e Ciências Biomédicas
Subsistema
Docentes Universitário
Regime
Parcial
Vínculo
CT em Funções Públicas a termo resolutivo certo

Projetos

Projetos
2019/01/01 - 2021/12/31. Oligómeros difusíveis de alfa-sinucleína e ataxina-3: uma oportunidade para o reposicionamento de fármacos em doenças neurodegenerativas, 9471 - RIDTI. Instituto de Biologia Molecular e Celular; Universidade Nova de Lisboa.
2016/06/01 - 2020/02/29. Defesas anti-glicação como alvo terapêutico para a doença de Parkinson, 3599-PPCDT. Universidade Nova de Lisboa Faculdade de Ciências Médicas; iNOVA4Health; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
2016/05/01 - 2020/02/29. Desenvolvimento de péptidos translocadores da barreira hematoencefálica - novas moléculas terapêuticas para sistema nervoso central, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes; Universidade Nova de Lisboa Faculdade de Ciências Médicas; Universidade de Lisboa Faculdade de Medicina Veterinária; Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento.
2016/05/01 - 2019/10/31. Alzheimer3D: Conjugados Trifuncionais para o Transporte Selectivo de Fármacos para a Doença de Alzheimer, 3599-PPCDT. Universidade Nova de Lisboa Faculdade de Ciências Médicas; Universidade de Lisboa Faculdade de Medicina Veterinária; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
2014/03/01 - 2017/10/31. Avaliação Abrangente e Não Enviesada de Fatores de Risco Genéticos e Ambientais para a Doença de Parkinson, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
2013/05/01 - 2015/10/31. Glucocerebrosidase na Doença de Parkinson: do factor de risco ao biomarcador, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
2013/06/01 - 2014/05/31. Alfa-sinucleína como biomarcador sanguíneo para a doença de Parkinson, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes; Instituto Nacional de Saúde Doutor Ricardo Jorge.
2010/02/05 - 2013/08/04. Análise das alterações da transcrição em modelos cerebrais e periféricos da doença de Huntington - influência da modulação das desacetilases das histonas, 5876-PPCDTI. Universidade de Coimbra Centro de Neurociências e Biologia Celular.
2010/02/05 - 2013/07/31. Análise dos mecanismos moleculares que determinam disfunção da alfa-sinucleína e a citoxicidade na doença de Parkinson - o papel do GDNF, 5876-PPCDTI. Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
2010/02/01 - 2013/07/31. Da fosforilação à clivagem: um "switch" para a agregação e a toxicidade da alfa-sinucleína, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
2010/01/01 - 2013/06/30. Derivados de Benzazolo Marcados com Fluor-18 e Tecnécio-99m para Visualização In Vivo de Depósitos de Amilóide, 3599-PPCDT. Universidade de Lisboa Instituto Superior Técnico; Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
2010/01/01 - 2013/06/30. Disgenesia tubular renal associada a misfolding da ACE: efeitos moleculares da nova mutação Q1069R, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
2010/02/05 - 2013/05/31. Alteração do tráfego intracelular mediado pela mitocôndria na doença de Parkinson, 5876-PPCDTI. Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
2010/01/01 - 2012/12/31. Papel dos receptores A2A de adenosina no stress crónico - implicações na aprendizagem e memória, 3599-PPCDT. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
2009/01/01 - 2012/12/31. Doença de Parkinson de Progressão Lenta e Rápida: Determinantes Moleculares e Biomarcadores, 5646-ICCMS. Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes.
1999/01/01 - 2002/12/31. AMYLOID FORMATION IN YEAST: COMPARATIVE STUDIES ON THE INFLUENCE OF CHAPERONES ON THE AGGREGATION PROCESS OF TRANSTHYRETIN AND OTHER AMYLOIDOGENIC PROTEINS, POCTI. Universidade do Porto Faculdade de Ciências.

Produções

Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. "Guidelines and recommendations on yeast cell death nomenclature". https://doi.org/10.15698/mic2018.01.607
Vaz, Rita L.; Outeiro, Tiago F.; Ferreira, Joaquim J.; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders". https://doi.org/10.3389/fneur.2018.00347
Menezes, R.; Macedo, Diana Leonor Constantino; Santos, Maria Claudia; Tenreiro, Sandra; Outeiro, Tiago F; Instituto de Tecnologia Química e Biológica (ITQB); NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "From the baker to the bedside: yeast models of Parkinson's disease". https://doi.org/10.15698/mic2015.08.219
Lopes da Fonseca, Tomás; Villar-Pique, Anna; Outeiro, Tiago F; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). "The interplay between alpha-Synuclein clearance and spreading". https://doi.org/10.3390/biom5020435
Vaz, Rita L.; Outeiro, Tiago F.; Ferreira, Joaquim J.. "Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders". https://doi.org/10.3389/fneur.2018.00347
Carmona-Gutierrez, Didac; Bauer, Maria Anna; Zimmermann, Andreas; Aguilera, Andrés; Austriaco, Nicanor; Ayscough, Kathryn; Balzan, Rena; et al. "Guidelines and recommendations on yeast cell death nomenclature". https://doi.org/10.15698/mic2018.01.607
MI Oliveira da Silva; M Santejo; IW Babcock; A Magalhães; LS Minamide; E Castillo; E Gerhardt; et al. 2021. Cofilin pathology is a new player on a-synuclein-induced spine impairment in models of hippocampal synucleinopathy. https://doi.org/10.1101/2021.02.02.425931
David J. Koss; Odeta Bondarevaite; Sara Adams; Marta Leite; Flaviano Giorgini; Johannes Attems; Tiago F. Outeiro. 2021. "RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aß plaques and Lewy bodies". Brain Pathology. https://doi.org/10.1111/bpa.12890
Tiago Fleming Outeiro. 2021. "Alpha-Synuclein Antibody Characterization: Why Semantics Matters". Molecular Neurobiology. https://doi.org/10.1007/s12035-020-02269-7
Tiago Fleming Outeiro. 2021. "Emerging concepts in synucleinopathies". Acta Neuropathologica. https://doi.org/10.1007/s00401-021-02290-7
Inês C. Brás; Tiago F. Outeiro. 2021. "Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies". Cells, 10 (2): 375-375. https://doi.org/10.3390/cells10020375
Tiago F. Outeiro; Anita Krisko. 2021. "Reply to: “Parkinson's Disease and COVID-19: Do We Need to Be More Patient?”". Movement Disorders. https://doi.org/10.1002/mds.28482
Eftychia Vasili; Antonio Dominguez-Meijide; Manuel Flores-León; Mohammed Al-Azzani; Angeliki Kanellidi; Ronald Melki; Leonidas Stefanis; Tiago Fleming Outeiro. 2021. Alpha-synuclein levels modulate seeding and aggregation in cultured cells. https://doi.org/10.21203/rs.3.rs-666210/v1
Inês Caldeira Brás; Mohammad Hossein Khani; Dietmar Riedel; Iwan Parfentev; Ellen Gerhardt; Christoph van Riesen; Henning Urlaub; Tim Gollisch; Tiago Fleming Outeiro. 2021. Ectosomes and exosomes are distinct proteomic entities that modulate spontaneous activity in neuronal cells. https://doi.org/10.1101/2021.06.24.449731
Rita Rosado-Ramos; Joana Godinho-Pereira; Daniela Marques; Inês Figueira; Tiago Fleming Outeiro; Regina Menezes; Cláudia Nunes dos Santos. 2021. "Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation". Molecules. https://doi.org/10.3390/molecules26113353
Koss, David J.; Bondarevaite, Odeta; Adams, Sara; Leite, Marta; Giorgini, Flaviano; Attems, Johannes; Outeiro, Tiago F.. 2021. "RAB39B is redistributed in dementia with Lewy bodies and is sequestered within a beta plaques and Lewy bodies". Brain Pathology. https://doi.org/10.1111/BPA.12890
Leonor Correia Guedes; Tiago Mestre; Tiago F. Outeiro; Joaquim J. Ferreira. 2020. "Are genetic and idiopathic forms of Parkinson's disease the same disease?". Journal of Neurochemistry, 152 (5): 515-522. https://doi.org/10.1111/jnc.14902
Tiago Fleming Outeiro. 2020. "The courage to change science". EMBO reports, 21 (3). https://doi.org/10.15252/embr.202050124
Hugo Vicente Miranda; Ana Chegão; Márcia Oliveira; Bárbara Fernandes Gomes; Francisco J. Enguita; Tiago Fleming Outeiro. 2020. Hsp27 reduces glycation-induced toxicity and aggregation of a-synuclein. https://doi.org/10.1101/2020.03.03.975037
Inês Caldeira Brás; Antonio Dominguez-Meijide; Ellen Gerhardt; David Koss; Diana F. Lázaro; Patrícia I. Santos; Eftychia Vasili; Mary Xylaki; Tiago Fleming Outeiro. 2020. "Synucleinopathies: Where we are and where we need to go". Journal of Neurochemistry. https://doi.org/10.1111/jnc.14965
Antonio Dominguez-Meijide; Eftychia Vasili; Annekatrin König; Maria-Sol Cima-Omori; Andrei Leonov; Sergey Ryazanov; Markus Zweckstetter; Christian Griesinger; Tiago F. Outeiro. 2020. Effects of pharmacological modulators of a-synuclein and tau aggregation and internalization. https://doi.org/10.1101/2020.01.27.921643
Vaz, R.L.; Sousa, S.; Chapela, D.; van der Linde, H.C.; Willemsen, R.; Correia, A.D.; Outeiro, T.F.; Afonso, N.D.. 2020. "Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model". Pharmacology Biochemistry and Behavior, 189. https://doi.org/10.1016/j.pbb.2019.172828
Masaracchia, C.; König, A.; Valiente-Gabioud, A.A.; Peralta, P.; Favretto, F.; Strohäker, T.; Lázaro, D.F.; et al. 2020. "Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies". Biochimica et Biophysica Acta - Proteins and Proteomics, 1868 (1). https://doi.org/10.1016/j.bbapap.2019.140298
Lázaro, D.F.; Bellucci, A.; Brundin, P.; Outeiro, T.F.. 2020. "Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases". Frontiers in Molecular Neuroscience, 12. https://doi.org/10.3389/fnmol.2019.00312
Rita L. Vaz; Diana Chapela; Joana E. Coelho; Luísa V. Lopes; Joaquim J. Ferreira; Nuno D. Afonso; Sara Sousa; Tiago F. Outeiro. 2020. "Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia". Neuroscience, 424: 58-71. https://doi.org/10.1016/j.neuroscience.2019.08.046
Vale, N.; Alves, C.; Sharma, V.; Lázaro, D.F.; Silva, S.; Gomes, P.; Outeiro, T.F.. 2020. "A new MAP-Rasagiline conjugate reduces a-synuclein inclusion formation in a cell model". Pharmacological Reports. https://doi.org/10.1007/s43440-019-00032-x
Patrícia I. Santos; Tiago F. Outeiro. 2020. "Protein trapping leads to altered synaptic proteostasis in synucleinopathies". The FEBS Journal. https://doi.org/10.1111/febs.15364
Panagiota S. Filippou; Tiago F. Outeiro. 2020. "Cancer and Parkinson's Disease: Common Targets, Emerging Hopes". Movement Disorders. https://doi.org/10.1002/mds.28425
Tiago Fleming Outeiro. 2020. "Alpha-synuclein oligomerization and aggregation: a model will always be a model". Journal of Neurochemistry. https://doi.org/10.1111/jnc.15264
Tiago F. Outeiro; Peter Heutink; Erwan Bezard; Angela M. Cenci. 2020. "From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease". Movement Disorders. https://doi.org/10.1002/mds.28387
Antonio Dominguez-Meijide; Eftychia Vasili; Tiago Fleming Outeiro. 2020. "Pharmacological Modulators of Tau Aggregation and Spreading". Brain Sciences. https://doi.org/10.3390/brainsci10110858
Tiago F. Outeiro; Anita Krisko. 2020. "Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases". Movement Disorders. https://doi.org/10.1002/mds.28178
Alice Lippi; Renato Domingues; Cristian Setz; Tiago F. Outeiro; Anita Krisko. 2020. "SARS-CoV -2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders. https://doi.org/10.1002/mds.28084
Belo, Rita F.; Martins, Margarida L.F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, Vera; et al. 2020. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid ß Peptide-Induced Alzheimer’s Disease Pathophysiology". https://doi.org/10.3389/fphar.2020.00985
Dionísio, Pedro A.. 2020. "Tuning cell death and inflammation in parkinson's disease". Doutoramento. http://hdl.handle.net/10451/42843
Menezes, Regina; Foito, Alexandre; Jardim, Carolina; Costa, Inês; Garcia, Gonçalo; Rosado-Ramos, Rita; Freitag, Sabine; et al. 2020. "Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases". https://doi.org/10.3390/antiox9090789
Vaz, Rita L.; Chapela, Diana; Coelho, Joana E.; Lopes, Luisa, V; Ferreira, Joaquim J.; Afonso, Nuno D.; Sousa, Sara; Outeiro, Tiago F.. 2020. "Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia". Neuroscience. https://doi.org/10.1016/J.NEUROSCIENCE.2019.08.046
Guedes, Leonor Correia; Mestre, Tiago; Outeiro, Tiago F.; Ferreira, Joaquim J.. 2020. "Are genetic and idiopathic forms of Parkinson's disease the same disease?". Journal of Neurochemistry. https://doi.org/10.1111/JNC.14902
Vaz, Rita L.; Sousa, Sara; Chapela, Diana; van der Linde, Hernia C.; Willemsen, Rob; Correia, Ana D.; Outeiro, Tiago F.; Afonso, Nuno D.. 2020. "Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model". Pharmacology, Biochemistry and Behavior. https://doi.org/10.1016/J.PBB.2019.172828
Lazaro, Diana F.; Bellucci, Arianna; Brundin, Patrik; Outeiro, Tiago F.. 2020. "Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases". Frontiers in Molecular Neuroscience. https://doi.org/10.3389/FNMOL.2019.00312
Masaracchia, Caterina; Koenig, Annekatrin; Valiente-Gabioud, Ariel A.; Peralta, Pablo; Favretto, Filippo; Strohaeker, Timo; Lazaro, Diana F.; et al. 2020. "Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. https://doi.org/10.1016/J.BBAPAP.2019.140298
Malik, Nauman; Miah, Mohi; McAleese, Kirsty; Outeiro, Tiago; Thomas, Alan; Koss, David J.. 2020. "Contribution of amyloid and tau white matter pathology to the spatial spread of Alzheimer's disease pathology". Neuropathology and Applied Neurobiology. https://publons.com/publon/36281129/
Placido, E.; Koss, D. J.; Brocardo, P. S.; Outeiro, T. F.. 2020. "Cell proliferation and differentiation in Parkinson's disease". Neuropathology and Applied Neurobiology. https://publons.com/publon/36281130/
Bras, Ines Caldeira; Dominguez-Meijide, Antonio; Gerhardt, Ellen; Koss, David; Lazaro, Diana F.; Santos, Patricia, I; Vasili, Eftychia; Xylaki, Mary; Outeiro, Tiago Fleming. 2020. "Synucleinopathies: Where we are and where we need to go". Journal of Neurochemistry. https://doi.org/10.1111/JNC.14965
Outeiro, Tiago Fleming. 2020. "The courage to change science". EMBO Reports. https://doi.org/10.15252/EMBR.202050124
Lazaro, Diana F.; Outeiro, Tiago F.. 2020. "The Interplay Between Proteostasis Systems and Parkinson's Disease". Advances in Experimental Medicine and Biology. https://doi.org/10.1007/978-3-030-38266-7_9
Outeiro, Tiago. 2020. "Effects of pharmacological modulators of alpha-synuclein and tau aggregation and internalization". Scientific Reports. https://doi.org/10.1038/S41598-020-69744-Y
Torres, C. Alejandra Morato; Wassouf, Zinah; Zafar, Faria; Sastre, Danuta; Outeiro, Tiago Fleming; Schule, Birgitt. 2020. "The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders". International Journal of Molecular Sciences. https://doi.org/10.3390/IJMS21165724
Outeiro, Tiago. 2020. "Reply to: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases". Movement Disorders. https://doi.org/10.1002/mds.28178
Domingues, Renato; Lippi, Alice; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. 2020. "SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime". Aging. https://doi.org/10.18632/AGING.103989
Temido-Ferreira, Mariana; Ferreira, Diana G.; Batalha, Vsnia L.; Marques-Morgado, Ines; Coelho, Joana E.; Pereira, Pedro; Gomes, Rui; et al. 2020. "Age-related shift in LTD is dependent on neuronal adenosine A(2A)receptors interplay with mGluR5 and NMDA receptors". Molecular Psychiatry. https://doi.org/10.1038/S41380-018-0110-9
Belo, Rita F.; Martins, Margarida L. F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, Joao; Neves, Vera; et al. 2020. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid beta Peptide-Induced Alzheimer's Disease Pathophysiology". Frontiers in Pharmacology. https://doi.org/10.3389/FPHAR.2020.00985
Vale, Nuno; Alves, Claudia; Sharma, Vaishali; Lazaro, Diana F.; Silva, Sara; Gomes, Paula; Outeiro, Tiago Fleming. 2020. "A new MAP-Rasagiline conjugate reduces alpha-synuclein inclusion formation in a cell model". Pharmacological Reports. https://doi.org/10.1007/S43440-019-00032-X
Miranda, Hugo Vicente; Chegao, Ana; Oliveira, Marcia S.; Gomes, Barbara Fernandes; Enguita, Francisco J.; Outeiro, Tiago Fleming. 2020. "Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein". The FASEB Journal. https://doi.org/10.1096/FJ.201902936R
Koss, D. J.; Erskine, D.; Attems, J.; Outeiro, T.. 2020. "Resolving the issue of nuclear localisation of alpha-synuclein in Lewy body diseases". Neuropathology and Applied Neurobiology. https://publons.com/publon/36281127/
Koss, D. J.; Bondarevaite, O.; Adams, S.; Leite, M.; Attems, J.; Giorgini, F.; Outeiro, T.. 2020. "Determination of the pathological involvement of the vesicular trafficking protein RAB39B in idiopathic variants of neurodegenerative disease". Neuropathology and Applied Neurobiology. https://publons.com/publon/36281128/
Lippi, Alice; Domingues, Renato; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. 2020. "SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders. https://doi.org/10.1002/MDS.2808410.1002/MDS.28084
Santos, Patricia, I; Outeiro, Tiago F.. 2020. "Protein trapping leads to altered synaptic proteostasis in synucleinopathies". The FEBS Journal. https://doi.org/10.1111/FEBS.15364
Francelle, Laetitia; Outeiro, Tiago F.; Rappold, Gudrun A.. 2020. "Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity". Scientific Reports. https://doi.org/10.1038/S41598-020-62678-5
Lippi, Alice; Domingues, Renato; Setz, Cristian; Outeiro, Tiago F.; Krisko, Anita. 2020. "SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration". Movement Disorders. https://doi.org/10.1002/MDS.28084
Outeiro, Tiago F.; Heutink, Peter; Bezard, Erwan; Cenci, Angela M.. 2020. "From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease". Movement Disorders. https://doi.org/10.1002/MDS.28387
Hentrich, Thomas; Wassouf, Zinah; Ehrhardt, Christine; Haas, Eva; Mills, James D.; Aronica, Eleonora; Outeiro, Tiago Fleming; et al. 2020. "Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson's disease patients". Aging. https://doi.org/10.18632/AGING.103935
Menezes, Regina; Foito, Alexandre; Jardim, Carolina; Costa, Ines; Garcia, Goncalo; Rosado-Ramos, Rita; Freitag, Sabine; et al. 2020. "Bioprospection of Natural Sources of Polyphenols with Therapeutic Potential for Redox-Related Diseases". Antioxidants. https://doi.org/10.3390/ANTIOX9090789
Filippou, PanagiotaS.; Outeiro, Tiago F.. 2020. "Cancer and Parkinson's Disease: Common Targets, Emerging Hopes". Movement Disorders. https://doi.org/10.1002/MDS.28425
Cukierman, Daphne S.; Lazaro, Diana F.; Sacco, Pamela; Ferreira, Patricia R.; Diniz, Renata; Fernandez, Claudio O.; Outeiro, Tiago F.; Rey, Nicolas A.. 2020. "X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(I)/copper(II)-alpha-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy". Dalton Transactions. https://doi.org/10.1039/D0DT01138J
Dominguez-Meijide, Antonio; Vasili, Eftychia; Outeiro, Tiago Fleming. 2020. "Pharmacological Modulators of Tau Aggregation and Spreading". Brain Sciences. https://doi.org/10.3390/BRAINSCI10110858
Tiago Fleming Outeiro; David J. Koss; Daniel Erskine; Lauren Walker; Marzena Kurzawa-Akanbi; David Burn; Paul Donaghy; et al. 2019. "Dementia with Lewy bodies: an update and outlook". Molecular Neurodegeneration, 14 (1). https://doi.org/10.1186/s13024-019-0306-8
Marion Delenclos; Jeremy D. Burgess; Agaristi Lamprokostopoulou; Tiago F. Outeiro; Kostas Vekrellis; Pamela J. McLean. 2019. "Cellular models of alpha-synuclein toxicity and aggregation". Journal of Neurochemistry. https://doi.org/10.1111/jnc.14806
Amir Tayaranian Marvian; David J. Koss; Farhang Aliakbari; Dina Morshedi; Tiago Fleming Outeiro. 2019. "In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies". Journal of Neurochemistry. https://doi.org/10.1111/jnc.14707
Nazareno González; Trinidad Arcos-López; Annekatrin König; Liliana Quintanar; Mauricio Menacho Márquez; Tiago F. Outeiro; Claudio O. Fernández. 2019. "Effects of alpha-synuclein post-translational modifications on metal binding". Journal of Neurochemistry. https://doi.org/10.1111/jnc.14721
Tiago Fleming Outeiro; Tiago A. Mestre. 2019. "Synuclein Meeting 2019: where we are and where we need to go". Journal of Neurochemistry, 150 (5): 462-466. https://doi.org/10.1111/jnc.14825
Tiago Fleming Outeiro; Kirsten Harvey; Antonio Dominguez-Meijide; Ellen Gerhardt. 2019. "LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?". Biochemical Society Transactions, 47 (3): 827-838. https://doi.org/10.1042/BST20180466
Jing Gong; Éva M. Szego; Andrei Leonov; Eva Benito; Stefan Becker; Andre Fischer; Markus Zweckstetter; Tiago Outeiro; Anja Schneider. 2019. "Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism". The Journal of Neuroscience, 2070-18. https://doi.org/10.1523/JNEUROSCI.2070-18.2019
Prasad, V.; Wasser, Y.; Hans, F.; Goswami, A.; Katona, I.; Outeiro, T.F.; Kahle, P.J.; Schulz, J.B.; Voigt, A.. 2019. "Monitoring a-synuclein multimerization in vivo". FASEB Journal, 33 (2): 2116-2131. https://doi.org/10.1096/fj.201800148RRR
Szego, É.M.; Dominguez-Meijide, A.; Gerhardt, E.; König, A.; Koss, D.J.; Li, W.; Pinho, R.; et al. 2019. "Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies". Cell Reports, 28 (1): 65-77.e6. https://doi.org/10.1016/j.celrep.2019.06.009
Rossetti, G.; Kless, A.; Lai, L.; Outeiro, T.F.; Carloni, P.. 2019. "Investigating targets for neuropharmacological intervention by molecular dynamics simulations". Biochemical Society Transactions, 47 (3): 909-918. https://doi.org/10.1042/BST20190048
Brás, I.C.; König, A.; Outeiro, T.F.. 2019. "Glycation in Huntington's disease: A possible modifier and target for intervention". Journal of Huntington's Disease, 8 (3): 245-256. https://doi.org/10.3233/JHD-190366
Paiva, I.; Carvalho, K.; Santos, P.; Cellai, L.; Pavlou, M.A.S.; Jain, G.; Gnad, T.; et al. 2019. "A<inf>2A</inf>R-induced transcriptional deregulation in astrocytes: An in vitro study". GLIA, 67 (12): 2329-2342. https://doi.org/10.1002/glia.23688
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Vicente Miranda, Hugo; Szego, Éva M.; Oliveira, Luís M.A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. 2017. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson&#39;s disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. https://doi.org/10.1093/brain/awx056.
de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. 2017. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson disease (PD). However, the precise molecular mechanisms involved remain unclear. Here, we provide mechanistic insight into the interplay between sirtuin . https://doi.org/10.1371/journal.pbio.2000374.
Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. 2017. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson’s disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. http://hdl.handle.net/10400.26/19438
Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. 2017. Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies. a-Synuclein misfolding and aggregation is a hallmark in Parkinson&#39;s disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of a-synuclein are conserved from yeast to man, but the precise underpinnings of the cellular pathologies associated are still elusive, complicating the development of effective therapeutic strategies. Combining molecular genet. https://doi.org/10.1093/brain/awx056
Miranda, Hugo Vicente; Cássio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos António; Chegão, Ana; Miranda, Elisa; Soares, Tiago; et al. 2017. Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson&#39;s disease. Parkinson&#39;s disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it is characterized by the intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and Lewy neurites. Currently, there are no established biochemical markers for diagnosing or for following disease progression, a major limitation for the clinical practic. https://doi.org/10.1038/s41598-017-14175-5
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Gonçalves, Susana Alexandra de Barros, 1983-. 2017. "Unraveling the molecular mechanisms underlying alpha-synuclein oligomerization and cytotoxicity". Doutoramento. http://hdl.handle.net/10451/28406
Lemos, V.; de Oliveira, R.M.; Naia, L.; Szegö, E.; Ramos, E.; Pinho, S.; Magro, F.; et al. 2017. "The NAD<sup>+</sup>-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes". Human Molecular Genetics, 26 (21): 4105-4117. https://doi.org/10.1093/hmg/ddx298
Pavlou, M.A.S.; Pinho, R.; Paiva, I.; Outeiro, T.F.. 2017. "The yin and yang of a-synuclein-associated epigenetics in Parkinson's disease". Brain, 140 (4): 878-886. https://doi.org/10.1093/brain/aww227
Cukierman, D.S.; Pinheiro, A.B.; Castiñeiras-Filho, S.L.P.; da Silva, A.S.P.; Miotto, M.C.; De Falco, A.; de P. Ribeiro, T.; et al. 2017. "A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies". Journal of Inorganic Biochemistry, 170: 160-168. https://doi.org/10.1016/j.jinorgbio.2017.02.020
Menges, S.; Minakaki, G.; Schaefer, P.M.; Meixner, H.; Prots, I.; Schlötzer-Schrehardt, U.; Friedland, K.; et al. 2017. "Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress". Scientific Reports, 7. https://doi.org/10.1038/srep42942
Morais, G.R.; Palma, E.; Marques, F.; Gano, L.; Oliveira, M.C.; Abrunhosa, A.; Miranda, H.V.; et al. 2017. "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents". Journal of Heterocyclic Chemistry, 54 (1): 255-267. https://doi.org/10.1002/jhet.2575
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Pardo, J.; Abba, M.C.; Lacunza, E.; Francelle, L.; Morel, G.R.; Outeiro, T.F.; Goya, R.G.. 2017. "Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats". Hippocampus, 27 (4): 435-449. https://doi.org/10.1002/hipo.22703
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Guerreiro, P.S.; Coelho, J.E.; Sousa-Lima, I.; Macedo, P.; Lopes, L.V.; Outeiro, T.F.; Pais, T.F.. 2017. "Mutant A53T a-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways". NeuroMolecular Medicine, 19 (1): 113-121. https://doi.org/10.1007/s12017-016-8435-5
Macedo, D.; Bertolin, T.E.; Oro, T.; Backes, L.T.H.; Brás, I.C.; Santos, C.N.; Tenreiro, S.; Outeiro, T.F.. 2017. "Phycocyanin protects against Alpha-Synuclein toxicity in yeast". Journal of Functional Foods, 38: 553-560. https://doi.org/10.1016/j.jff.2017.09.044
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Gustafsson, G.; Eriksson, F.; Möller, C.; da Fonseca, T.L.; Outeiro, T.F.; Lannfelt, L.; Bergström, J.; Ingelsson, M.. 2017. "Cellular Uptake of a-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of a-Synuclein and Mediated via Fc¿ Receptors". Cellular and Molecular Neurobiology, 37 (1): 121-131. https://doi.org/10.1007/s10571-016-0352-5
López-León, M.; Outeiro, T.F.; Goya, R.G.. 2017. "Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain". Ageing Research Reviews, 40: 168-181. https://doi.org/10.1016/j.arr.2017.09.002
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Miranda, H.V.; Cássio, R.; Correia-Guedes, L.; Gomes, M.A.; Chegão, A.; Miranda, E.; Soares, T.; et al. 2017. "Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease". Scientific Reports, 7 (1). https://doi.org/10.1038/s41598-017-14175-5
Bozek, T.; Blazekovic, A.; Perkovic, M.N.; Jercic, K.G.; Sustar, A.; Smircic-Duvnjak, L.; Outeiro, T.F.; Pivac, N.; Borovecki, F.. 2017. "The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus". Diabetology and Metabolic Syndrome, 9 (1). https://doi.org/10.1186/s13098-017-0295-0
Roodveldt, C.; Outeiro, T.F.; Braun, J.E.A.. 2017. "Editorial: Molecular chaperones and neurodegeneration". Frontiers in Neuroscience, 11 (OCT). https://doi.org/10.3389/fnins.2017.00565
Szego, É.M.; Gerhardt, E.; Outeiro, T.F.. 2017. "Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3ß/ß-catenin pathway". Neurobiology of Aging, 56: 7-16. https://doi.org/10.1016/j.neurobiolaging.2017.04.001
Guedes, L.C.; Chan, R.B.; Gomes, M.A.; Conceição, V.A.; Machado, R.B.; Soares, T.; Xu, Y.; et al. 2017. "Serum lipid alterations in GBA-associated Parkinson's disease". Parkinsonism and Related Disorders, 44: 58-65. https://doi.org/10.1016/j.parkreldis.2017.08.026
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Villar-Piqué, A.; Rossetti, G.; Ventura, S.; Carloni, P.; Fernández, C.O.; Outeiro, T.F.. 2017. "Copper(II) and the pathological H50Q a-synuclein mutant: Environment meets genetics". Communicative and Integrative Biology, 10 (1). https://doi.org/10.1080/19420889.2016.1270484
Branco-Santos, J.; Herrera, F.; Poças, G.M.; Pires-Afonso, Y.; Giorgini, F.; Domingos, P.M.; Outeiro, T.F.. 2017. "Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity". Human Molecular Genetics, 26 (19): 3763-3775. https://doi.org/10.1093/hmg/ddx260
Francelle, L.; Lotz, C.; Outeiro, T.; Brouillet, E.; Merienne, K.. 2017. "Contribution of neuroepigenetics to Huntington’s disease". Frontiers in Human Neuroscience, 11. https://doi.org/10.3389/fnhum.2017.00017
Paiva, I.; Pinho, R.; Pavlou, M.A.; Hennion, M.; Wales, P.; Schütz, A.-L.; Rajput, A.; et al. 2017. "Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage". Human molecular genetics, 26 (12): 2231-2246. https://doi.org/10.1093/hmg/ddx114
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Miranda, Hugo Vicente; Szego, Éva M.; Oliveira, Luís M. A.; Breda, Carlo; Darendelioglu, Ekrem; Oliveira, Rita M. de; Ferreira, Diana G.; et al. 2017. "Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies". https://doi.org/10.1093/brain/awx056
Gonçalves, Susana Alexandra de Barros, 1983-. 2017. "Unraveling the molecular mechanisms underlying alpha-synuclein oligomerization and cytotoxicity". Doutoramento. http://hdl.handle.net/10451/28406
Miranda, Hugo Vicente; Cássio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos António; Chegão, Ana; Miranda, Elisa; Soares, Tiago; et al. 2017. "Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease". https://doi.org/10.1038/s41598-017-14175-5
de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. 2017. "The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". https://doi.org/10.1371/journal.pbio.2000374
Lissek, Thomas; Adams, Michelle; Adelman, John; Ahissar, Ehud; Akaaboune, Mohammed; Akil, Huda; a&#39;Absi, Mustafa; et al. 2017. "Building Bridges through Science". Neuron. https://doi.org/10.1016/J.NEURON.2017.09.028
Menges, Stefanie; Minakaki, Georgia; Schaefer, Patrick M.; Meixner, Holger; Prots, Iryna; Schloetzer-Schrehardt, Ursula; Friedland, Kristina; et al. 2017. "Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress". Scientific Reports. https://doi.org/10.1038/SREP42942
Ferreira, Diana G.; Batalha, Vania L.; Vicente Miranda, Hugo; Coelho, Joana E.; Gomes, Rui; Goncalves, Francisco Q.; Real, Joana I.; et al. 2017. "Adenosine A(2A) Receptors Modulate alpha-Synuclein Aggregation and Toxicity". Cerebral Cortex. https://doi.org/10.1093/CERCOR/BHV268
Ferreira, Diana G.; Temido-Ferreira, Mariana; Miranda, Hugo Vicente; Batalha, Vania L.; Coelho, Joana E.; Szego, Eva M.; Marques-Morgado, Ines; et al. 2017. "alpha-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B". Nature Neuroscience. https://doi.org/10.1038/NN.4648
Guedes, Leonor Correia; Reimao, Sofia; Paulino, Patricia; Nunes, Rita G.; Bouca-Machado, Raquel; Abreu, Daisy; Goncalves, Nilza; et al. 2017. "Neuromelanin Magnetic Resonance Imaging of the Substantia Nigra in LRRK2-Related Parkinson's Disease". Movement Disorders. https://doi.org/10.1002/MDS.27083
Vicente Miranda, Hugo; Szego, Eva M.; Oliveira, Luis M. A.; Breda, Carlo; Darendelioglu, Ekrem; de Oliveira, Rita M.; Ferreira, Diana G.; et al. 2017. "Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies". Brain. https://doi.org/10.1093/BRAIN/AWX056
Guerreiro, Patricia S.; Coelho, Joana E.; Sousa-Lima, Ines; Macedo, Paula; Lopes, Luisa V.; Outeiro, Tiago F.; Pais, Teresa F.. 2017. "Mutant A53T alpha-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways". NeuroMolecular Medicine. https://doi.org/10.1007/S12017-016-8435-5
Paiva, Isabel; Pinho, Raquel; Pavlou, Maria Angeliki; Hennion, Magali; Wales, Pauline; Schuetz, Anna-Lena; Rajput, Ashish; et al. 2017. "Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDX114
Lemos, Vera; de Oliveira, Rita M.; Naia, Luana; Szego, Eva; Ramos, Elisabete; Pinho, Sonia; Magro, Fernando; et al. 2017. "The NAD(+)-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDX298
Cukierman, Daphne Schneider; Pinheiro, Ana Beatriz; Castineiras-Filho, Sergio L. P.; da Silva, Anastacia Sa P.; Miotto, Marco C.; De Falco, Anna; Ribeiro, Thales de P.; et al. 2017. "A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies". Journal of Inorganic Biochemistry. https://doi.org/10.1016/J.JINORGBIO.2017.02.020
Outeiro, Tiago. 2017. "Disease-modification in Translational Models of Parkinson's disease by the Rho Kinase Inhibitor Fasudil". Movement Disorders. https://publons.com/publon/9713493/
Vicente Miranda, Hugo; Cassio, Rafaela; Correia-Guedes, Leonor; Gomes, Marcos Antonio; Chegao, Ana; Miranda, Elisa; Soares, Tiago; et al. 2017. "Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease". Scientific Reports. https://doi.org/10.1038/S41598-017-14175-5
Guedes, Leonor Correia; Chan, Robin Barry; Gomes, Marcos Antonio; Conceicao, Vasco A.; Machado, Raquel Bouca; Soares, Tiago; Xu, Yimeng; et al. 2017. "Serum lipid alterations in GBA-associated Parkinson's disease". Parkinsonism and Related Disorders. https://doi.org/10.1016/J.PARKRELDIS.2017.08.026
Morais, Goreti Ribeiro; Palma, Elisa; Marques, Fernanda; Gano, Lurdes; Oliveira, Maria Cristina; Abrunhosa, Antero; Vicente Miranda, Hugo; et al. 2017. "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents". Journal of Heterocyclic Chemistry. https://doi.org/10.1002/JHET.2575
Pinho, Raquel; Guedes, Leonor C.; Soreq, Lilach; Lobo, Patricia P.; Mestre, Tiago; Coelho, Miguel; Rosa, Mario M.; et al. 2017. "Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles (vol 11, e157852, 2016)". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0190552
de Oliveira, Rita Machado; Miranda, Hugo Vicente; Francelle, Laetitia; Pinho, Raquel; Szego, Eva M.; Martinho, Renato; Munari, Francesca; et al. 2017. "The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease (vol 15, e2000374, 2017)". PLoS Biology. https://doi.org/10.1371/JOURNAL.PBIO.1002601
Branco-Santos, Joana; Herrera, Federico; Pocas, Goncalo M.; Pires-Afonso, Yolanda; Giorgini, Flaviano; Domingos, Pedro M.; Outeiro, Tiago F.. 2017. "Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDX260
Oliveira da Silva, M. I.; Outeiro, T. F.; Bamburg, J. R.; Liz, M. A.. 2017. "Cofilin-actin rods as mediators of alpha-synuclein-induced synaptic dysfunction in Parkinson's disease". Molecular Biology of the Cell. https://publons.com/publon/16533540/
Bozek, Tomislav; Blazekovic, Antonela; Perkovic, Matea Nikolac; Jercic, Kristina Gotovac; Sustar, Aleksandra; Smircic-Duvnjak, Lea; Outeiro, Tiago F.; Pivac, Nela; Borovecki, Fran. 2017. "The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus". Diabetology &amp; Metabolic Syndrome. https://doi.org/10.1186/S13098-017-0295-0
Macedo, Diana; Bertolin, Telma Elita; Oro, Tatiana; Hartmann Backes, Luana Tais; Bras, Ines Caldeira; Santos, Claudia Nunes; Tenreiro, Sandra; Outeiro, Tiago Fleming. 2017. "Phycocyanin protects against Alpha-Synuclein toxicity in yeast". Journal of Functional Foods. https://doi.org/10.1016/J.JFF.2017.09.044
Guedes, L. Correia; Reimao, S.; Paulino, P.; Nunes, R.; Bouca, R.; Abreu, D.; Goncalves, N.; et al. 2017. "Neuromelanin Magnetic Resonance Imaging of the Substatia Nigra in LRRK2-related Parkinson's disease". Movement Disorders. https://publons.com/publon/9713494/
Outeiro, Tiago. 2017. "Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats". Hippocampus. https://doi.org/10.1002/HIPO.22703
Outeiro, Tiago. 2017. "Contribution of Neuroepigenetics to Huntington’s Disease". Frontiers in Human Neuroscience. https://doi.org/10.3389/FNHUM.2017.00017
Gustafsson, Gabriel; Eriksson, Fredrik; Moller, Christer; da Fonseca, Tomas Lopes; Outeiro, Tiago F.; Lannfelt, Lars; Bergstrom, Joakim; Ingelsson, Martin. 2017. "Cellular Uptake of alpha-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of alpha-Synuclein and Mediated via Fc gamma Receptors". Cellular and Molecular Neurobiology. https://doi.org/10.1007/S10571-016-0352-5
Outeiro, Tiago. 2017. "Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3ß/ß-catenin pathway". Neurobiology of Aging. https://doi.org/10.1016/J.NEUROBIOLAGING.2017.04.001
Outeiro, Tiago. 2017. "Motor and Nonmotor clinical phenotype in LRRK2 Parkinson's disease patients: A Case-control study". Movement Disorders. https://publons.com/publon/9713495/
Outeiro, Tiago. 2017. "Yeast models of Parkinson’s disease-associated molecular pathologies". Current Opinion in Genetics &amp; Development. https://doi.org/10.1016/J.GDE.2017.01.013
Outeiro, Tiago. 2017. "The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". PLoS Biology. https://doi.org/10.1371/JOURNAL.PBIO.2000374
Moreira, Sara; Fonseca, Ines; Nunes, Maria Joao; Rosa, Alexandra; Lemos, Luisa; Rodrigues, Elsa; Carvalho, Andreia Neves; et al. 2017. "Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease". Experimental Neurology. https://doi.org/10.1016/J.EXPNEUROL.2017.05.009
Outeiro, Tiago. 2017. "Editorial: Molecular Chaperones and Neurodegeneration". Frontiers in Neuroscience. https://doi.org/10.3389/FNINS.2017.00565
Outeiro, Tiago. 2017. "Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain". Ageing Research Reviews. https://doi.org/10.1016/J.ARR.2017.09.002
Outeiro, Tiago. 2017. "The yin and yang of alpha-synuclein-associated epigenetics in Parkinson's disease". Brain. https://doi.org/10.1093/BRAIN/AWW227
Outeiro, Tiago. 2017. "Treatment with diphenyl–pyrazole compound anle138b/c reveals that a-synuclein protects melanoma cells from autophagic cell death". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.1700200114
Outeiro, Tiago. 2017. "Tau deletion promotes brain insulin resistance". Journal of Experimental Medicine. https://doi.org/10.1084/JEM.20161731
Pavlou MAS; Outeiro TF. 2017. "Epigenetics in Parkinson's Disease". Fortschritte der Neurologie Psychiatrie. https://doi.org/10.1055/S-0042-104501
Outeiro, Tiago. 2017. "Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease". Experimental Neurology. https://doi.org/10.1016/J.EXPNEUROL.2017.05.007
Lázaro, Diana F.; Dias, Mariana Castro; Carija, Anita; Navarro, Susanna; Madaleno, Carolina S; Tenreiro, Sandra; Ventura, Salvador; et al. 2016. The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation. a-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson&#39;s disease (PD), the second most common neurodegenerative disorder after Alzheimer&#39;s disease. In particular, multiplications and point mutations in the gene encoding for aSyn cause familial forms of PD. Moreover, the accumulation of aSyn in Lewy Bodies and Lewy neurites in disorders such as PD, dementia with Lewy bo. https://doi.org/10.1186/s40478-016-0402-8
Miranda, Hugo Vicente; Gomes, Marcos Antonio; Branco-Santos, Joana; Breda, Carlo; Lazaro, Diana F; Lopes, Lusa Vaqueiro; Herrera, Federico; et al. 2016. Glycation potentiates neurodegeneration in models of Huntington&#39;s disease. Protein glycation is an age-dependent posttranslational modification associated with several neurodegenerative disorders, including Alzheimer&#39;s and Parkinson&#39;s diseases. By modifying aminogroups, glycation interferes with folding of proteins, increasing their aggregation potential. Here, we studied the effect of pharmacological and genetic manipulation of glycation on huntingtin (HTT), the causati. https://doi.org/10.1038/srep36798
Pinho, Raquel; Guedes, Leonor C; Soreq, Lilach; Lobo, Patricia P; Mestre, Tiago; Coelho, Miguel; Rosa, Mario M; et al. 2016. Gene Expression Differences in Peripheral Blood of Parkinson&#39;s Disease Patients with Distinct Progression Profiles. The prognosis of neurodegenerative disorders is clinically challenging due to the inexistence of established biomarkers for predicting disease progression. Here, we performed an exploratory cross-sectional, case-control study aimed at determining whether gene expression differences in peripheral blood may be used as a signature of Parkinson&#39;s disease (PD) progression, thereby shedding light into p. https://doi.org/10.1371/journal.pone.0157852
Gonçalves, Susana; Outeiro, Tiago Fleming. 2016. A disfunção cognitiva nas doenças neurodegenerativas. As doenças neurodegenerativas são neuropatias que incluem as doenças de Parkinson (DP), de Alzheimer (DA) e de Hungtington, assim como a esclerose lateral amiotrófica e demências fronto-temporais. Podendo variar na sua patofisiologia, estas doenças estão associadas ao envelhecimento geral da população, e à presença comum de formas proteicas misfolded e agregadas no cérebro dos indivíduos afectados. http://seer.upf.br/index.php/rbceh/article/view/6007
Silva, Ana Maria Ferreira da, 1983-. 2016. "Use of genomic dna-reporter tools to dissect pathological mechanisms caused by GAA expansions in Friedreich’s Ataxia". Doutoramento. http://hdl.handle.net/10451/25153
Tenreiro, Sandra; Outeiro, Tiago Fleming. 2016. A levedura como modelo para estudar as bases moleculares da doença de Parkinson. A doença de Parkinson (DP) é uma doença neurodegenerativa sem cura, está associada ao envelhecimento e caracteriza-se pela acumulação de inclusões proteicas intraneuronais conhecidas como corpos de Lewy (CL) no cérebro. Os CL são inclusões maioritariamente compostas pela proteína alfa-sinucleína (aSyn), pensando-se estarem associados à neurodegeneração característica na DP. A aSyn está sujeita a v. http://seer.upf.br/index.php/rbceh/article/view/6006
Gonçalves, Susana A; Macedo, Diana; Raquel, Helena; Simões, Pedro D; Giorgini, Flaviano; Ramalho, José S; Barral, Duarte C; Ferreira Moita, Luís; Outeiro, Tiago Fleming. 2016. shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. Alpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson&#39;s disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and cell-to-cell trafficking of pathological forms of aSyn may explain the typical patterns of disease progression. However, the molecular mechanisms contro. http://hdl.handle.net/10400.7/591
Fonseca, Tomás Ribeiro da Silva Lopes da, 1987-. 2016. "The interplay between alpha-synuclein and ATP13A2 : towards the understanding of the molecular basis of Parkinson’s disease". Doutoramento. http://hdl.handle.net/10451/28900
Gonçalves, Susana; Outeiro, Tiago Fleming. 2016. A disfunção cognitiva nas doenças neurodegenerativas. As doenças neurodegenerativas são neuropatias que incluem as doenças de Parkinson (DP), de Alzheimer (DA) e de Hungtington, assim como a esclerose lateral amiotrófica e demências fronto-temporais. Podendo variar na sua patofisiologia, estas doenças estão associadas ao envelhecimento geral da população, e à presença comum de formas proteicas misfolded e agregadas no cérebro dos indivíduos afectados. http://seer.upf.br/index.php/rbceh/article/view/6007
Tenreiro, Sandra; Outeiro, Tiago Fleming. 2016. A levedura como modelo para estudar as bases moleculares da doença de Parkinson. A doença de Parkinson (DP) é uma doença neurodegenerativa sem cura, está associada ao envelhecimento e caracteriza-se pela acumulação de inclusões proteicas intraneuronais conhecidas como corpos de Lewy (CL) no cérebro. Os CL são inclusões maioritariamente compostas pela proteína alfa-sinucleína (aSyn), pensando-se estarem associados à neurodegeneração característica na DP. A aSyn está sujeita a v. http://seer.upf.br/index.php/rbceh/article/view/6006
Brás, Inês Filipa Caldeira. 2016. "Molecular insights into the role of alfa-synuclein phosphorylation in synucleinopathies". Mestrado. http://hdl.handle.net/10451/27689
Batalha, Vania L; Ferreira, Diana G; Coelho, Joana E.; Valadas, Jorge S; Gomes, Rui; Temido-Ferreira, Mariana; Shmidt, Tatiana; et al. 2016. The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A(2A) receptor (A(2A)R), which is upregulated in the human forebrain of aged and Alzheimer&#39;s disease (AD) patients. We have previously shown that an anti-A(2A)R therapy reverts age-like memory deficits, by reestablishment of the hypothalamic-pituitary-adrenal (HPA) axis feedback and corticos. https://doi.org/10.1038/srep31493
Dias, Ana Rita Abrantes. 2016. "The role of sirtuin 2 in oligodendroglia on dopaminergic neuron differentiation and regeneration". Mestrado. http://hdl.handle.net/10316/41275
Guerreiro, P.S.; Gerhardt, E.; Lopes da Fonseca, T.; Bähr, M.; Outeiro, T.F.; Eckermann, K.. 2016. "LRRK2 Promotes Tau Accumulation, Aggregation and Release". Molecular Neurobiology, 53 (5): 3124-3135. https://doi.org/10.1007/s12035-015-9209-z
Batalha, V.L.; Ferreira, D.G.; Coelho, J.E.; Valadas, J.S.; Gomes, R.; Temido-Ferreira, M.; Shmidt, T.; et al. 2016. "The caffeine-binding adenosine A 2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function". Scientific Reports, 6. https://doi.org/10.1038/srep31493
Vicente Miranda, H.; El-Agnaf, O.M.A.; Outeiro, T.F.. 2016. "Glycation in Parkinson's disease and Alzheimer's disease". Movement Disorders, 31 (6): 782-790. https://doi.org/10.1002/mds.26566
Pinho, R.; Guedes, L.C.; Soreq, L.; Lobo, P.P.; Mestre, T.; Coelho, M.; Rosa, M.M.; et al. 2016. "Gene expression differences in peripheral blood of Parkinson's disease patients with distinct progression profiles". PLoS ONE, 11 (6). https://doi.org/10.1371/journal.pone.0157852
Villar-Piqué, A.; Da Fonseca, T.L.; Sant&#39;Anna, R.; Szegö, E.M.; Fonseca-Ornelas, L.; Pinho, R.; Carija, A.; et al. 2016. "Environmental and genetic factors support the dissociation between a-synuclein aggregation and toxicity". Proceedings of the National Academy of Sciences of the United States of America, 113 (42): E6506-E6515. https://doi.org/10.1073/pnas.1606791113
Kleinknecht, A.; Popova, B.; Lázaro, D.F.; Pinho, R.; Valerius, O.; Outeiro, T.F.; Braus, G.H.. 2016. "C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of a-Synuclein in a Yeast Model of Parkinson's Disease". PLoS Genetics, 12 (6). https://doi.org/10.1371/journal.pgen.1006098
Lázaro, D.F.; Dias, M.C.; Carija, A.; Navarro, S.; Madaleno, C.S.; Tenreiro, S.; Ventura, S.; Outeiro, T.F.. 2016. "The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation". Acta neuropathologica communications, 4 (1): 128-128. https://doi.org/10.1186/s40478-016-0402-8
Villar-Piqué, A.; Lopes da Fonseca, T.; Outeiro, T.F.. 2016. "Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies". Journal of Neurochemistry, 139: 240-255. https://doi.org/10.1111/jnc.13249
Tenreiro, S.; Rosado-Ramos, R.; Gerhardt, E.; Favretto, F.; Magalhães, F.; Popova, B.; Becker, S.; et al. 2016. "Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity". Human Molecular Genetics, 25 (2): 275-290. https://doi.org/10.1093/hmg/ddv470
Letra-Vilela, R.; Sánchez-Sánchez, A.M.; Rocha, A.M.; Martin, V.; Branco-Santos, J.; Puente-Moncada, N.; Santa-Marta, M.; et al. 2016. "Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin". Molecular and Cellular Endocrinology, 434: 238-249. https://doi.org/10.1016/j.mce.2016.07.012
Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. 2016. "Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356". Autophagy, 12 (2): 443-443. https://doi.org/10.1080/15548627.2016.1147886
Fernandes, J.T.S.; Chutna, O.; Chu, V.; Conde, J.P.; Outeiro, T.F.. 2016. "A novel microfluidic cell co-culture platform for the study of the molecular mechanisms of Parkinson's disease and other synucleinopathies". Frontiers in Neuroscience, 10 (NOV). https://doi.org/10.3389/fnins.2016.00511
Vicente Miranda, H.; Gomes, M.A.; Branco-Santos, J.; Breda, C.; Lázaro, D.F.; Lopes, L.V.; Herrera, F.; Giorgini, F.; Outeiro, T.F.. 2016. "Glycation potentiates neurodegeneration in models of Huntington's disease". Scientific Reports, 6. https://doi.org/10.1038/srep36798
Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. 2016. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy, 12 (1): 1-222. https://doi.org/10.1080/15548627.2015.1100356
Pardo, J.; Uriarte, M.; Cónsole, G.M.; Reggiani, P.C.; Outeiro, T.F.; Morel, G.R.; Goya, R.G.. 2016. "Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats". European Journal of Neuroscience, 44 (4): 2120-2128. https://doi.org/10.1111/ejn.13278
Tatenhorst, L.; Eckermann, K.; Dambeck, V.; Fonseca-Ornelas, L.; Walle, H.; Lopes da Fonseca, T.; Koch, J.C.; et al. 2016. "Fasudil attenuates aggregation of a-synuclein in models of Parkinson's disease". Acta neuropathologica communications, 4: 39-39. https://doi.org/10.1186/s40478-016-0310-y
Fonseca, T.L.; Pinho, R.; Outeiro, T.F.. 2016. "A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death". Human Molecular Genetics, 25 (14): 2959-2971. https://doi.org/10.1093/hmg/ddw147
Oliveira, A.O.; Osmand, A.; Outeiro, T.F.; Muchowski, P.J.; Finkbeiner, S.. 2016. "aB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease". Human Molecular Genetics, 25 (9): 1677-1689. https://doi.org/10.1093/hmg/ddw028
Tenreiro, S.; Macedo, D.; Marijanovic, Z.; Outeiro, T.F.. 2016. "Analysis of protein oligomeric species by sucrose gradients". 331-339. Vol. 1449. https://doi.org/10.1007/978-1-4939-3756-1_21
Outeiro, T.F.. 2016. "Alpha-synuclein". 31-34. https://doi.org/10.1016/B978-0-12-809324-5.00471-5
Pinho, Raquel; Guedes, Leonor C.; Soreq, Lilach; Lobo, Patricia P.; Mestre, Tiago; Coelho, Miguel; Rosa, Mario M.; et al. 2016. "Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0157852
Lazaro, Diana F.; Dias, Mariana Castro; Carija, Anita; Navarro, Susanna; Madaleno, Carolina Silva; Tenreiro, Sandra; Ventura, Salvador; Outeiro, Tiago F.. 2016. "The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation". Acta Neuropathologica Communications. https://doi.org/10.1186/S40478-016-0402-8
Outeiro, Tiago Fleming; Miranda, Hugo V.. 2016. "GLYCATION POTENTIATES NEURODEGENERATION IN MODELS OF HUNTINGTON'S DISEASE". Journal of Neurology, Neurosurgery &amp; Psychiatry. https://doi.org/10.1136/JNNP-2016-314597.38
Letra-Vilela, Ricardo; Maria Sanchez-Sanchez, Ana; Rocha, Ana Maia; Martin, Vanesa; Branco-Santos, Joana; Puente-Moncada, Noelia; Santa-Marta, Mariana; et al. 2016. "Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin". Molecular and Cellular Endocrinology. https://doi.org/10.1016/J.MCE.2016.07.012
Villar-Pique, Anna; da Fonseca, Tomas Lopes; Sant&#39;Anna, Ricardo; Szegoe, Eva Monika; Fonseca-Ornelas, Luis; Pinho, Raquel; Carija, Anita; et al. 2016. "Environmental and genetic factors support the dissociation between alpha-synuclein aggregation and toxicity". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.1606791113
Batalha, Vania L.; Ferreira, Diana G.; Coelho, Joana E.; Valadas, Jorge S.; Gomes, Rui; Temido-Ferreira, Mariana; Shmidt, Tatiana; et al. 2016. "The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function". Scientific Reports. https://doi.org/10.1038/SREP31493
Outeiro, Tiago. 2016. "Glycation potentiates neurodegeneration in models of Huntington’s disease". Scientific Reports. https://doi.org/10.1038/SREP36798
João T. S. Fernandes; Oldriska Chutna; Virginia Chu; João P. Conde; Tiago F. Outeiro. 2016. "A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies". Frontiers in Neuroscience. https://doi.org/10.3389/FNINS.2016.00511
da Fonseca, Tomas Lopes; Pinho, Raquel; Outeiro, Tiago F.. 2016. "A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDW147
Outeiro, Tiago. 2016. "Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats". European Journal of Neuroscience. https://doi.org/10.1111/EJN.13278
Villar-Pique, Anna; da Fonseca, Tomas Lopes; Outeiro, Tiago Fleming. 2016. "Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies". Journal of Neurochemistry. https://doi.org/10.1111/JNC.13249
Outeiro, Tiago. 2016. "ROCK Inhibition by Fasudil as Disease-Modifying Translational Approach in the Treatment of Parkinson's Disease and Amyotrophic Lateral Sclerosis". Neurology. https://publons.com/publon/9713512/
Guerreiro, Patricia Silva; Gerhardt, Ellen; da Fonseca, Tomas Lopes; Baehr, Mathias; Outeiro, Tiago Fleming; Eckermann, Katrin. 2016. "LRRK2 Promotes Tau Accumulation, Aggregation and Release". Molecular Neurobiology. https://doi.org/10.1007/S12035-015-9209-Z
Outeiro, Tiago. 2016. "C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of a-Synuclein in a Yeast Model of Parkinson's Disease". PLOS Genetics. https://doi.org/10.1371/JOURNAL.PGEN.1006098
Outeiro, Tiago. 2016. "aB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDW028
Outeiro, Tiago. 2016. "Glycation in Parkinson's disease and Alzheimer's disease". Movement Disorders. https://doi.org/10.1002/MDS.26566
Outeiro, Tiago. 2016. "Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDV470
Goncalves, Susana A.; Macedo, Diana; Raquel, Helena; Simoes, Pedro D.; Giorgini, Flaviano; Ramalho, Jose S.; Barral, Duarte C.; Moita, Luis Ferreira; Outeiro, Tiago Fleming. 2016. "shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity". PLOS Genetics. https://doi.org/10.1371/JOURNAL.PGEN.1005995
Tatenhorst, Lars; Eckermann, Katrin; Dambeck, Vivian; Fonseca-Ornelas, Luis; Walle, Hagen; da Fonseca, Tomas Lopes; Koch, Jan C.; et al. 2016. "Fasudil attenuates aggregation of alpha-synuclein in models of Parkinson's disease". Acta Neuropathologica Communications. https://doi.org/10.1186/S40478-016-0310-Y
Guerreiro, Patricia I. da Silva. 2015. "The role of LRRK2 in Parkinson’s disease : from function to dysfunction". Doutoramento. http://hdl.handle.net/10451/22717
da Fonseca, T.L.; Villar-Piqué, A.; Outeiro, T.F.. 2015. "The interplay between alpha-synuclein clearance and spreading". Biomolecules, 5 (2): 435-471. https://doi.org/10.3390/biom5020435
Gomes, P.; Fleming Outeiro, T.; Cavadas, C.. 2015. "Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism". Trends in Pharmacological Sciences, 36 (11): 756-768. https://doi.org/10.1016/j.tips.2015.08.001
Nunes, P.; Morais, G.R.; Palma, E.; Silva, F.; Oliveira, M.C.; Ferreira, V.F.C.; Mendes, F.; et al. 2015. "Isostructural Re(i)/<sup>99m</sup>Tc(i) tricarbonyl complexes for cancer theranostics". Organic and Biomolecular Chemistry, 13 (18): 5182-5194. https://doi.org/10.1039/c5ob00124b
Macedo, D.; Tavares, L.; McDougall, G.J.; Vicente Miranda, H.; Stewart, D.; Ferreira, R.B.; Tenreiro, S.; Outeiro, T.F.; Santos, C.N.. 2015. "(Poly)phenols protect from a-synuclein toxicity by reducing oxidative stress and promoting autophagy". Human Molecular Genetics, 24 (6): 1717-1732. https://doi.org/10.1093/hmg/ddu585
Breda, C.; Nugent, M.L.; Estranero, J.G.; Kyriacou, C.P.; Outeiro, T.F.; Steinert, J.R.; Giorgini, F.. 2015. "Rab11 modulates a-synuclein-mediated defects in synaptic transmission and behaviour". Human Molecular Genetics, 24 (4): 1077-1091. https://doi.org/10.1093/hmg/ddu521
Chen, X.; Wales, P.; Quinti, L.; Zuo, F.; Moniot, S.; Herisson, F.; Rauf, N.A.; et al. 2015. "The sirtuin-2 inhibitor AK7 is neuroprotective in models of parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia". PLoS ONE, 10 (1). https://doi.org/10.1371/journal.pone.0116919
Blum, D.; Herrera, F.; Francelle, L.; Mendes, T.; Basquin, M.; Obriot, H.; Demeyer, D.; et al. 2015. "Mutant huntingtin alters Tau phosphorylation and subcellular distribution". Human Molecular Genetics, 24 (1): 76-85. https://doi.org/10.1093/hmg/ddu421
Krey, L.; Lühder, F.; Kusch, K.; Czech-Zechmeister, B.; Könnecke, B.; Outeiro, T.F.; Trendelenburg, G.. 2015. "Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice". Journal of Cerebral Blood Flow and Metabolism, 35 (12): 2080-2088. https://doi.org/10.1038/jcbfm.2015.178
Ducic, T.; Carboni, E.; Lai, B.; Chen, S.; Michalke, B.; Lázaro, D.F.; Outeiro, T.F.; et al. 2015. "Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium". ACS Chemical Neuroscience, 6 (10): 1769-1779. https://doi.org/10.1021/acschemneuro.5b00093
Oliveira, L.M.A.; Falomir-Lockhart, L.J.; Botelho, M.G.; Lin, K.-H.; Wales, P.; Koch, J.C.; Gerhardt, E.; et al. 2015. "Elevated a-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells". Cell Death and Disease, 6 (11). https://doi.org/10.1038/cddis.2015.318
Mbefo, M.K.; Fares, M.-B.; Paleologou, K.; Oueslati, A.; Yin, G.; Tenreiro, S.; Pinto, M.; et al. 2015. "Parkinson disease mutant E46K enhances a-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo". Journal of Biological Chemistry, 290 (15): 9412-9427. https://doi.org/10.1074/jbc.M114.610774
Moree, B.; Yin, G.; Lázaro, D.F.; Munari, F.; Strohäker, T.; Giller, K.; Becker, S.; et al. 2015. "Small molecules detected by second-harmonic generation modulate the conformation of monomeric a-synuclein and reduce its aggregation in cells". Journal of Biological Chemistry, 290 (46): 27582-27593. https://doi.org/10.1074/jbc.M114.636027
Amen, T.; Lázaro, D.F.; Outeiro, T.F.; Kaganovich, D.. 2015. "Modeling Neuronal Pathology in Yeast: Insights into the Molecular Basis of Parkinson's Disease". Israel Journal of Chemistry, 55 (11-12): 1252-1259. https://doi.org/10.1002/ijch.201500071
Vreja, I.C.; Nikic, I.; Göttfert, F.; Bates, M.; Kröhnert, K.; Outeiro, T.F.; Hell, S.W.; Lemke, E.A.; Rizzoli, S.O.. 2015. "Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies". ACS Nano, 9 (11): 11034-11041. https://doi.org/10.1021/acsnano.5b04434
Menezes, R.; Tenreiro, S.; Macedo, D.; Santos, C.N.; Outeiro, T.F.. 2015. "From the baker to the bedside: Yeast models of parkinson's disease". Microbial Cell, 2 (8): 262-279. https://doi.org/10.15698/mic2015.08.219
Ducic, Tanja; Carboni, Eleonora; Lai, Barry; Chen, Si; Michalke, Bernhard; Lazaro, Diana F.; Outeiro, Tiago F.; et al. 2015. "Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium". ACS Chemical Neuroscience. https://doi.org/10.1021/ACSCHEMNEURO.5B00093
Menezes, Regina; Tenreiro, Sandra; Macedo, Diana; Santos, Claudia N.; Outeiro, Tiago Fleming. 2015. "From the baker to the bedside: yeast models of Parkinson's disease". Microbial Cell. https://doi.org/10.15698/MIC2015.08.219
Outeiro, Tiago. 2015. "Modeling Neuronal Pathology in Yeast: Insights into the Molecular Basis of Parkinson's Disease". Israel Journal of Chemistry. https://doi.org/10.1002/IJCH.201500071
Nunes, Patrique; Morais, Goreti Ribeiro; Palma, Elisa; Silva, Francisco; Oliveira, Maria Cristina; Ferreira, Vera F. C.; Mendes, Filipa; et al. 2015. "Isostructural Re(I)/Tc-99m(I) tricarbonyl complexes for cancer theranostics". Organic &amp; Biomolecular Chemistry. https://doi.org/10.1039/C5OB00124B
Pocas, Goncalo M.; Branco-Santos, Joana; Herrera, Federico; Outeiro, Tiago Fleming; Domingos, Pedro M.. 2015. "alpha-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDU606
Breda, Carlo; Nugent, Marie L.; Estranero, Jasper G.; Kyriacou, Charalambos P.; Outeiro, Tiago F.; Steinert, Joern R.; Giorgini, Flaviano. 2015. "Rab11 modulates alpha-synuclein-mediated defects in synaptic transmission and behaviour". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDU521
Mbefo, Martial Kamdem; Fares, Mohamed-Bilal; Paleologou, Katerina; Oueslati, Abid; Yin, Guowei; Tenreiro, Sandra; Pinto, Madalena; et al. 2015. "Parkinson Disease Mutant E46K Enhances alpha-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in Vivo". Journal of Biological Chemistry. https://doi.org/10.1074/JBC.M114.610774
Vreja, Ingrid C.; Nikic, Ivana; Goettfert, Fabian; Bates, Mark; Kroehnert, Katharina; Outeiro, Tiago F.; Hell, Stefan W.; Lemke, Edward A.; Rizzoli, Silvio O.. 2015. "Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies". ACS Nano. https://doi.org/10.1021/ACSNANO.5B04434
Outeiro, Tiago. 2015. "The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0116919
da Fonseca, Tomas Lopes; Villar-Pique, Anna; Outeiro, Tiago Fleming. 2015. "The Interplay between Alpha-Synuclein Clearance and Spreading". Biomolecules. https://doi.org/10.3390/BIOM5020435
Outeiro, Tiago. 2015. "Mutant huntingtin alters Tau phosphorylation and subcellular distribution". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDU421
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Outeiro, Tiago. 2013. "Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy". Molecular Neurobiology. https://doi.org/10.1007/S12035-013-8406-X
Outeiro, Tiago. 2013. "Structural basis of kynurenine 3-monooxygenase inhibition". Nature. https://doi.org/10.1038/NATURE12039
Stefan Schildknecht; Hanne R. Gerding; Christiaan Karreman; Malte Drescher; Hilal A. Lashuel; Tiago F. Outeiro; Donato A. Di Monte; Marcel Leist. 2013. "Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies". Journal of Neurochemistry. https://doi.org/10.1111/JNC.12226
Herrera, F.; Gonalves, S.; Outeiro, T.F.. 2012. "Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation". Methods in Enzymology, 506: 157-174. https://doi.org/10.1016/B978-0-12-391856-7.00033-0
Herrera, F.; Outeiro, T.F.. 2012. "a-Synuclein modifies huntingtin aggregation in living cells". FEBS Letters, 586 (1): 7-12. https://doi.org/10.1016/j.febslet.2011.11.019
Kemppainen, S.; Rantamäki, T.; Jerónimo-Santos, A.; Lavasseur, G.; Autio, H.; Karpova, N.; Kärkkäinen, E.; et al. 2012. "Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice". Neurobiology of Aging, 33 (6). https://doi.org/10.1016/j.neurobiolaging.2011.11.006
Sancenon, V.; Lee, S.-A.; Patrick, C.; Griffith, J.; Paulino, A.; Outeiro, T.F.; Reggiori, F.; Masliah, E.; Muchowski, P.J.. 2012. "Suppression of a-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context". Human Molecular Genetics, 21 (11): 2432-2449. https://doi.org/10.1093/hmg/dds058
Gonçalves, S.; Miranda, H.V.; Outeiro, T.F.. 2012. "Novel Molecular Therapeutics in Parkinson's Disease". Molecular and Cellular Therapeutics, 245-265. https://doi.org/10.1002/9781119967309.ch11
Rosa, P.; Tenreiro, S.; Chu, V.; Outeiro, T.F.; Conde, J.P.. 2012. "High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment". Biomicrofluidics, 6 (1). https://doi.org/10.1063/1.3683161
Diógenes, M.J.; Dias, R.B.; Rombo, D.M.; Miranda, H.V.; Maiolino, F.; Guerreiro, P.; Näsström, T.; et al. 2012. "Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation". Journal of Neuroscience, 32 (34): 11750-11762. https://doi.org/10.1523/JNEUROSCI.0234-12.2012
Petroi, D.; Popova, B.; Taheri-Talesh, N.; Irniger, S.; Shahpasandzadeh, H.; Zweckstetters, M.; Outeiro, T.F.; Braus, G.H.. 2012. "Aggregate clearance of a-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome". Journal of Biological Chemistry, 287 (33): 27567-27579. https://doi.org/10.1074/jbc.M112.361865
Marques, O.; Outeiro, T.F.. 2012. "Alpha-synuclein: From secretion to dysfunction and death". Cell Death and Disease, 3 (7). https://doi.org/10.1038/cddis.2012.94
Maxwell, M.M.; Zaldivar-Jolissaint, J.F.; Mai, A.; Outeiro, T.F.; Kazanstev, A.G.. 2012. "Highlights of the Keystone Symposium: Sirtuins in metabolism, aging and disease". EMBO Molecular Medicine, 4 (7): 557-560. https://doi.org/10.1002/emmm.201201452
Sampaio-Marques, B.; Felgueiras, C.; Silva, A.; Rodrigues, M.; Tenreiro, S.; Franssens, V.; Reichert, A.S.; et al. 2012. "SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy". Autophagy, 8 (10): 1494-1509. https://doi.org/10.4161/auto.21275
Marques, S.C.F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonça, A.; Santana, I.; Outeiro, T.F.; Pereira, C.M.F.. 2012. "Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice". Neuroscience, 220: 256-266. https://doi.org/10.1016/j.neuroscience.2012.06.029
de Oliveira, R.M.; Sarkander, J.; Kazantsev, A.G.; Outeiro, T.F.. 2012. "SIRT2 as a therapeutic target for age-related disorders". Frontiers in Pharmacology, 3 MAY. https://doi.org/10.3389/fphar.2012.00082
Kazantsev, A.G.; Outeiro, T.F.. 2012. "Editorial on special topic: Sirtuins in metabolism, aging, and disease". Frontiers in Pharmacology, 3 APR. https://doi.org/10.3389/fphar.2012.00071
Marques, Belém Sampaio; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Márcio; Tenreiro, Sandra; Franssens, Vanessa; Reichert, Andreas S.; et al. 2012. SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. SNCA (a-synuclein) misfolding and aggregation is strongly associated with both idiopathic and familial forms of Parkinson disease (PD). Evidence suggests that SNCA has an impact on cell clearance routes and protein quality control systems such as the ubiquitin-proteasome system (UPS) and autophagy. Recent advances in the key role of the autosomal recessive PARK2/PARKIN and PINK1 genes in mitophagy. https://doi.org/10.4161/auto.21275
Diógenes, Maria José; Dias, Raquel B.; Rombo, Diogo M.; Miranda, Hugo Vicente; Maiolino, Francesca; Guerreiro, Patrícia; Näsström, Thomas; et al. 2012. Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation. Parkinson’s disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of -synuclein (a-syn) in various brain regions is themajorpathological hallmark. Indeed, themotorsymptomsinPDare causedby a heterogeneous degeneration of brain neurons not only in substantia nigra pars compacta but also in other extrastriatal areas of t. https://doi.org/10.1523/¿JNEUROSCI.0234-12.2012
Igrejas Peres, Aitor Tiago; Tobio Espinho, Paulo; Fernandes Outeiro, Paula; Malvar Fernandes, Paulo. 2012. Galiza, esse lugar da Europa. Paper presented on the 6th International Anthropology Students Conference held at University Fernando Pessoa in 1998. Ponencia presentada en el 6º Congreso Internacional de Estudiantes de Antropología realizado en la Universidad Fernando Pessoa en 1998. Document présenté lors de le 6ème  Congrès International des Étudiants d&#39;Anthropologie réalisé à l&#39;Université Fernando Pessoa en 1998. Comunicação. https://revistas.rcaap.pt/antropologicas/article/view/1052
Rodrigues, Eva Sofia Ferreira. 2012. "Comparative study of the effect of selected mutations on alpha-synuclein oligomerization in living cells using bimolecular fluorescence complementation (BiFC) assay". Mestrado. http://hdl.handle.net/10316/25140
Lázaro, Diana Fernandes. 2012. "Systematic comparison of the effects of a-synuclein mutations on aggregation in Parkinson’s Diseases". Mestrado. http://hdl.handle.net/10451/7246
Santos, Joana Margarida Marques Branco dos, 1987-. 2012. "The role of N-terminal phosphorylation on Huntingtin oligomerization, aggregation and toxicity". Mestrado. http://hdl.handle.net/10451/7554
Gonçalves, S.; Miranda, H.V.; Outeiro, T.F.. 2012. "Novel Molecular Therapeutics in Parkinson's Disease". 245-265. https://doi.org/10.1002/9781119967309.ch11
Maxwell, Michele M.; Zaldivar-Jolissaint, Julien Francisco; Mai, Antonello; Outeiro, Tiago F.; Kazanstev, Aleksey G.. 2012. "Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease". EMBO Molecular Medicine. https://doi.org/10.1002/EMMM.201201452
Outeiro, Tiago. 2012. "Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice". Neurobiology of Aging. https://doi.org/10.1016/J.NEUROBIOLAGING.2011.11.006
Outeiro, Tiago. 2012. "Suppression of -synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context". Human Molecular Genetics. https://doi.org/10.1093/HMG/DDS058
Outeiro, Tiago. 2012. "Insulin resistance is associated with reduced levels of the age-related protein SIRT2". The FASEB Journal. https://publons.com/publon/9713525/
Outeiro, Tiago. 2012. "B10 The role of n-terminal phosphorylation in huntingtin's oligomerisation, aggregation and toxicity". Journal of Neurology, Neurosurgery &amp; Psychiatry. https://doi.org/10.1136/JNNP-2012-303524.26
Outeiro, Tiago. 2012. "SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy". Autophagy. https://doi.org/10.4161/AUTO.21275
Outeiro, Tiago. 2012. "Editorial on Special Topic: Sirtuins in Metabolism, Aging, and Disease". Frontiers in Pharmacology. https://doi.org/10.3389/FPHAR.2012.00071
Outeiro, Tiago. 2012. "Alpha-synuclein: from secretion to dysfunction and death". Cell Death and Disease. https://doi.org/10.1038/CDDIS.2012.94
Marques, S. C. F.; Lemos, R.; Ferreiro, E.; Martins, M.; de Mendonca, A.; Santana, I.; Outeiro, T. F.; Pereira, C. M. F.. 2012. "EPIGENETIC REGULATION OF BACE1 IN ALZHEIMER'S DISEASE PATIENTS AND IN TRANSGENIC MICE". Neuroscience. https://doi.org/10.1016/J.NEUROSCIENCE.2012.06.029
Outeiro, Tiago. 2012. "Aggregate Clearance of alpha-Synuclein in Saccharomyces cerevisiae Depends More on Autophagosome and Vacuole Function Than on the Proteasome". Journal of Biological Chemistry. https://doi.org/10.1074/JBC.M112.361865
Outeiro, Tiago. 2012. "SIRT2 as a Therapeutic Target for Age-Related Disorders". Frontiers in Pharmacology. https://doi.org/10.3389/FPHAR.2012.00082
Outeiro, Tiago. 2012. "alpha-Synuclein modifies huntingtin aggregation in living cells". FEBS Letters. https://doi.org/10.1016/J.FEBSLET.2011.11.019
Maxwell, Michele M.; Zaldivar-Jolissaint, Julien Francisco; Mai, Antonello; Outeiro, Tiago F.; Kazantsev, Aleksey G.. 2012. "Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease. (vol 4, pg 557, 2012)". EMBO Molecular Medicine. https://doi.org/10.1002/EMMM.201290007
Tauber, E.; Miller-Fleming, L.; Mason, R.P.; Kwan, W.; Clapp, J.; Butler, N.J.; Outeiro, T.F.; Muchowski, P.J.; Giorgini, F.. 2011. "Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity". Journal of Biological Chemistry, 286 (1): 410-419. https://doi.org/10.1074/jbc.M110.101527
Jorge, C.D.; Ventura, R.; Maycock, C.; Outeiro, T.F.; Santos, H.; Costa, J.. 2011. "Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases". Neurochemical Research, 36 (6): 1005-1011. https://doi.org/10.1007/s11064-011-0440-3
Marques, S.C.F.; Pereira, C.M.F.; Outeiro, T.F.. 2011. "Epigenetics and neurodegeneration: Unveiling the complexity". Bio Tech International, 23 (JUNE): 16-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960753413&amp;partnerID=MN8TOARS
Marques, S.C.F.; Oliveira, C.R.; Pereira, C.M.F.; Outeiro, T.F.. 2011. "Epigenetics in neurodegeneration: A new layer of complexity". Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35 (2): 348-355. https://doi.org/10.1016/j.pnpbp.2010.08.008
Hansen, C.; Angot, E.; Bergström, A.-L.; Steiner, J.A.; Pieri, L.; Paul, G.; Outeiro, T.F.; et al. 2011. "a-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells". Journal of Clinical Investigation, 121 (2): 715-725. https://doi.org/10.1172/JCI43366
Martins, M.; Rosa, A.; Guedes, L.C.; Fonseca, B.V.; Gotovac, K.; Violante, S.; Mestre, T.; et al. 2011. "Convergence of mirna expression profiling, a-synuclein interacton and GWAS in Parkinson's disease". PLoS ONE, 6 (10). https://doi.org/10.1371/journal.pone.0025443
Swinnen, E.; Büttner, S.; Outeiro, T.F.; Galas, M.-C.; Madeo, F.; Winderickx, J.; Franssens, V.. 2011. "Aggresome formation and segregation of inclusions influence toxicity of a-synuclein and synphilin-1 in yeast". Biochemical Society Transactions, 39 (5): 1476-1481. https://doi.org/10.1042/BST0391476
Outeiro, T.F.. 2011. "Amyloidogenesis: FlAsH illuminates Aß aggregation". Nature Chemical Biology, 7 (9): 581-582. https://doi.org/10.1038/nchembio.636
de Oliveira, R.M.; Marijanovic, Z.; Carvalho, F.; Miltényi, G.M.; Matos, J.E.; Tenreiro, S.; Oliveira, S.; et al. 2011. "Impaired proteostasis contributes to renal tubular dysgenesis". PLoS ONE, 6 (6). https://doi.org/10.1371/journal.pone.0020854
Herrera, F.; Tenreiro, S.; Miller-Fleming, L.; Outeiro, T.F.. 2011. "Visualization of cell-to-cell transmission of mutant huntingtin oligomers". PLoS Currents. https://doi.org/10.1371/currents.RRN1210
Szego, E.M.; Gerhardt, E.; Outeiro, T.F.; Kermer, P.. 2011. "Dopamine-depletion and increased a-synuclein load induce degeneration of cortical cholinergic fibers in mice". Journal of the Neurological Sciences, 310 (1-2): 90-95. https://doi.org/10.1016/j.jns.2011.06.048
Näsström, T.; Gonçalves, S.; Sahlin, C.; Nordström, E.; Sundquist, V.S.; Lannfelt, L.; Bergström, J.; Outeiro, T.F.; Ingelsson, M.. 2011. "Antibodies against alpha-synuclein reduce oligomerization in living cells". PLoS ONE, 6 (10). https://doi.org/10.1371/journal.pone.0027230
Badiola, N.; de Oliveira, R.M.; Herrera, F.; Guardia-Laguarta, C.; Gonçalves, S.A.; Pera, M.; Suárez-Calvet, M.; et al. 2011. "Tau enhances a-synuclein aggregation and toxicity in cellular models of synucleinopathy". PLoS ONE, 6 (10). https://doi.org/10.1371/journal.pone.0026609
Marques S; Batalha VL; Lopes LV; Outeiro TF. 2011. "Modulating Alzheimer's disease through caffeine: a putative link to epigenetics.". https://doi.org/10.3233/JAD-2011-110032
Gerhardt, E.; Gräber, S.; Szego, E.M.; Moisoi, N.; Martins, L.M.; Outeiro, T.F.; Kermer, P.. 2011. "Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice". PLoS ONE, 6 (12). https://doi.org/10.1371/journal.pone.0028855
Ribeiro Morais, G.; Vicente Miranda, H.; Santos, I.C.; Santos, I.; Outeiro, T.F.; Paulo, A.. 2011. "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes". Bioorganic and Medicinal Chemistry, 19 (24): 7698-7710. https://doi.org/10.1016/j.bmc.2011.09.065
Marques, Sueli Cristina Ferreira. 2011. "Chromatin remodeling in Alzheimer's disease pathogenesis". Doutoramento. http://hdl.handle.net/10316/20157
Outeiro, T.F.; Lopes, L.V.. 2011. "Synaptic dysfunction in Parkinson's disease: From protein misfolding to functional alterations". 257-267. https://doi.org/10.1007/978-1-4419-7061-9-13
Marques, S.C.F.; Pereira, C.M.F.; Outeiro, T.F.. 2011. "Epigenetics and neurodegeneration: A connection overlooked". 241-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895241928&amp;partnerID=MN8TOARS
Outeiro, Tiago. 2011. "Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity". Journal of Biological Chemistry. https://doi.org/10.1074/JBC.M110.101527
Jorge, Carla D.; Ventura, Rita; Maycock, Christopher; Outeiro, Tiago F.; Santos, Helena; Costa, Julia. 2011. "Assessment of the Efficacy of Solutes from Extremophiles on Protein Aggregation in Cell Models of Huntington's and Parkinson's Diseases". Neurochemical Research. https://doi.org/10.1007/S11064-011-0440-3
Outeiro, Tiago. 2011. "Dopamine-depletion and increased a-synuclein load induce degeneration of cortical cholinergic fibers in mice". Journal of the Neurological Sciences. https://doi.org/10.1016/J.JNS.2011.06.048
Outeiro, Tiago. 2011. "Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0027230
Outeiro, Tiago. 2011. "FlAsH illuminates Aß aggregation". Nature Chemical Biology. https://doi.org/10.1038/NCHEMBIO.636
Outeiro, Tiago. 2011. "A stem-cell ageing hypothesis on the origin of Parkinson's disease". Journal of Neurology. https://publons.com/publon/9713539/
Outeiro, Tiago. 2011. "Impaired Proteostasis Contributes to Renal Tubular Dysgenesis". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0020854
Outeiro, Tiago. 2011. "Synaptic Dysfunction in Parkinson's Disease: From Protein Misfolding to Functional Alterations". Folding for the Synapse. https://doi.org/10.1007/978-1-4419-7061-9_13
Outeiro, Tiago. 2011. "SIRTUINS: A NOVEL LINK BETWEEN NEUROIFLAMMATION AND NEURODEGENERATION". Glia. https://publons.com/publon/9713537/
Correia Guedes, L.; Lobo, P.; Valadas, A.; Neutel, D.; Mestre, T.; Coelho, M.; Rosa, M. M.; et al. 2011. "Non-motor symptoms in Portuguese Parkinson's disease patients". Movement Disorders. https://publons.com/publon/9713535/
Outeiro, Tiago. 2011. "SIRT2 is downregulated in insulin-resistant HepG2 cells: a possible role of oxidative stress.". Molecular Biology of the Cell. https://publons.com/publon/9713554/
Ellen Gerhardt; Simone Gräber; Éva M. Szego; Nicoleta Moisoi; L. Miguel Martins; Tiago F. Outeiro; Pawel Kermer. 2011. "Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0028855
Morais, Goreti Ribeiro; Vicente Miranda, Hugo; Santos, Isabel C.; Santos, Isabel; Outeiro, Tiago F.; Paulo, Antonio. 2011. "Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes". Bioorganic &amp; Medicinal Chemistry. https://doi.org/10.1016/J.BMC.2011.09.065
Martins, Madalena; Rosa, Alexandra; Guedes, Leonor C.; Fonseca, Benedita V.; Gotovac, Kristina; Violante, Sara; Mestre, Tiago; et al. 2011. "Convergence of miRNA Expression Profiling, alpha-Synuclein Interacton and GWAS in Parkinson's Disease". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0025443
Marques, Sueli C. F.; Oliveira, Catarina R.; Pereira, Claudia M. F.; Outeiro, Tiago F.. 2011. "Epigenetics in neurodegeneration: A new layer of complexity". Progress in Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/J.PNPBP.2010.08.008
Badiola, Nahuai; de Oliveira, Rita Machado; Herrera, Federico; Guardia-Laguarta, Cristina; Goncalves, Susana A.; Pera, Marta; Suarez-Calvet, Marc; et al. 2011. "Tau Enhances alpha-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0026609
Kazantsev AG; Outeiro TF. 2010. "Drug discovery for CNS disorders: from bench to bedside.". https://doi.org/10.2174/187152710793237395
Diógenes MJ; Outeiro TF. 2010. "Neurotrophic factors as a protective strategy in Parkinson's disease.". https://doi.org/10.2174/187152710793237449
de Oliveira RM; Pais TF; Outeiro TF. 2010. "Sirtuins: common targets in aging and in neurodegeneration.". https://doi.org/10.2174/1389450111007011270
Tenreiro, S.; Outeiro, T.F.. 2010. "Simple is good: Yeast models of neurodegeneration". FEMS Yeast Research, 10 (8): 970-979. https://doi.org/10.1111/j.1567-1364.2010.00649.x
Kazantsev, A.G.; Outeiro, T.F.. 2010. "Drug discovery for cns disorders: From bench to bedside". CNS and Neurological Disorders - Drug Targets, 9 (6): 668-668. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649337104&amp;partnerID=MN8TOARS
Diógenes, M.J.; Outeiro, T.F.. 2010. "Neurotrophic factors as a protective strategy in Parkinson's disease". CNS and Neurological Disorders - Drug Targets, 9 (6): 754-763. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649251977&amp;partnerID=MN8TOARS
Marques, S.C.F.; Oliveira, C.R.; Outeiro, T.F.; Pereira, C.M.F.. 2010. "Alzheimer's disease: The quest to understand complexity". Journal of Alzheimer&#39;s Disease, 21 (2): 373-383. https://doi.org/10.3233/JAD-2010-100303
da Costa, G.; Guerreiro, A.; Correia, C.F.; Gomes, R.J.; Freire, A.; Monteiro, E.; Barroso, E.; et al. 2010. "A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS". Proteomics - Clinical Applications, 4 (6-7): 674-678. https://doi.org/10.1002/prca.200900118
Miranda, H.V.; Outeiro, T.F.. 2010. "The sour side of neurodegenerative disorders: The effects of protein glycation". Journal of Pathology, 221 (1): 13-25. https://doi.org/10.1002/path.2682
Su, L.J.; Auluck, P.K.; Outeiro, T.F.; Yeger-Lotem, E.; Kritzer, J.A.; Tardiff, D.F.; Strathearn, K.E.; et al. 2010. "Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models". DMM Disease Models and Mechanisms, 3 (3-4): 194-208. https://doi.org/10.1242/dmm.004267
Büttner, S.; Delay, C.; Franssens, V.; Bammens, T.; Ruli, D.; Zaunschirm, S.; de Oliveira, R.M.; et al. 2010. "Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a sir2-dependent manner". PLoS ONE, 5 (10). https://doi.org/10.1371/journal.pone.0013700
Gonçalves, S.A.; Matos, J.E.; Outeiro, T.F.. 2010. "Zooming into protein oligomerization in neurodegeneration using BiFC". Trends in Biochemical Sciences, 35 (11): 643-651. https://doi.org/10.1016/j.tibs.2010.05.007
Nakhjavani, M.; Morteza, A.; Khajeali, L.; Esteghamati, A.; Khalilzadeh, O.; Asgarani, F.; Outeiro, T.F.. 2010. "Increased serum HSP70 levels are associated with the duration of diabetes". Cell Stress and Chaperones, 15 (6): 959-964. https://doi.org/10.1007/s12192-010-0204-z
de Oliveira, R.M.; Pais, T.F.; Outeiro, T.F.. 2010. "Irtuins: Common targets in aging and in neurodegeneration". Current Drug Targets, 11 (10): 1270-1280. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958001297&amp;partnerID=MN8TOARS
Fonseca, Tomás Ribeiro da Silva Lopes da, 1987-. 2010. "Zebrafish : a new model of Parkinson's disease". Mestrado. http://hdl.handle.net/10451/2214
Büttne, Sabrina; Delay, Charlotte; Franssens, Vanessa; Bammens, Tine; Ruli, Doris; Zaunschirm, Sandra; Oliveira, Rita Machado de; et al. 2010. Synphilin-1 enhances a-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. Background: Parkinson’s disease is characterized by the presence of cytoplasmic inclusions, known as Lewy bodies, containing both aggregated a-synuclein and its interaction partner, synphilin-1. While synphilin-1 is known to accelerate inclusion formation by a-synuclein in mammalian cells, its effect on cytotoxicity remains elusive. Methodology/Principal Findings: We expressed wild-type synphilin-. https://doi.org/10.1371/journal.pone.0013700
Gonçalves, Susana A.; Matos, Joana E.; Outeiro, Tiago F.. 2010. Zooming into protein oligomerization in neurodegeneration using BiFC. Several neurodegenerative diseases are characterized by the accumulation of misfolded and aggregated proteins, which lead to neurotoxicity. However, the nature of those toxic species is controversial. Developments in optical microscopy and live-cell imaging are essential in providing crucial insight into the molecular mechanisms involved. In particular, the technique of bimolecular fluorescence co. https://doi.org/10.1016/j.tibs.2010.05.007
Costa, Gonçalo da; Guerreiro, Ana; Correia, Catarina F.; Gomes, Ricardo J.; Freire, António; Monteiro, Estela; Barroso, Eduardo; et al. 2010. A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS. Purpose: To identify, characterize and perform a relative quantification of human transthyretin (TTR) variants in human saliva. Experimental design: Serum and saliva samples were collected from healthy and familial amyloidotic polyneuropathy (FAP) patients, proteins separated by SDS-PAGE, TTR bands excised, in-gel digested and analyzed by MALDI-FTICR. Results: We identified and performed a relativ. https://doi.org/10.1002/prca.200900118
Nakhjavani, Manouchehr; Morteza, Afsaneh; Khajeali, Leila; Esteghamati, Alireza; Khalilzadeh, Omid; Asgarani, Firouzeh; Outeiro, Tiago F.. 2010. "Increased serum HSP70 levels are associated with the duration of diabetes". Cell Stress and Chaperones. https://doi.org/10.1007/S12192-010-0204-Z
Marques, Sueli C. F.; Pereira, Claudia M. F.; Outeiro, Tiago F.. 2010. "Epigenetics and Neurodegeneration: A Connection Overlooked". Epigenetics: Mechanism, Functions and Human Effects. https://publons.com/publon/12719845/
Outeiro, Tiago. 2010. "B07 Identification of protein interaction partners for kynurenine 3-monooxygenase, a candidate therapeutic target for Huntington's disease". Journal of Neurology, Neurosurgery &amp; Psychiatry. https://doi.org/10.1136/JNNP.2010.222596.7
Outeiro, Tiago. 2010. "The sour side of neurodegenerative disorders: the effects of protein glycation". The Journal of Pathology. https://doi.org/10.1002/PATH.2682
Outeiro, Tiago. 2010. "Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models". Disease Models &amp; Mechanisms. https://doi.org/10.1242/DMM.004267
Outeiro, Tiago. 2010. "A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS". Proteomics – Clinical Applications. https://doi.org/10.1002/PRCA.200900118
Outeiro, Tiago. 2010. "Simple is good: yeast models of neurodegeneration". FEMS Yeast Research. https://doi.org/10.1111/J.1567-1364.2010.00649.X
Outeiro, Tiago. 2010. "Zooming into protein oligomerization in neurodegeneration using BiFC". Trends in Biochemical Sciences. https://doi.org/10.1016/J.TIBS.2010.05.007
Outeiro, Tiago. 2010. "Neurotrophic factors as a protective strategy in Parkinson's disease". CNS and Neurological Disorders - Drug Targets. https://publons.com/publon/9713560/
Outeiro, Tiago. 2010. "Drug discovery for CNS disorders: from bench to bedside". CNS and Neurological Disorders - Drug Targets. https://publons.com/publon/9713556/
Buettner, Sabrina; Delay, Charlotte; Franssens, Vanessa; Bammens, Tine; Ruli, Doris; Zaunschirm, Sandra; de Oliveira, Rita Machado; et al. 2010. "Synphilin-1 Enhances alpha-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0013700
Outeiro, T.F.; Ferreira, J.. 2009. "Current and future therapeutic strategies for Parkinson's disease". Current Pharmaceutical Design, 15 (34): 3968-3976. https://doi.org/10.2174/138161209789649321
Da Costa, G.; Gomes, R.; Correia, C.F.; Freire, A.; Monteiro, E.; Martins, A.; Barroso, E.; et al. 2009. "Identification and quantitative analysis of human transthyretin variants in human serum by Fourier transform ion-cyclotron resonance mass spectrometry". Amyloid, 16 (4): 201-207. https://doi.org/10.3109/13506120903421561
Outeiro TF; Klucken J; Bercury K; Tetzlaff J; Putcha P; Oliveira LM; Quintas A; McLean PJ; Hyman BT. 2009. "Dopamine-induced conformational changes in alpha-synuclein.". https://doi.org/10.1371/journal.pone.0006906
Outeiro, Tiago. 2009. A biomedicina na prevenção, diagnóstico e terapia de doenças. A biomedicina assume um papel cada vez mais importante na prevenção, diagnóstico e terapia de inúmeras doenças que afectam a população mundial, contribuindo para uma significativa melhoria das condições de vida e um consequente aumento da longevidade. A caracterização molecular das populações no contexto do seu estado de saúde, e as novas disciplinas que surgem dos avanços tecnológicos, permitem-n. http://hdl.handle.net/10400.14/9872
Almeida, Bruno. 2009. "Elucidation of molecular pathways involved in Saccharomyces cerevisiae apoptotic cell death". Doutoramento. http://hdl.handle.net/1822/9511
Outeiro, Tiago Fleming. 2009. Biomedicina na prevenção, diagnóstico e terapia de doenças. Desde que o Homem povoou a Terra que procura compreender a origem da sua existência. No ano 2000, assinalou-se um marco notável na história da Biologia, mas também da Humanidade: foi apresentada a primeira versão do código da vida humana – a sequência de DNA que constitui o genoma humano. As cerca de 3x109 (3 mil milhões) de bases de DNA que constituem o genoma humano formam os cerca de 25 mil gen. http://hdl.handle.net/11144/1118
Outeiro, Tiago. 2009. "Dopamine-Induced Conformational Changes in Alpha-Synuclein". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0006906
Outeiro, Tiago. 2009. "Intracellular signaling - cellular models to investigate alpha-synuclein function and dysfunction". Journal of Neurochemistry. https://publons.com/publon/9713573/
Outeiro, T.F.. 2008. "From mad cows to neurotic yeast: Novel molecular approaches to understand neurodegeneration". Microscopy and Microanalysis, 14 (SUPPL. 3): 105-106. https://doi.org/10.1017/S143192760808954X
Tetzlaff, J.E.; Putcha, P.; Outeiro, T.F.; Ivanov, A.; Berezovska, O.; Hyman, B.T.; McLean, P.J.. 2008. "CHIP targets toxic a-synuclein oligomers for degradation". Journal of Biological Chemistry, 283 (26): 17962-17968. https://doi.org/10.1074/jbc.M802283200
Outeiro, T.F.; Marques, O.; Kazantsev, A.. 2008. "Therapeutic role of sirtuins in neurodegenerative disease". Biochimica et Biophysica Acta - Molecular Basis of Disease, 1782 (6): 363-369. https://doi.org/10.1016/j.bbadis.2008.02.010
Outeiro TF; Putcha P; Tetzlaff JE; Spoelgen R; Koker M; Carvalho F; Hyman BT; McLean PJ. 2008. "Correction: Formation of Toxic Oligomeric ?-Synuclein Species in Living Cells.". http://europepmc.org/abstract/PMC/PMC2556498
Mollenhauer, B.; Cullen, V.; Kahn, I.; Krastins, B.; Outeiro, T.F.; Pepivani, I.; Ng, J.; et al. 2008. "Direct quantification of CSF a-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration". Experimental Neurology, 213 (2): 315-325. https://doi.org/10.1016/j.expneurol.2008.06.004
Fleming, J.; Outeiro, T.F.; Slack, M.; Lindquist, S.L.; Bulawa, C.E.. 2008. "Detection of Compounds That Rescue Rab1-Synuclein Toxicity". Methods in Enzymology, 439: 339-351. https://doi.org/10.1016/S0076-6879(07)00425-9
Outeiro TF; Kazantsev A. 2008. "Drug Targeting of alpha-Synuclein Oligomerization in Synucleinopathies.". http://europepmc.org/abstract/med/19787096
Outeiro, T.F.; Kazantsev, A.. 2008. "Drug targeting of a-synuclein oligomerization in synucleinopathies". Perspectives in Medicinal Chemistry, 2008 (2): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953408910&amp;partnerID=MN8TOARS
Outeiro, T.F.; Putcha, P.; Tetzlaff, J.E.; Spoelgen, R.; Koker, M.; Carvalho, F.; Hyman, B.T.; McLean, P.J.. 2008. "Formation of toxic oligomeric a-synuclein species in living cells". PLoS ONE, 3 (4). https://doi.org/10.1371/journal.pone.0001867
Miller-Fleming, L.; Giorgini, F.; Outeiro, T.F.. 2008. "Yeast as a model for studying human neurodegenerative disorders". Biotechnology Journal, 3 (3): 325-338. https://doi.org/10.1002/biot.200700217
Marques, Oldriska. 2008. "SIRT2 as a putative target in parkinson's disease therapy". Mestrado. http://catalogo.ul.pt/F/?func=item-global&amp;doc_library=ULB01&amp;type=03&amp;doc_number=000583288
Miller-Fleming, L.; Giorgini, F.; Outeiro, T.F.. 2008. "Erratum: Yeast as a model for studying human neurodegenerative disorders (Biotechnology Journal (2008) vol. 3 (325-338))". Biotechnology Journal, 3 (3): 421-421. https://doi.org/10.1002/biot.421
Kazantsev, A. G.; Outeiro, T. F.; Amore, A. M.; Pallos, J.; Kontopoulos, E.; Atmann, S.; Kufareva, I.; et al. 2008. "Development small molecule inhibitors of deacetylasee sirtuin 2 for treatment aggregate-associated neurodegenerative diseases". Journal of Neurochemistry. https://publons.com/publon/9713450/
Outeiro, Tiago. 2008. "CHIP Targets Toxic a-Synuclein Oligomers for Degradation". Journal of Biological Chemistry. https://doi.org/10.1074/JBC.M802283200
Outeiro, Tiago. 2008. "Direct quantification of CSF a-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration". Experimental Neurology. https://doi.org/10.1016/J.EXPNEUROL.2008.06.004
Outeiro, Tiago Fleming; Putcha, Preeti; Tetzlaff, Julie E.; Spoelgen, Robert; Koker, Mirjam; Carvalho, Filipe; Hyman, Bradley T.; McLean, Pamela J.. 2008. "Formation of Toxic Oligomeric alpha-Synuclein Species in Living Cells". Plos One. https://doi.org/10.1371/JOURNAL.PONE.0001867
Outeiro, Tiago Fleming; Marques, Oldriska; Kazantsev, Aleksey. 2008. "Therapeutic role of sirtuins in neurodegenerative disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. https://doi.org/10.1016/J.BBADIS.2008.02.010
Tiago Outeiro. 2008. "Drug Targeting of a-Synuclein Oligomerization in Synucleinopathies". Perspectives in Medicinal Chemistry. https://publons.com/publon/9713570/
St Martin, J.L.; Klucken, J.; Outeiro, T.F.; Nguyen, P.; Keller-McGandy, C.; Cantuti-Castelvetri, I.; Grammatopoulos, T.N.; et al. 2007. "Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra". Journal of Neurochemistry, 100 (6): 1449-1457. https://doi.org/10.1111/j.1471-4159.2006.04310.x
Fleming Outeiro, T.; Tetzlaff, J.. 2007. "Mechanisms of Disease II: Cellular Protein Quality Control". Seminars in Pediatric Neurology, 14 (1): 15-25. https://doi.org/10.1016/j.spen.2006.11.005
Outeiro, T.F.; McLean, P.J.; Hyman, B.T.. 2007. "Protein aggregation disorders". Neurobiology of Disease, 111-123. https://doi.org/10.1016/B978-012088592-3/50012-8
Grammatopoulos, T.N.; Outeiro, T.F.; Hyman, B.T.; Standaert, D.G.. 2007. "Angiotensin II protects against a-synuclein toxicity and reduces protein aggregation in vitro". Biochemical and Biophysical Research Communications, 363 (3): 846-851. https://doi.org/10.1016/j.bbrc.2007.09.043
Outeiro, T.F.; Kontopoulos, E.; Altmann, S.M.; Kufareva, I.; Strathearn, K.E.; Amore, A.M.; Volk, C.B.; et al. 2007. "Sirtuin 2 inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson's disease". Science, 317 (5837): 516-519. https://doi.org/10.1126/science.1143780
Outeiro, T.F.; Grammatopoulos, T.N.; Altmann, S.; Amore, A.; Standaert, D.G.; Hyman, B.T.; Kazantsev, A.G.. 2007. "Pharmacological inhibition of PARP-1 reduces a-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models". Biochemical and Biophysical Research Communications, 357 (3): 596-602. https://doi.org/10.1016/j.bbrc.2007.03.163
Outeiro, T.F.; McLean, P.J.; Hyman, B.T.. 2007. "Protein aggregation disorders". 111-123. https://doi.org/10.1016/B978-012088592-3/50012-8
Outeiro, Tiago. 2007. "Pharmacological inhibition of PARP-1 reduces a-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease in vitro models". Biochemical and Biophysical Research Communications. https://doi.org/10.1016/J.BBRC.2007.03.163
Outeiro, Tiago. 2007. "Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra". Journal of Neurochemistry. https://doi.org/10.1111/J.1471-4159.2006.04310.X
Outeiro, Tiago. 2007. "Angiotensin II protects against a-synuclein toxicity and reduces protein aggregation in vitro". Biochemical and Biophysical Research Communications. https://doi.org/10.1016/J.BBRC.2007.09.043
Outeiro, Tiago Fleming; Kontopoulos, Eirene; Altmann, Stephen M.; Kufareva, Irina; Strathearn, Katherine E.; Amore, Allison M.; Volk, Catherine B.; et al. 2007. "Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease". Science. https://doi.org/10.1126/SCIENCE.1143780
Outeiro TF. 2006. "A bridge from Portugal to the States.". http://europepmc.org/abstract/med/17001768
Outeiro, T.F.. 2006. "A bridge from Portugal to the States.". Nature., 443 (7107). http://www.scopus.com/inward/record.url?eid=2-s2.0-33749364368&amp;partnerID=MN8TOARS
Bodner, R.A.; Outeiro, T.F.; Altmann, S.; Maxwell, M.M.; Cho, S.H.; Hyman, B.T.; McLean, P.J.; et al. 2006. "Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases". Proceedings of the National Academy of Sciences of the United States of America, 103 (11): 4246-4251. https://doi.org/10.1073/pnas.0511256103
Outeiro, T.F.; Giorgini, F.. 2006. "Yeast as a drug discovery platform in Huntington's and Parkinson's diseases". Biotechnology Journal, 1 (3): 258-269. https://doi.org/10.1002/biot.200500043
Outeiro, T.F.; Klucken, J.; Strathearn, K.E.; Liu, F.; Nguyen, P.; Rochet, J.-C.; Hyman, B.T.; McLean, P.J.. 2006. "Small heat shock proteins protect against a-synuclein-induced toxicity and aggregation". Biochemical and Biophysical Research Communications, 351 (3): 631-638. https://doi.org/10.1016/j.bbrc.2006.10.085
Klucken, J.; Outeiro, T.F.; Nguyen, P.; McLean, P.J.; Hyman, B.T.. 2006. "Detection of novel intracellular a-synuclein oligomeric species by fluorescence lifetime imaging". FASEB Journal, 20 (12): 2050-2057. https://doi.org/10.1096/fj.05-5422com
Bodner, RA; Outeiro, TF; Altmann, S; Maxwell, MM; Cho, SH; Hyman, BT; McLean, PJ; et al. 2006. "Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.0511256103
Outeiro, Tiago. 2006. "Small heat shock proteins protect against a-synuclein-induced toxicity and aggregation". Biochemical and Biophysical Research Communications. https://doi.org/10.1016/J.BBRC.2006.10.085
Outeiro, Tiago. 2006. "Detection of novel intracellular a-synuclein oligomeric species by fluorescence lifetime imaging". The FASEB Journal. https://doi.org/10.1096/FJ.05-5422COM
Lindquist, S.; Fraenkel, E.; Outeiro, T.; Gitler, A.; Su, J.; Cashikar, A.; Jagadish, S.. 2005. "Yeast cells as a discovery platform for neurodegenerative disease". Lecture Notes in Bioinformatics (Subseries of Lecture Notes in Computer Science), 3500. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444497156&amp;partnerID=MN8TOARS
Outeiro, Tiago. 2005. "Yeast cells as a discovery platform for neurodegenerative disease". Research in Computational Molecular Biology, Proceedings. https://doi.org/10.1007/11415770_8
Rochet JC; Outeiro TF; Conway KA; Ding TT; Volles MJ; Lashuel HA; Bieganski RM; Lindquist SL; Lansbury PT. 2004. "Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease.". https://doi.org/10.1385/JMN:23:1-2:023
Outeiro TF; Muchowski PJ. 2004. "Molecular genetics approaches in yeast to study amyloid diseases.". https://doi.org/10.1385/JMN:23:1-2:049
Derkatch, I.L.; Uptain, S.M.; Outeiro, T.F.; Krishnan, R.; Lindquist, S.L.; Liebman, S.W.. 2004. "Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro". Proceedings of the National Academy of Sciences of the United States of America, 101 (35): 12934-12939. https://doi.org/10.1073/pnas.0404968101
Outeiro, T.F.; Muchowski, P.J.. 2004. "Molecular genetics approaches in yeast to study amyloid diseases". Journal of Molecular Neuroscience, 23 (1-2): 49-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344669436&amp;partnerID=MN8TOARS
Rochet, J.-C.; Outeiro, T.F.; Conway, K.A.; Ding, T.T.; Volles, M.J.; Lashuel, H.A.; Bieganski, R.M.; Lindquist, S.L.; Lansbury Jr., P.J.. 2004. "Interactions among a-synuclein, dopamine, and biomembranes: Some clues for understanding neurodegeneration in Parkinson's disease". Journal of Molecular Neuroscience, 23 (1-2): 23-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344641972&amp;partnerID=MN8TOARS
Outeiro, Tiago Fleming de Oliveira. 2004. "Yeast as a model organism to study diseases of protein misfolding". Doutoramento. http://hdl.handle.net/10216/10638
Da Cruz E Silva, E.F.; Outeiro, T.F.; Da Cruz E Silva, O.A.B.. 2004. "Symposium on novel therapeutic opportunities for neurodegenerative disease". Journal of Molecular Neuroscience, 23 (1-2): 1-2. https://doi.org/10.1385/JMN:23:1-2:001
Outeiro, Tiago. 2004. "Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro". Proceedings of the National Academy of Sciences. https://doi.org/10.1073/PNAS.0404968101
Willingham, S.; Outeiro, T.F.; DeVit, M.J.; Lindquist, S.L.; Muchowski, P.J.. 2003. "Yeast Genes that Enhance the Toxicity of a Mutant Huntingtin Fragment or a-Synuclein". Science, 302 (5651): 1769-1772. https://doi.org/10.1126/science.1090389
Outeiro, T.F.; Lindquist, S.. 2003. "Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology". Science, 302 (5651): 1772-1775. https://doi.org/10.1126/science.1090439
Resende, C.G.; Outeiro, T.F.; Sands, L.; Lindquist, S.; Tuite, M.F.. 2003. "Prion protein gene polymorphisms in Saccharomyces cerevisiae". Molecular Microbiology, 49 (4): 1005-1017. https://doi.org/10.1046/j.1365-2958.2003.03608.x
Resende, CG; Outeiro, TF; Sands, L; Lindquist, S; Tuite, MF. 2003. "Prion protein gene polymorphisms in Saccharomyces cerevisiae". Molecular Microbiology. https://doi.org/10.1046/J.1365-2958.2003.03608.X
Outeiro, Tiago. 2003. "Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology". Science. https://doi.org/10.1126/SCIENCE.1090439
Outeiro, Tiago. 2003. "Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or -Synuclein". Science. https://doi.org/10.1126/SCIENCE.1090389
 

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